Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_006197                                                              20     390
XP_006714104                                                           20     390
XP_005265800                                                           20     390
XP_006714103                                                           20     390
XP_006714102                                                           20     390
NP_060664                                                              18    1935
NP_001164059                                                           18    1935
NP_001116306                                                           18    1935
NP_001164051                                                           18    1935
NP_001164058                                                           18    1935
XP_006711504                                                           18    1935
NP_001017924                                                           17    3301
NP_001271152                                                           17    3301
NP_002153                                                              17    4312
NP_443100                                                              17    4312
NP_001363                                                              17    4312
NP_001193594                                                           17    4312
XP_006721530                                                           17    4312
XP_006721529                                                           17    4312
XP_006721528                                                           17    4312
XP_006711694                                                           17    4312
XP_005245671                                                           17    4312
NP_001186438                                                           16    5631
NP_003175                                                              16    5631
NP_001186439                                                           16    5631
XP_006716684                                                           16    5631
NP_004819                                                              16    5631
NP_065840                                                              16    5631
NP_001128522                                                           16    5631
NP_079285                                                              16    7355
NP_005202                                                              16    7355
NP_001275634                                                           16    7355
XP_006724037                                                           16    7355
XP_006714118                                                           16    7355
NP_001073913                                                           16    7355
NP_001124295                                                           15    9605
NP_001370                                                              15    9605
NP_733765                                                              15    9605
NP_001672                                                              15    9605
NP_001273004                                                           15    9605
NP_004311                                                              15    9605
NP_775293                                                              15    9605
NP_003647                                                              15    9605
NP_008985                                                              15    9605
NP_002727                                                              15    9605
NP_777613                                                              15    9605
NP_777617                                                              15    9605
NP_777614                                                              15    9605
NP_005164                                                              15    9605
NP_777618                                                              15    9605
NP_777615                                                              15    9605
XP_003960846                                                           15    9605
XP_006722744                                                           15    9605
XP_005266713                                                           15    9605
XP_005256713                                                           15    9605
XP_005253945                                                           15    9605
XP_005271926                                                           15    9605
XP_006714589                                                           15    9605
XP_005271925                                                           15    9605
XP_005265573                                                           15    9605
XP_003846680                                                           15    9605
NP_055728                                                              15    9605
NP_777616                                                              15    9605
>NP_006197
          Length = 1089

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TITVRCLAK 9
           TI VRCLAK
Sbjct: 496 TIAVRCLAK 504
>XP_006714104
          Length = 832

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TITVRCLAK 9
           TI VRCLAK
Sbjct: 521 TIAVRCLAK 529
>XP_005265800
          Length = 1089

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TITVRCLAK 9
           TI VRCLAK
Sbjct: 496 TIAVRCLAK 504
>XP_006714103
          Length = 1111

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TITVRCLAK 9
           TI VRCLAK
Sbjct: 518 TIAVRCLAK 526
>XP_006714102
          Length = 1114

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TITVRCLAK 9
           TI VRCLAK
Sbjct: 521 TIAVRCLAK 529
>NP_060664
          Length = 493

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TITVRCL 7
           T+TVRCL
Sbjct: 172 TLTVRCL 178
>NP_001164059
          Length = 428

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TITVRCL 7
           T+TVRCL
Sbjct: 107 TLTVRCL 113
>NP_001116306
          Length = 493

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TITVRCL 7
           T+TVRCL
Sbjct: 172 TLTVRCL 178
>NP_001164051
          Length = 493

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TITVRCL 7
           T+TVRCL
Sbjct: 172 TLTVRCL 178
>NP_001164058
          Length = 494

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TITVRCL 7
           T+TVRCL
Sbjct: 173 TLTVRCL 179
>XP_006711504
          Length = 527

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TITVRCL 7
           T+TVRCL
Sbjct: 206 TLTVRCL 212
>NP_001017924
          Length = 550

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ITVRCLAK 9
           +T+RCLA+
Sbjct: 270 VTLRCLAQ 277
>NP_001271152
          Length = 560

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ITVRCLAK 9
           +T+RCLA+
Sbjct: 270 VTLRCLAQ 277
>NP_002153
          Length = 547

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TITVRCLA 8
           T+TV C+A
Sbjct: 331 TVTVSCMA 338
>NP_443100
          Length = 613

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   TVRCLAK 9
           T RCLAK
Sbjct: 403 TYRCLAK 409
>NP_001363
          Length = 4486

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   TITVRCLAK 9
           TITVR +AK
Sbjct: 271 TITVRGMAK 279
>NP_001193594
          Length = 613

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   TVRCLAK 9
           T RCLAK
Sbjct: 403 TYRCLAK 409
>XP_006721530
          Length = 2746

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   TITVRCLAK 9
           TITVR +AK
Sbjct: 271 TITVRGMAK 279
>XP_006721529
          Length = 2817

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   TITVRCLAK 9
           TITVR +AK
Sbjct: 271 TITVRGMAK 279
>XP_006721528
          Length = 3869

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   TITVRCLAK 9
           TITVR +AK
Sbjct: 271 TITVRGMAK 279
>XP_006711694
          Length = 596

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   TVRCLAK 9
           T RCLAK
Sbjct: 386 TYRCLAK 392
>XP_005245671
          Length = 613

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   TVRCLAK 9
           T RCLAK
Sbjct: 403 TYRCLAK 409
>NP_001186438
          Length = 270

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  TITVRC 6
          T+TVRC
Sbjct: 35 TLTVRC 40
>NP_003175
          Length = 1199

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   TITVRCL 7
           TITV CL
Sbjct: 849 TITVSCL 855
>NP_001186439
          Length = 258

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  TITVRC 6
          T+TVRC
Sbjct: 35 TLTVRC 40
>XP_006716684
          Length = 1251

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   TITVRCL 7
           TITV CL
Sbjct: 849 TITVSCL 855
>NP_004819
          Length = 276

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  TITVRC 6
          T+TVRC
Sbjct: 35 TLTVRC 40
>NP_065840
          Length = 1163

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   ITVRCLAK 9
           +T+RC+A+
Sbjct: 154 VTLRCVAR 161
>NP_001128522
          Length = 1179

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   ITVRCLAK 9
           +T+RC+A+
Sbjct: 154 VTLRCVAR 161
>NP_079285
          Length = 1140

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  TITVRCL 7
          T+TV CL
Sbjct: 24 TLTVECL 30
>NP_005202
          Length = 972

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1  TITVRCL 7
          T+T+RC+
Sbjct: 37 TVTLRCV 43
>NP_001275634
          Length = 972

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1  TITVRCL 7
          T+T+RC+
Sbjct: 37 TVTLRCV 43
>XP_006724037
          Length = 407

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   TITVRC 6
           T+T+RC
Sbjct: 282 TLTIRC 287
>XP_006714118
          Length = 1129

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  TITVRCL 7
          T+TV CL
Sbjct: 24 TLTVECL 30
>NP_001073913
          Length = 407

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   TITVRC 6
           T+T+RC
Sbjct: 282 TLTIRC 287
>NP_001124295
          Length = 1632

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    ITVRCLAK 9
            +T+RCL +
Sbjct: 1298 LTLRCLVR 1305
>NP_001370
          Length = 1616

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    ITVRCLAK 9
            +T+RCL +
Sbjct: 1282 LTLRCLVR 1289
>NP_733765
          Length = 1042

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   TVRCLA 8
           T+RCLA
Sbjct: 557 TLRCLA 562
>NP_001672
          Length = 997

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   TVRCLA 8
           T+RCLA
Sbjct: 557 TLRCLA 562
>NP_001273004
          Length = 869

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   TVRCLA 8
           T+RCLA
Sbjct: 433 TLRCLA 438
>NP_004311
          Length = 994

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   TVRCLA 8
           T+RCLA
Sbjct: 558 TLRCLA 563
>NP_775293
          Length = 1001

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   TVRCLA 8
           T+RCLA
Sbjct: 558 TLRCLA 563
>NP_003647
          Length = 370

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/8 (37%), Positives = 7/8 (87%)

Query: 2  ITVRCLAK 9
          + ++C+AK
Sbjct: 46 VAIKCIAK 53
>NP_008985
          Length = 699

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   TITVRCLAK 9
           TIT+ C  K
Sbjct: 225 TITIECSEK 233
>NP_002727
          Length = 418

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   TVRCLA 8
           TV+CLA
Sbjct: 370 TVKCLA 375
>NP_777613
          Length = 1052

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   TVRCLA 8
           T+RCLA
Sbjct: 558 TLRCLA 563
>NP_777617
          Length = 998

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   TVRCLA 8
           T+RCLA
Sbjct: 558 TLRCLA 563
>NP_777614
          Length = 1044

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   TVRCLA 8
           T+RCLA
Sbjct: 558 TLRCLA 563
>NP_005164
          Length = 999

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   TVRCLA 8
           T+RCLA
Sbjct: 558 TLRCLA 563
>NP_777618
          Length = 1029

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   TVRCLA 8
           T+RCLA
Sbjct: 558 TLRCLA 563
>NP_777615
          Length = 1043

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   TVRCLA 8
           T+RCLA
Sbjct: 558 TLRCLA 563
>XP_003960846
          Length = 259

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   TITVRCLA 8
           T+T +CL+
Sbjct: 229 TLTAKCLS 236
>XP_006722744
          Length = 1495

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    ITVRCLAK 9
            +T+RCL +
Sbjct: 1161 LTLRCLVR 1168
>XP_005266713
          Length = 1131

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   TVRCLA 8
           TVRCL+
Sbjct: 746 TVRCLS 751
>XP_005256713
          Length = 1100

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   TVRCLA 8
           T+RCLA
Sbjct: 558 TLRCLA 563
>XP_005253945
          Length = 999

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   TVRCLA 8
           T+RCLA
Sbjct: 557 TLRCLA 562
>XP_005271926
          Length = 702

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   TITVRCLAK 9
           TIT+ C  K
Sbjct: 225 TITIECSEK 233
>XP_006714589
          Length = 724

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   TITVRCLAK 9
           TIT+ C  K
Sbjct: 225 TITIECSEK 233
>XP_005271925
          Length = 726

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   TITVRCLAK 9
           TIT+ C  K
Sbjct: 225 TITIECSEK 233
>XP_005265573
          Length = 413

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/8 (37%), Positives = 7/8 (87%)

Query: 2  ITVRCLAK 9
          + ++C+AK
Sbjct: 46 VAIKCIAK 53
>XP_003846680
          Length = 259

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   TITVRCLA 8
           T+T +CL+
Sbjct: 229 TLTAKCLS 236
>NP_055728
          Length = 1131

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   TVRCLA 8
           TVRCL+
Sbjct: 746 TVRCLS 751
>NP_777616
          Length = 1029

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   TVRCLA 8
           T+RCLA
Sbjct: 558 TLRCLA 563
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.336    0.135    0.411 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 597,460
Number of extensions: 781
Number of successful extensions: 63
Number of sequences better than 10000.0: 63
Number of HSP's gapped: 63
Number of HSP's successfully gapped: 63
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.5 bits)
S2: 28 (15.4 bits)

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