Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_073713                                                              19     869
XP_005273507                                                           18    1935
NP_689997                                                              17    4312
NP_001073291                                                           16    5631
NP_000417                                                              16    5631
NP_258428                                                              16    5631
NP_004817                                                              16    5631
NP_001277716                                                           16    5631
NP_001191055                                                           16    5631
NP_006143                                                              16    5631
NP_001191056                                                           16    5631
XP_005253431                                                           16    5631
XP_006719140                                                           16    5631
XP_006719139                                                           16    5631
XP_005253429                                                           16    5631
XP_006719138                                                           16    5631
XP_005253428                                                           16    5631
XP_005253427                                                           16    5631
XP_005267039                                                           16    5631
XP_005267038                                                           16    5631
NP_001275927                                                           16    7355
NP_001275928                                                           16    7355
NP_057657                                                              16    7355
NP_001245215                                                           16    7355
NP_778205                                                              16    7355
NP_778204                                                              16    7355
NP_001269358                                                           16    7355
NP_001245216                                                           16    7355
NP_775785                                                              16    7355
XP_005259984                                                           16    7355
XP_005251979                                                           16    7355
XP_006714605                                                           16    7355
XP_006714604                                                           16    7355
XP_006714603                                                           16    7355
XP_006714602                                                           16    7355
XP_006714601                                                           16    7355
XP_006714600                                                           16    7355
NP_001265514                                                           15    9605
NP_001278232                                                           15    9605
NP_001278214                                                           15    9605
NP_006578                                                              15    9605
NP_065944                                                              15    9605
NP_065170                                                              15    9605
XP_005245054                                                           15    9605
XP_006711299                                                           15    9605
XP_005245053                                                           15    9605
XP_006711298                                                           15    9605
XP_005245050                                                           15    9605
XP_005245049                                                           15    9605
XP_005245048                                                           15    9605
XP_005245046                                                           15    9605
XP_005245043                                                           15    9605
XP_006711297                                                           15    9605
XP_006711296                                                           15    9605
XP_006711295                                                           15    9605
XP_006711294                                                           15    9605
XP_006711293                                                           15    9605
XP_005245042                                                           15    9605
XP_006711292                                                           15    9605
XP_006711291                                                           15    9605
XP_006711290                                                           15    9605
XP_006711289                                                           15    9605
XP_005245034                                                           15    9605
>NP_073713
          Length = 985

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SYRVLGSRT 9
           SY VLGSRT
Sbjct: 138 SYGVLGSRT 146
>XP_005273507
          Length = 362

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  YRVLGSR 8
          YR+LGSR
Sbjct: 22 YRILGSR 28
>NP_689997
          Length = 798

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YRVLGSRT 9
           Y++LG RT
Sbjct: 668 YQILGGRT 675
>NP_001073291
          Length = 3118

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    YRVLGSRT 9
            YR++ SRT
Sbjct: 2230 YRIVASRT 2237
>NP_000417
          Length = 3122

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    YRVLGSRT 9
            YR++ SRT
Sbjct: 2230 YRIVASRT 2237
>NP_258428
          Length = 779

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   YRVLGS 7
           YRVLGS
Sbjct: 746 YRVLGS 751
>NP_004817
          Length = 775

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   YRVLGS 7
           YRVLGS
Sbjct: 742 YRVLGS 747
>NP_001277716
          Length = 773

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   YRVLGS 7
           YRVLGS
Sbjct: 740 YRVLGS 745
>NP_001191055
          Length = 499

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SYRVLGSR 8
           S+R+LGS+
Sbjct: 348 SWRILGSK 355
>NP_006143
          Length = 499

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SYRVLGSR 8
           S+R+LGS+
Sbjct: 348 SWRILGSK 355
>NP_001191056
          Length = 499

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SYRVLGSR 8
           S+R+LGS+
Sbjct: 348 SWRILGSK 355
>XP_005253431
          Length = 499

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SYRVLGSR 8
           S+R+LGS+
Sbjct: 348 SWRILGSK 355
>XP_006719140
          Length = 446

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SYRVLGSR 8
           S+R+LGS+
Sbjct: 295 SWRILGSK 302
>XP_006719139
          Length = 499

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SYRVLGSR 8
           S+R+LGS+
Sbjct: 348 SWRILGSK 355
>XP_005253429
          Length = 499

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SYRVLGSR 8
           S+R+LGS+
Sbjct: 348 SWRILGSK 355
>XP_006719138
          Length = 499

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SYRVLGSR 8
           S+R+LGS+
Sbjct: 348 SWRILGSK 355
>XP_005253428
          Length = 499

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SYRVLGSR 8
           S+R+LGS+
Sbjct: 348 SWRILGSK 355
>XP_005253427
          Length = 499

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SYRVLGSR 8
           S+R+LGS+
Sbjct: 348 SWRILGSK 355
>XP_005267039
          Length = 3206

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    YRVLGSRT 9
            YR++ SRT
Sbjct: 2318 YRIVASRT 2325
>XP_005267038
          Length = 3210

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    YRVLGSRT 9
            YR++ SRT
Sbjct: 2318 YRIVASRT 2325
>NP_001275927
          Length = 941

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   YRVLGSR 8
           YRV GSR
Sbjct: 557 YRVSGSR 563
>NP_001275928
          Length = 944

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   YRVLGSR 8
           YRV GSR
Sbjct: 560 YRVSGSR 566
>NP_057657
          Length = 970

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   YRVLGSR 8
           YRV GSR
Sbjct: 586 YRVSGSR 592
>NP_001245215
          Length = 498

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YRVLGSRT 9
           YRV+ SRT
Sbjct: 103 YRVVKSRT 110
>NP_778205
          Length = 218

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  RVLGSRT 9
          RVLG RT
Sbjct: 75 RVLGGRT 81
>NP_778204
          Length = 302

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   RVLGSRT 9
           RVLG RT
Sbjct: 159 RVLGGRT 165
>NP_001269358
          Length = 437

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  YRVLGSRT 9
          YRV+ SRT
Sbjct: 42 YRVVKSRT 49
>NP_001245216
          Length = 498

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YRVLGSRT 9
           YRV+ SRT
Sbjct: 139 YRVVKSRT 146
>NP_775785
          Length = 561

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YRVLGSRT 9
           YRV+ SRT
Sbjct: 166 YRVVKSRT 173
>XP_005259984
          Length = 967

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   YRVLGSR 8
           YRV GSR
Sbjct: 583 YRVSGSR 589
>XP_005251979
          Length = 216

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   RVLGSRT 9
           RVLG RT
Sbjct: 159 RVLGGRT 165
>XP_006714605
          Length = 496

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YRVLGSRT 9
           YRV+ SRT
Sbjct: 166 YRVVKSRT 173
>XP_006714604
          Length = 531

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YRVLGSRT 9
           YRV+ SRT
Sbjct: 166 YRVVKSRT 173
>XP_006714603
          Length = 561

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YRVLGSRT 9
           YRV+ SRT
Sbjct: 166 YRVVKSRT 173
>XP_006714602
          Length = 561

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YRVLGSRT 9
           YRV+ SRT
Sbjct: 166 YRVVKSRT 173
>XP_006714601
          Length = 561

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YRVLGSRT 9
           YRV+ SRT
Sbjct: 166 YRVVKSRT 173
>XP_006714600
          Length = 561

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YRVLGSRT 9
           YRV+ SRT
Sbjct: 166 YRVVKSRT 173
>NP_001265514
          Length = 938

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   RVLGSRT 9
           R+LG RT
Sbjct: 697 RILGGRT 703
>NP_001278232
          Length = 4983

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1    SYRVLGSRT 9
            SYR++G  +
Sbjct: 2400 SYRIIGGNS 2408
>NP_001278214
          Length = 4982

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1    SYRVLGSRT 9
            SYR++G  +
Sbjct: 2400 SYRIIGGNS 2408
>NP_006578
          Length = 1042

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   RVLGSRT 9
           R+LG RT
Sbjct: 801 RILGGRT 807
>NP_065944
          Length = 1701

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    YRVLGSR 8
            YRVLG +
Sbjct: 1359 YRVLGDK 1365
>NP_065170
          Length = 369

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SYRVLGS 7
           +YR+LGS
Sbjct: 250 TYRLLGS 256
>XP_005245054
          Length = 762

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   RVLGSR 8
           RVLGSR
Sbjct: 137 RVLGSR 142
>XP_006711299
          Length = 1042

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   RVLGSR 8
           RVLGSR
Sbjct: 137 RVLGSR 142
>XP_005245053
          Length = 1232

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   RVLGSR 8
           RVLGSR
Sbjct: 137 RVLGSR 142
>XP_006711298
          Length = 1299

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   RVLGSR 8
           RVLGSR
Sbjct: 137 RVLGSR 142
>XP_005245050
          Length = 1306

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   RVLGSR 8
           RVLGSR
Sbjct: 137 RVLGSR 142
>XP_005245049
          Length = 1318

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   RVLGSR 8
           RVLGSR
Sbjct: 137 RVLGSR 142
>XP_005245048
          Length = 1323

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   RVLGSR 8
           RVLGSR
Sbjct: 137 RVLGSR 142
>XP_005245046
          Length = 1338

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   RVLGSR 8
           RVLGSR
Sbjct: 137 RVLGSR 142
>XP_005245043
          Length = 1389

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   RVLGSR 8
           RVLGSR
Sbjct: 137 RVLGSR 142
>XP_006711297
          Length = 1391

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   RVLGSR 8
           RVLGSR
Sbjct: 137 RVLGSR 142
>XP_006711296
          Length = 1391

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  RVLGSR 8
          RVLGSR
Sbjct: 47 RVLGSR 52
>XP_006711295
          Length = 1400

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  RVLGSR 8
          RVLGSR
Sbjct: 56 RVLGSR 61
>XP_006711294
          Length = 1400

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   RVLGSR 8
           RVLGSR
Sbjct: 137 RVLGSR 142
>XP_006711293
          Length = 1402

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   RVLGSR 8
           RVLGSR
Sbjct: 137 RVLGSR 142
>XP_005245042
          Length = 1406

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   RVLGSR 8
           RVLGSR
Sbjct: 137 RVLGSR 142
>XP_006711292
          Length = 1428

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  RVLGSR 8
          RVLGSR
Sbjct: 90 RVLGSR 95
>XP_006711291
          Length = 1430

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   RVLGSR 8
           RVLGSR
Sbjct: 137 RVLGSR 142
>XP_006711290
          Length = 1434

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  RVLGSR 8
          RVLGSR
Sbjct: 90 RVLGSR 95
>XP_006711289
          Length = 1475

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   RVLGSR 8
           RVLGSR
Sbjct: 137 RVLGSR 142
>XP_005245034
          Length = 1481

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   RVLGSR 8
           RVLGSR
Sbjct: 137 RVLGSR 142
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.320    0.131    0.356 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 540,395
Number of extensions: 1108
Number of successful extensions: 63
Number of sequences better than 10000.0: 63
Number of HSP's gapped: 63
Number of HSP's successfully gapped: 63
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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