Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001165907                                                           17    4312
NP_002628                                                              17    4312
NP_001116142                                                           17    4312
XP_006724724                                                           17    4312
NP_000433                                                              16    5631
NP_775871                                                              16    5631
XP_005276940                                                           16    5631
XP_005276939                                                           16    5631
XP_005276938                                                           16    5631
XP_005276937                                                           16    5631
XP_006722008                                                           16    5631
XP_006722007                                                           16    5631
NP_001360                                                              16    7355
NP_000843                                                              16    7355
XP_005248319                                                           16    7355
NP_476506                                                              15    9605
NP_001137292                                                           15    9605
NP_476505                                                              15    9605
NP_004360                                                              15    9605
NP_005229                                                              15    9605
NP_476508                                                              15    9605
NP_476507                                                              15    9605
NP_002448                                                              15    9605
NP_689493                                                              15    9605
NP_640337                                                              15    9605
NP_001121187                                                           15    9605
NP_055907                                                              15    9605
NP_005662                                                              15    9605
NP_001269128                                                           15    9605
NP_001269118                                                           15    9605
XP_005255242                                                           15    9605
XP_005255241                                                           15    9605
XP_005255240                                                           15    9605
XP_005255239                                                           15    9605
XP_005271485                                                           15    9605
XP_006715402                                                           15    9605
XP_005246123                                                           15    9605
XP_005246122                                                           15    9605
XP_006712316                                                           15    9605
XP_005245071                                                           15    9605
NP_003699                                                              15    9605
>NP_001165907
          Length = 1151

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   TKQEVVT 8
           TKQE++T
Sbjct: 279 TKQEIIT 285
>NP_002628
          Length = 1223

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   TKQEVVT 8
           TKQE++T
Sbjct: 279 TKQEIIT 285
>NP_001116142
          Length = 1210

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   TKQEVVT 8
           TKQE++T
Sbjct: 279 TKQEIIT 285
>XP_006724724
          Length = 1164

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   TKQEVVT 8
           TKQE++T
Sbjct: 279 TKQEIIT 285
>NP_000433
          Length = 738

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TTKQEVVTV 9
           +TK E+VTV
Sbjct: 221 STKSELVTV 229
>NP_775871
          Length = 8384

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    TTKQEVVT 8
            TTK E++T
Sbjct: 6916 TTKAEIIT 6923
>XP_005276940
          Length = 706

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TTKQEVVTV 9
           +TK E+VTV
Sbjct: 221 STKSELVTV 229
>XP_005276939
          Length = 717

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TTKQEVVTV 9
           +TK E+VTV
Sbjct: 221 STKSELVTV 229
>XP_005276938
          Length = 719

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TTKQEVVTV 9
           +TK E+VTV
Sbjct: 221 STKSELVTV 229
>XP_005276937
          Length = 727

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TTKQEVVTV 9
           +TK E+VTV
Sbjct: 221 STKSELVTV 229
>XP_006722008
          Length = 757

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TTKQEVVTV 9
           +TK E+VTV
Sbjct: 221 STKSELVTV 229
>XP_006722007
          Length = 757

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TTKQEVVTV 9
           +TK E+VTV
Sbjct: 221 STKSELVTV 229
>NP_001360
          Length = 4624

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    TTKQEVVT 8
            +TK+EV+T
Sbjct: 1129 STKKEVIT 1136
>NP_000843
          Length = 210

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  KQEVVTV 9
          K+EVVTV
Sbjct: 30 KEEVVTV 36
>XP_005248319
          Length = 4609

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    TTKQEVVT 8
            +TK+EV+T
Sbjct: 1114 STKKEVIT 1121
>NP_476506
          Length = 1237

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   TKQEVVT 8
           TK+EV+T
Sbjct: 298 TKREVIT 304
>NP_001137292
          Length = 485

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   KQEVVT 8
           KQEVVT
Sbjct: 271 KQEVVT 276
>NP_476505
          Length = 1036

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   TKQEVVT 8
           TK+EV+T
Sbjct: 97  TKREVIT 103
>NP_004360
          Length = 3177

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   TKQEVVT 8
           TK+EV+T
Sbjct: 504 TKREVIT 510
>NP_005229
          Length = 441

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   KQEVVT 8
           KQEVVT
Sbjct: 227 KQEVVT 232
>NP_476508
          Length = 2971

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   TKQEVVT 8
           TK+EV+T
Sbjct: 298 TKREVIT 304
>NP_476507
          Length = 2570

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   TKQEVVT 8
           TK+EV+T
Sbjct: 97  TKREVIT 103
>NP_002448
          Length = 5179

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    TTKQEVVTV 9
            TTK+  VTV
Sbjct: 4667 TTKRPAVTV 4675
>NP_689493
          Length = 431

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   TTKQEVV 7
           TTK EVV
Sbjct: 387 TTKNEVV 393
>NP_640337
          Length = 1115

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   TKQEVVT 8
           +KQEV+T
Sbjct: 531 SKQEVIT 537
>NP_001121187
          Length = 1151

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   TKQEVVT 8
           +KQEV+T
Sbjct: 531 SKQEVIT 537
>NP_055907
          Length = 3661

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    KQEVVTV 9
            KQE VTV
Sbjct: 2729 KQEAVTV 2735
>NP_005662
          Length = 270

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TKQEVVTV 9
           T +EVVTV
Sbjct: 187 TAEEVVTV 194
>NP_001269128
          Length = 229

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TKQEVVTV 9
           T +EVVTV
Sbjct: 146 TAEEVVTV 153
>NP_001269118
          Length = 233

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TKQEVVTV 9
           T +EVVTV
Sbjct: 150 TAEEVVTV 157
>XP_005255242
          Length = 3609

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    KQEVVTV 9
            KQE VTV
Sbjct: 2677 KQEAVTV 2683
>XP_005255241
          Length = 3637

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    KQEVVTV 9
            KQE VTV
Sbjct: 2705 KQEAVTV 2711
>XP_005255240
          Length = 3663

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    KQEVVTV 9
            KQE VTV
Sbjct: 2731 KQEAVTV 2737
>XP_005255239
          Length = 3689

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    KQEVVTV 9
            KQE VTV
Sbjct: 2757 KQEAVTV 2763
>XP_005271485
          Length = 418

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   KQEVVT 8
           KQEVVT
Sbjct: 204 KQEVVT 209
>XP_006715402
          Length = 1135

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   TKQEVVT 8
           +KQEV+T
Sbjct: 531 SKQEVIT 537
>XP_005246123
          Length = 2770

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   TKQEVVT 8
           TK+EV+T
Sbjct: 97  TKREVIT 103
>XP_005246122
          Length = 2977

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   TKQEVVT 8
           TK+EV+T
Sbjct: 504 TKREVIT 510
>XP_006712316
          Length = 3010

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   TKQEVVT 8
           TK+EV+T
Sbjct: 504 TKREVIT 510
>XP_005245071
          Length = 430

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   TTKQEVV 7
           TTK EVV
Sbjct: 386 TTKNEVV 392
>NP_003699
          Length = 317

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TKQEVVTV 9
           TKQ+ VT+
Sbjct: 126 TKQDFVTI 133
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.300    0.110    0.252 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 420,459
Number of extensions: 518
Number of successful extensions: 41
Number of sequences better than 10000.0: 41
Number of HSP's gapped: 41
Number of HSP's successfully gapped: 41
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

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