Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_919047                                                              19     869
XP_005250598                                                           19     869
NP_689775                                                              18    1135
XP_005273475                                                           18    1135
XP_006716359                                                           18    1135
XP_006716358                                                           18    1135
XP_006716357                                                           18    1135
NP_001180267                                                           17    2528
NP_001160158                                                           17    3301
NP_000280                                                              17    3301
NP_001160160                                                           17    3301
XP_006719527                                                           17    3301
XP_006719526                                                           17    3301
XP_005269037                                                           17    3301
XP_005269036                                                           17    3301
XP_005269035                                                           17    3301
XP_005269034                                                           17    3301
XP_005269033                                                           17    3301
XP_005269032                                                           17    3301
XP_005269031                                                           17    3301
XP_005245824                                                           17    3301
NP_001160159                                                           17    3301
NP_001002021                                                           17    4312
NP_002617                                                              17    4312
XP_005261194                                                           17    4312
XP_005261193                                                           17    4312
XP_005261192                                                           17    4312
XP_006724075                                                           17    4312
XP_006724074                                                           17    4312
NP_001138604                                                           17    4312
NP_000537                                                              16    5631
NP_001263689                                                           16    5631
NP_001119584                                                           16    5631
NP_001119586                                                           16    5631
NP_001263625                                                           16    5631
NP_001119590                                                           16    5631
NP_001263690                                                           16    5631
NP_001119585                                                           16    5631
NP_001263624                                                           16    5631
NP_001119588                                                           16    5631
NP_001119587                                                           16    5631
NP_001119589                                                           16    5631
NP_005338                                                              16    5631
NP_001263627                                                           16    5631
NP_001263628                                                           16    5631
NP_596870                                                              16    5631
NP_001263626                                                           16    5631
NP_001135932                                                           16    7355
NP_001127909                                                           16    7355
NP_001177645                                                           15    9605
NP_004936                                                              15    9605
NP_001005361                                                           15    9605
NP_001005360                                                           15    9605
NP_001005362                                                           15    9605
NP_976221                                                              15    9605
NP_001230829                                                           15    9605
NP_005327                                                              15    9605
NP_001269955                                                           15    9605
NP_065770                                                              15    9605
NP_064601                                                              15    9605
NP_003684                                                              15    9605
XP_006721216                                                           15    9605
XP_005251896                                                           15    9605
XP_005251895                                                           15    9605
XP_005251894                                                           15    9605
XP_006712539                                                           15    9605
XP_005247059                                                           15    9605
XP_005247058                                                           15    9605
XP_006712538                                                           15    9605
XP_005247060                                                           15    9605
XP_005247057                                                           15    9605
XP_005245478                                                           15    9605
XP_005245477                                                           15    9605
XP_005245476                                                           15    9605
XP_005245475                                                           15    9605
NP_055925                                                              15    9605
>NP_919047
          Length = 520

 Score = 18.9 bits (37), Expect =   869
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   TKRALPKQH 9
           TK ALP QH
Sbjct: 405 TKMALPSQH 413
>XP_005250598
          Length = 457

 Score = 18.9 bits (37), Expect =   869
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   TKRALPKQH 9
           TK ALP QH
Sbjct: 342 TKMALPSQH 350
>NP_689775
          Length = 1023

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   TKRALPKQ 8
           TKRALPK+
Sbjct: 548 TKRALPKK 555
>XP_005273475
          Length = 635

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   TKRALPKQ 8
           TKRALPK+
Sbjct: 548 TKRALPKK 555
>XP_006716359
          Length = 1028

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   TKRALPKQ 8
           TKRALPK+
Sbjct: 553 TKRALPKK 560
>XP_006716358
          Length = 1028

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   TKRALPKQ 8
           TKRALPK+
Sbjct: 553 TKRALPKK 560
>XP_006716357
          Length = 1028

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   TKRALPKQ 8
           TKRALPK+
Sbjct: 553 TKRALPKK 560
>NP_001180267
          Length = 306

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   ALPKQH 9
           ALPKQH
Sbjct: 265 ALPKQH 270
>NP_001160158
          Length = 851

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TKRALPKQ 8
           TKR LPK+
Sbjct: 540 TKRTLPKK 547
>NP_000280
          Length = 780

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TKRALPKQ 8
           TKR LPK+
Sbjct: 469 TKRTLPKK 476
>NP_001160160
          Length = 780

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TKRALPKQ 8
           TKR LPK+
Sbjct: 469 TKRTLPKK 476
>XP_006719527
          Length = 780

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TKRALPKQ 8
           TKR LPK+
Sbjct: 469 TKRTLPKK 476
>XP_006719526
          Length = 780

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TKRALPKQ 8
           TKR LPK+
Sbjct: 469 TKRTLPKK 476
>XP_005269037
          Length = 811

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TKRALPKQ 8
           TKR LPK+
Sbjct: 500 TKRTLPKK 507
>XP_005269036
          Length = 851

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TKRALPKQ 8
           TKR LPK+
Sbjct: 540 TKRTLPKK 547
>XP_005269035
          Length = 851

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TKRALPKQ 8
           TKR LPK+
Sbjct: 540 TKRTLPKK 547
>XP_005269034
          Length = 851

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TKRALPKQ 8
           TKR LPK+
Sbjct: 540 TKRTLPKK 547
>XP_005269033
          Length = 883

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TKRALPKQ 8
           TKR LPK+
Sbjct: 572 TKRTLPKK 579
>XP_005269032
          Length = 883

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TKRALPKQ 8
           TKR LPK+
Sbjct: 572 TKRTLPKK 579
>XP_005269031
          Length = 883

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TKRALPKQ 8
           TKR LPK+
Sbjct: 572 TKRTLPKK 579
>XP_005245824
          Length = 823

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   TKRALPKQ 8
           T+RALP+Q
Sbjct: 761 TERALPQQ 768
>NP_001160159
          Length = 780

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TKRALPKQ 8
           TKR LPK+
Sbjct: 469 TKRTLPKK 476
>NP_001002021
          Length = 830

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   TKRALPK 7
           TKR LPK
Sbjct: 518 TKRTLPK 524
>NP_002617
          Length = 780

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   TKRALPK 7
           TKR LPK
Sbjct: 468 TKRTLPK 474
>XP_005261194
          Length = 751

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   TKRALPK 7
           TKR LPK
Sbjct: 439 TKRTLPK 445
>XP_005261193
          Length = 774

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   TKRALPK 7
           TKR LPK
Sbjct: 462 TKRTLPK 468
>XP_005261192
          Length = 803

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   TKRALPK 7
           TKR LPK
Sbjct: 491 TKRTLPK 497
>XP_006724075
          Length = 830

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   TKRALPK 7
           TKR LPK
Sbjct: 518 TKRTLPK 524
>XP_006724074
          Length = 853

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   TKRALPK 7
           TKR LPK
Sbjct: 541 TKRTLPK 547
>NP_001138604
          Length = 159

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  KRALPKQH 9
          K+ LPK H
Sbjct: 81 KKTLPKSH 88
>NP_000537
          Length = 393

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TKRALP 6
           TKRALP
Sbjct: 304 TKRALP 309
>NP_001263689
          Length = 354

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TKRALP 6
           TKRALP
Sbjct: 265 TKRALP 270
>NP_001119584
          Length = 393

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TKRALP 6
           TKRALP
Sbjct: 304 TKRALP 309
>NP_001119586
          Length = 341

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TKRALP 6
           TKRALP
Sbjct: 304 TKRALP 309
>NP_001263625
          Length = 302

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TKRALP 6
           TKRALP
Sbjct: 265 TKRALP 270
>NP_001119590
          Length = 354

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TKRALP 6
           TKRALP
Sbjct: 265 TKRALP 270
>NP_001263690
          Length = 354

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TKRALP 6
           TKRALP
Sbjct: 265 TKRALP 270
>NP_001119585
          Length = 346

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TKRALP 6
           TKRALP
Sbjct: 304 TKRALP 309
>NP_001263624
          Length = 307

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TKRALP 6
           TKRALP
Sbjct: 265 TKRALP 270
>NP_001119588
          Length = 209

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TKRALP 6
           TKRALP
Sbjct: 172 TKRALP 177
>NP_001119587
          Length = 261

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TKRALP 6
           TKRALP
Sbjct: 172 TKRALP 177
>NP_001119589
          Length = 214

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TKRALP 6
           TKRALP
Sbjct: 172 TKRALP 177
>NP_005338
          Length = 654

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   KRALPKQH 9
           KRAL  QH
Sbjct: 296 KRALSSQH 303
>NP_001263627
          Length = 182

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TKRALP 6
           TKRALP
Sbjct: 145 TKRALP 150
>NP_001263628
          Length = 187

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TKRALP 6
           TKRALP
Sbjct: 145 TKRALP 150
>NP_596870
          Length = 5604

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    KRALPKQH 9
            K +LPK H
Sbjct: 3815 KESLPKDH 3822
>NP_001263626
          Length = 234

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TKRALP 6
           TKRALP
Sbjct: 145 TKRALP 150
>NP_001135932
          Length = 429

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   ALPKQH 9
           ALPK+H
Sbjct: 365 ALPKKH 370
>NP_001127909
          Length = 1237

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  TKRALPKQ 8
          TKR +PK+
Sbjct: 6  TKREVPKE 13
>NP_001177645
          Length = 869

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   KRALPKQ 8
           KRA+P Q
Sbjct: 509 KRAIPNQ 515
>NP_004936
          Length = 866

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   KRALPKQ 8
           KRA+P Q
Sbjct: 509 KRAIPNQ 515
>NP_001005361
          Length = 870

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   KRALPKQ 8
           KRA+P Q
Sbjct: 509 KRAIPNQ 515
>NP_001005360
          Length = 870

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   KRALPKQ 8
           KRA+P Q
Sbjct: 509 KRAIPNQ 515
>NP_001005362
          Length = 866

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   KRALPKQ 8
           KRA+P Q
Sbjct: 509 KRAIPNQ 515
>NP_976221
          Length = 1268

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   ALPKQH 9
           A+PK+H
Sbjct: 156 AIPKEH 161
>NP_001230829
          Length = 1235

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   ALPKQH 9
           A+PK+H
Sbjct: 192 AIPKEH 197
>NP_005327
          Length = 1268

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   ALPKQH 9
           A+PK+H
Sbjct: 156 AIPKEH 161
>NP_001269955
          Length = 204

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  TKRALPK 7
          TKR +PK
Sbjct: 14 TKRQIPK 20
>NP_065770
          Length = 2036

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   KRALPKQ 8
           +RALP+Q
Sbjct: 279 ERALPRQ 285
>NP_064601
          Length = 650

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TKRALPKQH 9
           T RAL +QH
Sbjct: 374 TGRALLRQH 382
>NP_003684
          Length = 830

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   KRALPK 7
           KRA+PK
Sbjct: 725 KRAIPK 730
>XP_006721216
          Length = 877

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TKRALPK 7
           ++RALPK
Sbjct: 824 SRRALPK 830
>XP_005251896
          Length = 1063

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TKRALPK 7
          +KRALP+
Sbjct: 16 SKRALPR 22
>XP_005251895
          Length = 1077

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TKRALPK 7
          +KRALP+
Sbjct: 16 SKRALPR 22
>XP_005251894
          Length = 1086

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TKRALPK 7
          +KRALP+
Sbjct: 16 SKRALPR 22
>XP_006712539
          Length = 1250

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   ALPKQH 9
           A+PK+H
Sbjct: 156 AIPKEH 161
>XP_005247059
          Length = 1268

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   ALPKQH 9
           A+PK+H
Sbjct: 156 AIPKEH 161
>XP_005247058
          Length = 1268

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   ALPKQH 9
           A+PK+H
Sbjct: 156 AIPKEH 161
>XP_006712538
          Length = 1268

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   ALPKQH 9
           A+PK+H
Sbjct: 156 AIPKEH 161
>XP_005247060
          Length = 1268

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   ALPKQH 9
           A+PK+H
Sbjct: 156 AIPKEH 161
>XP_005247057
          Length = 1268

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   ALPKQH 9
           A+PK+H
Sbjct: 156 AIPKEH 161
>XP_005245478
          Length = 360

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  TKRALPKQH 9
          T RAL +QH
Sbjct: 84 TGRALLRQH 92
>XP_005245477
          Length = 360

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  TKRALPKQH 9
          T RAL +QH
Sbjct: 84 TGRALLRQH 92
>XP_005245476
          Length = 446

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TKRALPKQH 9
           T RAL +QH
Sbjct: 170 TGRALLRQH 178
>XP_005245475
          Length = 519

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TKRALPKQH 9
           T RAL +QH
Sbjct: 243 TGRALLRQH 251
>NP_055925
          Length = 1101

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TKRALPK 7
          +KRALP+
Sbjct: 16 SKRALPR 22
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.315    0.124    0.366 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 739,334
Number of extensions: 1409
Number of successful extensions: 76
Number of sequences better than 10000.0: 76
Number of HSP's gapped: 76
Number of HSP's successfully gapped: 76
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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