Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001268421                                                           20     509
NP_000170                                                              20     509
NP_001268422                                                           20     509
NP_001268423                                                           20     509
XP_005264328                                                           20     509
NP_061992                                                              17    4312
NP_258260                                                              17    4312
NP_061761                                                              17    4312
XP_006714867                                                           17    4312
XP_006714866                                                           17    4312
XP_005268581                                                           17    4312
NP_061993                                                              17    4312
NP_055490                                                              16    5631
NP_065782                                                              16    5631
NP_001229341                                                           16    5631
XP_006726469                                                           16    5631
XP_006713516                                                           16    5631
XP_006711123                                                           16    5631
XP_006711122                                                           16    5631
XP_006711121                                                           16    5631
XP_006711120                                                           16    5631
XP_006711119                                                           16    5631
NP_002430                                                              16    7355
NP_852469                                                              16    7355
NP_005641                                                              16    7355
XP_006725846                                                           16    7355
XP_006725845                                                           16    7355
XP_006725844                                                           16    7355
XP_005277014                                                           16    7355
XP_005277013                                                           16    7355
XP_005277012                                                           16    7355
XP_005261781                                                           16    7355
XP_005261780                                                           16    7355
XP_006724377                                                           16    7355
XP_006724376                                                           16    7355
XP_005261779                                                           16    7355
NP_003473                                                              15    9605
NP_001158268                                                           15    9605
NP_066008                                                              15    9605
NP_079128                                                              15    9605
NP_064506                                                              15    9605
NP_775742                                                              15    9605
NP_660289                                                              15    9605
NP_061757                                                              15    9605
NP_061759                                                              15    9605
NP_061760                                                              15    9605
NP_061758                                                              15    9605
NP_056484                                                              15    9605
NP_061763                                                              15    9605
NP_001273327                                                           15    9605
NP_803171                                                              15    9605
XP_006719679                                                           15    9605
XP_005269219                                                           15    9605
XP_006719678                                                           15    9605
XP_006719677                                                           15    9605
XP_006718117                                                           15    9605
XP_005269573                                                           15    9605
XP_005269572                                                           15    9605
XP_006715413                                                           15    9605
XP_006713019                                                           15    9605
XP_005270633                                                           15    9605
XP_006710467                                                           15    9605
XP_005270632                                                           15    9605
NP_061762                                                              15    9605
NP_061753                                                              15    9605
NP_061754                                                              15    9605
>NP_001268421
          Length = 1230

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    TRLGASDR 8
            TRLGASDR
Sbjct: 1045 TRLGASDR 1052
>NP_000170
          Length = 1360

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    TRLGASDR 8
            TRLGASDR
Sbjct: 1175 TRLGASDR 1182
>NP_001268422
          Length = 1058

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   TRLGASDR 8
           TRLGASDR
Sbjct: 873 TRLGASDR 880
>NP_001268423
          Length = 1058

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   TRLGASDR 8
           TRLGASDR
Sbjct: 873 TRLGASDR 880
>XP_005264328
          Length = 1261

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    TRLGASDR 8
            TRLGASDR
Sbjct: 1076 TRLGASDR 1083
>NP_061992
          Length = 797

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RLGASDR 8
           R+GASDR
Sbjct: 530 RVGASDR 536
>NP_258260
          Length = 690

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   TRLGASDR 8
           TRL ASDR
Sbjct: 99  TRLQASDR 106
>NP_061761
          Length = 795

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RLGASDR 8
           R+GASDR
Sbjct: 529 RVGASDR 535
>XP_006714867
          Length = 632

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   TRLGASDR 8
           TRL ASDR
Sbjct: 99  TRLQASDR 106
>XP_006714866
          Length = 647

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   TRLGASDR 8
           TRL ASDR
Sbjct: 99  TRLQASDR 106
>XP_005268581
          Length = 688

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   TRLGASDR 8
           TRL ASDR
Sbjct: 97  TRLQASDR 104
>NP_061993
          Length = 801

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RLGASDR 8
           R+GASDR
Sbjct: 531 RVGASDR 537
>NP_055490
          Length = 2017

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    TRLGASDR 8
            +RLG SDR
Sbjct: 1668 SRLGLSDR 1675
>NP_065782
          Length = 719

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LGASDRT 9
           LGASDR+
Sbjct: 577 LGASDRS 583
>NP_001229341
          Length = 701

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LGASDRT 9
           LGASDR+
Sbjct: 559 LGASDRS 565
>XP_006726469
          Length = 175

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TRLGASDRT 9
           T +GA DRT
Sbjct: 159 TGVGAEDRT 167

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  TRLGASDR 8
          +R GASDR
Sbjct: 48 SRRGASDR 55
>XP_006713516
          Length = 263

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TRLGASDRT 9
           T +GA DRT
Sbjct: 247 TGVGAEDRT 255

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TRLGASDR 8
           +R GASDR
Sbjct: 136 SRRGASDR 143
>XP_006711123
          Length = 1737

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    TRLGASDR 8
            +RLG SDR
Sbjct: 1630 SRLGLSDR 1637
>XP_006711122
          Length = 1918

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    TRLGASDR 8
            +RLG SDR
Sbjct: 1630 SRLGLSDR 1637
>XP_006711121
          Length = 1945

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    TRLGASDR 8
            +RLG SDR
Sbjct: 1596 SRLGLSDR 1603
>XP_006711120
          Length = 1972

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    TRLGASDR 8
            +RLG SDR
Sbjct: 1630 SRLGLSDR 1637
>XP_006711119
          Length = 1979

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    TRLGASDR 8
            +RLG SDR
Sbjct: 1630 SRLGLSDR 1637
>NP_002430
          Length = 1137

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TRLGASD 7
           TR+GA+D
Sbjct: 937 TRMGAAD 943
>NP_852469
          Length = 1938

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TRLGASDR 8
           TR+G +DR
Sbjct: 892 TRIGRNDR 899
>NP_005641
          Length = 1960

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TRLGASDR 8
           TR+G +DR
Sbjct: 892 TRIGRNDR 899
>XP_006725846
          Length = 1938

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TRLGASDR 8
           TR+G +DR
Sbjct: 892 TRIGRNDR 899
>XP_006725845
          Length = 1949

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TRLGASDR 8
           TR+G +DR
Sbjct: 892 TRIGRNDR 899
>XP_006725844
          Length = 1960

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TRLGASDR 8
           TR+G +DR
Sbjct: 892 TRIGRNDR 899
>XP_005277014
          Length = 1938

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TRLGASDR 8
           TR+G +DR
Sbjct: 892 TRIGRNDR 899
>XP_005277013
          Length = 1949

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TRLGASDR 8
           TR+G +DR
Sbjct: 892 TRIGRNDR 899
>XP_005277012
          Length = 1960

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TRLGASDR 8
           TR+G +DR
Sbjct: 892 TRIGRNDR 899
>XP_005261781
          Length = 1938

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TRLGASDR 8
           TR+G +DR
Sbjct: 892 TRIGRNDR 899
>XP_005261780
          Length = 1949

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TRLGASDR 8
           TR+G +DR
Sbjct: 892 TRIGRNDR 899
>XP_006724377
          Length = 1960

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TRLGASDR 8
           TR+G +DR
Sbjct: 892 TRIGRNDR 899
>XP_006724376
          Length = 1960

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TRLGASDR 8
           TR+G +DR
Sbjct: 892 TRIGRNDR 899
>XP_005261779
          Length = 1960

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TRLGASDR 8
           TR+G +DR
Sbjct: 892 TRIGRNDR 899
>NP_003473
          Length = 5537

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TRLGAS 6
           TRLGAS
Sbjct: 176 TRLGAS 181
>NP_001158268
          Length = 186

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LGASDRT 9
           LGA DRT
Sbjct: 168 LGAYDRT 174
>NP_066008
          Length = 776

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RLGASDR 8
           R+GA+DR
Sbjct: 530 RVGATDR 536
>NP_079128
          Length = 860

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TRLGASDRT 9
           TRL  +DRT
Sbjct: 714 TRLFCADRT 722
>NP_064506
          Length = 1516

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    RLGASDR 8
            R+GA DR
Sbjct: 1402 RIGAGDR 1408
>NP_775742
          Length = 274

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LGASDRT 9
           LGA DRT
Sbjct: 256 LGAYDRT 262
>NP_660289
          Length = 315

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RLGASDRT 9
           RLG +D+T
Sbjct: 97  RLGENDKT 104
>NP_061757
          Length = 798

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RLGASDR 8
           R+GA+DR
Sbjct: 530 RVGATDR 536
>NP_061759
          Length = 798

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RLGASDR 8
           R+GA+DR
Sbjct: 532 RVGAADR 538
>NP_061760
          Length = 796

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RLGASDR 8
           R+GA+DR
Sbjct: 530 RVGATDR 536
>NP_061758
          Length = 787

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RLGASDR 8
           R+GA+DR
Sbjct: 530 RVGATDR 536
>NP_056484
          Length = 795

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RLGASDR 8
           R+GA+DR
Sbjct: 529 RVGATDR 535
>NP_061763
          Length = 793

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RLGASDR 8
           R+GA+DR
Sbjct: 530 RVGATDR 536
>NP_001273327
          Length = 542

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TRLGASD 7
           TR+GA+D
Sbjct: 137 TRVGAAD 143
>NP_803171
          Length = 626

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TRLGASDRT 9
           TRL  +DRT
Sbjct: 480 TRLFCADRT 488
>XP_006719679
          Length = 5536

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TRLGAS 6
           TRLGAS
Sbjct: 176 TRLGAS 181
>XP_005269219
          Length = 5537

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TRLGAS 6
           TRLGAS
Sbjct: 176 TRLGAS 181
>XP_006719678
          Length = 5539

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TRLGAS 6
           TRLGAS
Sbjct: 176 TRLGAS 181
>XP_006719677
          Length = 5540

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TRLGAS 6
           TRLGAS
Sbjct: 176 TRLGAS 181
>XP_006718117
          Length = 732

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  RLGASDRT 9
          RLG ++RT
Sbjct: 69 RLGVAERT 76
>XP_005269573
          Length = 315

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RLGASDRT 9
           RLG +D+T
Sbjct: 97  RLGENDKT 104
>XP_005269572
          Length = 315

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RLGASDRT 9
           RLG +D+T
Sbjct: 97  RLGENDKT 104
>XP_006715413
          Length = 464

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TRLGASD 7
           TR+GA+D
Sbjct: 137 TRVGAAD 143
>XP_006713019
          Length = 259

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LGASDRT 9
           LGA DRT
Sbjct: 241 LGAYDRT 247
>XP_005270633
          Length = 585

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TRLGASDRT 9
           TRL  +DRT
Sbjct: 439 TRLFCADRT 447
>XP_006710467
          Length = 626

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TRLGASDRT 9
           TRL  +DRT
Sbjct: 480 TRLFCADRT 488
>XP_005270632
          Length = 860

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TRLGASDRT 9
           TRL  +DRT
Sbjct: 714 TRLFCADRT 722
>NP_061762
          Length = 794

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RLGASDR 8
           R+GA+DR
Sbjct: 528 RVGATDR 534
>NP_061753
          Length = 800

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RLGASDR 8
           R+GA+DR
Sbjct: 530 RVGATDR 536
>NP_061754
          Length = 797

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RLGASDR 8
           R+GA+DR
Sbjct: 530 RVGATDR 536
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.312    0.124    0.329 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 441,805
Number of extensions: 645
Number of successful extensions: 68
Number of sequences better than 10000.0: 66
Number of HSP's gapped: 68
Number of HSP's successfully gapped: 68
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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