Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001728                                                              18    1482
NP_694540                                                              18    1935
NP_001265552                                                           18    1935
NP_001265553                                                           18    1935
NP_006715                                                              16    5631
NP_005913                                                              16    5631
XP_005267046                                                           16    5631
XP_005267045                                                           16    5631
NP_940968                                                              16    7355
NP_057308                                                              16    7355
NP_789790                                                              16    7355
NP_055642                                                              16    7355
NP_075526                                                              16    7355
XP_005258905                                                           16    7355
XP_005267072                                                           16    7355
XP_005248617                                                           16    7355
XP_006714536                                                           16    7355
XP_005245703                                                           16    7355
XP_006711736                                                           16    7355
XP_005245701                                                           16    7355
XP_005245700                                                           16    7355
NP_001271324                                                           15    9605
NP_001035947                                                           15    9605
NP_071890                                                              15    9605
NP_112489                                                              15    9605
NP_689966                                                              15    9605
NP_064597                                                              15    9605
XP_006720681                                                           15    9605
XP_006720680                                                           15    9605
XP_006720679                                                           15    9605
XP_006720678                                                           15    9605
XP_006720677                                                           15    9605
XP_006718069                                                           15    9605
XP_006715987                                                           15    9605
XP_005250031                                                           15    9605
XP_005250029                                                           15    9605
XP_005250028                                                           15    9605
XP_005250027                                                           15    9605
XP_005249005                                                           15    9605
XP_005249004                                                           15    9605
XP_005249003                                                           15    9605
XP_005249000                                                           15    9605
XP_006710665                                                           15    9605
NP_848643                                                              15    9605
>NP_001728
          Length = 559

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RCIKMRM 8
           RCIKMR+
Sbjct: 111 RCIKMRL 117
>NP_694540
          Length = 911

 Score = 17.7 bits (34), Expect =  1935
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TRCIKMR 7
           T+C+KMR
Sbjct: 468 TKCVKMR 474
>NP_001265552
          Length = 911

 Score = 17.7 bits (34), Expect =  1935
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TRCIKMR 7
           T+C+KMR
Sbjct: 468 TKCVKMR 474
>NP_001265553
          Length = 911

 Score = 17.7 bits (34), Expect =  1935
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TRCIKMR 7
           T+C+KMR
Sbjct: 468 TKCVKMR 474
>NP_006715
          Length = 1558

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   CIKMRME 9
           C+K+R+E
Sbjct: 630 CLKLRLE 636
>NP_005913
          Length = 1608

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   CIKMRME 9
           C+K+R+E
Sbjct: 630 CLKLRLE 636
>XP_005267046
          Length = 1554

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   CIKMRME 9
           C+K+R+E
Sbjct: 630 CLKLRLE 636
>XP_005267045
          Length = 1604

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   CIKMRME 9
           C+K+R+E
Sbjct: 630 CLKLRLE 636
>NP_940968
          Length = 638

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   CIKMRM 8
           C+KMR+
Sbjct: 420 CVKMRL 425
>NP_057308
          Length = 595

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   IKMRME 9
           IKMRME
Sbjct: 324 IKMRME 329
>NP_789790
          Length = 991

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   CIKMRME 9
           C+K R+E
Sbjct: 346 CVKQRLE 352
>NP_055642
          Length = 810

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   TRCIKMRME 9
           T CIK++++
Sbjct: 429 TTCIKLKID 437
>NP_075526
          Length = 313

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   RCIKMRME 9
           +C+KM +E
Sbjct: 262 KCVKMLLE 269
>XP_005258905
          Length = 903

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   CIKMRME 9
           C+K R+E
Sbjct: 255 CVKQRLE 261
>XP_005267072
          Length = 588

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   IKMRME 9
           IKMRME
Sbjct: 317 IKMRME 322
>XP_005248617
          Length = 245

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   RCIKMRME 9
           +C+KM +E
Sbjct: 194 KCVKMLLE 201
>XP_006714536
          Length = 524

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   CIKMRM 8
           C+KMR+
Sbjct: 306 CVKMRL 311
>XP_005245703
          Length = 474

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   TRCIKMRME 9
           T CIK++++
Sbjct: 93  TTCIKLKID 101
>XP_006711736
          Length = 810

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   TRCIKMRME 9
           T CIK++++
Sbjct: 429 TTCIKLKID 437
>XP_005245701
          Length = 810

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   TRCIKMRME 9
           T CIK++++
Sbjct: 429 TTCIKLKID 437
>XP_005245700
          Length = 810

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   TRCIKMRME 9
           T CIK++++
Sbjct: 429 TTCIKLKID 437
>NP_001271324
          Length = 658

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   TRCIKMRM 8
           T CIKM +
Sbjct: 194 TTCIKMEI 201
>NP_001035947
          Length = 194

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   TRCIKM 6
           T+C+KM
Sbjct: 102 TKCLKM 107
>NP_071890
          Length = 243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   TRCIKM 6
           T+C+KM
Sbjct: 102 TKCLKM 107
>NP_112489
          Length = 364

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   CIKMRME 9
           C+K RM+
Sbjct: 95  CVKTRMQ 101
>NP_689966
          Length = 993

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   CIKMRME 9
           C++ RME
Sbjct: 571 CLRQRME 577
>NP_064597
          Length = 686

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   TRCIKMRM 8
           T CIKM +
Sbjct: 194 TTCIKMEI 201
>XP_006720681
          Length = 468

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   TRCIKMRM 8
           T CIKM +
Sbjct: 194 TTCIKMEI 201
>XP_006720680
          Length = 608

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   TRCIKMRM 8
           T CIKM +
Sbjct: 194 TTCIKMEI 201
>XP_006720679
          Length = 681

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   TRCIKMRM 8
           T CIKM +
Sbjct: 194 TTCIKMEI 201
>XP_006720678
          Length = 696

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   TRCIKMRM 8
           T CIKM +
Sbjct: 194 TTCIKMEI 201
>XP_006720677
          Length = 725

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   TRCIKMRM 8
           T CIKM +
Sbjct: 194 TTCIKMEI 201
>XP_006718069
          Length = 193

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   CIKMRME 9
           C+K RM+
Sbjct: 95  CVKTRMQ 101
>XP_006715987
          Length = 170

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   TRCIKM 6
           T+C+KM
Sbjct: 102 TKCLKM 107
>XP_005250031
          Length = 188

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1  TRCIKM 6
          T+C+KM
Sbjct: 47 TKCLKM 52
>XP_005250029
          Length = 208

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   TRCIKM 6
           T+C+KM
Sbjct: 102 TKCLKM 107
>XP_005250028
          Length = 243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   TRCIKM 6
           T+C+KM
Sbjct: 102 TKCLKM 107
>XP_005250027
          Length = 243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   TRCIKM 6
           T+C+KM
Sbjct: 102 TKCLKM 107
>XP_005249005
          Length = 531

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   CIKMRME 9
           C++ RME
Sbjct: 109 CLRQRME 115
>XP_005249004
          Length = 955

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   CIKMRME 9
           C++ RME
Sbjct: 587 CLRQRME 593
>XP_005249003
          Length = 987

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   CIKMRME 9
           C++ RME
Sbjct: 565 CLRQRME 571
>XP_005249000
          Length = 1009

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   CIKMRME 9
           C++ RME
Sbjct: 587 CLRQRME 593
>XP_006710665
          Length = 479

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   RCIKMRME 9
           RC++ R+E
Sbjct: 307 RCLRERLE 314
>NP_848643
          Length = 442

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   RCIKMRME 9
           RC++ R+E
Sbjct: 270 RCLRERLE 277
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.342    0.136    0.429 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 552,112
Number of extensions: 486
Number of successful extensions: 44
Number of sequences better than 10000.0: 44
Number of HSP's gapped: 44
Number of HSP's successfully gapped: 44
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.7 bits)
S2: 28 (15.4 bits)

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