Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000537                                                              18    1482
NP_001263689                                                           18    1482
NP_001119584                                                           18    1482
NP_001119586                                                           18    1482
NP_001263625                                                           18    1482
NP_001119590                                                           18    1482
NP_001263690                                                           18    1482
NP_001119585                                                           18    1482
NP_001263624                                                           18    1482
NP_001119588                                                           18    1482
NP_001119587                                                           18    1482
NP_001119589                                                           18    1482
NP_001263627                                                           18    1482
NP_001263628                                                           18    1482
NP_001263626                                                           18    1482
NP_001243275                                                           17    3301
NP_001026872                                                           17    3301
NP_001243277                                                           17    3301
NP_001243276                                                           17    3301
NP_061152                                                              17    4312
NP_891847                                                              17    4312
XP_006716112                                                           17    4312
XP_005250550                                                           17    4312
NP_062550                                                              16    5631
NP_054878                                                              16    5631
NP_003091                                                              16    5631
NP_031377                                                              16    5631
XP_005262913                                                           16    5631
XP_005265151                                                           16    5631
XP_006713183                                                           16    5631
XP_006713182                                                           16    5631
NP_001265612                                                           16    7355
NP_602296                                                              16    7355
NP_005572                                                              16    7355
NP_001139395                                                           16    7355
NP_001013275                                                           16    7355
NP_065894                                                              16    7355
XP_005254476                                                           16    7355
XP_005254474                                                           16    7355
XP_005253778                                                           16    7355
XP_005253777                                                           16    7355
NP_055791                                                              15    9605
NP_057285                                                              15    9605
NP_001265614                                                           15    9605
NP_078966                                                              15    9605
NP_001273988                                                           15    9605
NP_055867                                                              15    9605
NP_001027539                                                           15    9605
NP_006539                                                              15    9605
NP_001007226                                                           15    9605
NP_991331                                                              15    9605
NP_001265125                                                           15    9605
NP_056243                                                              15    9605
NP_001006657                                                           15    9605
NP_003701                                                              15    9605
NP_857593                                                              15    9605
NP_006343                                                              15    9605
XP_006720720                                                           15    9605
XP_005269704                                                           15    9605
XP_006715736                                                           15    9605
XP_006715735                                                           15    9605
XP_005249722                                                           15    9605
XP_006715734                                                           15    9605
XP_006715733                                                           15    9605
XP_005247723                                                           15    9605
XP_006713718                                                           15    9605
XP_006713717                                                           15    9605
XP_005247577                                                           15    9605
XP_006713541                                                           15    9605
XP_006713540                                                           15    9605
XP_005273063                                                           15    9605
>NP_000537
          Length = 393

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TISTLEDSS 9
           TI TLEDSS
Sbjct: 253 TIITLEDSS 261
>NP_001263689
          Length = 354

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TISTLEDSS 9
           TI TLEDSS
Sbjct: 214 TIITLEDSS 222
>NP_001119584
          Length = 393

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TISTLEDSS 9
           TI TLEDSS
Sbjct: 253 TIITLEDSS 261
>NP_001119586
          Length = 341

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TISTLEDSS 9
           TI TLEDSS
Sbjct: 253 TIITLEDSS 261
>NP_001263625
          Length = 302

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TISTLEDSS 9
           TI TLEDSS
Sbjct: 214 TIITLEDSS 222
>NP_001119590
          Length = 354

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TISTLEDSS 9
           TI TLEDSS
Sbjct: 214 TIITLEDSS 222
>NP_001263690
          Length = 354

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TISTLEDSS 9
           TI TLEDSS
Sbjct: 214 TIITLEDSS 222
>NP_001119585
          Length = 346

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TISTLEDSS 9
           TI TLEDSS
Sbjct: 253 TIITLEDSS 261
>NP_001263624
          Length = 307

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TISTLEDSS 9
           TI TLEDSS
Sbjct: 214 TIITLEDSS 222
>NP_001119588
          Length = 209

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TISTLEDSS 9
           TI TLEDSS
Sbjct: 121 TIITLEDSS 129
>NP_001119587
          Length = 261

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TISTLEDSS 9
           TI TLEDSS
Sbjct: 121 TIITLEDSS 129
>NP_001119589
          Length = 214

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TISTLEDSS 9
           TI TLEDSS
Sbjct: 121 TIITLEDSS 129
>NP_001263627
          Length = 182

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TISTLEDSS 9
           TI TLEDSS
Sbjct: 94  TIITLEDSS 102
>NP_001263628
          Length = 187

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TISTLEDSS 9
           TI TLEDSS
Sbjct: 94  TIITLEDSS 102
>NP_001263626
          Length = 234

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TISTLEDSS 9
           TI TLEDSS
Sbjct: 94  TIITLEDSS 102
>NP_001243275
          Length = 1151

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   STLEDSS 9
           STLEDSS
Sbjct: 583 STLEDSS 589
>NP_001026872
          Length = 1151

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   STLEDSS 9
           STLEDSS
Sbjct: 583 STLEDSS 589
>NP_001243277
          Length = 1057

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   STLEDSS 9
           STLEDSS
Sbjct: 525 STLEDSS 531
>NP_001243276
          Length = 1205

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   STLEDSS 9
           STLEDSS
Sbjct: 637 STLEDSS 643
>NP_061152
          Length = 1858

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   TISTLEDSS 9
           TIST ED S
Sbjct: 105 TISTSEDGS 113
>NP_891847
          Length = 1858

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   TISTLEDSS 9
           TIST ED S
Sbjct: 105 TISTSEDGS 113
>XP_006716112
          Length = 1816

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   TISTLEDSS 9
           TIST ED S
Sbjct: 105 TISTSEDGS 113
>XP_005250550
          Length = 1858

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   TISTLEDSS 9
           TIST ED S
Sbjct: 105 TISTSEDGS 113
>NP_062550
          Length = 393

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TISTLEDSS 9
           T+S  EDSS
Sbjct: 244 TVSVTEDSS 252
>NP_054878
          Length = 2564

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TISTLEDSS 9
           T+ST E+SS
Sbjct: 123 TLSTAEESS 131
>NP_003091
          Length = 519

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  TISTLEDS 8
          T+STLE S
Sbjct: 31 TVSTLESS 38
>NP_031377
          Length = 1228

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   TISTLEDSS 9
           T+ST++D+S
Sbjct: 751 TLSTIKDNS 759
>XP_005262913
          Length = 1193

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   TISTLEDSS 9
           T+ST++D+S
Sbjct: 716 TLSTIKDNS 724
>XP_005265151
          Length = 2058

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TISTLEDSS 9
           T+ST E+SS
Sbjct: 123 TLSTAEESS 131
>XP_006713183
          Length = 2258

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TISTLEDSS 9
           T+ST E+SS
Sbjct: 123 TLSTAEESS 131
>XP_006713182
          Length = 2422

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TISTLEDSS 9
           T+ST E+SS
Sbjct: 123 TLSTAEESS 131
>NP_001265612
          Length = 837

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  TISTLEDSS 9
          ++ TLEDSS
Sbjct: 58 SMRTLEDSS 66
>NP_602296
          Length = 418

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ISTLEDSS 9
           I TLED+S
Sbjct: 322 IKTLEDNS 329
>NP_005572
          Length = 628

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TISTLEDSS 9
           T+S +EDS+
Sbjct: 158 TLSVMEDSA 166
>NP_001139395
          Length = 1154

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TISTLED 7
           T+STL+D
Sbjct: 101 TVSTLDD 107
>NP_001013275
          Length = 588

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TISTLEDSS 9
           T+S +EDS+
Sbjct: 158 TLSVMEDSA 166
>NP_065894
          Length = 1400

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TISTLED 7
           T+STL+D
Sbjct: 347 TVSTLDD 353
>XP_005254476
          Length = 1400

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TISTLED 7
           T+STL+D
Sbjct: 347 TVSTLDD 353
>XP_005254474
          Length = 1406

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TISTLED 7
           T+STL+D
Sbjct: 347 TVSTLDD 353
>XP_005253778
          Length = 418

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ISTLEDSS 9
           I TLED+S
Sbjct: 322 IKTLEDNS 329
>XP_005253777
          Length = 418

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ISTLEDSS 9
           I TLED+S
Sbjct: 322 IKTLEDNS 329
>NP_055791
          Length = 1871

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TISTLED 7
           T+S+LED
Sbjct: 193 TVSSLED 199
>NP_057285
          Length = 780

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4 TLEDSS 9
         TLEDSS
Sbjct: 3 TLEDSS 8
>NP_001265614
          Length = 777

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4 TLEDSS 9
         TLEDSS
Sbjct: 3 TLEDSS 8
>NP_078966
          Length = 14507

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    TISTLEDSS 9
            T ST+ED++
Sbjct: 4863 TTSTMEDTT 4871
>NP_001273988
          Length = 1572

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   STLEDSS 9
           STL+DSS
Sbjct: 589 STLKDSS 595
>NP_055867
          Length = 1606

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   STLEDSS 9
           STL+DSS
Sbjct: 589 STLKDSS 595
>NP_001027539
          Length = 513

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TISTLEDS 8
           T+ST ED+
Sbjct: 494 TVSTTEDT 501
>NP_006539
          Length = 599

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TISTLEDSS 9
           TIS+L+D S
Sbjct: 309 TISSLQDLS 317
>NP_001007226
          Length = 556

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TISTLEDSS 9
           TIS+L+D S
Sbjct: 309 TISSLQDLS 317
>NP_991331
          Length = 531

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   TLEDSS 9
           TLEDSS
Sbjct: 521 TLEDSS 526
>NP_001265125
          Length = 522

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   TLEDSS 9
           TLEDSS
Sbjct: 512 TLEDSS 517
>NP_056243
          Length = 871

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TISTLEDS 8
           T+ST EDS
Sbjct: 161 TVSTGEDS 168
>NP_001006657
          Length = 871

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TISTLEDS 8
           T+ST EDS
Sbjct: 161 TVSTGEDS 168
>NP_003701
          Length = 513

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TISTLEDS 8
           T+ST ED+
Sbjct: 494 TVSTTEDT 501
>NP_857593
          Length = 529

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TISTLEDS 8
           T+ST ED+
Sbjct: 510 TVSTTEDT 517
>NP_006343
          Length = 522

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   TLEDSS 9
           TLEDSS
Sbjct: 512 TLEDSS 517
>XP_006720720
          Length = 529

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TISTLEDS 8
           T+ST ED+
Sbjct: 510 TVSTTEDT 517
>XP_005269704
          Length = 1872

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TISTLED 7
           T+S+LED
Sbjct: 193 TVSSLED 199
>XP_006715736
          Length = 1573

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   STLEDSS 9
           STL+DSS
Sbjct: 590 STLKDSS 596
>XP_006715735
          Length = 1606

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   STLEDSS 9
           STL+DSS
Sbjct: 589 STLKDSS 595
>XP_005249722
          Length = 1607

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   STLEDSS 9
           STL+DSS
Sbjct: 590 STLKDSS 596
>XP_006715734
          Length = 1607

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   STLEDSS 9
           STL+DSS
Sbjct: 590 STLKDSS 596
>XP_006715733
          Length = 1608

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   STLEDSS 9
           STL+DSS
Sbjct: 591 STLKDSS 597
>XP_005247723
          Length = 1481

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   STLEDS 8
           STLEDS
Sbjct: 529 STLEDS 534
>XP_006713718
          Length = 779

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4 TLEDSS 9
         TLEDSS
Sbjct: 3 TLEDSS 8
>XP_006713717
          Length = 779

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4 TLEDSS 9
         TLEDSS
Sbjct: 3 TLEDSS 8
>XP_005247577
          Length = 780

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4 TLEDSS 9
         TLEDSS
Sbjct: 3 TLEDSS 8
>XP_006713541
          Length = 300

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  TISTLEDSS 9
          TIS+L+D S
Sbjct: 53 TISSLQDLS 61
>XP_006713540
          Length = 343

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  TISTLEDSS 9
          TIS+L+D S
Sbjct: 53 TISSLQDLS 61
>XP_005273063
          Length = 522

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   TLEDSS 9
           TLEDSS
Sbjct: 512 TLEDSS 517
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.285    0.103    0.227 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 572,165
Number of extensions: 932
Number of successful extensions: 71
Number of sequences better than 10000.0: 71
Number of HSP's gapped: 71
Number of HSP's successfully gapped: 71
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 18 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.8 bits)
S2: 28 (15.4 bits)

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