Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005148                                                              20     509
NP_009297                                                              20     509
NP_001161710                                                           20     509
NP_001161709                                                           20     509
NP_001161708                                                           20     509
NP_009298                                                              20     509
NP_001129473                                                           20     509
NP_005149                                                              20     509
NP_001161711                                                           20     509
XP_005245145                                                           20     509
NP_001129472                                                           20     509
NP_000474                                                              17    4312
XP_005245103                                                           16    5631
XP_005245102                                                           16    5631
NP_002013                                                              16    5631
NP_001265444                                                           16    7355
NP_001274456                                                           16    7355
NP_852147                                                              16    7355
NP_852146                                                              16    7355
NP_078968                                                              16    7355
NP_954639                                                              16    7355
NP_954638                                                              16    7355
NP_954640                                                              16    7355
NP_001242905                                                           16    7355
NP_064567                                                              16    7355
NP_001003675                                                           16    7355
NP_001263178                                                           16    7355
NP_001003674                                                           16    7355
NP_001263180                                                           16    7355
XP_006722418                                                           16    7355
XP_006722417                                                           16    7355
XP_006722416                                                           16    7355
XP_006722415                                                           16    7355
XP_006722414                                                           16    7355
XP_006722413                                                           16    7355
XP_005258197                                                           16    7355
XP_006712168                                                           16    7355
XP_005264621                                                           16    7355
XP_005264620                                                           16    7355
XP_006712167                                                           16    7355
XP_005264619                                                           16    7355
NP_001274457                                                           16    7355
NP_060811                                                              15    9605
NP_001265460                                                           15    9605
NP_001265462                                                           15    9605
NP_001258604                                                           15    9605
NP_840056                                                              15    9605
NP_055642                                                              15    9605
NP_005190                                                              15    9605
NP_002355                                                              15    9605
XP_006725074                                                           15    9605
XP_006725073                                                           15    9605
XP_006716018                                                           15    9605
XP_006715573                                                           15    9605
XP_006715572                                                           15    9605
XP_006711736                                                           15    9605
XP_005245701                                                           15    9605
XP_005245700                                                           15    9605
NP_002535                                                              15    9605
>NP_005148
          Length = 1130

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  TLSITKGEE 9
          TLSITKGE+
Sbjct: 79 TLSITKGEK 87
>NP_009297
          Length = 1149

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TLSITKGEE 9
           TLSITKGE+
Sbjct: 98  TLSITKGEK 106
>NP_001161710
          Length = 1058

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TLSITKGEE 9
           TLSITKGE+
Sbjct: 104 TLSITKGEK 112
>NP_001161709
          Length = 1079

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TLSITKGEE 9
           TLSITKGE+
Sbjct: 125 TLSITKGEK 133
>NP_001161708
          Length = 1161

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TLSITKGEE 9
           TLSITKGE+
Sbjct: 104 TLSITKGEK 112
>NP_009298
          Length = 1182

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TLSITKGEE 9
           TLSITKGE+
Sbjct: 125 TLSITKGEK 133
>NP_001129473
          Length = 542

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TLSITKGEE 9
           TLSITKGE+
Sbjct: 104 TLSITKGEK 112
>NP_005149
          Length = 1167

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TLSITKGEE 9
           TLSITKGE+
Sbjct: 110 TLSITKGEK 118
>NP_001161711
          Length = 1043

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  TLSITKGEE 9
          TLSITKGE+
Sbjct: 89 TLSITKGEK 97
>XP_005245145
          Length = 1146

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  TLSITKGEE 9
          TLSITKGE+
Sbjct: 89 TLSITKGEK 97
>NP_001129472
          Length = 1064

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TLSITKGEE 9
           TLSITKGE+
Sbjct: 110 TLSITKGEK 118
>NP_000474
          Length = 101

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LSITKGEE 9
           LS+ KGEE
Sbjct: 94  LSVLKGEE 101
>XP_005245103
          Length = 495

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LSITKGEE 9
           LSITKG++
Sbjct: 208 LSITKGKK 215
>XP_005245102
          Length = 508

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LSITKGEE 9
           LSITKG++
Sbjct: 221 LSITKGKK 228
>NP_002013
          Length = 558

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LSITKGEE 9
           LSITKG++
Sbjct: 271 LSITKGKK 278
>NP_001265444
          Length = 136

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  SITKGEE 9
          S+T+GEE
Sbjct: 63 SVTEGEE 69
>NP_001274456
          Length = 705

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TLSITKGEE 9
           TLS+  GEE
Sbjct: 402 TLSLPPGEE 410
>NP_852147
          Length = 288

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TLSITKGEE 9
           T+S++ GEE
Sbjct: 153 TISLSDGEE 161
>NP_852146
          Length = 306

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TLSITKGEE 9
           T+S++ GEE
Sbjct: 171 TISLSDGEE 179
>NP_078968
          Length = 705

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TLSITKGEE 9
           TLS+  GEE
Sbjct: 402 TLSLPPGEE 410
>NP_954639
          Length = 237

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TLSITKGEE 9
           T+S++ GEE
Sbjct: 99  TISLSDGEE 107
>NP_954638
          Length = 252

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TLSITKGEE 9
           T+S++ GEE
Sbjct: 114 TISLSDGEE 122
>NP_954640
          Length = 237

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TLSITKGEE 9
           T+S++ GEE
Sbjct: 99  TISLSDGEE 107
>NP_001242905
          Length = 259

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TLSITKGEE 9
           T+S++ GEE
Sbjct: 121 TISLSDGEE 129
>NP_064567
          Length = 287

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TLSITKGEE 9
           T+S++ GEE
Sbjct: 149 TISLSDGEE 157
>NP_001003675
          Length = 251

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TLSITKGEE 9
           T+S++ GEE
Sbjct: 116 TISLSDGEE 124
>NP_001263178
          Length = 229

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TLSITKGEE 9
           T+S++ GEE
Sbjct: 94  TISLSDGEE 102
>NP_001003674
          Length = 269

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TLSITKGEE 9
           T+S++ GEE
Sbjct: 134 TISLSDGEE 142
>NP_001263180
          Length = 208

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  TLSITKGEE 9
          T+S++ GEE
Sbjct: 73 TISLSDGEE 81
>XP_006722418
          Length = 306

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TLSITKGEE 9
           T+S++ GEE
Sbjct: 171 TISLSDGEE 179
>XP_006722417
          Length = 306

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TLSITKGEE 9
           T+S++ GEE
Sbjct: 171 TISLSDGEE 179
>XP_006722416
          Length = 306

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TLSITKGEE 9
           T+S++ GEE
Sbjct: 171 TISLSDGEE 179
>XP_006722415
          Length = 306

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TLSITKGEE 9
           T+S++ GEE
Sbjct: 171 TISLSDGEE 179
>XP_006722414
          Length = 306

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TLSITKGEE 9
           T+S++ GEE
Sbjct: 171 TISLSDGEE 179
>XP_006722413
          Length = 306

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TLSITKGEE 9
           T+S++ GEE
Sbjct: 171 TISLSDGEE 179
>XP_005258197
          Length = 306

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TLSITKGEE 9
           T+S++ GEE
Sbjct: 171 TISLSDGEE 179
>XP_006712168
          Length = 596

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TLSITKGEE 9
           TLS+  GEE
Sbjct: 402 TLSLPPGEE 410
>XP_005264621
          Length = 687

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TLSITKGEE 9
           TLS+  GEE
Sbjct: 384 TLSLPPGEE 392
>XP_005264620
          Length = 705

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TLSITKGEE 9
           TLS+  GEE
Sbjct: 402 TLSLPPGEE 410
>XP_006712167
          Length = 705

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TLSITKGEE 9
           TLS+  GEE
Sbjct: 402 TLSLPPGEE 410
>XP_005264619
          Length = 705

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TLSITKGEE 9
           TLS+  GEE
Sbjct: 402 TLSLPPGEE 410
>NP_001274457
          Length = 599

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TLSITKGEE 9
           TLS+  GEE
Sbjct: 402 TLSLPPGEE 410
>NP_060811
          Length = 678

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  LSITKGE 8
          LS+TKG+
Sbjct: 83 LSLTKGQ 89
>NP_001265460
          Length = 631

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  LSITKGE 8
          LS+TKG+
Sbjct: 83 LSLTKGQ 89
>NP_001265462
          Length = 605

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  LSITKGE 8
          LS+TKG+
Sbjct: 83 LSLTKGQ 89
>NP_001258604
          Length = 805

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TLSITKGEE 9
           TLS  +GEE
Sbjct: 265 TLSTKQGEE 273
>NP_840056
          Length = 230

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LSITKGEE 9
           LSIT+G++
Sbjct: 147 LSITQGQQ 154
>NP_055642
          Length = 810

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TLSITKGEE 9
           TLS  +GEE
Sbjct: 265 TLSTKQGEE 273
>NP_005190
          Length = 517

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SITKGEE 9
           SIT GEE
Sbjct: 382 SITTGEE 388
>NP_002355
          Length = 319

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   SITKGE 8
           S+TKGE
Sbjct: 131 SVTKGE 136
>XP_006725074
          Length = 678

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  LSITKGE 8
          LS+TKG+
Sbjct: 93 LSLTKGQ 99
>XP_006725073
          Length = 688

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  LSITKGE 8
          LS+TKG+
Sbjct: 93 LSLTKGQ 99
>XP_006716018
          Length = 257

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LSITKGEE 9
           LSIT+G++
Sbjct: 174 LSITQGQQ 181
>XP_006715573
          Length = 678

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  LSITKGE 8
          LS+TKG+
Sbjct: 93 LSLTKGQ 99
>XP_006715572
          Length = 688

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  LSITKGE 8
          LS+TKG+
Sbjct: 93 LSLTKGQ 99
>XP_006711736
          Length = 810

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TLSITKGEE 9
           TLS  +GEE
Sbjct: 265 TLSTKQGEE 273
>XP_005245701
          Length = 810

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TLSITKGEE 9
           TLS  +GEE
Sbjct: 265 TLSTKQGEE 273
>XP_005245700
          Length = 810

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TLSITKGEE 9
           TLS  +GEE
Sbjct: 265 TLSTKQGEE 273
>NP_002535
          Length = 440

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   TLSITKG 7
           TLSIT G
Sbjct: 379 TLSITSG 385
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.292    0.118    0.280 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 521,368
Number of extensions: 711
Number of successful extensions: 59
Number of sequences better than 10000.0: 59
Number of HSP's gapped: 59
Number of HSP's successfully gapped: 59
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.9 bits)
S2: 28 (15.4 bits)

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