Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001011718                                                           18    1482
NP_000537                                                              17    3301
NP_001263689                                                           17    3301
NP_001119584                                                           17    3301
NP_001119586                                                           17    3301
NP_001263625                                                           17    3301
NP_001119590                                                           17    3301
NP_001263690                                                           17    3301
NP_001119585                                                           17    3301
NP_001263624                                                           17    3301
NP_001119588                                                           17    3301
NP_001119587                                                           17    3301
NP_001119589                                                           17    3301
NP_060132                                                              17    3301
NP_001263627                                                           17    3301
NP_001263628                                                           17    3301
NP_001263626                                                           17    3301
NP_001170781                                                           17    3301
NP_112145                                                              17    3301
XP_005275584                                                           17    3301
XP_005275585                                                           17    3301
XP_005275535                                                           17    3301
XP_006726054                                                           17    3301
XP_005275424                                                           17    3301
XP_006726053                                                           17    3301
XP_005275425                                                           17    3301
XP_005275363                                                           17    3301
XP_005275290                                                           17    3301
XP_005275291                                                           17    3301
XP_005275240                                                           17    3301
XP_006725873                                                           17    3301
XP_005275148                                                           17    3301
XP_006725872                                                           17    3301
XP_005275149                                                           17    3301
XP_005275105                                                           17    3301
XP_005274994                                                           17    3301
XP_005274995                                                           17    3301
XP_005272950                                                           17    3301
XP_005272848                                                           17    3301
XP_005272849                                                           17    3301
XP_005274949                                                           17    3301
XP_006725096                                                           17    3301
XP_005274902                                                           17    3301
XP_006725095                                                           17    3301
XP_005274903                                                           17    3301
XP_005249464                                                           17    3301
XP_005249065                                                           17    3301
XP_005249066                                                           17    3301
NP_001170782                                                           17    3301
NP_009091                                                              17    3301
NP_001091947                                                           17    4312
NP_002083                                                              17    4312
XP_005265742                                                           17    4312
XP_005265738                                                           17    4312
NP_000403                                                              15    9605
NP_116166                                                              15    9605
NP_001005236                                                           15    9605
NP_001073996                                                           15    9605
NP_872332                                                              15    9605
XP_006720125                                                           15    9605
XP_005267432                                                           15    9605
XP_005267431                                                           15    9605
XP_005267430                                                           15    9605
XP_006716388                                                           15    9605
XP_005247472                                                           15    9605
XP_006712602                                                           15    9605
NP_001004454                                                           15    9605
>NP_001011718
          Length = 579

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   TIITLEYSS 9
           TI+ LEYSS
Sbjct: 547 TILALEYSS 555
>NP_000537
          Length = 393

 Score = 16.9 bits (32), Expect =  3301
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TIITLEYSS 9
           TIITLE SS
Sbjct: 253 TIITLEDSS 261
>NP_001263689
          Length = 354

 Score = 16.9 bits (32), Expect =  3301
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TIITLEYSS 9
           TIITLE SS
Sbjct: 214 TIITLEDSS 222
>NP_001119584
          Length = 393

 Score = 16.9 bits (32), Expect =  3301
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TIITLEYSS 9
           TIITLE SS
Sbjct: 253 TIITLEDSS 261
>NP_001119586
          Length = 341

 Score = 16.9 bits (32), Expect =  3301
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TIITLEYSS 9
           TIITLE SS
Sbjct: 253 TIITLEDSS 261
>NP_001263625
          Length = 302

 Score = 16.9 bits (32), Expect =  3301
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TIITLEYSS 9
           TIITLE SS
Sbjct: 214 TIITLEDSS 222
>NP_001119590
          Length = 354

 Score = 16.9 bits (32), Expect =  3301
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TIITLEYSS 9
           TIITLE SS
Sbjct: 214 TIITLEDSS 222
>NP_001263690
          Length = 354

 Score = 16.9 bits (32), Expect =  3301
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TIITLEYSS 9
           TIITLE SS
Sbjct: 214 TIITLEDSS 222
>NP_001119585
          Length = 346

 Score = 16.9 bits (32), Expect =  3301
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TIITLEYSS 9
           TIITLE SS
Sbjct: 253 TIITLEDSS 261
>NP_001263624
          Length = 307

 Score = 16.9 bits (32), Expect =  3301
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TIITLEYSS 9
           TIITLE SS
Sbjct: 214 TIITLEDSS 222
>NP_001119588
          Length = 209

 Score = 16.9 bits (32), Expect =  3301
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TIITLEYSS 9
           TIITLE SS
Sbjct: 121 TIITLEDSS 129
>NP_001119587
          Length = 261

 Score = 16.9 bits (32), Expect =  3301
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TIITLEYSS 9
           TIITLE SS
Sbjct: 121 TIITLEDSS 129
>NP_001119589
          Length = 214

 Score = 16.9 bits (32), Expect =  3301
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TIITLEYSS 9
           TIITLE SS
Sbjct: 121 TIITLEDSS 129
>NP_060132
          Length = 2022

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TIITLEYSS 9
           TI+TLE+ S
Sbjct: 756 TILTLEFKS 764
>NP_001263627
          Length = 182

 Score = 16.9 bits (32), Expect =  3301
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TIITLEYSS 9
           TIITLE SS
Sbjct: 94  TIITLEDSS 102
>NP_001263628
          Length = 187

 Score = 16.9 bits (32), Expect =  3301
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TIITLEYSS 9
           TIITLE SS
Sbjct: 94  TIITLEDSS 102
>NP_001263626
          Length = 234

 Score = 16.9 bits (32), Expect =  3301
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TIITLEYSS 9
           TIITLE SS
Sbjct: 94  TIITLEDSS 102
>NP_001170781
          Length = 2017

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TIITLEYSS 9
           TI+TLE+ S
Sbjct: 751 TILTLEFKS 759
>NP_112145
          Length = 316

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TIITLEYSS 9
           T++TL YSS
Sbjct: 244 TVVTLFYSS 252
>XP_005275584
          Length = 316

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TIITLEYSS 9
           T++TL YSS
Sbjct: 244 TVVTLFYSS 252
>XP_005275585
          Length = 316

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TIITLEYSS 9
           T++TL YSS
Sbjct: 244 TVVTLFYSS 252
>XP_005275535
          Length = 312

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TIITLEYSS 9
           T++TL YSS
Sbjct: 244 TVVTLFYSS 252
>XP_006726054
          Length = 238

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TIITLEYSS 9
           T++TL YSS
Sbjct: 166 TVVTLFYSS 174
>XP_005275424
          Length = 316

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TIITLEYSS 9
           T++TL YSS
Sbjct: 244 TVVTLFYSS 252
>XP_006726053
          Length = 316

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TIITLEYSS 9
           T++TL YSS
Sbjct: 244 TVVTLFYSS 252
>XP_005275425
          Length = 316

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TIITLEYSS 9
           T++TL YSS
Sbjct: 244 TVVTLFYSS 252
>XP_005275363
          Length = 312

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TIITLEYSS 9
           T++TL YSS
Sbjct: 244 TVVTLFYSS 252
>XP_005275290
          Length = 316

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TIITLEYSS 9
           T++TL YSS
Sbjct: 244 TVVTLFYSS 252
>XP_005275291
          Length = 316

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TIITLEYSS 9
           T++TL YSS
Sbjct: 244 TVVTLFYSS 252
>XP_005275240
          Length = 312

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TIITLEYSS 9
           T++TL YSS
Sbjct: 244 TVVTLFYSS 252
>XP_006725873
          Length = 238

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TIITLEYSS 9
           T++TL YSS
Sbjct: 166 TVVTLFYSS 174
>XP_005275148
          Length = 316

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TIITLEYSS 9
           T++TL YSS
Sbjct: 244 TVVTLFYSS 252
>XP_006725872
          Length = 316

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TIITLEYSS 9
           T++TL YSS
Sbjct: 244 TVVTLFYSS 252
>XP_005275149
          Length = 316

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TIITLEYSS 9
           T++TL YSS
Sbjct: 244 TVVTLFYSS 252
>XP_005275105
          Length = 312

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TIITLEYSS 9
           T++TL YSS
Sbjct: 244 TVVTLFYSS 252
>XP_005274994
          Length = 316

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TIITLEYSS 9
           T++TL YSS
Sbjct: 244 TVVTLFYSS 252
>XP_005274995
          Length = 316

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TIITLEYSS 9
           T++TL YSS
Sbjct: 244 TVVTLFYSS 252
>XP_005272950
          Length = 312

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TIITLEYSS 9
           T++TL YSS
Sbjct: 244 TVVTLFYSS 252
>XP_005272848
          Length = 316

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TIITLEYSS 9
           T++TL YSS
Sbjct: 244 TVVTLFYSS 252
>XP_005272849
          Length = 316

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TIITLEYSS 9
           T++TL YSS
Sbjct: 244 TVVTLFYSS 252
>XP_005274949
          Length = 312

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TIITLEYSS 9
           T++TL YSS
Sbjct: 244 TVVTLFYSS 252
>XP_006725096
          Length = 238

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TIITLEYSS 9
           T++TL YSS
Sbjct: 166 TVVTLFYSS 174
>XP_005274902
          Length = 316

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TIITLEYSS 9
           T++TL YSS
Sbjct: 244 TVVTLFYSS 252
>XP_006725095
          Length = 316

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TIITLEYSS 9
           T++TL YSS
Sbjct: 244 TVVTLFYSS 252
>XP_005274903
          Length = 316

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TIITLEYSS 9
           T++TL YSS
Sbjct: 244 TVVTLFYSS 252
>XP_005249464
          Length = 312

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TIITLEYSS 9
           T++TL YSS
Sbjct: 244 TVVTLFYSS 252
>XP_005249065
          Length = 316

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TIITLEYSS 9
           T++TL YSS
Sbjct: 244 TVVTLFYSS 252
>XP_005249066
          Length = 316

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TIITLEYSS 9
           T++TL YSS
Sbjct: 244 TVVTLFYSS 252
>NP_001170782
          Length = 2017

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TIITLEYSS 9
           TI+TLE+ S
Sbjct: 751 TILTLEFKS 759
>NP_009091
          Length = 312

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TIITLEYSS 9
           T++TL YSS
Sbjct: 244 TVVTLFYSS 252
>NP_001091947
          Length = 318

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   ITLEYSS 9
           IT+EYSS
Sbjct: 267 ITMEYSS 273
>NP_002083
          Length = 480

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   ITLEYSS 9
           IT+EYSS
Sbjct: 429 ITMEYSS 435
>XP_005265742
          Length = 362

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   ITLEYSS 9
           IT+EYSS
Sbjct: 311 ITMEYSS 317
>XP_005265738
          Length = 561

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   ITLEYSS 9
           IT+EYSS
Sbjct: 510 ITMEYSS 516
>NP_000403
          Length = 525

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  IITLEYS 8
          +ITL+YS
Sbjct: 10 LITLQYS 16
>NP_116166
          Length = 1338

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   ITLEYSS 9
           ITL YSS
Sbjct: 840 ITLHYSS 846
>NP_001005236
          Length = 310

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TIITLEYSS 9
           T++TL Y S
Sbjct: 246 TVVTLFYGS 254
>NP_001073996
          Length = 2116

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   IITLEYSS 9
           I+TL YSS
Sbjct: 577 ILTLVYSS 584
>NP_872332
          Length = 167

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   IITLEYS 8
           +ITLEY+
Sbjct: 115 LITLEYA 121
>XP_006720125
          Length = 167

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   IITLEYS 8
           +ITLEY+
Sbjct: 115 LITLEYA 121
>XP_005267432
          Length = 167

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   IITLEYS 8
           +ITLEY+
Sbjct: 115 LITLEYA 121
>XP_005267431
          Length = 167

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   IITLEYS 8
           +ITLEY+
Sbjct: 115 LITLEYA 121
>XP_005267430
          Length = 167

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   IITLEYS 8
           +ITLEY+
Sbjct: 115 LITLEYA 121
>XP_006716388
          Length = 1314

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   ITLEYSS 9
           ITL YSS
Sbjct: 816 ITLHYSS 822
>XP_005247472
          Length = 533

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  IITLEYS 8
          +ITL+YS
Sbjct: 10 LITLQYS 16
>XP_006712602
          Length = 2142

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   IITLEYSS 9
           I+TL YSS
Sbjct: 577 ILTLVYSS 584
>NP_001004454
          Length = 309

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TIITLEYSS 9
           T++TL Y S
Sbjct: 247 TVVTLFYGS 255
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.309    0.124    0.296 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 519,224
Number of extensions: 643
Number of successful extensions: 67
Number of sequences better than 10000.0: 67
Number of HSP's gapped: 67
Number of HSP's successfully gapped: 67
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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