Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005742                                                              20     390
NP_671714                                                              20     390
XP_006715890                                                           20     390
XP_005250160                                                           20     390
XP_005250159                                                           20     390
NP_001121188                                                           17    3301
NP_000117                                                              17    3301
NP_008952                                                              17    4312
NP_443149                                                              17    4312
NP_009141                                                              17    4312
NP_078918                                                              17    4312
XP_006726895                                                           17    4312
XP_006726881                                                           17    4312
XP_006726879                                                           17    4312
XP_006726878                                                           17    4312
XP_006724469                                                           17    4312
XP_006724467                                                           17    4312
XP_006724162                                                           17    4312
XP_006724159                                                           17    4312
XP_006719277                                                           17    4312
XP_005268665                                                           17    4312
XP_005268664                                                           17    4312
XP_006712293                                                           17    4312
NP_003795                                                              16    5631
NP_001127928                                                           16    5631
NP_659474                                                              16    5631
NP_073738                                                              16    5631
NP_001245302                                                           16    5631
NP_001245301                                                           16    5631
XP_006715300                                                           16    5631
XP_005249515                                                           16    5631
XP_006715299                                                           16    5631
XP_005249514                                                           16    5631
NP_115991                                                              16    5631
NP_003740                                                              16    7355
NP_059119                                                              16    7355
NP_079514                                                              16    7355
NP_001011885                                                           16    7355
NP_060267                                                              16    7355
XP_006726891                                                           16    7355
XP_006726890                                                           16    7355
XP_006726888                                                           16    7355
XP_006726887                                                           16    7355
XP_006726886                                                           16    7355
XP_006726885                                                           16    7355
XP_006726884                                                           16    7355
XP_006726882                                                           16    7355
XP_005276751                                                           16    7355
XP_006726877                                                           16    7355
XP_006726876                                                           16    7355
XP_006726875                                                           16    7355
XP_006726874                                                           16    7355
XP_006726873                                                           16    7355
XP_006724994                                                           16    7355
XP_006724464                                                           16    7355
XP_006724463                                                           16    7355
XP_006724462                                                           16    7355
XP_006724161                                                           16    7355
XP_006724160                                                           16    7355
XP_006724157                                                           16    7355
XP_006724156                                                           16    7355
XP_006724155                                                           16    7355
XP_006724154                                                           16    7355
XP_006724153                                                           16    7355
XP_005259650                                                           16    7355
XP_006720636                                                           16    7355
XP_005263119                                                           16    7355
NP_005193                                                              15    9605
XP_005270536                                                           15    9605
XP_005270535                                                           15    9605
XP_005270534                                                           15    9605
NP_055714                                                              15    9605
>NP_005742
          Length = 3907

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  TIMRTLYSG 9
          TIMRTL+SG
Sbjct: 82 TIMRTLHSG 90
>NP_671714
          Length = 3899

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  TIMRTLYSG 9
          TIMRTL+SG
Sbjct: 82 TIMRTLHSG 90
>XP_006715890
          Length = 3860

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  TIMRTLYSG 9
          TIMRTL+SG
Sbjct: 82 TIMRTLHSG 90
>XP_005250160
          Length = 3939

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  TIMRTLYSG 9
          TIMRTL+SG
Sbjct: 82 TIMRTLHSG 90
>XP_005250159
          Length = 3952

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  TIMRTLYSG 9
          TIMRTL+SG
Sbjct: 82 TIMRTLHSG 90
>NP_001121188
          Length = 284

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TIMRTLYSG 9
           T +RT+Y+G
Sbjct: 94  TFVRTIYAG 102
>NP_000117
          Length = 333

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TIMRTLYSG 9
           T +RT+Y+G
Sbjct: 143 TFVRTIYAG 151
>NP_008952
          Length = 212

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   TIMRTLYS 8
           +++RTLYS
Sbjct: 197 SVLRTLYS 204
>NP_443149
          Length = 556

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   TIMRTLYS 8
           T++RT+YS
Sbjct: 130 TLLRTVYS 137
>NP_009141
          Length = 622

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   TIMRTLYS 8
           T++RT+YS
Sbjct: 192 TLLRTVYS 199
>NP_078918
          Length = 581

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   TIMRTLYS 8
           T++RT+YS
Sbjct: 151 TLLRTVYS 158
>XP_006726895
          Length = 2288

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    TIMRTLYS 8
            ++MRTLY+
Sbjct: 2179 SVMRTLYT 2186
>XP_006726881
          Length = 486

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   TIMRTLYS 8
           ++MRTLY+
Sbjct: 419 SVMRTLYT 426
>XP_006726879
          Length = 375

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   TIMRTLYS 8
           ++MRTLY+
Sbjct: 308 SVMRTLYT 315
>XP_006726878
          Length = 445

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   TIMRTLYS 8
           ++MRTLY+
Sbjct: 378 SVMRTLYT 385

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TIMRTLY 7
           ++MRTLY
Sbjct: 273 SVMRTLY 279
>XP_006724469
          Length = 2373

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    TIMRTLYS 8
            ++MRTLY+
Sbjct: 2295 SVMRTLYT 2302
>XP_006724467
          Length = 450

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   TIMRTLYS 8
           ++MRTLY+
Sbjct: 383 SVMRTLYT 390

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TIMRTLY 7
           ++MRTLY
Sbjct: 278 SVMRTLY 284
>XP_006724162
          Length = 408

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   TIMRTLYS 8
           ++MRTLY+
Sbjct: 341 SVMRTLYT 348

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   IMRTLY 7
           +MRTLY
Sbjct: 237 VMRTLY 242
>XP_006724159
          Length = 375

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   TIMRTLYS 8
           ++MRTLY+
Sbjct: 308 SVMRTLYT 315
>XP_006719277
          Length = 622

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   TIMRTLYS 8
           T++RT+YS
Sbjct: 192 TLLRTVYS 199
>XP_005268665
          Length = 622

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   TIMRTLYS 8
           T++RT+YS
Sbjct: 192 TLLRTVYS 199
>XP_005268664
          Length = 622

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   TIMRTLYS 8
           T++RT+YS
Sbjct: 192 TLLRTVYS 199
>XP_006712293
          Length = 556

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   TIMRTLYS 8
           T++RT+YS
Sbjct: 130 TLLRTVYS 137
>NP_003795
          Length = 671

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  IMRTLYSG 9
          IM+T+Y G
Sbjct: 43 IMKTVYKG 50
>NP_001127928
          Length = 559

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TIMRTLYSG 9
           TI+R ++SG
Sbjct: 507 TILRRMFSG 515
>NP_659474
          Length = 559

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TIMRTLYSG 9
           TI+R ++SG
Sbjct: 507 TILRRMFSG 515
>NP_073738
          Length = 802

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IMRTLYSG 9
           +MRT Y+G
Sbjct: 567 LMRTCYTG 574
>NP_001245302
          Length = 742

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IMRTLYSG 9
           +MRT Y+G
Sbjct: 507 LMRTCYTG 514
>NP_001245301
          Length = 786

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IMRTLYSG 9
           +MRT Y+G
Sbjct: 551 LMRTCYTG 558
>XP_006715300
          Length = 526

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IMRTLYSG 9
           IM+T+Y G
Sbjct: 213 IMKTVYKG 220
>XP_005249515
          Length = 671

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  IMRTLYSG 9
          IM+T+Y G
Sbjct: 43 IMKTVYKG 50
>XP_006715299
          Length = 712

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  IMRTLYSG 9
          IM+T+Y G
Sbjct: 84 IMKTVYKG 91
>XP_005249514
          Length = 841

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IMRTLYSG 9
           IM+T+Y G
Sbjct: 213 IMKTVYKG 220
>NP_115991
          Length = 543

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   IMRTLY 7
           IMRTLY
Sbjct: 238 IMRTLY 243
>NP_003740
          Length = 1338

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TIMRTLYSG 9
           T+MR  +SG
Sbjct: 599 TLMRATFSG 607
>NP_059119
          Length = 657

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   TIMRTLYS 8
           T+MRT++S
Sbjct: 222 TLMRTVHS 229
>NP_079514
          Length = 482

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TIMRTLYS 8
           T+M TLY+
Sbjct: 147 TVMTTLYT 154
>NP_001011885
          Length = 385

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TIMRTLYS 8
           T+M TLY+
Sbjct: 147 TVMTTLYT 154
>NP_060267
          Length = 525

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TIMRTLYS 8
           T+M TLY+
Sbjct: 189 TVMTTLYT 196
>XP_006726891
          Length = 215

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TIMRTLY 7
          ++MRTLY
Sbjct: 15 SLMRTLY 21
>XP_006726890
          Length = 215

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TIMRTLY 7
          ++MRTLY
Sbjct: 15 SLMRTLY 21
>XP_006726888
          Length = 215

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TIMRTLY 7
          ++MRTLY
Sbjct: 15 SLMRTLY 21
>XP_006726887
          Length = 215

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TIMRTLY 7
          ++MRTLY
Sbjct: 15 SLMRTLY 21
>XP_006726886
          Length = 215

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TIMRTLY 7
          ++MRTLY
Sbjct: 15 SLMRTLY 21
>XP_006726885
          Length = 215

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TIMRTLY 7
          ++MRTLY
Sbjct: 15 SLMRTLY 21
>XP_006726884
          Length = 215

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TIMRTLY 7
          ++MRTLY
Sbjct: 15 SLMRTLY 21
>XP_006726882
          Length = 212

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TIMRTLY 7
          ++MRTLY
Sbjct: 15 SLMRTLY 21
>XP_005276751
          Length = 208

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TIMRTLY 7
          ++MRTLY
Sbjct: 15 SLMRTLY 21
>XP_006726877
          Length = 215

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TIMRTLY 7
          ++MRTLY
Sbjct: 15 SLMRTLY 21
>XP_006726876
          Length = 215

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TIMRTLY 7
          ++MRTLY
Sbjct: 15 SLMRTLY 21
>XP_006726875
          Length = 215

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TIMRTLY 7
          ++MRTLY
Sbjct: 15 SLMRTLY 21
>XP_006726874
          Length = 215

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TIMRTLY 7
          ++MRTLY
Sbjct: 15 SLMRTLY 21
>XP_006726873
          Length = 215

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TIMRTLY 7
          ++MRTLY
Sbjct: 15 SLMRTLY 21
>XP_006724994
          Length = 215

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TIMRTLY 7
          ++MRTLY
Sbjct: 15 SLMRTLY 21
>XP_006724464
          Length = 215

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TIMRTLY 7
          ++MRTLY
Sbjct: 15 SLMRTLY 21
>XP_006724463
          Length = 215

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TIMRTLY 7
          ++MRTLY
Sbjct: 15 SLMRTLY 21
>XP_006724462
          Length = 215

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TIMRTLY 7
          ++MRTLY
Sbjct: 15 SLMRTLY 21
>XP_006724161
          Length = 215

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TIMRTLY 7
          ++MRTLY
Sbjct: 15 SLMRTLY 21
>XP_006724160
          Length = 215

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TIMRTLY 7
          ++MRTLY
Sbjct: 15 SLMRTLY 21
>XP_006724157
          Length = 215

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TIMRTLY 7
          ++MRTLY
Sbjct: 15 SLMRTLY 21
>XP_006724156
          Length = 215

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TIMRTLY 7
          ++MRTLY
Sbjct: 15 SLMRTLY 21
>XP_006724155
          Length = 215

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TIMRTLY 7
          ++MRTLY
Sbjct: 15 SLMRTLY 21
>XP_006724154
          Length = 215

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TIMRTLY 7
          ++MRTLY
Sbjct: 15 SLMRTLY 21
>XP_006724153
          Length = 215

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TIMRTLY 7
          ++MRTLY
Sbjct: 15 SLMRTLY 21
>XP_005259650
          Length = 377

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  TIMRTLYS 8
          T+M TLY+
Sbjct: 41 TVMTTLYT 48
>XP_006720636
          Length = 354

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TIMRTLYS 8
           T+M TLY+
Sbjct: 147 TVMTTLYT 154
>XP_005263119
          Length = 657

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   TIMRTLYS 8
           T+MRT++S
Sbjct: 222 TLMRTVHS 229
>NP_005193
          Length = 703

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RTLYSG 9
           RTLY+G
Sbjct: 596 RTLYNG 601
>XP_005270536
          Length = 638

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RTLYSG 9
           RTLY+G
Sbjct: 531 RTLYNG 536
>XP_005270535
          Length = 703

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RTLYSG 9
           RTLY+G
Sbjct: 596 RTLYNG 601
>XP_005270534
          Length = 780

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RTLYSG 9
           RTLY+G
Sbjct: 673 RTLYNG 678
>NP_055714
          Length = 611

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IMRTLYSG 9
           I+R +YSG
Sbjct: 343 ILRFIYSG 350
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.327    0.136    0.378 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 399,906
Number of extensions: 709
Number of successful extensions: 75
Number of sequences better than 10000.0: 72
Number of HSP's gapped: 75
Number of HSP's successfully gapped: 75
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package