Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_006197                                                              21     175
XP_006714104                                                           21     175
XP_005265800                                                           21     175
XP_006714103                                                           21     175
XP_006714102                                                           21     175
NP_056234                                                              18    1482
XP_005274542                                                           18    1482
NP_003647                                                              17    2528
XP_005265573                                                           17    2528
NP_009225                                                              17    3301
NP_009228                                                              17    3301
NP_009231                                                              17    3301
NP_001092906                                                           17    3301
NP_001271293                                                           17    3301
XP_006722099                                                           17    3301
XP_006722098                                                           17    3301
XP_006722097                                                           17    3301
XP_006722096                                                           17    3301
XP_006722095                                                           17    3301
XP_006722094                                                           17    3301
XP_006722093                                                           17    3301
XP_006722092                                                           17    3301
XP_005254346                                                           17    3301
XP_005254347                                                           17    3301
NP_006209                                                              16    5631
NP_003296                                                              16    5631
NP_001124170                                                           16    5631
NP_277045                                                              16    5631
NP_077309                                                              16    5631
XP_006722949                                                           16    5631
XP_006714359                                                           16    5631
XP_006714358                                                           16    5631
XP_006713721                                                           16    5631
NP_006411                                                              16    7355
NP_055160                                                              16    7355
NP_078841                                                              16    7355
XP_006723746                                                           16    7355
XP_005260309                                                           16    7355
XP_006714981                                                           16    7355
XP_005266039                                                           16    7355
XP_006714980                                                           16    7355
NP_003556                                                              15    9605
NP_001010938                                                           15    9605
NP_005772                                                              15    9605
NP_001103373                                                           15    9605
NP_116203                                                              15    9605
NP_005662                                                              15    9605
NP_001269128                                                           15    9605
NP_001269118                                                           15    9605
XP_005257532                                                           15    9605
XP_005257530                                                           15    9605
XP_005254026                                                           15    9605
XP_005254025                                                           15    9605
XP_006713531                                                           15    9605
XP_005269330                                                           15    9605
XP_005269329                                                           15    9605
XP_005269328                                                           15    9605
XP_005269327                                                           15    9605
XP_006713530                                                           15    9605
XP_006713529                                                           15    9605
XP_005269326                                                           15    9605
XP_006713528                                                           15    9605
XP_006713527                                                           15    9605
XP_005269325                                                           15    9605
XP_006713526                                                           15    9605
XP_006713525                                                           15    9605
XP_006713524                                                           15    9605
XP_006713523                                                           15    9605
>NP_006197
          Length = 1089

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TVAVRCLAK 9
           T+AVRCLAK
Sbjct: 496 TIAVRCLAK 504
>XP_006714104
          Length = 832

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TVAVRCLAK 9
           T+AVRCLAK
Sbjct: 521 TIAVRCLAK 529
>XP_005265800
          Length = 1089

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TVAVRCLAK 9
           T+AVRCLAK
Sbjct: 496 TIAVRCLAK 504
>XP_006714103
          Length = 1111

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TVAVRCLAK 9
           T+AVRCLAK
Sbjct: 518 TIAVRCLAK 526
>XP_006714102
          Length = 1114

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TVAVRCLAK 9
           T+AVRCLAK
Sbjct: 521 TIAVRCLAK 529
>NP_056234
          Length = 2828

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    TVAVRCLAK 9
            T+A+ CLAK
Sbjct: 1967 TIAMECLAK 1975
>XP_005274542
          Length = 2853

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    TVAVRCLAK 9
            T+A+ CLAK
Sbjct: 1992 TIAMECLAK 2000
>NP_003647
          Length = 370

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  VAVRCLAK 9
          VA++C+AK
Sbjct: 46 VAIKCIAK 53
>XP_005265573
          Length = 413

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  VAVRCLAK 9
          VA++C+AK
Sbjct: 46 VAIKCIAK 53
>NP_009225
          Length = 1863

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    TVAVRCLAK 9
            TVA  CL+K
Sbjct: 1246 TVATECLSK 1254
>NP_009228
          Length = 1816

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    TVAVRCLAK 9
            TVA  CL+K
Sbjct: 1199 TVATECLSK 1207
>NP_009231
          Length = 1884

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    TVAVRCLAK 9
            TVA  CL+K
Sbjct: 1246 TVATECLSK 1254
>NP_001092906
          Length = 515

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  VAVRCLAK 9
          VA++C+AK
Sbjct: 84 VAIKCVAK 91
>NP_001271293
          Length = 513

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  VAVRCLAK 9
          VA++C+AK
Sbjct: 84 VAIKCVAK 91
>XP_006722099
          Length = 1736

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    TVAVRCLAK 9
            TVA  CL+K
Sbjct: 1119 TVATECLSK 1127
>XP_006722098
          Length = 1793

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    TVAVRCLAK 9
            TVA  CL+K
Sbjct: 1176 TVATECLSK 1184
>XP_006722097
          Length = 1862

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    TVAVRCLAK 9
            TVA  CL+K
Sbjct: 1246 TVATECLSK 1254
>XP_006722096
          Length = 1862

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    TVAVRCLAK 9
            TVA  CL+K
Sbjct: 1246 TVATECLSK 1254
>XP_006722095
          Length = 1862

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    TVAVRCLAK 9
            TVA  CL+K
Sbjct: 1245 TVATECLSK 1253
>XP_006722094
          Length = 1863

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    TVAVRCLAK 9
            TVA  CL+K
Sbjct: 1246 TVATECLSK 1254
>XP_006722093
          Length = 1863

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    TVAVRCLAK 9
            TVA  CL+K
Sbjct: 1246 TVATECLSK 1254
>XP_006722092
          Length = 1863

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    TVAVRCLAK 9
            TVA  CL+K
Sbjct: 1246 TVATECLSK 1254
>XP_005254346
          Length = 483

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  VAVRCLAK 9
          VA++C+AK
Sbjct: 52 VAIKCVAK 59
>XP_005254347
          Length = 483

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  VAVRCLAK 9
          VA++C+AK
Sbjct: 52 VAIKCVAK 59
>NP_006209
          Length = 1068

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   AVRCLAK 9
           AVRCL K
Sbjct: 615 AVRCLEK 621
>NP_003296
          Length = 848

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   TVAVRCL 7
           T+A++CL
Sbjct: 345 TIAIKCL 351
>NP_001124170
          Length = 921

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   TVAVRCL 7
           T+A++CL
Sbjct: 418 TIAIKCL 424
>NP_277045
          Length = 1401

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   AVRCLA 8
           AVRCLA
Sbjct: 614 AVRCLA 619
>NP_077309
          Length = 496

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   AVRCLAK 9
           AVRCL K
Sbjct: 477 AVRCLQK 483
>XP_006722949
          Length = 439

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   AVRCLAK 9
           AVRCL K
Sbjct: 420 AVRCLQK 426
>XP_006714359
          Length = 544

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   TVAVRCL 7
           T+A++CL
Sbjct: 345 TIAIKCL 351
>XP_006714358
          Length = 820

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   TVAVRCL 7
           T+A++CL
Sbjct: 345 TIAIKCL 351
>XP_006713721
          Length = 1068

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   AVRCLAK 9
           AVRCL K
Sbjct: 615 AVRCLEK 621
>NP_006411
          Length = 1785

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    VAVRCLAK 9
            +A+RC+A+
Sbjct: 1202 MAIRCIAQ 1209
>NP_055160
          Length = 2279

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TVAVRCL 7
           +VAVRC+
Sbjct: 735 SVAVRCM 741
>NP_078841
          Length = 435

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  TVAVRCL 7
          TVAV CL
Sbjct: 84 TVAVSCL 90
>XP_006723746
          Length = 1177

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   VAVRCLAK 9
           +A+RC+A+
Sbjct: 594 MAIRCIAQ 601
>XP_005260309
          Length = 1784

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    VAVRCLAK 9
            +A+RC+A+
Sbjct: 1201 MAIRCIAQ 1208
>XP_006714981
          Length = 365

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  TVAVRCL 7
          TVAV CL
Sbjct: 14 TVAVSCL 20
>XP_005266039
          Length = 387

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  TVAVRCL 7
          TVAV CL
Sbjct: 84 TVAVSCL 90
>XP_006714980
          Length = 432

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  TVAVRCL 7
          TVAV CL
Sbjct: 81 TVAVSCL 87
>NP_003556
          Length = 1050

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  VAVRCLAK 9
          VAV+C+ K
Sbjct: 43 VAVKCINK 50
>NP_001010938
          Length = 1086

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TVAVRCL 7
           +VAV+CL
Sbjct: 217 SVAVKCL 223
>NP_005772
          Length = 1038

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TVAVRCL 7
           +VAV+CL
Sbjct: 154 SVAVKCL 160
>NP_001103373
          Length = 444

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   TVAVRCL 7
           T+A++CL
Sbjct: 274 TIALKCL 280
>NP_116203
          Length = 420

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   TVAVRCL 7
           T+A++CL
Sbjct: 274 TIALKCL 280
>NP_005662
          Length = 270

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   TVAVRC 6
           TVA+RC
Sbjct: 193 TVALRC 198
>NP_001269128
          Length = 229

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   TVAVRC 6
           TVA+RC
Sbjct: 152 TVALRC 157
>NP_001269118
          Length = 233

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   TVAVRC 6
           TVA+RC
Sbjct: 156 TVALRC 161
>XP_005257532
          Length = 928

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   VAVRCLAK 9
           VAV+C  K
Sbjct: 881 VAVKCFGK 888
>XP_005257530
          Length = 943

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   VAVRCLAK 9
           VAV+C  K
Sbjct: 896 VAVKCFGK 903
>XP_005254026
          Length = 444

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   TVAVRCL 7
           T+A++CL
Sbjct: 274 TIALKCL 280
>XP_005254025
          Length = 444

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   TVAVRCL 7
           T+A++CL
Sbjct: 274 TIALKCL 280
>XP_006713531
          Length = 566

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TVAVRCL 7
           +VAV+CL
Sbjct: 232 SVAVKCL 238
>XP_005269330
          Length = 979

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TVAVRCL 7
          +VAV+CL
Sbjct: 78 SVAVKCL 84
>XP_005269329
          Length = 1040

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TVAVRCL 7
           +VAV+CL
Sbjct: 186 SVAVKCL 192
>XP_005269328
          Length = 1055

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TVAVRCL 7
           +VAV+CL
Sbjct: 154 SVAVKCL 160
>XP_005269327
          Length = 1055

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TVAVRCL 7
           +VAV+CL
Sbjct: 154 SVAVKCL 160
>XP_006713530
          Length = 1063

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TVAVRCL 7
           +VAV+CL
Sbjct: 162 SVAVKCL 168
>XP_006713529
          Length = 1085

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TVAVRCL 7
           +VAV+CL
Sbjct: 232 SVAVKCL 238
>XP_005269326
          Length = 1087

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TVAVRCL 7
           +VAV+CL
Sbjct: 186 SVAVKCL 192
>XP_006713528
          Length = 1101

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TVAVRCL 7
           +VAV+CL
Sbjct: 232 SVAVKCL 238
>XP_006713527
          Length = 1115

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TVAVRCL 7
           +VAV+CL
Sbjct: 232 SVAVKCL 238
>XP_005269325
          Length = 1118

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TVAVRCL 7
           +VAV+CL
Sbjct: 217 SVAVKCL 223
>XP_006713526
          Length = 1118

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TVAVRCL 7
           +VAV+CL
Sbjct: 232 SVAVKCL 238
>XP_006713525
          Length = 1119

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TVAVRCL 7
           +VAV+CL
Sbjct: 218 SVAVKCL 224
>XP_006713524
          Length = 1131

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TVAVRCL 7
           +VAV+CL
Sbjct: 232 SVAVKCL 238
>XP_006713523
          Length = 1133

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TVAVRCL 7
           +VAV+CL
Sbjct: 232 SVAVKCL 238
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.336    0.131    0.394 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 526,958
Number of extensions: 527
Number of successful extensions: 68
Number of sequences better than 10000.0: 68
Number of HSP's gapped: 68
Number of HSP's successfully gapped: 68
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.5 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package