Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004351                                                              21     229
NP_001784                                                              17    4312
NP_001135817                                                           17    4312
NP_001135815                                                           17    4312
NP_001135816                                                           17    4312
NP_004063                                                              17    4312
NP_001264771                                                           16    5631
NP_001231                                                              16    5631
NP_775922                                                              16    5631
NP_490595                                                              16    5631
XP_006726617                                                           16    5631
XP_006720409                                                           16    5631
XP_005250117                                                           16    5631
XP_005263887                                                           16    5631
XP_006710039                                                           16    5631
NP_001232                                                              16    5631
NP_003583                                                              16    5631
NP_689730                                                              16    5631
NP_689488                                                              16    5631
NP_776183                                                              16    7355
XP_005246532                                                           16    7355
XP_006712507                                                           16    7355
XP_006712506                                                           16    7355
XP_006712505                                                           16    7355
XP_006712504                                                           16    7355
XP_005246531                                                           16    7355
NP_001015882                                                           16    7355
NP_001177957                                                           15    9605
NP_036602                                                              15    9605
NP_004955                                                              15    9605
NP_001518                                                              15    9605
NP_001032208                                                           15    9605
NP_004202                                                              15    9605
NP_009162                                                              15    9605
NP_055729                                                              15    9605
NP_054815                                                              15    9605
NP_001276109                                                           15    9605
NP_001276108                                                           15    9605
NP_001276106                                                           15    9605
NP_001265135                                                           15    9605
NP_001265130                                                           15    9605
NP_060081                                                              15    9605
NP_955361                                                              15    9605
XP_005259710                                                           15    9605
XP_006722978                                                           15    9605
XP_005253282                                                           15    9605
XP_006715974                                                           15    9605
XP_006712302                                                           15    9605
XP_006712301                                                           15    9605
XP_006712300                                                           15    9605
XP_005246116                                                           15    9605
XP_006712299                                                           15    9605
XP_005246115                                                           15    9605
XP_006712298                                                           15    9605
XP_006712297                                                           15    9605
NP_115271                                                              15    9605
NP_061749                                                              15    9605
NP_112186                                                              15    9605
NP_001276107                                                           15    9605
>NP_004351
          Length = 882

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TYNTAIAYT 9
           TYN AIAYT
Sbjct: 295 TYNAAIAYT 303
>NP_001784
          Length = 829

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TYNTAIAYT 9
           TYN  +AY+
Sbjct: 248 TYNGVVAYS 256
>NP_001135817
          Length = 373

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  YNTAIAY 8
          YNT+I+Y
Sbjct: 8  YNTSISY 14
>NP_001135815
          Length = 373

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  YNTAIAY 8
          YNT+I+Y
Sbjct: 8  YNTSISY 14
>NP_001135816
          Length = 373

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  YNTAIAY 8
          YNT+I+Y
Sbjct: 8  YNTSISY 14
>NP_004063
          Length = 371

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  YNTAIAY 8
          YNT+I+Y
Sbjct: 6  YNTSISY 12
>NP_001264771
          Length = 184

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  TYNTAIAY 8
          T NTAI Y
Sbjct: 58 TINTAIVY 65
>NP_001231
          Length = 726

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  TYNTAIAY 8
          T NTAI Y
Sbjct: 58 TINTAIVY 65
>NP_775922
          Length = 6996

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    YNTAIAYT 9
            YNT + YT
Sbjct: 4549 YNTLLPYT 4556
>NP_490595
          Length = 730

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  TYNTAIAY 8
          T NTAI Y
Sbjct: 57 TINTAIVY 64
>XP_006726617
          Length = 1688

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    YNTAIAYT 9
            YN A+ YT
Sbjct: 1311 YNRALCYT 1318
>XP_006720409
          Length = 1688

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    YNTAIAYT 9
            YN A+ YT
Sbjct: 1311 YNRALCYT 1318
>XP_005250117
          Length = 776

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   YNTAIAYT 9
           YNT  AYT
Sbjct: 614 YNTEDAYT 621
>XP_005263887
          Length = 709

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  TYNTAIAY 8
          T NTAI Y
Sbjct: 57 TINTAIVY 64
>XP_006710039
          Length = 1584

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    YNTAIAYT 9
            YN A+ YT
Sbjct: 1207 YNRALCYT 1214
>NP_001232
          Length = 663

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  TYNTAIAY 8
          T NTAI Y
Sbjct: 57 TINTAIVY 64
>NP_003583
          Length = 776

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   YNTAIAYT 9
           YNT  AYT
Sbjct: 614 YNTEDAYT 621
>NP_689730
          Length = 665

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TYNTAIAY 8
           +YN A+AY
Sbjct: 191 SYNLALAY 198
>NP_689488
          Length = 665

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TYNTAIAY 8
           +YN A+AY
Sbjct: 191 SYNLALAY 198
>NP_776183
          Length = 530

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   YNTAIAY 8
           YN+AI Y
Sbjct: 188 YNSAIVY 194
>XP_005246532
          Length = 504

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   YNTAIAY 8
           YN+AI Y
Sbjct: 106 YNSAIVY 112
>XP_006712507
          Length = 586

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   YNTAIAY 8
           YN+AI Y
Sbjct: 188 YNSAIVY 194
>XP_006712506
          Length = 586

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   YNTAIAY 8
           YN+AI Y
Sbjct: 188 YNSAIVY 194
>XP_006712505
          Length = 586

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   YNTAIAY 8
           YN+AI Y
Sbjct: 188 YNSAIVY 194
>XP_006712504
          Length = 586

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   YNTAIAY 8
           YN+AI Y
Sbjct: 188 YNSAIVY 194
>XP_005246531
          Length = 586

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   YNTAIAY 8
           YN+AI Y
Sbjct: 188 YNSAIVY 194
>NP_001015882
          Length = 360

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TYNTAIAY 8
           +YN AI+Y
Sbjct: 170 SYNKAISY 177
>NP_001177957
          Length = 859

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TYNTAIAYT 9
           T +TA+ YT
Sbjct: 472 TVHTAVRYT 480
>NP_036602
          Length = 923

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TYNTAIAYT 9
           T +TA+ YT
Sbjct: 472 TVHTAVRYT 480
>NP_004955
          Length = 482

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   TYNTAIA 7
           TY TA+A
Sbjct: 313 TYETAVA 319
>NP_001518
          Length = 488

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   TYNTAIA 7
           TY TA+A
Sbjct: 314 TYETAVA 320
>NP_001032208
          Length = 857

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NTAIAY 8
           NTA+AY
Sbjct: 803 NTALAY 808
>NP_004202
          Length = 797

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 2   YNTAIAYT 9
           YN  I YT
Sbjct: 287 YNVIICYT 294
>NP_009162
          Length = 642

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   YNTAIAYT 9
           YN  IAY+
Sbjct: 132 YNVIIAYS 139
>NP_055729
          Length = 804

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NTAIAY 8
           NTA+AY
Sbjct: 750 NTALAY 755
>NP_054815
          Length = 491

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   TYNTAIAYT 9
           TY  A A+T
Sbjct: 317 TYTNAFAFT 325
>NP_001276109
          Length = 479

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   YNTAIAY 8
           YNT ++Y
Sbjct: 178 YNTPVSY 184
>NP_001276108
          Length = 638

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   YNTAIAY 8
           YNT ++Y
Sbjct: 365 YNTPVSY 371
>NP_001276106
          Length = 666

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   YNTAIAY 8
           YNT ++Y
Sbjct: 365 YNTPVSY 371
>NP_001265135
          Length = 504

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   TYNTAIAYT 9
           TY  A A+T
Sbjct: 330 TYTNAFAFT 338
>NP_001265130
          Length = 491

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   TYNTAIAYT 9
           TY  A A+T
Sbjct: 317 TYTNAFAFT 325
>NP_060081
          Length = 491

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   TYNTAIAYT 9
           TY  A A+T
Sbjct: 317 TYTNAFAFT 325
>NP_955361
          Length = 491

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   TYNTAIAYT 9
           TY  A A+T
Sbjct: 317 TYTNAFAFT 325
>XP_005259710
          Length = 566

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   YNTAIAY 8
           YNT ++Y
Sbjct: 365 YNTPVSY 371
>XP_006722978
          Length = 651

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   YNTAIAY 8
           YNT ++Y
Sbjct: 365 YNTPVSY 371
>XP_005253282
          Length = 563

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 2  YNTAIAYT 9
          YN  I YT
Sbjct: 53 YNVIICYT 60
>XP_006715974
          Length = 875

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TYNTAIAYT 9
           T +TA+ YT
Sbjct: 424 TVHTAVRYT 432
>XP_006712302
          Length = 782

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NTAIAY 8
           NTA+AY
Sbjct: 728 NTALAY 733
>XP_006712301
          Length = 748

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NTAIAY 8
           NTA+AY
Sbjct: 694 NTALAY 699
>XP_006712300
          Length = 748

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NTAIAY 8
           NTA+AY
Sbjct: 694 NTALAY 699
>XP_005246116
          Length = 808

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NTAIAY 8
           NTA+AY
Sbjct: 754 NTALAY 759
>XP_006712299
          Length = 833

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NTAIAY 8
           NTA+AY
Sbjct: 779 NTALAY 784
>XP_005246115
          Length = 861

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NTAIAY 8
           NTA+AY
Sbjct: 807 NTALAY 812
>XP_006712298
          Length = 882

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NTAIAY 8
           NTA+AY
Sbjct: 828 NTALAY 833
>XP_006712297
          Length = 886

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NTAIAY 8
           NTA+AY
Sbjct: 832 NTALAY 837
>NP_115271
          Length = 820

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TYNTAIAYT 9
           +YN  IA+T
Sbjct: 751 SYNLCIAHT 759
>NP_061749
          Length = 930

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TYNTAIAYT 9
           +YN  IA+T
Sbjct: 751 SYNLCIAHT 759
>NP_112186
          Length = 666

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   YNTAIAY 8
           YNT ++Y
Sbjct: 365 YNTPVSY 371
>NP_001276107
          Length = 666

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   YNTAIAY 8
           YNT ++Y
Sbjct: 365 YNTPVSY 371
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.313    0.118    0.330 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 398,813
Number of extensions: 686
Number of successful extensions: 59
Number of sequences better than 10000.0: 59
Number of HSP's gapped: 59
Number of HSP's successfully gapped: 59
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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