Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005091                                                              20     509
XP_005267290                                                           20     509
NP_001275918                                                           17    4312
NP_057425                                                              17    4312
XP_006717952                                                           17    4312
XP_006717951                                                           17    4312
XP_006717950                                                           17    4312
XP_006717949                                                           17    4312
XP_006717948                                                           17    4312
NP_001014436                                                           16    5631
NP_001116428                                                           16    5631
NP_054782                                                              16    5631
NP_001271244                                                           16    5631
NP_001271242                                                           16    5631
NP_001137378                                                           16    7355
NP_006691                                                              16    7355
NP_055907                                                              16    7355
XP_006726695                                                           16    7355
XP_005255242                                                           16    7355
XP_005255241                                                           16    7355
XP_005255240                                                           16    7355
XP_005255239                                                           16    7355
NP_001240842                                                           15    9605
NP_001240841                                                           15    9605
NP_055988                                                              15    9605
NP_001240844                                                           15    9605
NP_001240843                                                           15    9605
XP_006714064                                                           15    9605
XP_005262708                                                           15    9605
XP_005262706                                                           15    9605
XP_006714063                                                           15    9605
XP_005262705                                                           15    9605
XP_006714062                                                           15    9605
XP_005262704                                                           15    9605
XP_005262703                                                           15    9605
>NP_005091
          Length = 1782

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  TINSVAEQD 9
          TIN VAEQD
Sbjct: 64 TINGVAEQD 72
>XP_005267290
          Length = 1782

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  TINSVAEQD 9
          TIN VAEQD
Sbjct: 64 TINGVAEQD 72
>NP_001275918
          Length = 2286

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   NSVAEQD 9
           NSVAE+D
Sbjct: 127 NSVAEED 133
>NP_057425
          Length = 2302

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   NSVAEQD 9
           NSVAE+D
Sbjct: 127 NSVAEED 133
>XP_006717952
          Length = 2300

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   NSVAEQD 9
           NSVAE+D
Sbjct: 127 NSVAEED 133
>XP_006717951
          Length = 2315

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   NSVAEQD 9
           NSVAE+D
Sbjct: 127 NSVAEED 133
>XP_006717950
          Length = 2316

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   NSVAEQD 9
           NSVAE+D
Sbjct: 127 NSVAEED 133
>XP_006717949
          Length = 2316

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   NSVAEQD 9
           NSVAE+D
Sbjct: 127 NSVAEED 133
>XP_006717948
          Length = 2316

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   NSVAEQD 9
           NSVAE+D
Sbjct: 127 NSVAEED 133
>NP_001014436
          Length = 430

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TINSVAEQD 9
           TIN+ AE+D
Sbjct: 114 TINARAEED 122
>NP_001116428
          Length = 439

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TINSVAEQD 9
           TIN+ AE+D
Sbjct: 114 TINARAEED 122
>NP_054782
          Length = 431

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TINSVAEQD 9
           TIN+ AE+D
Sbjct: 114 TINARAEED 122
>NP_001271244
          Length = 336

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  TINSVAEQD 9
          TIN+ AE+D
Sbjct: 19 TINARAEED 27
>NP_001271242
          Length = 327

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  TINSVAEQD 9
          TIN+ AE+D
Sbjct: 11 TINARAEED 19
>NP_001137378
          Length = 582

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   NSVAEQD 9
           +SVAEQD
Sbjct: 255 SSVAEQD 261
>NP_006691
          Length = 582

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   NSVAEQD 9
           +SVAEQD
Sbjct: 255 SSVAEQD 261
>NP_055907
          Length = 3661

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    INSVAEQ 8
            INSVA+Q
Sbjct: 1107 INSVAQQ 1113
>XP_006726695
          Length = 747

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   INSVAEQ 8
           INSVA+Q
Sbjct: 622 INSVAQQ 628
>XP_005255242
          Length = 3609

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    INSVAEQ 8
            INSVA+Q
Sbjct: 1055 INSVAQQ 1061
>XP_005255241
          Length = 3637

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    INSVAEQ 8
            INSVA+Q
Sbjct: 1055 INSVAQQ 1061
>XP_005255240
          Length = 3663

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    INSVAEQ 8
            INSVA+Q
Sbjct: 1081 INSVAQQ 1087
>XP_005255239
          Length = 3689

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    INSVAEQ 8
            INSVA+Q
Sbjct: 1107 INSVAQQ 1113
>NP_001240842
          Length = 265

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   TINSVAEQD 9
           TIN V E D
Sbjct: 138 TINQVFEMD 146
>NP_001240841
          Length = 1159

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    TINSVAEQD 9
            TIN V E D
Sbjct: 1032 TINQVFEMD 1040
>NP_055988
          Length = 1168

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    TINSVAEQD 9
            TIN V E D
Sbjct: 1041 TINQVFEMD 1049
>NP_001240844
          Length = 180

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  TINSVAEQD 9
          TIN V E D
Sbjct: 53 TINQVFEMD 61
>NP_001240843
          Length = 265

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   TINSVAEQD 9
           TIN V E D
Sbjct: 138 TINQVFEMD 146
>XP_006714064
          Length = 546

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   TINSVAEQD 9
           TIN V E D
Sbjct: 419 TINQVFEMD 427
>XP_005262708
          Length = 1039

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   TINSVAEQD 9
           TIN V E D
Sbjct: 912 TINQVFEMD 920
>XP_005262706
          Length = 1146

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    TINSVAEQD 9
            TIN V E D
Sbjct: 1019 TINQVFEMD 1027
>XP_006714063
          Length = 1168

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    TINSVAEQD 9
            TIN V E D
Sbjct: 1041 TINQVFEMD 1049
>XP_005262705
          Length = 1181

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    TINSVAEQD 9
            TIN V E D
Sbjct: 1054 TINQVFEMD 1062
>XP_006714062
          Length = 1262

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    TINSVAEQD 9
            TIN V E D
Sbjct: 1135 TINQVFEMD 1143
>XP_005262704
          Length = 1262

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    TINSVAEQD 9
            TIN V E D
Sbjct: 1135 TINQVFEMD 1143
>XP_005262703
          Length = 1275

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    TINSVAEQD 9
            TIN V E D
Sbjct: 1148 TINQVFEMD 1156
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.294    0.111    0.260 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 383,672
Number of extensions: 549
Number of successful extensions: 35
Number of sequences better than 10000.0: 35
Number of HSP's gapped: 35
Number of HSP's successfully gapped: 35
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.1 bits)
S2: 28 (15.4 bits)

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