Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_722576                                                              20     509
XP_005262424                                                           20     509
NP_002007                                                              17    3301
NP_002449                                                              17    3301
NP_940895                                                              17    4312
NP_001005376                                                           16    5631
NP_694985                                                              16    5631
NP_001005377                                                           16    5631
NP_006738                                                              16    5631
NP_002650                                                              16    5631
NP_001159764                                                           16    5631
NP_003729                                                              16    5631
XP_005259047                                                           16    5631
XP_005259046                                                           16    5631
XP_006723304                                                           16    5631
XP_005259045                                                           16    5631
XP_005257441                                                           16    5631
XP_005257440                                                           16    5631
XP_005257439                                                           16    5631
XP_005274246                                                           16    5631
NP_001010905                                                           16    7355
NP_001191827                                                           16    7355
NP_001191826                                                           16    7355
NP_612470                                                              16    7355
NP_006589                                                              16    7355
NP_066022                                                              16    7355
XP_006725069                                                           16    7355
XP_006723369                                                           16    7355
XP_005248288                                                           16    7355
XP_006711061                                                           16    7355
XP_006711060                                                           16    7355
XP_005244868                                                           16    7355
XP_003119848                                                           16    7355
NP_001098099                                                           16    7355
NP_060772                                                              16    7355
NP_001121636                                                           15    9605
NP_000323                                                              15    9605
NP_067047                                                              15    9605
NP_001188410                                                           15    9605
NP_001257941                                                           15    9605
NP_115912                                                              15    9605
NP_001257939                                                           15    9605
NP_001161153                                                           15    9605
NP_002008                                                              15    9605
NP_001188411                                                           15    9605
NP_001188409                                                           15    9605
NP_116739                                                              15    9605
NP_001157860                                                           15    9605
NP_001157859                                                           15    9605
NP_001157858                                                           15    9605
NP_057424                                                              15    9605
XP_006717280                                                           15    9605
XP_006717279                                                           15    9605
XP_006717278                                                           15    9605
XP_006717277                                                           15    9605
XP_006717276                                                           15    9605
XP_006717275                                                           15    9605
XP_006717274                                                           15    9605
XP_006717273                                                           15    9605
XP_006717272                                                           15    9605
XP_005246325                                                           15    9605
XP_006712295                                                           15    9605
XP_006712294                                                           15    9605
>NP_722576
          Length = 3080

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    THTEASSRT 9
            TH EASSRT
Sbjct: 2103 THPEASSRT 2111
>XP_005262424
          Length = 2875

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    THTEASSRT 9
            TH EASSRT
Sbjct: 1898 THPEASSRT 1906
>NP_002007
          Length = 4061

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    HTEASSR 8
            HTE+SSR
Sbjct: 1981 HTESSSR 1987

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    HTEASSR 8
            H EASSR
Sbjct: 1885 HHEASSR 1891

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    HTEASSR 8
            H EASSR
Sbjct: 2534 HHEASSR 2540
>NP_002449
          Length = 5762

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    HTEASSRT 9
            HT A+SRT
Sbjct: 2832 HTRATSRT 2839

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    HTEASSRT 9
            HT A+SRT
Sbjct: 2275 HTTATSRT 2282

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    HTEASSRT 9
            HT A+SRT
Sbjct: 4089 HTTATSRT 4096

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    HTEASSRT 9
            HT  +SRT
Sbjct: 3532 HTRGTSRT 3539
>NP_940895
          Length = 266

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   THTEAS 6
           THTEAS
Sbjct: 213 THTEAS 218
>NP_001005376
          Length = 281

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  THTEASSRT 9
          TH+E ++RT
Sbjct: 68 THSEKTNRT 76
>NP_694985
          Length = 1042

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   THTEASSRT 9
           +H+EASS T
Sbjct: 137 SHSEASSGT 145
>NP_001005377
          Length = 290

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  THTEASSRT 9
          TH+E ++RT
Sbjct: 68 THSEKTNRT 76
>NP_006738
          Length = 1042

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   THTEASSRT 9
           +H+EASS T
Sbjct: 137 SHSEASSGT 145
>NP_002650
          Length = 335

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  THTEASSRT 9
          TH+E ++RT
Sbjct: 68 THSEKTNRT 76
>NP_001159764
          Length = 1146

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   THTEASSR 8
           TH EASS+
Sbjct: 604 THCEASSQ 611
>NP_003729
          Length = 1203

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   THTEASSR 8
           TH EASS+
Sbjct: 604 THCEASSQ 611
>XP_005259047
          Length = 279

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  THTEASSRT 9
          TH+E ++RT
Sbjct: 68 THSEKTNRT 76
>XP_005259046
          Length = 286

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  THTEASSRT 9
          TH+E ++RT
Sbjct: 68 THSEKTNRT 76
>XP_006723304
          Length = 310

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  THTEASSRT 9
          TH+E ++RT
Sbjct: 43 THSEKTNRT 51
>XP_005259045
          Length = 330

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  THTEASSRT 9
          TH+E ++RT
Sbjct: 63 THSEKTNRT 71
>XP_005257441
          Length = 213

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  HTEASSRT 9
          HTEAS+ T
Sbjct: 61 HTEASTGT 68
>XP_005257440
          Length = 220

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  HTEASSRT 9
          HTEAS+ T
Sbjct: 61 HTEASTGT 68
>XP_005257439
          Length = 247

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  HTEASSRT 9
          HTEAS+ T
Sbjct: 61 HTEASTGT 68
>XP_005274246
          Length = 1042

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   THTEASSRT 9
           +H+EASS T
Sbjct: 137 SHSEASSGT 145
>NP_001010905
          Length = 330

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   HTEASSRT 9
           H+E+SSR+
Sbjct: 318 HSESSSRS 325
>NP_001191827
          Length = 183

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  TEASSRT 9
          T+ASSRT
Sbjct: 7  TQASSRT 13
>NP_001191826
          Length = 242

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  TEASSRT 9
          T+ASSRT
Sbjct: 7  TQASSRT 13
>NP_612470
          Length = 209

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  TEASSRT 9
          T+ASSRT
Sbjct: 7  TQASSRT 13
>NP_006589
          Length = 1083

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   THTEASSRT 9
           +HT A++RT
Sbjct: 960 SHTAAAART 968
>NP_066022
          Length = 2564

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   HTEASSR 8
           H EASSR
Sbjct: 803 HDEASSR 809
>XP_006725069
          Length = 1088

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   THTEASSRT 9
           +HT A++RT
Sbjct: 960 SHTAAAART 968
>XP_006723369
          Length = 2394

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   HTEASSR 8
           H EASSR
Sbjct: 803 HDEASSR 809
>XP_005248288
          Length = 1088

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   THTEASSRT 9
           +HT A++RT
Sbjct: 960 SHTAAAART 968
>XP_006711061
          Length = 1553

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    HTEASSR 8
            H EASSR
Sbjct: 1419 HREASSR 1425
>XP_006711060
          Length = 1595

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    HTEASSR 8
            H EASSR
Sbjct: 1461 HREASSR 1467
>XP_005244868
          Length = 1639

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    HTEASSR 8
            H EASSR
Sbjct: 1505 HREASSR 1511
>XP_003119848
          Length = 515

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   HTEASSR 8
           H EASSR
Sbjct: 381 HREASSR 387
>NP_001098099
          Length = 314

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  TEASSRT 9
          TE+SSRT
Sbjct: 64 TESSSRT 70
>NP_060772
          Length = 314

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  TEASSRT 9
          TE+SSRT
Sbjct: 64 TESSSRT 70
>NP_001121636
          Length = 815

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   THTEASSRT 9
           TH EAS  T
Sbjct: 401 THREASPST 409
>NP_000323
          Length = 815

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   THTEASSRT 9
           TH EAS  T
Sbjct: 401 THREASPST 409
>NP_067047
          Length = 2506

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    THTEASSRT 9
            TH  A+SRT
Sbjct: 1727 THCLAASRT 1735
>NP_001188410
          Length = 903

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  THTEASSRT 9
          TH  ASS T
Sbjct: 18 THRSASSST 26
>NP_001257941
          Length = 259

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  THTEASSR 8
          +HT+ SSR
Sbjct: 13 SHTDQSSR 20
>NP_115912
          Length = 934

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  THTEASSRT 9
          TH  ASS T
Sbjct: 18 THRSASSST 26
>NP_001257939
          Length = 386

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   THTEASSR 8
           +HT+ SSR
Sbjct: 140 SHTDQSSR 147
>NP_001161153
          Length = 419

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   THTEASSR 8
           +HT+ SSR
Sbjct: 173 SHTDQSSR 180
>NP_002008
          Length = 452

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   THTEASSR 8
           +HT+ SSR
Sbjct: 206 SHTDQSSR 213
>NP_001188411
          Length = 898

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  THTEASSRT 9
          TH  ASS T
Sbjct: 18 THRSASSST 26
>NP_001188409
          Length = 959

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  THTEASSRT 9
          TH  ASS T
Sbjct: 18 THRSASSST 26
>NP_116739
          Length = 93

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  THTEASSR 8
          T TE+SSR
Sbjct: 20 TKTESSSR 27
>NP_001157860
          Length = 1504

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    THTEASSRT 9
            +H+E SSR+
Sbjct: 1273 SHSEISSRS 1281
>NP_001157859
          Length = 1509

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    THTEASSRT 9
            +H+E SSR+
Sbjct: 1278 SHSEISSRS 1286
>NP_001157858
          Length = 1609

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    THTEASSRT 9
            +H+E SSR+
Sbjct: 1273 SHSEISSRS 1281
>NP_057424
          Length = 1601

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    THTEASSRT 9
            +H+E SSR+
Sbjct: 1265 SHSEISSRS 1273
>XP_006717280
          Length = 2221

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    THTEASSRT 9
            TH  A+SRT
Sbjct: 1727 THCLAASRT 1735
>XP_006717279
          Length = 2506

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    THTEASSRT 9
            TH  A+SRT
Sbjct: 1727 THCLAASRT 1735
>XP_006717278
          Length = 2566

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    THTEASSRT 9
            TH  A+SRT
Sbjct: 1727 THCLAASRT 1735
>XP_006717277
          Length = 2567

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    THTEASSRT 9
            TH  A+SRT
Sbjct: 1727 THCLAASRT 1735
>XP_006717276
          Length = 2567

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    THTEASSRT 9
            TH  A+SRT
Sbjct: 1727 THCLAASRT 1735
>XP_006717275
          Length = 2567

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    THTEASSRT 9
            TH  A+SRT
Sbjct: 1727 THCLAASRT 1735
>XP_006717274
          Length = 2567

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    THTEASSRT 9
            TH  A+SRT
Sbjct: 1727 THCLAASRT 1735
>XP_006717273
          Length = 2567

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    THTEASSRT 9
            TH  A+SRT
Sbjct: 1727 THCLAASRT 1735
>XP_006717272
          Length = 2567

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    THTEASSRT 9
            TH  A+SRT
Sbjct: 1727 THCLAASRT 1735
>XP_005246325
          Length = 508

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  THTEASSRT 9
          TH  ASS T
Sbjct: 18 THRSASSST 26
>XP_006712295
          Length = 923

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  THTEASSRT 9
          TH  ASS T
Sbjct: 18 THRSASSST 26
>XP_006712294
          Length = 928

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  THTEASSRT 9
          TH  ASS T
Sbjct: 18 THRSASSST 26
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.289   0.0926    0.228 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 451,699
Number of extensions: 576
Number of successful extensions: 68
Number of sequences better than 10000.0: 63
Number of HSP's gapped: 68
Number of HSP's successfully gapped: 68
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.1 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package