Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001013433                                                           18    1135
NP_060785                                                              18    1135
NP_361014                                                              18    1135
NP_004854                                                              17    3301
NP_060797                                                              17    3301
NP_001192179                                                           17    4312
NP_001192177                                                           17    4312
NP_001009185                                                           17    4312
NP_056071                                                              17    4312
NP_001192180                                                           17    4312
NP_001192176                                                           17    4312
NP_001078867                                                           17    4312
XP_006714644                                                           17    4312
XP_006714643                                                           17    4312
XP_006714642                                                           17    4312
XP_006711500                                                           17    4312
NP_001035026                                                           16    5631
NP_067017                                                              16    5631
NP_036273                                                              16    5631
NP_006080                                                              16    5631
NP_872346                                                              16    5631
XP_006724804                                                           16    5631
XP_006724803                                                           16    5631
XP_005262451                                                           16    5631
XP_006724521                                                           16    5631
XP_006724520                                                           16    5631
XP_005266397                                                           16    5631
NP_056383                                                              16    5631
NP_061183                                                              16    7355
NP_659418                                                              16    7355
NP_037522                                                              16    7355
NP_001129292                                                           16    7355
NP_005551                                                              16    7355
XP_006723861                                                           16    7355
XP_006723860                                                           16    7355
XP_006723859                                                           16    7355
XP_005252872                                                           16    7355
XP_005252871                                                           16    7355
XP_006718231                                                           16    7355
XP_005252869                                                           16    7355
XP_005252868                                                           16    7355
XP_006718230                                                           16    7355
XP_006717096                                                           16    7355
XP_005251926                                                           16    7355
NP_055664                                                              15    9605
NP_001265432                                                           15    9605
NP_689926                                                              15    9605
NP_036565                                                              15    9605
NP_061928                                                              15    9605
NP_078997                                                              15    9605
NP_757385                                                              15    9605
NP_277053                                                              15    9605
NP_115807                                                              15    9605
NP_065712                                                              15    9605
NP_001265648                                                           15    9605
XP_006724633                                                           15    9605
XP_005272755                                                           15    9605
XP_006724632                                                           15    9605
XP_005272754                                                           15    9605
XP_005272753                                                           15    9605
XP_005272752                                                           15    9605
XP_005272751                                                           15    9605
XP_005271654                                                           15    9605
XP_005271653                                                           15    9605
XP_006718924                                                           15    9605
XP_006718776                                                           15    9605
XP_006718775                                                           15    9605
XP_005246485                                                           15    9605
NP_997046                                                              15    9605
>NP_001013433
          Length = 589

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  TTFGYLRAA 9
          TTFG LRAA
Sbjct: 89 TTFGDLRAA 97
>NP_060785
          Length = 627

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TTFGYLRAA 9
           TTFG LRAA
Sbjct: 127 TTFGDLRAA 135
>NP_361014
          Length = 707

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TTFGYLRAA 9
           TTFG LRAA
Sbjct: 207 TTFGDLRAA 215
>NP_004854
          Length = 562

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  TTFGYLR 7
          T FGYLR
Sbjct: 82 TLFGYLR 88
>NP_060797
          Length = 552

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  TTFGYLR 7
          T FGYLR
Sbjct: 74 TLFGYLR 80
>NP_001192179
          Length = 708

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TTFGYLRAA 9
           T  G+LRAA
Sbjct: 452 TVLGFLRAA 460
>NP_001192177
          Length = 697

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TTFGYLRAA 9
           T  G+LRAA
Sbjct: 441 TVLGFLRAA 449
>NP_001009185
          Length = 722

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TTFGYLRAA 9
           T  G+LRAA
Sbjct: 466 TVLGFLRAA 474
>NP_056071
          Length = 722

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TTFGYLRAA 9
           T  G+LRAA
Sbjct: 466 TVLGFLRAA 474
>NP_001192180
          Length = 622

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TTFGYLRAA 9
           T  G+LRAA
Sbjct: 366 TVLGFLRAA 374
>NP_001192176
          Length = 687

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TTFGYLRAA 9
           T  G+LRAA
Sbjct: 431 TVLGFLRAA 439
>NP_001078867
          Length = 122

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  TTFGYLRA 8
          T +GYLRA
Sbjct: 37 TPWGYLRA 44
>XP_006714644
          Length = 687

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TTFGYLRAA 9
           T  G+LRAA
Sbjct: 431 TVLGFLRAA 439
>XP_006714643
          Length = 697

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TTFGYLRAA 9
           T  G+LRAA
Sbjct: 441 TVLGFLRAA 449
>XP_006714642
          Length = 697

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TTFGYLRAA 9
           T  G+LRAA
Sbjct: 441 TVLGFLRAA 449
>XP_006711500
          Length = 372

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  TTFGYLRA 8
          +T+G+LRA
Sbjct: 19 STYGFLRA 26
>NP_001035026
          Length = 874

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   FGYLRAA 9
           FGYL+A+
Sbjct: 352 FGYLKAS 358
>NP_067017
          Length = 507

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  TFGYLRA 8
          TFG++RA
Sbjct: 71 TFGWIRA 77
>NP_036273
          Length = 887

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   FGYLRAA 9
           FGYL+A+
Sbjct: 365 FGYLKAS 371
>NP_006080
          Length = 700

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   TTFGYLR 7
           T FGYL+
Sbjct: 408 TVFGYLK 414
>NP_872346
          Length = 861

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   FGYLRAA 9
           FGYL+A+
Sbjct: 369 FGYLKAS 375
>XP_006724804
          Length = 854

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   FGYLRAA 9
           FGYL+A+
Sbjct: 369 FGYLKAS 375
>XP_006724803
          Length = 894

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   FGYLRAA 9
           FGYL+A+
Sbjct: 369 FGYLKAS 375
>XP_005262451
          Length = 898

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   FGYLRAA 9
           FGYL+A+
Sbjct: 369 FGYLKAS 375
>XP_006724521
          Length = 609

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   TTFGYLR 7
           T FGYL+
Sbjct: 408 TVFGYLK 414
>XP_006724520
          Length = 617

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   TTFGYLR 7
           T FGYL+
Sbjct: 408 TVFGYLK 414
>XP_005266397
          Length = 709

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   FGYLRAA 9
           FGYL+A+
Sbjct: 187 FGYLKAS 193
>NP_056383
          Length = 567

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   GYLRAA 9
           GYLRAA
Sbjct: 240 GYLRAA 245
>NP_061183
          Length = 485

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  TFGYLRA 8
          T+GY RA
Sbjct: 71 TYGYARA 77
>NP_659418
          Length = 166

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   FGYLRAA 9
           FG+LRA+
Sbjct: 151 FGFLRAS 157
>NP_037522
          Length = 1383

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    TFGYLR 7
            TFGYL+
Sbjct: 1084 TFGYLQ 1089
>NP_001129292
          Length = 1320

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    TFGYLR 7
            TFGYL+
Sbjct: 1021 TFGYLQ 1026
>NP_005551
          Length = 3695

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    TFGYLR 7
            +FGYLR
Sbjct: 1385 SFGYLR 1390
>XP_006723861
          Length = 2300

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    TFGYLR 7
            +FGYLR
Sbjct: 1385 SFGYLR 1390
>XP_006723860
          Length = 2586

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    TFGYLR 7
            +FGYLR
Sbjct: 1385 SFGYLR 1390
>XP_006723859
          Length = 3700

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    TFGYLR 7
            +FGYLR
Sbjct: 1385 SFGYLR 1390
>XP_005252872
          Length = 130

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   FGYLRAA 9
           FG+LRA+
Sbjct: 115 FGFLRAS 121
>XP_005252871
          Length = 166

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   FGYLRAA 9
           FG+LRA+
Sbjct: 151 FGFLRAS 157
>XP_006718231
          Length = 166

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   FGYLRAA 9
           FG+LRA+
Sbjct: 151 FGFLRAS 157
>XP_005252869
          Length = 166

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   FGYLRAA 9
           FG+LRA+
Sbjct: 151 FGFLRAS 157
>XP_005252868
          Length = 166

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   FGYLRAA 9
           FG+LRA+
Sbjct: 151 FGFLRAS 157
>XP_006718230
          Length = 202

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   FGYLRAA 9
           FG+LRA+
Sbjct: 187 FGFLRAS 193
>XP_006717096
          Length = 1217

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    TFGYLR 7
            TFGYL+
Sbjct: 1084 TFGYLQ 1089
>XP_005251926
          Length = 1383

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    TFGYLR 7
            TFGYL+
Sbjct: 1084 TFGYLQ 1089
>NP_055664
          Length = 742

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   TTFGYLRA 8
           T FG+L A
Sbjct: 684 TAFGFLNA 691
>NP_001265432
          Length = 705

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1 TTFGYLR 7
         T FG+LR
Sbjct: 2 TKFGFLR 8
>NP_689926
          Length = 705

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1 TTFGYLR 7
         T FG+LR
Sbjct: 2 TKFGFLR 8
>NP_036565
          Length = 1304

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    TFGYLRAA 9
            TFGY+  A
Sbjct: 1080 TFGYIAKA 1087
>NP_061928
          Length = 1007

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   TTFGYL 6
           TT+GY+
Sbjct: 826 TTYGYI 831
>NP_078997
          Length = 3616

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   TFGYLRA 8
           +FGY+R+
Sbjct: 286 SFGYIRS 292
>NP_757385
          Length = 617

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  FGYLRAA 9
          FG LRAA
Sbjct: 66 FGQLRAA 72
>NP_277053
          Length = 472

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2   TFGYL 6
           TFGYL
Sbjct: 310 TFGYL 314
>NP_115807
          Length = 616

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  FGYLRAA 9
          FG LRAA
Sbjct: 66 FGQLRAA 72
>NP_065712
          Length = 198

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 3  FGYLR 7
          FGYLR
Sbjct: 46 FGYLR 50
>NP_001265648
          Length = 194

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   TTFGYLRA 8
           T FG+L A
Sbjct: 136 TAFGFLNA 143
>XP_006724633
          Length = 441

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2   TFGYL 6
           TFGYL
Sbjct: 259 TFGYL 263
>XP_005272755
          Length = 492

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2   TFGYL 6
           TFGYL
Sbjct: 310 TFGYL 314
>XP_006724632
          Length = 492

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2   TFGYL 6
           TFGYL
Sbjct: 310 TFGYL 314
>XP_005272754
          Length = 498

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2   TFGYL 6
           TFGYL
Sbjct: 316 TFGYL 320
>XP_005272753
          Length = 519

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2   TFGYL 6
           TFGYL
Sbjct: 357 TFGYL 361
>XP_005272752
          Length = 519

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2   TFGYL 6
           TFGYL
Sbjct: 357 TFGYL 361
>XP_005272751
          Length = 539

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2   TFGYL 6
           TFGYL
Sbjct: 357 TFGYL 361
>XP_005271654
          Length = 862

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   TTFGYL 6
           TT+GY+
Sbjct: 681 TTYGYI 686
>XP_005271653
          Length = 862

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   TTFGYL 6
           TT+GY+
Sbjct: 681 TTYGYI 686
>XP_006718924
          Length = 969

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   TTFGYL 6
           TT+GY+
Sbjct: 788 TTYGYI 793
>XP_006718776
          Length = 669

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  FGYLRAA 9
          FG LRAA
Sbjct: 66 FGQLRAA 72
>XP_006718775
          Length = 670

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  FGYLRAA 9
          FG LRAA
Sbjct: 66 FGQLRAA 72
>XP_005246485
          Length = 1158

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   TFGYLRAA 9
           TFGY+  A
Sbjct: 934 TFGYIAKA 941
>NP_997046
          Length = 547

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1 TTFGYLR 7
         +TFGY R
Sbjct: 2 STFGYRR 8
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.331    0.138    0.412 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 513,623
Number of extensions: 573
Number of successful extensions: 69
Number of sequences better than 10000.0: 69
Number of HSP's gapped: 69
Number of HSP's successfully gapped: 69
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

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