Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_722576                                                              20     390
XP_005262424                                                           20     390
NP_840054                                                              18    1135
NP_775871                                                              18    1135
XP_005262121                                                           18    1135
NP_443168                                                              18    1135
NP_001188333                                                           18    1935
NP_008921                                                              18    1935
NP_000114                                                              17    4312
NP_001274744                                                           17    4312
NP_001120792                                                           17    4312
NP_001274745                                                           17    4312
NP_055662                                                              17    4312
NP_001191354                                                           17    4312
XP_006711752                                                           17    4312
XP_006711751                                                           17    4312
XP_006711750                                                           17    4312
XP_006711749                                                           17    4312
XP_005245731                                                           17    4312
XP_005245730                                                           17    4312
XP_005245729                                                           17    4312
XP_005245727                                                           17    4312
XP_005245726                                                           17    4312
XP_005245725                                                           17    4312
XP_005245724                                                           17    4312
XP_005245715                                                           17    4312
XP_006711748                                                           17    4312
XP_006711747                                                           17    4312
XP_006711746                                                           17    4312
XP_006711745                                                           17    4312
XP_006711744                                                           17    4312
XP_006711743                                                           17    4312
XP_006711742                                                           17    4312
NP_852002                                                              17    4312
NP_001156956                                                           17    4312
NP_079506                                                              17    4312
NP_115545                                                              16    5631
NP_694563                                                              16    5631
NP_036595                                                              16    7355
XP_006719381                                                           16    7355
XP_006719380                                                           16    7355
NP_006506                                                              15    9605
NP_733793                                                              15    9605
NP_004832                                                              15    9605
NP_001230652                                                           15    9605
NP_001007103                                                           15    9605
NP_115814                                                              15    9605
NP_002588                                                              15    9605
NP_150229                                                              15    9605
NP_079215                                                              15    9605
XP_006721337                                                           15    9605
XP_006721336                                                           15    9605
XP_005256210                                                           15    9605
XP_005267218                                                           15    9605
XP_006715641                                                           15    9605
XP_006715640                                                           15    9605
XP_006715639                                                           15    9605
XP_006713360                                                           15    9605
XP_006713358                                                           15    9605
XP_006713357                                                           15    9605
XP_006713356                                                           15    9605
XP_006713355                                                           15    9605
XP_005245679                                                           15    9605
XP_005245678                                                           15    9605
XP_005245677                                                           15    9605
XP_006711697                                                           15    9605
NP_072098                                                              15    9605
>NP_722576
          Length = 3080

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TTGQEFIES 9
           T GQEFIES
Sbjct: 432 TAGQEFIES 440
>XP_005262424
          Length = 2875

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TTGQEFIES 9
           T GQEFIES
Sbjct: 227 TAGQEFIES 235
>NP_840054
          Length = 336

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   TTGQEFIES 9
           TTG EFI+S
Sbjct: 310 TTGAEFIDS 318
>NP_775871
          Length = 8384

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    TTGQEFIES 9
            TTG+ FIES
Sbjct: 2272 TTGKSFIES 2280
>XP_005262121
          Length = 321

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   TTGQEFIES 9
           TTG EFI+S
Sbjct: 295 TTGAEFIDS 303
>NP_443168
          Length = 398

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   TTGQEFIES 9
           TTG EFI+S
Sbjct: 372 TTGAEFIDS 380
>NP_001188333
          Length = 281

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   GQEFIES 9
           GQEF+ES
Sbjct: 209 GQEFVES 215
>NP_008921
          Length = 498

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   GQEFIES 9
           GQEF+ES
Sbjct: 209 GQEFVES 215
>NP_000114
          Length = 1186

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TGQEFIES 9
           TGQ F+ES
Sbjct: 765 TGQMFLES 772
>NP_001274744
          Length = 976

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TTGQEFIE 8
           TTG +F+E
Sbjct: 350 TTGSQFLE 357
>NP_001120792
          Length = 983

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TTGQEFIE 8
           TTG +F+E
Sbjct: 357 TTGSQFLE 364
>NP_001274745
          Length = 1078

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TTGQEFIE 8
           TTG +F+E
Sbjct: 368 TTGSQFLE 375
>NP_055662
          Length = 1087

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TTGQEFIE 8
           TTG +F+E
Sbjct: 357 TTGSQFLE 364
>NP_001191354
          Length = 1640

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    TGQEFIES 9
            TGQ F+ES
Sbjct: 1219 TGQMFLES 1226
>XP_006711752
          Length = 1085

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TTGQEFIE 8
           TTG +F+E
Sbjct: 357 TTGSQFLE 364
>XP_006711751
          Length = 820

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  TTGQEFIE 8
          TTG +F+E
Sbjct: 17 TTGSQFLE 24
>XP_006711750
          Length = 930

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TTGQEFIE 8
           TTG +F+E
Sbjct: 127 TTGSQFLE 134
>XP_006711749
          Length = 965

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TTGQEFIE 8
           TTG +F+E
Sbjct: 162 TTGSQFLE 169
>XP_005245731
          Length = 983

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TTGQEFIE 8
           TTG +F+E
Sbjct: 357 TTGSQFLE 364
>XP_005245730
          Length = 994

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TTGQEFIE 8
           TTG +F+E
Sbjct: 368 TTGSQFLE 375
>XP_005245729
          Length = 1067

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TTGQEFIE 8
           TTG +F+E
Sbjct: 357 TTGSQFLE 364
>XP_005245727
          Length = 1079

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TTGQEFIE 8
           TTG +F+E
Sbjct: 368 TTGSQFLE 375
>XP_005245726
          Length = 1095

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TTGQEFIE 8
           TTG +F+E
Sbjct: 368 TTGSQFLE 375
>XP_005245725
          Length = 1096

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TTGQEFIE 8
           TTG +F+E
Sbjct: 368 TTGSQFLE 375
>XP_005245724
          Length = 1098

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TTGQEFIE 8
           TTG +F+E
Sbjct: 368 TTGSQFLE 375
>XP_005245715
          Length = 1115

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TTGQEFIE 8
           TTG +F+E
Sbjct: 368 TTGSQFLE 375
>XP_006711748
          Length = 1160

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TTGQEFIE 8
           TTG +F+E
Sbjct: 357 TTGSQFLE 364
>XP_006711747
          Length = 1160

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TTGQEFIE 8
           TTG +F+E
Sbjct: 357 TTGSQFLE 364
>XP_006711746
          Length = 1160

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TTGQEFIE 8
           TTG +F+E
Sbjct: 357 TTGSQFLE 364
>XP_006711745
          Length = 1170

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TTGQEFIE 8
           TTG +F+E
Sbjct: 368 TTGSQFLE 375
>XP_006711744
          Length = 1171

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TTGQEFIE 8
           TTG +F+E
Sbjct: 368 TTGSQFLE 375
>XP_006711743
          Length = 1171

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TTGQEFIE 8
           TTG +F+E
Sbjct: 368 TTGSQFLE 375
>XP_006711742
          Length = 1171

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TTGQEFIE 8
           TTG +F+E
Sbjct: 368 TTGSQFLE 375
>NP_852002
          Length = 520

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TTGQEFIES 9
           +TGQ+FI S
Sbjct: 424 STGQQFIYS 432
>NP_001156956
          Length = 546

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TTGQEFIES 9
           +TGQ+FI S
Sbjct: 450 STGQQFIYS 458
>NP_079506
          Length = 546

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TTGQEFIES 9
           +TGQ+FI S
Sbjct: 450 STGQQFIYS 458
>NP_115545
          Length = 780

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TTGQEFIES 9
           TTGQ F+++
Sbjct: 368 TTGQLFVQT 376
>NP_694563
          Length = 502

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TTGQEFIE 8
           T+GQ F+E
Sbjct: 117 TSGQNFLE 124
>NP_036595
          Length = 856

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   TGQEFIE 8
           TGQE+++
Sbjct: 643 TGQEYVQ 649
>XP_006719381
          Length = 582

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   TGQEFIE 8
           TGQE+++
Sbjct: 369 TGQEYVQ 375
>XP_006719380
          Length = 685

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   TGQEFIE 8
           TGQE+++
Sbjct: 472 TGQEYVQ 478
>NP_006506
          Length = 684

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   QEFIES 9
           QEF+ES
Sbjct: 650 QEFVES 655
>NP_733793
          Length = 1280

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   TGQEFIE 8
           TG++F+E
Sbjct: 406 TGRQFVE 412
>NP_004832
          Length = 1139

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   TGQEFIE 8
           TG++F+E
Sbjct: 258 TGRQFVE 264
>NP_001230652
          Length = 545

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   QEFIES 9
           QEF+ES
Sbjct: 511 QEFVES 516
>NP_001007103
          Length = 755

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  TTGQEF 6
          T+GQEF
Sbjct: 8  TSGQEF 13
>NP_115814
          Length = 780

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  TTGQEF 6
          T+GQEF
Sbjct: 8  TSGQEF 13
>NP_002588
          Length = 246

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   TGQEFIES 9
           TG++F+E+
Sbjct: 119 TGKQFLET 126
>NP_150229
          Length = 1359

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   TGQEFIES 9
           TG EF+++
Sbjct: 752 TGSEFVDT 759
>NP_079215
          Length = 717

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   TGQEFIE 8
           TG+EF++
Sbjct: 323 TGEEFVK 329
>XP_006721337
          Length = 591

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   TGQEFIE 8
           TG+EF++
Sbjct: 197 TGEEFVK 203
>XP_006721336
          Length = 591

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   TGQEFIE 8
           TG+EF++
Sbjct: 197 TGEEFVK 203
>XP_005256210
          Length = 716

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   TGQEFIE 8
           TG+EF++
Sbjct: 322 TGEEFVK 328
>XP_005267218
          Length = 780

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  TTGQEF 6
          T+GQEF
Sbjct: 8  TSGQEF 13
>XP_006715641
          Length = 780

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  TTGQEF 6
          T+GQEF
Sbjct: 8  TSGQEF 13
>XP_006715640
          Length = 780

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  TTGQEF 6
          T+GQEF
Sbjct: 8  TSGQEF 13
>XP_006715639
          Length = 815

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  TTGQEF 6
          T+GQEF
Sbjct: 8  TSGQEF 13
>XP_006713360
          Length = 362

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   QEFIES 9
           QEF+ES
Sbjct: 328 QEFVES 333
>XP_006713358
          Length = 396

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   QEFIES 9
           QEF+ES
Sbjct: 362 QEFVES 367
>XP_006713357
          Length = 428

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   QEFIES 9
           QEF+ES
Sbjct: 394 QEFVES 399
>XP_006713356
          Length = 428

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   QEFIES 9
           QEF+ES
Sbjct: 394 QEFVES 399
>XP_006713355
          Length = 448

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   QEFIES 9
           QEF+ES
Sbjct: 414 QEFVES 419
>XP_005245679
          Length = 1142

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   TGQEFIE 8
           TG++F+E
Sbjct: 258 TGRQFVE 264
>XP_005245678
          Length = 1145

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   TGQEFIE 8
           TG++F+E
Sbjct: 261 TGRQFVE 267
>XP_005245677
          Length = 1173

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   TGQEFIE 8
           TG++F+E
Sbjct: 289 TGRQFVE 295
>XP_006711697
          Length = 1179

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   TGQEFIE 8
           TG++F+E
Sbjct: 298 TGRQFVE 304
>NP_072098
          Length = 194

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2  TGQEFIES 9
          TG++F+E+
Sbjct: 67 TGKQFLET 74
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.303    0.122    0.311 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 579,850
Number of extensions: 973
Number of successful extensions: 67
Number of sequences better than 10000.0: 67
Number of HSP's gapped: 67
Number of HSP's successfully gapped: 67
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

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