Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000360                                                              19     665
XP_005268094                                                           19     665
NP_061875                                                              18    1482
XP_005264434                                                           18    1482
XP_005264433                                                           18    1482
XP_005264432                                                           18    1482
XP_005264431                                                           18    1482
NP_116248                                                              17    4312
NP_001229734                                                           17    4312
NP_001229739                                                           17    4312
NP_002255                                                              17    4312
NP_001229735                                                           17    4312
NP_001230396                                                           17    4312
NP_061834                                                              17    4312
NP_001001895                                                           17    4312
XP_005247496                                                           17    4312
XP_005247494                                                           17    4312
XP_006710921                                                           17    4312
XP_006710920                                                           17    4312
XP_006710919                                                           17    4312
XP_006710918                                                           17    4312
XP_006710917                                                           17    4312
XP_005271208                                                           17    4312
XP_006710916                                                           17    4312
XP_005270768                                                           17    4312
NP_001717                                                              17    4312
NP_997072                                                              17    4312
NP_036448                                                              17    4312
NP_899232                                                              16    5631
NP_001274152                                                           16    7355
NP_057332                                                              16    7355
NP_054858                                                              16    7355
XP_005266307                                                           16    7355
XP_005266306                                                           16    7355
XP_005266305                                                           16    7355
XP_005266304                                                           16    7355
XP_005267021                                                           16    7355
XP_006715537                                                           16    7355
NP_002260                                                              16    7355
NP_008835                                                              15    9605
NP_001075109                                                           15    9605
NP_001182502                                                           15    9605
NP_001258211                                                           15    9605
NP_003831                                                              15    9605
NP_085124                                                              15    9605
NP_803187                                                              15    9605
NP_899243                                                              15    9605
NP_001432                                                              15    9605
NP_443179                                                              15    9605
NP_115971                                                              15    9605
NP_065784                                                              15    9605
NP_004496                                                              15    9605
XP_006724608                                                           15    9605
XP_006724606                                                           15    9605
XP_005266703                                                           15    9605
XP_005256902                                                           15    9605
XP_006720135                                                           15    9605
XP_006720134                                                           15    9605
XP_006720133                                                           15    9605
XP_005247723                                                           15    9605
>NP_000360
          Length = 764

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SYAKVSNCL 9
           SYAKVS CL
Sbjct: 562 SYAKVSICL 570
>XP_005268094
          Length = 764

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SYAKVSNCL 9
           SYAKVS CL
Sbjct: 562 SYAKVSICL 570
>NP_061875
          Length = 926

 Score = 18.1 bits (35), Expect =  1482
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   YAKVSNC 8
           Y+K+SNC
Sbjct: 739 YSKISNC 745
>XP_005264434
          Length = 843

 Score = 18.1 bits (35), Expect =  1482
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   YAKVSNC 8
           Y+K+SNC
Sbjct: 656 YSKISNC 662
>XP_005264433
          Length = 899

 Score = 18.1 bits (35), Expect =  1482
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   YAKVSNC 8
           Y+K+SNC
Sbjct: 712 YSKISNC 718
>XP_005264432
          Length = 899

 Score = 18.1 bits (35), Expect =  1482
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   YAKVSNC 8
           Y+K+SNC
Sbjct: 712 YSKISNC 718
>XP_005264431
          Length = 928

 Score = 18.1 bits (35), Expect =  1482
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   YAKVSNC 8
           Y+K+SNC
Sbjct: 741 YSKISNC 747
>NP_116248
          Length = 337

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   SYAKVSNC 8
           SY K+S C
Sbjct: 249 SYRKISQC 256
>NP_001229734
          Length = 947

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  YAKVSNCL 9
          YAK S C+
Sbjct: 88 YAKASECI 95
>NP_001229739
          Length = 874

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  YAKVSNCL 9
          YAK S C+
Sbjct: 15 YAKASECI 22
>NP_002255
          Length = 538

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YAKVSNCL 9
           +AKVS CL
Sbjct: 249 FAKVSPCL 256
>NP_001229735
          Length = 951

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  YAKVSNCL 9
          YAK S C+
Sbjct: 88 YAKASECI 95
>NP_001230396
          Length = 526

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  YAKVSNCL 9
          YAKVSN L
Sbjct: 9  YAKVSNKL 16
>NP_061834
          Length = 661

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  YAKVSNCL 9
          YAKVSN L
Sbjct: 9  YAKVSNKL 16
>NP_001001895
          Length = 623

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  YAKVSNCL 9
          YAKVSN L
Sbjct: 9  YAKVSNKL 16
>XP_005247496
          Length = 337

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  YAKVSNCL 9
          +AKVS CL
Sbjct: 48 FAKVSPCL 55
>XP_005247494
          Length = 538

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YAKVSNCL 9
           +AKVS CL
Sbjct: 249 FAKVSPCL 256
>XP_006710921
          Length = 668

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  YAKVSNCL 9
          YAK S C+
Sbjct: 88 YAKASECI 95
>XP_006710920
          Length = 947

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  YAKVSNCL 9
          YAK S C+
Sbjct: 88 YAKASECI 95
>XP_006710919
          Length = 947

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  YAKVSNCL 9
          YAK S C+
Sbjct: 88 YAKASECI 95
>XP_006710918
          Length = 947

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  YAKVSNCL 9
          YAK S C+
Sbjct: 88 YAKASECI 95
>XP_006710917
          Length = 947

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  YAKVSNCL 9
          YAK S C+
Sbjct: 88 YAKASECI 95
>XP_005271208
          Length = 947

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  YAKVSNCL 9
          YAK S C+
Sbjct: 88 YAKASECI 95
>XP_006710916
          Length = 947

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  YAKVSNCL 9
          YAK S C+
Sbjct: 88 YAKASECI 95
>XP_005270768
          Length = 566

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YAKVSNCL 9
           +AKVS CL
Sbjct: 277 FAKVSPCL 284
>NP_001717
          Length = 947

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  YAKVSNCL 9
          YAK S C+
Sbjct: 88 YAKASECI 95
>NP_997072
          Length = 947

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  YAKVSNCL 9
          YAK S C+
Sbjct: 88 YAKASECI 95
>NP_036448
          Length = 536

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YAKVSNCL 9
           +AKVS CL
Sbjct: 247 FAKVSPCL 254
>NP_899232
          Length = 418

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   YAKVSNC 8
           YA++ NC
Sbjct: 215 YAEIENC 221
>NP_001274152
          Length = 1791

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SYAKVSNCL 9
           S+A V NC+
Sbjct: 652 SFADVMNCV 660
>NP_057332
          Length = 1901

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    AKVSNCL 9
            AKV NC+
Sbjct: 1275 AKVRNCM 1281
>NP_054858
          Length = 1791

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SYAKVSNCL 9
           S+A V NC+
Sbjct: 652 SFADVMNCV 660
>XP_005266307
          Length = 1796

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    AKVSNCL 9
            AKV NC+
Sbjct: 1275 AKVRNCM 1281
>XP_005266306
          Length = 1824

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    AKVSNCL 9
            AKV NC+
Sbjct: 1275 AKVRNCM 1281
>XP_005266305
          Length = 1856

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    AKVSNCL 9
            AKV NC+
Sbjct: 1230 AKVRNCM 1236
>XP_005266304
          Length = 1873

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    AKVSNCL 9
            AKV NC+
Sbjct: 1275 AKVRNCM 1281
>XP_005267021
          Length = 536

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SYAKVSNCL 9
           +++KVS CL
Sbjct: 246 NFSKVSPCL 254
>XP_006715537
          Length = 539

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SYAKVSNCL 9
           +++KVS CL
Sbjct: 249 NFSKVSPCL 257
>NP_002260
          Length = 539

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SYAKVSNCL 9
           +++KVS CL
Sbjct: 249 NFSKVSPCL 257
>NP_008835
          Length = 4128

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1    SYAKVSNC 8
            SY ++S+C
Sbjct: 3279 SYCRLSHC 3286
>NP_001075109
          Length = 4097

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1    SYAKVSNC 8
            SY ++S+C
Sbjct: 3279 SYCRLSHC 3286
>NP_001182502
          Length = 1829

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4    KVSNC 8
            KVSNC
Sbjct: 1350 KVSNC 1354
>NP_001258211
          Length = 1922

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4    KVSNC 8
            KVSNC
Sbjct: 1350 KVSNC 1354
>NP_003831
          Length = 386

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4   KVSNC 8
           KVSNC
Sbjct: 168 KVSNC 172
>NP_085124
          Length = 1922

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4    KVSNC 8
            KVSNC
Sbjct: 1350 KVSNC 1354
>NP_803187
          Length = 1922

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4    KVSNC 8
            KVSNC
Sbjct: 1350 KVSNC 1354
>NP_899243
          Length = 1977

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 2   YAKVSNCL 9
           Y KV  CL
Sbjct: 441 YKKVGECL 448
>NP_001432
          Length = 579

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   SYAKVSNCL 9
           SY  + NCL
Sbjct: 492 SYTMLYNCL 500
>NP_443179
          Length = 2170

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 2    YAKVSNCL 9
            Y K S CL
Sbjct: 2069 YQKTSGCL 2076
>NP_115971
          Length = 1604

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    SYAKVSNC 8
            +YAK  NC
Sbjct: 1529 TYAKNPNC 1536
>NP_065784
          Length = 1381

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   SYAKVSN 7
           SY K+SN
Sbjct: 586 SYIKISN 592
>NP_004496
          Length = 1406

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    SYAKVSNC 8
            +YAK  NC
Sbjct: 1331 TYAKNPNC 1338
>XP_006724608
          Length = 478

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  SYAKVSNCL 9
          SY K  +CL
Sbjct: 53 SYCKAVSCL 61
>XP_006724606
          Length = 525

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   SYAKVSNCL 9
           SY K  +CL
Sbjct: 100 SYCKAVSCL 108
>XP_005266703
          Length = 1501

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 2    YAKVSNCL 9
            Y K S CL
Sbjct: 1400 YQKTSGCL 1407
>XP_005256902
          Length = 1406

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    SYAKVSNC 8
            +YAK  NC
Sbjct: 1331 TYAKNPNC 1338
>XP_006720135
          Length = 1454

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 2   YAKVSNCL 9
           Y KV  CL
Sbjct: 441 YKKVGECL 448
>XP_006720134
          Length = 1579

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 2   YAKVSNCL 9
           Y KV  CL
Sbjct: 441 YKKVGECL 448
>XP_006720133
          Length = 1969

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 2   YAKVSNCL 9
           Y KV  CL
Sbjct: 441 YKKVGECL 448
>XP_005247723
          Length = 1481

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   SYAKVSN 7
           SY K+SN
Sbjct: 686 SYIKISN 692
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.316    0.121    0.364 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 480,841
Number of extensions: 637
Number of successful extensions: 60
Number of sequences better than 10000.0: 60
Number of HSP's gapped: 60
Number of HSP's successfully gapped: 60
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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