Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001166245                                                           18    1935
XP_005258618                                                           18    1935
NP_997208                                                              18    1935
NP_005742                                                              17    3301
NP_671714                                                              17    3301
XP_006715890                                                           17    3301
XP_005250160                                                           17    3301
XP_005250159                                                           17    3301
NP_001273028                                                           17    4312
NP_005275                                                              17    4312
NP_055928                                                              16    5631
NP_001020466                                                           16    5631
XP_005256618                                                           16    5631
XP_005256617                                                           16    5631
NP_570853                                                              16    7355
NP_570854                                                              16    7355
NP_000453                                                              16    7355
NP_001273636                                                           16    7355
NP_001273648                                                           16    7355
NP_057117                                                              16    7355
NP_001137502                                                           16    7355
XP_005268328                                                           16    7355
XP_006720739                                                           16    7355
XP_005268327                                                           16    7355
XP_005268326                                                           16    7355
XP_005268324                                                           16    7355
XP_005268325                                                           16    7355
XP_006720738                                                           16    7355
XP_006720737                                                           16    7355
XP_006720736                                                           16    7355
XP_005253056                                                           16    7355
XP_006716639                                                           16    7355
XP_005251007                                                           16    7355
XP_006716637                                                           16    7355
XP_005251005                                                           16    7355
XP_006716636                                                           16    7355
XP_005251004                                                           16    7355
XP_005251003                                                           16    7355
XP_005251002                                                           16    7355
XP_005251001                                                           16    7355
NP_001159349                                                           16    7355
NP_078938                                                              16    7355
NP_008864                                                              15    9605
NP_000334                                                              15    9605
NP_570855                                                              15    9605
NP_570856                                                              15    9605
NP_065683                                                              15    9605
NP_001243243                                                           15    9605
NP_001171809                                                           15    9605
NP_001098713                                                           15    9605
NP_065817                                                              15    9605
NP_065803                                                              15    9605
NP_689813                                                              15    9605
XP_005250451                                                           15    9605
XP_005250450                                                           15    9605
XP_006713672                                                           15    9605
NP_060523                                                              15    9605
>NP_001166245
          Length = 716

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   SVLLAAFW 8
           S LLAAFW
Sbjct: 187 SGLLAAFW 194
>XP_005258618
          Length = 682

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   SVLLAAFW 8
           S LLAAFW
Sbjct: 187 SGLLAAFW 194
>NP_997208
          Length = 716

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   SVLLAAFW 8
           S LLAAFW
Sbjct: 187 SGLLAAFW 194
>NP_005742
          Length = 3907

 Score = 16.9 bits (32), Expect =  3301
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SVLLAAFWT 9
            SVLLAAF T
Sbjct: 3039 SVLLAAFRT 3047
>NP_671714
          Length = 3899

 Score = 16.9 bits (32), Expect =  3301
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SVLLAAFWT 9
            SVLLAAF T
Sbjct: 3031 SVLLAAFRT 3039
>XP_006715890
          Length = 3860

 Score = 16.9 bits (32), Expect =  3301
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SVLLAAFWT 9
            SVLLAAF T
Sbjct: 2992 SVLLAAFRT 3000
>XP_005250160
          Length = 3939

 Score = 16.9 bits (32), Expect =  3301
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SVLLAAFWT 9
            SVLLAAF T
Sbjct: 3071 SVLLAAFRT 3079
>XP_005250159
          Length = 3952

 Score = 16.9 bits (32), Expect =  3301
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SVLLAAFWT 9
            SVLLAAF T
Sbjct: 3084 SVLLAAFRT 3092
>NP_001273028
          Length = 377

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VLLAAFWT 9
           +LLAA WT
Sbjct: 202 LLLAATWT 209
>NP_005275
          Length = 362

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VLLAAFWT 9
           +LLAA WT
Sbjct: 187 LLLAATWT 194
>NP_055928
          Length = 2961

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SVLLAAFWT 9
           SVL + FW+
Sbjct: 958 SVLFSLFWS 966
>NP_001020466
          Length = 132

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  LLAAFWT 9
          +LAA WT
Sbjct: 87 ILAAMWT 93
>XP_005256618
          Length = 2962

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SVLLAAFWT 9
           SVL + FW+
Sbjct: 959 SVLFSLFWS 967
>XP_005256617
          Length = 2966

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SVLLAAFWT 9
           SVL + FW+
Sbjct: 959 SVLFSLFWS 967
>NP_570853
          Length = 852

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   SVLLAAFW 8
           SVL+  FW
Sbjct: 761 SVLIREFW 768
>NP_570854
          Length = 872

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   SVLLAAFW 8
           SVL+  FW
Sbjct: 781 SVLIREFW 788
>NP_000453
          Length = 875

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   SVLLAAFW 8
           SVL+  FW
Sbjct: 784 SVLIREFW 791
>NP_001273636
          Length = 271

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4   LAAFW 8
           LAAFW
Sbjct: 235 LAAFW 239
>NP_001273648
          Length = 284

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4   LAAFW 8
           LAAFW
Sbjct: 248 LAAFW 252
>NP_057117
          Length = 314

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4   LAAFW 8
           LAAFW
Sbjct: 278 LAAFW 282
>NP_001137502
          Length = 953

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4   LAAFW 8
           LAAFW
Sbjct: 692 LAAFW 696
>XP_005268328
          Length = 852

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   SVLLAAFW 8
           SVL+  FW
Sbjct: 761 SVLIREFW 768
>XP_006720739
          Length = 852

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   SVLLAAFW 8
           SVL+  FW
Sbjct: 761 SVLIREFW 768
>XP_005268327
          Length = 852

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   SVLLAAFW 8
           SVL+  FW
Sbjct: 761 SVLIREFW 768
>XP_005268326
          Length = 852

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   SVLLAAFW 8
           SVL+  FW
Sbjct: 761 SVLIREFW 768
>XP_005268324
          Length = 852

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   SVLLAAFW 8
           SVL+  FW
Sbjct: 761 SVLIREFW 768
>XP_005268325
          Length = 852

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   SVLLAAFW 8
           SVL+  FW
Sbjct: 761 SVLIREFW 768
>XP_006720738
          Length = 852

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   SVLLAAFW 8
           SVL+  FW
Sbjct: 761 SVLIREFW 768
>XP_006720737
          Length = 872

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   SVLLAAFW 8
           SVL+  FW
Sbjct: 781 SVLIREFW 788
>XP_006720736
          Length = 872

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   SVLLAAFW 8
           SVL+  FW
Sbjct: 781 SVLIREFW 788
>XP_005253056
          Length = 1025

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4   LAAFW 8
           LAAFW
Sbjct: 764 LAAFW 768
>XP_006716639
          Length = 248

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4   LAAFW 8
           LAAFW
Sbjct: 221 LAAFW 225
>XP_005251007
          Length = 301

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4   LAAFW 8
           LAAFW
Sbjct: 265 LAAFW 269
>XP_006716637
          Length = 305

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4   LAAFW 8
           LAAFW
Sbjct: 278 LAAFW 282
>XP_005251005
          Length = 339

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4   LAAFW 8
           LAAFW
Sbjct: 234 LAAFW 238
>XP_006716636
          Length = 339

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4   LAAFW 8
           LAAFW
Sbjct: 234 LAAFW 238
>XP_005251004
          Length = 353

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4   LAAFW 8
           LAAFW
Sbjct: 248 LAAFW 252
>XP_005251003
          Length = 370

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4   LAAFW 8
           LAAFW
Sbjct: 265 LAAFW 269
>XP_005251002
          Length = 372

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4   LAAFW 8
           LAAFW
Sbjct: 278 LAAFW 282
>XP_005251001
          Length = 383

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4   LAAFW 8
           LAAFW
Sbjct: 278 LAAFW 282
>NP_001159349
          Length = 100

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4  LAAFW 8
          LAAFW
Sbjct: 27 LAAFW 31
>NP_078938
          Length = 1025

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4   LAAFW 8
           LAAFW
Sbjct: 764 LAAFW 768
>NP_008864
          Length = 718

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3   LLAAFW 8
           LLA FW
Sbjct: 457 LLAIFW 462
>NP_000334
          Length = 664

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3   LLAAFW 8
           LLA FW
Sbjct: 472 LLAIFW 477
>NP_570855
          Length = 840

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VLLAAFW 8
           +LLAA W
Sbjct: 418 MLLAALW 424
>NP_570856
          Length = 840

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VLLAAFW 8
           +LLAA W
Sbjct: 418 MLLAALW 424
>NP_065683
          Length = 840

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VLLAAFW 8
           +LLAA W
Sbjct: 418 MLLAALW 424
>NP_001243243
          Length = 537

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3   LLAAFW 8
           LLA FW
Sbjct: 345 LLAIFW 350
>NP_001171809
          Length = 1148

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  VLLAAFWT 9
          +LLA  WT
Sbjct: 10 LLLAILWT 17
>NP_001098713
          Length = 1101

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  VLLAAFWT 9
          +LLA  WT
Sbjct: 10 LLLAILWT 17
>NP_065817
          Length = 1100

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  VLLAAFWT 9
          +LLA  WT
Sbjct: 10 LLLAILWT 17
>NP_065803
          Length = 1215

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 5/7 (71%)

Query: 2   VLLAAFW 8
           +LL  FW
Sbjct: 533 ILLVVFW 539
>NP_689813
          Length = 562

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   VLLAAFWT 9
           VLL A WT
Sbjct: 222 VLLQADWT 229
>XP_005250451
          Length = 840

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VLLAAFW 8
           +LLAA W
Sbjct: 418 MLLAALW 424
>XP_005250450
          Length = 840

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VLLAAFW 8
           +LLAA W
Sbjct: 418 MLLAALW 424
>XP_006713672
          Length = 452

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   SVLLAAFW 8
           SVLL A W
Sbjct: 445 SVLLLASW 452
>NP_060523
          Length = 395

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   SVLLAAFW 8
           S+LL A W
Sbjct: 296 SILLVATW 303
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.333    0.129    0.469 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 391,022
Number of extensions: 534
Number of successful extensions: 57
Number of sequences better than 10000.0: 57
Number of HSP's gapped: 57
Number of HSP's successfully gapped: 57
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.4 bits)
S2: 28 (15.4 bits)

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