Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

XP_005250685                                                           18    1135
XP_005250684                                                           18    1135
XP_005250683                                                           18    1135
XP_005250682                                                           18    1135
NP_714913                                                              17    2528
NP_061182                                                              17    2528
XP_005262943                                                           17    2528
XP_005262942                                                           17    2528
NP_001123509                                                           17    2528
NP_006141                                                              17    3301
XP_005272662                                                           17    3301
NP_057502                                                              17    4312
NP_861969                                                              17    4312
NP_000259                                                              17    4312
NP_861968                                                              17    4312
NP_861966                                                              17    4312
NP_861970                                                              17    4312
NP_861546                                                              17    4312
NP_861967                                                              17    4312
NP_001013758                                                           17    4312
NP_981953                                                              17    4312
NP_689844                                                              17    4312
NP_057191                                                              17    4312
NP_001615                                                              17    4312
NP_112598                                                              17    4312
XP_005266896                                                           17    4312
XP_006714540                                                           17    4312
NP_001120702                                                           16    5631
NP_001120701                                                           16    5631
NP_060370                                                              16    5631
NP_872620                                                              16    5631
XP_005245344                                                           16    5631
NP_055444                                                              16    7355
NP_002731                                                              16    7355
NP_001103132                                                           16    7355
NP_065811                                                              16    7355
XP_006725174                                                           16    7355
XP_006725172                                                           16    7355
XP_006725171                                                           16    7355
XP_006725170                                                           16    7355
XP_006725169                                                           16    7355
XP_006725168                                                           16    7355
XP_006725167                                                           16    7355
XP_005254540                                                           16    7355
XP_005266099                                                           16    7355
XP_006716303                                                           16    7355
XP_006716302                                                           16    7355
XP_005266098                                                           16    7355
XP_005266097                                                           16    7355
XP_005266096                                                           16    7355
XP_006716301                                                           16    7355
XP_006712712                                                           16    7355
XP_006712711                                                           16    7355
XP_006712710                                                           16    7355
XP_006712709                                                           16    7355
NP_068566                                                              15    9605
NP_001258791                                                           15    9605
NP_775787                                                              15    9605
XP_005255279                                                           15    9605
XP_006718479                                                           15    9605
XP_006718474                                                           15    9605
NP_001073886                                                           15    9605
>XP_005250685
          Length = 193

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   PKISFRGM 9
           P+I+FRGM
Sbjct: 177 PRITFRGM 184
>XP_005250684
          Length = 204

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   PKISFRGM 9
           P+I+FRGM
Sbjct: 188 PRITFRGM 195
>XP_005250683
          Length = 204

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   PKISFRGM 9
           P+I+FRGM
Sbjct: 188 PRITFRGM 195
>XP_005250682
          Length = 204

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   PKISFRGM 9
           P+I+FRGM
Sbjct: 188 PRITFRGM 195
>NP_714913
          Length = 293

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   PKISFRGM 9
           PK  FRGM
Sbjct: 162 PKTDFRGM 169
>NP_061182
          Length = 334

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   PKISFRGM 9
           PK  FRGM
Sbjct: 169 PKTDFRGM 176
>XP_005262943
          Length = 293

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   PKISFRGM 9
           PK  FRGM
Sbjct: 162 PKTDFRGM 169
>XP_005262942
          Length = 305

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   PKISFRGM 9
           PK  FRGM
Sbjct: 174 PKTDFRGM 181
>NP_001123509
          Length = 326

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   PKISFRGM 9
           PK  FRGM
Sbjct: 169 PKTDFRGM 176
>NP_006141
          Length = 615

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TPKISFR 7
           TP++SFR
Sbjct: 471 TPRVSFR 477
>XP_005272662
          Length = 547

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TPKISFR 7
           TP++SFR
Sbjct: 403 TPRVSFR 409
>NP_057502
          Length = 590

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TPKISF 6
           TPKISF
Sbjct: 251 TPKISF 256
>NP_861969
          Length = 507

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TPKISF 6
           TPKISF
Sbjct: 168 TPKISF 173
>NP_000259
          Length = 595

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TPKISF 6
           TPKISF
Sbjct: 251 TPKISF 256
>NP_861968
          Length = 507

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TPKISF 6
           TPKISF
Sbjct: 168 TPKISF 173
>NP_861966
          Length = 548

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TPKISF 6
           TPKISF
Sbjct: 209 TPKISF 214
>NP_861970
          Length = 590

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TPKISF 6
           TPKISF
Sbjct: 251 TPKISF 256
>NP_861546
          Length = 590

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TPKISF 6
           TPKISF
Sbjct: 251 TPKISF 256
>NP_861967
          Length = 549

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TPKISF 6
           TPKISF
Sbjct: 210 TPKISF 215
>NP_001013758
          Length = 1035

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  PKISFRG 8
          PKIS RG
Sbjct: 79 PKISLRG 85
>NP_981953
          Length = 791

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  PKISFRG 8
          PKIS RG
Sbjct: 79 PKISLRG 85
>NP_689844
          Length = 645

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  PKISFRG 8
          PKIS RG
Sbjct: 79 PKISLRG 85
>NP_057191
          Length = 1074

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TPKISFRG 8
           TPKI+F G
Sbjct: 499 TPKINFVG 506
>NP_001615
          Length = 1723

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    PKISFRGM 9
            P ISF GM
Sbjct: 994  PSISFSGM 1001
>NP_112598
          Length = 5088

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    KISFRGM 9
            K+SFRG+
Sbjct: 2707 KVSFRGL 2713

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    KISFRGM 9
            K+SFRG+
Sbjct: 3238 KVSFRGL 3244

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    KISFRGM 9
            K+SFRG+
Sbjct: 3772 KVSFRGL 3778

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    KISFRGM 9
            K+SFRG+
Sbjct: 4306 KVSFRGL 4312

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    KISFRGM 9
            K+SFRG+
Sbjct: 4839 KVSFRGL 4845
>XP_005266896
          Length = 2131

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    PKISFRGM 9
            P ISF GM
Sbjct: 1402 PSISFSGM 1409
>XP_006714540
          Length = 1030

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TPKISFRG 8
           TPKI+F G
Sbjct: 455 TPKINFVG 462
>NP_001120702
          Length = 199

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   TPKISFRG 8
           TPKI  RG
Sbjct: 191 TPKIYLRG 198
>NP_001120701
          Length = 199

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   TPKISFRG 8
           TPKI  RG
Sbjct: 191 TPKIYLRG 198
>NP_060370
          Length = 199

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   TPKISFRG 8
           TPKI  RG
Sbjct: 191 TPKIYLRG 198
>NP_872620
          Length = 370

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  TPKISFRGM 9
          TP++  RGM
Sbjct: 4  TPEVKSRGM 12
>XP_005245344
          Length = 341

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  TPKISFRGM 9
          TP++  RGM
Sbjct: 4  TPEVKSRGM 12
>NP_055444
          Length = 1344

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    PKISFRGM 9
            PK++ RGM
Sbjct: 1170 PKVTGRGM 1177
>NP_002731
          Length = 596

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  PKISFRGM 9
          P ISF G+
Sbjct: 43 PSISFEGL 50
>NP_001103132
          Length = 4284

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    PKISFRGM 9
            PK + RGM
Sbjct: 2646 PKFAIRGM 2653
>NP_065811
          Length = 1572

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   TPKISFR 7
           TPK SFR
Sbjct: 381 TPKHSFR 387
>XP_006725174
          Length = 1306

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    PKISFRGM 9
            PK++ RGM
Sbjct: 1132 PKVTGRGM 1139
>XP_006725172
          Length = 1329

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    PKISFRGM 9
            PK++ RGM
Sbjct: 1155 PKVTGRGM 1162
>XP_006725171
          Length = 1330

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    PKISFRGM 9
            PK++ RGM
Sbjct: 1156 PKVTGRGM 1163
>XP_006725170
          Length = 1345

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    PKISFRGM 9
            PK++ RGM
Sbjct: 1171 PKVTGRGM 1178
>XP_006725169
          Length = 1368

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    PKISFRGM 9
            PK++ RGM
Sbjct: 1194 PKVTGRGM 1201
>XP_006725168
          Length = 1368

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    PKISFRGM 9
            PK++ RGM
Sbjct: 1194 PKVTGRGM 1201
>XP_006725167
          Length = 1369

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    PKISFRGM 9
            PK++ RGM
Sbjct: 1195 PKVTGRGM 1202
>XP_005254540
          Length = 924

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   PKISFRGM 9
           P +SF+GM
Sbjct: 917 PVLSFQGM 924
>XP_005266099
          Length = 1306

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    PKISFRGM 9
            PK++ RGM
Sbjct: 1132 PKVTGRGM 1139
>XP_006716303
          Length = 1329

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    PKISFRGM 9
            PK++ RGM
Sbjct: 1155 PKVTGRGM 1162
>XP_006716302
          Length = 1330

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    PKISFRGM 9
            PK++ RGM
Sbjct: 1156 PKVTGRGM 1163
>XP_005266098
          Length = 1345

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    PKISFRGM 9
            PK++ RGM
Sbjct: 1171 PKVTGRGM 1178
>XP_005266097
          Length = 1368

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    PKISFRGM 9
            PK++ RGM
Sbjct: 1194 PKVTGRGM 1201
>XP_005266096
          Length = 1368

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    PKISFRGM 9
            PK++ RGM
Sbjct: 1194 PKVTGRGM 1201
>XP_006716301
          Length = 1369

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    PKISFRGM 9
            PK++ RGM
Sbjct: 1195 PKVTGRGM 1202
>XP_006712712
          Length = 1414

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   TPKISFR 7
           TPK SFR
Sbjct: 223 TPKHSFR 229
>XP_006712711
          Length = 1448

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   TPKISFR 7
           TPK SFR
Sbjct: 257 TPKHSFR 263
>XP_006712710
          Length = 1528

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   TPKISFR 7
           TPK SFR
Sbjct: 388 TPKHSFR 394
>XP_006712709
          Length = 1579

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   TPKISFR 7
           TPK SFR
Sbjct: 388 TPKHSFR 394
>NP_068566
          Length = 790

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  KISFRG 8
          K+SFRG
Sbjct: 48 KLSFRG 53
>NP_001258791
          Length = 531

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   PKISFRG 8
           PKI+F G
Sbjct: 417 PKINFSG 423
>NP_775787
          Length = 520

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   PKISFRG 8
           PKI+F G
Sbjct: 406 PKINFSG 412
>XP_005255279
          Length = 855

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   TPKISFRG 8
           +P++ FRG
Sbjct: 602 SPRLPFRG 609
>XP_006718479
          Length = 414

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   PKISFRG 8
           PKI+ RG
Sbjct: 155 PKITLRG 161
>XP_006718474
          Length = 897

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   PKISFRG 8
           PKI+ RG
Sbjct: 155 PKITLRG 161
>NP_001073886
          Length = 869

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   TPKISFRG 8
           +P++ FRG
Sbjct: 616 SPRLPFRG 623
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.328    0.141    0.427 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 663,364
Number of extensions: 1457
Number of successful extensions: 66
Number of sequences better than 10000.0: 62
Number of HSP's gapped: 66
Number of HSP's successfully gapped: 66
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

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