Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001185761                                                           20     299
NP_001185763                                                           20     299
NP_055459                                                              20     299
XP_006726410                                                           20     299
XP_006711719                                                           20     299
XP_006711718                                                           20     299
XP_006711717                                                           20     299
XP_006711716                                                           20     299
XP_006711715                                                           20     299
XP_006711714                                                           20     299
XP_006711713                                                           20     299
XP_006711712                                                           20     299
XP_006711711                                                           20     299
XP_006711710                                                           20     299
XP_006711709                                                           20     299
XP_005277503                                                           20     299
XP_005273038                                                           20     299
XP_006711708                                                           20     299
XP_005277500                                                           20     299
XP_006711707                                                           20     299
XP_005277499                                                           20     299
XP_006711706                                                           20     299
XP_006711705                                                           20     299
XP_006711164                                                           20     299
XP_006710140                                                           20     299
NP_612154                                                              18    1935
NP_060876                                                              18    1935
NP_004523                                                              18    1935
NP_001265478                                                           17    4312
NP_002601                                                              17    4312
NP_570971                                                              17    4312
NP_775179                                                              17    4312
NP_001167532                                                           17    4312
NP_963862                                                              17    4312
NP_963863                                                              17    4312
XP_005258568                                                           17    4312
XP_006720476                                                           17    4312
XP_006712658                                                           17    4312
XP_006712657                                                           17    4312
XP_006711741                                                           17    4312
XP_006711740                                                           17    4312
XP_005245713                                                           17    4312
XP_005245712                                                           17    4312
XP_005245710                                                           17    4312
XP_005245711                                                           17    4312
XP_006711739                                                           17    4312
XP_005245709                                                           17    4312
XP_006711738                                                           17    4312
XP_006711737                                                           17    4312
XP_005245706                                                           17    4312
XP_005245705                                                           17    4312
XP_005245704                                                           17    4312
NP_789781                                                              17    4312
NP_005425                                                              16    5631
NP_005637                                                              16    7355
NP_057349                                                              16    7355
NP_008887                                                              16    7355
XP_006711875                                                           16    7355
XP_005273291                                                           16    7355
NP_001103408                                                           15    9605
NP_001154848                                                           15    9605
NP_659466                                                              15    9605
NP_821074                                                              15    9605
XP_005260717                                                           15    9605
NP_001004058                                                           15    9605
NP_542789                                                              15    9605
>NP_001185761
          Length = 2240

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    SYYLNSAQ 8
            SYYLNSAQ
Sbjct: 1672 SYYLNSAQ 1679
>NP_001185763
          Length = 2362

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    SYYLNSAQ 8
            SYYLNSAQ
Sbjct: 1778 SYYLNSAQ 1785
>NP_055459
          Length = 2346

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    SYYLNSAQ 8
            SYYLNSAQ
Sbjct: 1778 SYYLNSAQ 1785
>XP_006726410
          Length = 2087

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    SYYLNSAQ 8
            SYYLNSAQ
Sbjct: 1519 SYYLNSAQ 1526
>XP_006711719
          Length = 2302

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    SYYLNSAQ 8
            SYYLNSAQ
Sbjct: 1734 SYYLNSAQ 1741
>XP_006711718
          Length = 1436

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   SYYLNSAQ 8
           SYYLNSAQ
Sbjct: 785 SYYLNSAQ 792
>XP_006711717
          Length = 2385

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    SYYLNSAQ 8
            SYYLNSAQ
Sbjct: 1734 SYYLNSAQ 1741
>XP_006711716
          Length = 2411

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    SYYLNSAQ 8
            SYYLNSAQ
Sbjct: 1843 SYYLNSAQ 1850
>XP_006711715
          Length = 2428

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    SYYLNSAQ 8
            SYYLNSAQ
Sbjct: 1777 SYYLNSAQ 1784
>XP_006711714
          Length = 2429

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    SYYLNSAQ 8
            SYYLNSAQ
Sbjct: 1778 SYYLNSAQ 1785
>XP_006711713
          Length = 2432

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    SYYLNSAQ 8
            SYYLNSAQ
Sbjct: 1781 SYYLNSAQ 1788
>XP_006711712
          Length = 2473

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    SYYLNSAQ 8
            SYYLNSAQ
Sbjct: 1941 SYYLNSAQ 1948
>XP_006711711
          Length = 2482

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    SYYLNSAQ 8
            SYYLNSAQ
Sbjct: 1831 SYYLNSAQ 1838
>XP_006711710
          Length = 2494

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    SYYLNSAQ 8
            SYYLNSAQ
Sbjct: 1843 SYYLNSAQ 1850
>XP_006711709
          Length = 2495

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    SYYLNSAQ 8
            SYYLNSAQ
Sbjct: 1844 SYYLNSAQ 1851
>XP_005277503
          Length = 2498

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    SYYLNSAQ 8
            SYYLNSAQ
Sbjct: 1941 SYYLNSAQ 1948
>XP_005273038
          Length = 2509

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    SYYLNSAQ 8
            SYYLNSAQ
Sbjct: 1941 SYYLNSAQ 1948
>XP_006711708
          Length = 2512

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    SYYLNSAQ 8
            SYYLNSAQ
Sbjct: 1941 SYYLNSAQ 1948
>XP_005277500
          Length = 2525

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    SYYLNSAQ 8
            SYYLNSAQ
Sbjct: 1941 SYYLNSAQ 1948
>XP_006711707
          Length = 2553

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    SYYLNSAQ 8
            SYYLNSAQ
Sbjct: 1941 SYYLNSAQ 1948
>XP_005277499
          Length = 2561

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    SYYLNSAQ 8
            SYYLNSAQ
Sbjct: 1941 SYYLNSAQ 1948
>XP_006711706
          Length = 2591

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    SYYLNSAQ 8
            SYYLNSAQ
Sbjct: 1940 SYYLNSAQ 1947
>XP_006711705
          Length = 2592

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    SYYLNSAQ 8
            SYYLNSAQ
Sbjct: 1941 SYYLNSAQ 1948
>XP_006711164
          Length = 2087

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    SYYLNSAQ 8
            SYYLNSAQ
Sbjct: 1519 SYYLNSAQ 1526
>XP_006710140
          Length = 290

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1  SYYLNSAQ 8
          SYYLNSAQ
Sbjct: 31 SYYLNSAQ 38
>NP_612154
          Length = 1125

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    SYYLNSAQ 8
            SY+LNSA+
Sbjct: 1115 SYFLNSAE 1122
>NP_060876
          Length = 5412

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    SYYLNSAQ 8
            SY+LNSA+
Sbjct: 5402 SYFLNSAE 5409
>NP_004523
          Length = 1176

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    SYYLNSAQ 8
            SY+LNSA+
Sbjct: 1166 SYFLNSAE 1173
>NP_001265478
          Length = 456

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YYLNSAQL 9
           YY+NS +L
Sbjct: 263 YYINSPEL 270
>NP_002601
          Length = 436

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YYLNSAQL 9
           YY+NS +L
Sbjct: 243 YYINSPEL 250
>NP_570971
          Length = 926

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   YYLNSAQ 8
           YYL SAQ
Sbjct: 656 YYLTSAQ 662
>NP_775179
          Length = 1137

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SYYLNSAQL 9
           SYY ++AQL
Sbjct: 173 SYYRHAAQL 181
>NP_001167532
          Length = 1145

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SYYLNSAQL 9
           SYY ++AQL
Sbjct: 131 SYYRHAAQL 139
>NP_963862
          Length = 1091

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SYYLNSAQL 9
           SYY ++AQL
Sbjct: 173 SYYRHAAQL 181
>NP_963863
          Length = 1178

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SYYLNSAQL 9
           SYY ++AQL
Sbjct: 173 SYYRHAAQL 181
>XP_005258568
          Length = 1029

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SYYLNSAQL 9
           +YYL+ AQL
Sbjct: 833 AYYLSVAQL 841
>XP_006720476
          Length = 933

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   YYLNSAQ 8
           YYL SAQ
Sbjct: 663 YYLTSAQ 669
>XP_006712658
          Length = 244

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  YYLNSAQL 9
          YY+NS +L
Sbjct: 51 YYINSPEL 58
>XP_006712657
          Length = 281

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YYLNSAQL 9
           YY+NS +L
Sbjct: 263 YYINSPEL 270
>XP_006711741
          Length = 1141

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SYYLNSAQL 9
           SYY ++AQL
Sbjct: 173 SYYRHAAQL 181
>XP_006711740
          Length = 1143

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SYYLNSAQL 9
           SYY ++AQL
Sbjct: 225 SYYRHAAQL 233
>XP_005245713
          Length = 1169

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SYYLNSAQL 9
           SYY ++AQL
Sbjct: 155 SYYRHAAQL 163
>XP_005245712
          Length = 1169

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SYYLNSAQL 9
           SYY ++AQL
Sbjct: 155 SYYRHAAQL 163
>XP_005245710
          Length = 1169

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SYYLNSAQL 9
           SYY ++AQL
Sbjct: 155 SYYRHAAQL 163
>XP_005245711
          Length = 1169

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SYYLNSAQL 9
           SYY ++AQL
Sbjct: 155 SYYRHAAQL 163
>XP_006711739
          Length = 1170

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SYYLNSAQL 9
           SYY ++AQL
Sbjct: 202 SYYRHAAQL 210
>XP_005245709
          Length = 1187

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SYYLNSAQL 9
           SYY ++AQL
Sbjct: 173 SYYRHAAQL 181
>XP_006711738
          Length = 1189

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SYYLNSAQL 9
           SYY ++AQL
Sbjct: 225 SYYRHAAQL 233
>XP_006711737
          Length = 1193

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SYYLNSAQL 9
           SYY ++AQL
Sbjct: 225 SYYRHAAQL 233
>XP_005245706
          Length = 1216

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SYYLNSAQL 9
           SYY ++AQL
Sbjct: 202 SYYRHAAQL 210
>XP_005245705
          Length = 1216

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SYYLNSAQL 9
           SYY ++AQL
Sbjct: 202 SYYRHAAQL 210
>XP_005245704
          Length = 1239

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SYYLNSAQL 9
           SYY ++AQL
Sbjct: 225 SYYRHAAQL 233
>NP_789781
          Length = 1048

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SYYLNSAQL 9
           +YYL+ AQL
Sbjct: 833 AYYLSVAQL 841
>NP_005425
          Length = 153

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YYLNSA 7
           YY+NSA
Sbjct: 126 YYINSA 131
>NP_005637
          Length = 1621

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    YYLNSAQ 8
            YY+NS Q
Sbjct: 1159 YYVNSLQ 1165
>NP_057349
          Length = 697

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SYYLNSA 7
           ++YLNSA
Sbjct: 473 TFYLNSA 479
>NP_008887
          Length = 659

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SYYLNSA 7
           ++YLNSA
Sbjct: 435 TFYLNSA 441
>XP_006711875
          Length = 1165

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   YYLNSAQ 8
           YY+NS Q
Sbjct: 703 YYVNSLQ 709
>XP_005273291
          Length = 1620

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    YYLNSAQ 8
            YY+NS Q
Sbjct: 1158 YYVNSLQ 1164
>NP_001103408
          Length = 315

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SYYLNSAQL 9
           ++YLNS+ L
Sbjct: 262 TFYLNSSGL 270
>NP_001154848
          Length = 496

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SYYLNSAQL 9
           ++YLNS+ L
Sbjct: 443 TFYLNSSGL 451
>NP_659466
          Length = 181

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SYYLNSAQL 9
           ++YLNS+ L
Sbjct: 128 TFYLNSSGL 136
>NP_821074
          Length = 1113

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2  YYLNS 6
          YYLNS
Sbjct: 14 YYLNS 18
>XP_005260717
          Length = 931

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2   YYLNS 6
           YYLNS
Sbjct: 798 YYLNS 802
>NP_001004058
          Length = 307

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SYYLNSAQL 9
           SYY  +AQL
Sbjct: 93  SYYACAAQL 101
>NP_542789
          Length = 906

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2   YYLNS 6
           YYLNS
Sbjct: 773 YYLNS 777
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.311    0.122    0.322 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 397,123
Number of extensions: 314
Number of successful extensions: 66
Number of sequences better than 10000.0: 66
Number of HSP's gapped: 66
Number of HSP's successfully gapped: 66
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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