Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

• Home Page
• Cancer-specific
• Epitope Search
• Data Retrieval
• Browse Gene
• Browse Tissue
• Sequence Similarity
• Partially Personalized
• Submit a Protein
• Vaccine Target
• Proteome Data
• NGS data
• BLAST & Predict
• Fully Personalized
• Proteins Pair
• Proteome Pair
• Advanced Tools
• Epitope Mapping
• Cross Reactivity
• Important Information
• Acknowledgement
• Algorithm
• Help
• Developers
• Contact

Blast-Search of mutated query peptide against human proteome

BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000537                                                              17    3301
NP_001263689                                                           17    3301
NP_001119584                                                           17    3301
NP_001119586                                                           17    3301
NP_001263625                                                           17    3301
NP_001119590                                                           17    3301
NP_001263690                                                           17    3301
NP_001119585                                                           17    3301
NP_001263624                                                           17    3301
NP_001119588                                                           17    3301
NP_001119587                                                           17    3301
NP_001119589                                                           17    3301
NP_001263627                                                           17    3301
NP_001263628                                                           17    3301
NP_001263626                                                           17    3301
NP_001138397                                                           17    4312
NP_001269849                                                           17    4312
NP_001171517                                                           17    4312
NP_002453                                                              17    4312
XP_005261039                                                           17    4312
XP_005261038                                                           17    4312
XP_005261037                                                           17    4312
XP_005261036                                                           17    4312
XP_005261035                                                           17    4312
XP_006724068                                                           17    4312
NP_001073005                                                           16    7355
NP_004952                                                              16    7355
NP_803235                                                              16    7355
NP_060132                                                              15    9605
NP_001170781                                                           15    9605
NP_001170782                                                           15    9605

>NP_000537
          Length = 393

 Score = 16.9 bits (32), Expect =  3301
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TIITLEVSS 9
           TIITLE SS
Sbjct: 253 TIITLEDSS 261



>NP_001263689
          Length = 354

 Score = 16.9 bits (32), Expect =  3301
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TIITLEVSS 9
           TIITLE SS
Sbjct: 214 TIITLEDSS 222



>NP_001119584
          Length = 393

 Score = 16.9 bits (32), Expect =  3301
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TIITLEVSS 9
           TIITLE SS
Sbjct: 253 TIITLEDSS 261



>NP_001119586
          Length = 341

 Score = 16.9 bits (32), Expect =  3301
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TIITLEVSS 9
           TIITLE SS
Sbjct: 253 TIITLEDSS 261



>NP_001263625
          Length = 302

 Score = 16.9 bits (32), Expect =  3301
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TIITLEVSS 9
           TIITLE SS
Sbjct: 214 TIITLEDSS 222



>NP_001119590
          Length = 354

 Score = 16.9 bits (32), Expect =  3301
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TIITLEVSS 9
           TIITLE SS
Sbjct: 214 TIITLEDSS 222



>NP_001263690
          Length = 354

 Score = 16.9 bits (32), Expect =  3301
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TIITLEVSS 9
           TIITLE SS
Sbjct: 214 TIITLEDSS 222



>NP_001119585
          Length = 346

 Score = 16.9 bits (32), Expect =  3301
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TIITLEVSS 9
           TIITLE SS
Sbjct: 253 TIITLEDSS 261



>NP_001263624
          Length = 307

 Score = 16.9 bits (32), Expect =  3301
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TIITLEVSS 9
           TIITLE SS
Sbjct: 214 TIITLEDSS 222



>NP_001119588
          Length = 209

 Score = 16.9 bits (32), Expect =  3301
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TIITLEVSS 9
           TIITLE SS
Sbjct: 121 TIITLEDSS 129



>NP_001119587
          Length = 261

 Score = 16.9 bits (32), Expect =  3301
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TIITLEVSS 9
           TIITLE SS
Sbjct: 121 TIITLEDSS 129



>NP_001119589
          Length = 214

 Score = 16.9 bits (32), Expect =  3301
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TIITLEVSS 9
           TIITLE SS
Sbjct: 121 TIITLEDSS 129



>NP_001263627
          Length = 182

 Score = 16.9 bits (32), Expect =  3301
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TIITLEVSS 9
           TIITLE SS
Sbjct: 94  TIITLEDSS 102



>NP_001263628
          Length = 187

 Score = 16.9 bits (32), Expect =  3301
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TIITLEVSS 9
           TIITLE SS
Sbjct: 94  TIITLEDSS 102



>NP_001263626
          Length = 234

 Score = 16.9 bits (32), Expect =  3301
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TIITLEVSS 9
           TIITLE SS
Sbjct: 94  TIITLEDSS 102



>NP_001138397
          Length = 662

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   IITLEVSS 9
           +ITLE+SS
Sbjct: 161 LITLEISS 168



>NP_001269849
          Length = 508

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   IITLEVSS 9
           +ITLE+SS
Sbjct: 161 LITLEISS 168



>NP_001171517
          Length = 662

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   IITLEVSS 9
           +ITLE+SS
Sbjct: 161 LITLEISS 168



>NP_002453
          Length = 662

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   IITLEVSS 9
           +ITLE+SS
Sbjct: 161 LITLEISS 168



>XP_005261039
          Length = 662

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   IITLEVSS 9
           +ITLE+SS
Sbjct: 161 LITLEISS 168



>XP_005261038
          Length = 662

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   IITLEVSS 9
           +ITLE+SS
Sbjct: 161 LITLEISS 168



>XP_005261037
          Length = 662

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   IITLEVSS 9
           +ITLE+SS
Sbjct: 161 LITLEISS 168



>XP_005261036
          Length = 662

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   IITLEVSS 9
           +ITLE+SS
Sbjct: 161 LITLEISS 168



>XP_005261035
          Length = 662

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   IITLEVSS 9
           +ITLE+SS
Sbjct: 161 LITLEISS 168



>XP_006724068
          Length = 685

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   IITLEVSS 9
           +ITLE+SS
Sbjct: 184 LITLEISS 191



>NP_001073005
          Length = 158

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TIITLEVSS 9
           +I+T EVSS
Sbjct: 137 SIVTAEVSS 145



>NP_004952
          Length = 506

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   TIITLEVS 8
           T++T+E+S
Sbjct: 95  TVVTVEIS 102



>NP_803235
          Length = 130

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TIITLEVSS 9
           +I+T EVSS
Sbjct: 109 SIVTAEVSS 117



>NP_060132
          Length = 2022

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TIITLEVSS 9
           TI+TLE  S
Sbjct: 756 TILTLEFKS 764



>NP_001170781
          Length = 2017

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TIITLEVSS 9
           TI+TLE  S
Sbjct: 751 TILTLEFKS 759



>NP_001170782
          Length = 2017

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TIITLEVSS 9
           TI+TLE  S
Sbjct: 751 TILTLEFKS 759



  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.308    0.122    0.266 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 329,509
Number of extensions: 366
Number of successful extensions: 31
Number of sequences better than 10000.0: 31
Number of HSP's gapped: 31
Number of HSP's successfully gapped: 31
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)