Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

• Home Page
• Cancer-specific
• Epitope Search
• Data Retrieval
• Browse Gene
• Browse Tissue
• Sequence Similarity
• Partially Personalized
• Submit a Protein
• Vaccine Target
• Proteome Data
• NGS data
• BLAST & Predict
• Fully Personalized
• Proteins Pair
• Proteome Pair
• Advanced Tools
• Epitope Mapping
• Cross Reactivity
• Important Information
• Acknowledgement
• Algorithm
• Help
• Developers
• Contact

Blast-Search of mutated query peptide against human proteome

BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000537                                                              18    1135
NP_001263689                                                           18    1135
NP_001119584                                                           18    1135
NP_001119586                                                           18    1135
NP_001263625                                                           18    1135
NP_001119590                                                           18    1135
NP_001263690                                                           18    1135
NP_001119585                                                           18    1135
NP_001263624                                                           18    1135
NP_001171134                                                           16    5631
NP_001138552                                                           16    5631
NP_060621                                                              16    5631
NP_061836                                                              16    5631
NP_001171136                                                           16    5631
NP_387505                                                              16    5631
XP_005261051                                                           16    5631
XP_005257293                                                           16    5631
XP_006712674                                                           16    5631
XP_006712673                                                           16    5631
XP_006712672                                                           16    5631
XP_005246722                                                           16    5631
NP_001171135                                                           16    5631
NP_001123885                                                           15    9605
NP_064710                                                              15    9605
NP_998769                                                              15    9605
XP_006722801                                                           15    9605
XP_006722800                                                           15    9605
XP_005259606                                                           15    9605
XP_005255493                                                           15    9605
XP_006721128                                                           15    9605
XP_005255492                                                           15    9605

>NP_000537
          Length = 393

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SVLSQKTYQ 9
           SV SQKTYQ
Sbjct: 96  SVPSQKTYQ 104



>NP_001263689
          Length = 354

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  SVLSQKTYQ 9
          SV SQKTYQ
Sbjct: 57 SVPSQKTYQ 65



>NP_001119584
          Length = 393

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SVLSQKTYQ 9
           SV SQKTYQ
Sbjct: 96  SVPSQKTYQ 104



>NP_001119586
          Length = 341

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SVLSQKTYQ 9
           SV SQKTYQ
Sbjct: 96  SVPSQKTYQ 104



>NP_001263625
          Length = 302

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  SVLSQKTYQ 9
          SV SQKTYQ
Sbjct: 57 SVPSQKTYQ 65



>NP_001119590
          Length = 354

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  SVLSQKTYQ 9
          SV SQKTYQ
Sbjct: 57 SVPSQKTYQ 65



>NP_001263690
          Length = 354

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  SVLSQKTYQ 9
          SV SQKTYQ
Sbjct: 57 SVPSQKTYQ 65



>NP_001119585
          Length = 346

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SVLSQKTYQ 9
           SV SQKTYQ
Sbjct: 96  SVPSQKTYQ 104



>NP_001263624
          Length = 307

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  SVLSQKTYQ 9
          SV SQKTYQ
Sbjct: 57 SVPSQKTYQ 65



>NP_001171134
          Length = 2446

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    SVLSQKTYQ 9
            S LS+KT+Q
Sbjct: 1706 SSLSEKTFQ 1714



>NP_001138552
          Length = 952

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LSQKTYQ 9
           LSQ TYQ
Sbjct: 629 LSQNTYQ 635



>NP_060621
          Length = 2472

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    SVLSQKTYQ 9
            S LS+KT+Q
Sbjct: 1706 SSLSEKTFQ 1714



>NP_061836
          Length = 2320

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    SVLSQKTYQ 9
            +VLSQ+ YQ
Sbjct: 1085 TVLSQEPYQ 1093



>NP_001171136
          Length = 2446

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    SVLSQKTYQ 9
            S LS+KT+Q
Sbjct: 1706 SSLSEKTFQ 1714



>NP_387505
          Length = 2269

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    SVLSQKTYQ 9
            +VLSQ+ YQ
Sbjct: 1085 TVLSQEPYQ 1093



>XP_005261051
          Length = 2242

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    SVLSQKTYQ 9
            +VLSQ+ YQ
Sbjct: 1007 TVLSQEPYQ 1015



>XP_005257293
          Length = 920

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LSQKTYQ 9
           LSQ TYQ
Sbjct: 629 LSQNTYQ 635



>XP_006712674
          Length = 2436

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    SVLSQKTYQ 9
            S LS+KT+Q
Sbjct: 1670 SSLSEKTFQ 1678



>XP_006712673
          Length = 2441

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    SVLSQKTYQ 9
            S LS+KT+Q
Sbjct: 1675 SSLSEKTFQ 1683



>XP_006712672
          Length = 2443

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    SVLSQKTYQ 9
            S LS+KT+Q
Sbjct: 1677 SSLSEKTFQ 1685



>XP_005246722
          Length = 2472

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    SVLSQKTYQ 9
            S LS+KT+Q
Sbjct: 1706 SSLSEKTFQ 1714



>NP_001171135
          Length = 2446

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    SVLSQKTYQ 9
            S LS+KT+Q
Sbjct: 1706 SSLSEKTFQ 1714



>NP_001123885
          Length = 802

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1 SVLSQKT 7
         +VLSQKT
Sbjct: 3 AVLSQKT 9



>NP_064710
          Length = 1052

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SVLSQKTY 8
           S +SQ+TY
Sbjct: 918 SAMSQETY 925



>NP_998769
          Length = 471

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   SQKTYQ 9
           +QKTYQ
Sbjct: 109 TQKTYQ 114



>XP_006722801
          Length = 372

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   SQKTYQ 9
           +QKTYQ
Sbjct: 119 TQKTYQ 124



>XP_006722800
          Length = 415

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   SQKTYQ 9
           +QKTYQ
Sbjct: 119 TQKTYQ 124



>XP_005259606
          Length = 481

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   SQKTYQ 9
           +QKTYQ
Sbjct: 119 TQKTYQ 124



>XP_005255493
          Length = 959

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SVLSQKTY 8
           S +SQ+TY
Sbjct: 825 SAMSQETY 832



>XP_006721128
          Length = 985

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SVLSQKTY 8
           S +SQ+TY
Sbjct: 851 SAMSQETY 858



>XP_005255492
          Length = 1026

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SVLSQKTY 8
           S +SQ+TY
Sbjct: 892 SAMSQETY 899



  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.302    0.110    0.260 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 451,244
Number of extensions: 628
Number of successful extensions: 31
Number of sequences better than 10000.0: 31
Number of HSP's gapped: 31
Number of HSP's successfully gapped: 31
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.4 bits)
S2: 28 (15.4 bits)