Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_006501                                                              18    1135
NP_115758                                                              17    2528
NP_002604                                                              17    4312
NP_001248745                                                           17    4312
XP_005255413                                                           17    4312
XP_005275825                                                           17    4312
XP_003960932                                                           17    4312
XP_006710060                                                           17    4312
NP_001129474                                                           17    4312
NP_919299                                                              16    5631
NP_001257625                                                           16    5631
NP_001257624                                                           16    5631
NP_060757                                                              16    5631
NP_058641                                                              16    5631
XP_006719831                                                           16    5631
XP_006717604                                                           16    5631
XP_006717603                                                           16    5631
NP_006149                                                              16    7355
NP_078858                                                              16    7355
NP_001278232                                                           16    7355
NP_001278214                                                           16    7355
NP_001137420                                                           16    7355
NP_116133                                                              16    7355
NP_003974                                                              16    7355
NP_001070253                                                           16    7355
NP_001121904                                                           16    7355
NP_008970                                                              16    7355
NP_001264154                                                           16    7355
NP_078904                                                              16    7355
NP_001182412                                                           16    7355
NP_066024                                                              16    7355
XP_006720074                                                           16    7355
XP_005267344                                                           16    7355
XP_005268801                                                           16    7355
XP_005268800                                                           16    7355
XP_005268799                                                           16    7355
XP_005249511                                                           16    7355
NP_056090                                                              16    7355
NP_001926                                                              15    9605
NP_115495                                                              15    9605
NP_570629                                                              15    9605
NP_001034439                                                           15    9605
NP_001927                                                              15    9605
NP_001277181                                                           15    9605
NP_001275756                                                           15    9605
NP_005251                                                              15    9605
NP_001275754                                                           15    9605
NP_001275753                                                           15    9605
NP_001275755                                                           15    9605
NP_001275757                                                           15    9605
NP_002800                                                              15    9605
NP_078988                                                              15    9605
XP_005272299                                                           15    9605
XP_006715935                                                           15    9605
XP_006715934                                                           15    9605
XP_006714648                                                           15    9605
XP_005272014                                                           15    9605
XP_005246428                                                           15    9605
XP_006710661                                                           15    9605
XP_006710659                                                           15    9605
XP_006710658                                                           15    9605
XP_006710657                                                           15    9605
NP_055857                                                              15    9605
NP_001053                                                              15    9605
NP_001968                                                              15    9605
>NP_006501
          Length = 513

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   YFSLSYS 8
           YFSLSYS
Sbjct: 473 YFSLSYS 479
>NP_115758
          Length = 612

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YFSLSYSR 9
           YF LS+SR
Sbjct: 351 YFGLSFSR 358
>NP_002604
          Length = 556

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YFSLSYSR 9
           YF LSY++
Sbjct: 156 YFGLSYAK 163
>NP_001248745
          Length = 454

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YFSLSYSR 9
           YF LSY++
Sbjct: 156 YFGLSYAK 163
>XP_005255413
          Length = 529

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YFSLSYSR 9
           YF LSY++
Sbjct: 129 YFGLSYAK 136
>XP_005275825
          Length = 218

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YFSLSYSR 9
           YF LSY++
Sbjct: 129 YFGLSYAK 136
>XP_003960932
          Length = 396

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YFSLSYSR 9
           YF LSY++
Sbjct: 129 YFGLSYAK 136
>XP_006710060
          Length = 425

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YFSLSYSR 9
           YF LSY++
Sbjct: 129 YFGLSYAK 136
>NP_001129474
          Length = 380

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   YFSLSYSR 9
           YF L YSR
Sbjct: 295 YFHLHYSR 302
>NP_919299
          Length = 498

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   YFSLSYSR 9
           +FS++YSR
Sbjct: 116 HFSVTYSR 123
>NP_001257625
          Length = 816

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SYFSLSYSR 9
           +Y+S SYS+
Sbjct: 323 NYYSTSYSQ 331
>NP_001257624
          Length = 841

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SYFSLSYSR 9
           +Y+S SYS+
Sbjct: 323 NYYSTSYSQ 331
>NP_060757
          Length = 846

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SYFSLSYSR 9
           +Y+S SYS+
Sbjct: 323 NYYSTSYSQ 331
>NP_058641
          Length = 291

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  SYFSLSY 7
          SYF+L+Y
Sbjct: 70 SYFNLNY 76
>XP_006719831
          Length = 479

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   YFSLSYSR 9
           +FS++YSR
Sbjct: 97  HFSVTYSR 104
>XP_006717604
          Length = 820

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SYFSLSYSR 9
           +Y+S SYS+
Sbjct: 323 NYYSTSYSQ 331
>XP_006717603
          Length = 846

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SYFSLSYSR 9
           +Y+S SYS+
Sbjct: 323 NYYSTSYSQ 331
>NP_006149
          Length = 543

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  YFSLSYSR 9
          Y+S SY R
Sbjct: 9  YYSTSYKR 16
>NP_078858
          Length = 4981

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    SYFSLS 6
            SYFSLS
Sbjct: 3556 SYFSLS 3561
>NP_001278232
          Length = 4983

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    SYFSLS 6
            SYFSLS
Sbjct: 3558 SYFSLS 3563
>NP_001278214
          Length = 4982

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    SYFSLS 6
            SYFSLS
Sbjct: 3558 SYFSLS 3563
>NP_001137420
          Length = 248

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SYFSLSY 7
           ++FSLSY
Sbjct: 213 AFFSLSY 219
>NP_116133
          Length = 230

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SYFSLSY 7
           ++FSLSY
Sbjct: 195 AFFSLSY 201
>NP_003974
          Length = 515

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   SYFSLSY 7
           +YFS SY
Sbjct: 391 NYFSFSY 397
>NP_001070253
          Length = 515

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   SYFSLSY 7
           +YFS SY
Sbjct: 391 NYFSFSY 397
>NP_001121904
          Length = 162

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  FSLSYSR 9
          FSLS+SR
Sbjct: 76 FSLSWSR 82
>NP_008970
          Length = 1174

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   FSLSYS 8
           FSLSYS
Sbjct: 512 FSLSYS 517
>NP_001264154
          Length = 470

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  FSLSYSR 9
          FSLS+SR
Sbjct: 77 FSLSWSR 83
>NP_078904
          Length = 714

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SYFSLS 6
           SYFSLS
Sbjct: 401 SYFSLS 406
>NP_001182412
          Length = 714

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SYFSLS 6
           SYFSLS
Sbjct: 401 SYFSLS 406
>NP_066024
          Length = 469

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  FSLSYSR 9
          FSLS+SR
Sbjct: 76 FSLSWSR 82
>XP_006720074
          Length = 1051

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   FSLSYS 8
           FSLSYS
Sbjct: 389 FSLSYS 394
>XP_005267344
          Length = 1174

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   FSLSYS 8
           FSLSYS
Sbjct: 512 FSLSYS 517
>XP_005268801
          Length = 985

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YFSLSYSR 9
           YFSLS +R
Sbjct: 936 YFSLSSAR 943
>XP_005268800
          Length = 986

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YFSLSYSR 9
           YFSLS +R
Sbjct: 937 YFSLSSAR 944
>XP_005268799
          Length = 1174

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    YFSLSYSR 9
            YFSLS +R
Sbjct: 1125 YFSLSSAR 1132
>XP_005249511
          Length = 230

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SYFSLSY 7
           ++FSLSY
Sbjct: 195 AFFSLSY 201
>NP_056090
          Length = 1173

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    YFSLSYSR 9
            YFSLS +R
Sbjct: 1124 YFSLSSAR 1131
>NP_001926
          Length = 766

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   YFSLSYSR 9
           Y+S+S+S+
Sbjct: 456 YYSVSFSK 463
>NP_115495
          Length = 6306

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YFSLSYSR 9
           Y SLS++R
Sbjct: 536 YLSLSFTR 543
>NP_570629
          Length = 865

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SYFSLSYS 8
           +YFS S+S
Sbjct: 537 TYFSASFS 544
>NP_001034439
          Length = 801

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SYFSLSYS 8
           +YFS S+S
Sbjct: 473 TYFSASFS 480
>NP_001927
          Length = 803

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SYFSLSYS 8
           +YFS S+S
Sbjct: 475 TYFSASFS 482
>NP_001277181
          Length = 758

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SYFSLSYS 8
           +YFS S+S
Sbjct: 430 TYFSASFS 437
>NP_001275756
          Length = 366

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SYFSLSYSR 9
           S++SL Y R
Sbjct: 189 SWYSLHYKR 197
>NP_005251
          Length = 454

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SYFSLSYSR 9
           S++SL Y R
Sbjct: 277 SWYSLHYKR 285
>NP_001275754
          Length = 366

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SYFSLSYSR 9
           S++SL Y R
Sbjct: 189 SWYSLHYKR 197
>NP_001275753
          Length = 366

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SYFSLSYSR 9
           S++SL Y R
Sbjct: 189 SWYSLHYKR 197
>NP_001275755
          Length = 366

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SYFSLSYSR 9
           S++SL Y R
Sbjct: 189 SWYSLHYKR 197
>NP_001275757
          Length = 366

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SYFSLSYSR 9
           S++SL Y R
Sbjct: 189 SWYSLHYKR 197
>NP_002800
          Length = 534

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SLSYSR 9
           SLSYSR
Sbjct: 411 SLSYSR 416
>NP_078988
          Length = 773

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   FSLSYSR 9
           FS+SY R
Sbjct: 681 FSISYDR 687
>XP_005272299
          Length = 599

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SLSYSR 9
           SLSYSR
Sbjct: 159 SLSYSR 164

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SLSYSR 9
           SLSYSR
Sbjct: 187 SLSYSR 192

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SLSYSR 9
           SLSYSR
Sbjct: 243 SLSYSR 248

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SLSYSR 9
           SLSYSR
Sbjct: 336 SLSYSR 341

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SLSYSR 9
           SLSYSR
Sbjct: 392 SLSYSR 397

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SLSYSR 9
           SLSYSR
Sbjct: 448 SLSYSR 453

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SLSYSR 9
           SLSYSR
Sbjct: 466 SLSYSR 471
>XP_006715935
          Length = 804

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SYFSLSYS 8
           +YFS S+S
Sbjct: 476 TYFSASFS 483
>XP_006715934
          Length = 804

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SYFSLSYS 8
           +YFS S+S
Sbjct: 476 TYFSASFS 483
>XP_006714648
          Length = 366

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SYFSLSYSR 9
           S++SL Y R
Sbjct: 189 SWYSLHYKR 197
>XP_005272014
          Length = 366

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SYFSLSYSR 9
           S++SL Y R
Sbjct: 189 SWYSLHYKR 197
>XP_005246428
          Length = 765

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   YFSLSYSR 9
           Y+S+S+S+
Sbjct: 455 YYSVSFSK 462
>XP_006710661
          Length = 4057

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    SYFSLSY 7
            S FSLSY
Sbjct: 1561 SQFSLSY 1567
>XP_006710659
          Length = 4556

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    SYFSLSY 7
            S FSLSY
Sbjct: 1537 SQFSLSY 1543
>XP_006710658
          Length = 4563

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    SYFSLSY 7
            S FSLSY
Sbjct: 1544 SQFSLSY 1550
>XP_006710657
          Length = 4579

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    SYFSLSY 7
            S FSLSY
Sbjct: 1560 SQFSLSY 1566
>NP_055857
          Length = 1411

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SYFSLSYSR 9
           SY+S SY++
Sbjct: 897 SYYSPSYAQ 905
>NP_001053
          Length = 433

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SYFSLSYS 8
           SY S++YS
Sbjct: 332 SYISVNYS 339
>NP_001968
          Length = 957

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   YFSLSYS 8
           YF+++YS
Sbjct: 336 YFAMNYS 342
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.321    0.125    0.343 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 539,895
Number of extensions: 849
Number of successful extensions: 71
Number of sequences better than 10000.0: 65
Number of HSP's gapped: 71
Number of HSP's successfully gapped: 71
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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