Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_997239                                                              17    3301
NP_821158                                                              17    4312
NP_006333                                                              16    5631
NP_006571                                                              16    5631
NP_003289                                                              16    5631
NP_068752                                                              16    5631
NP_463459                                                              16    5631
XP_006723459                                                           16    5631
XP_006723458                                                           16    5631
XP_005247987                                                           16    5631
XP_006713918                                                           16    5631
XP_005247986                                                           16    5631
XP_006713542                                                           16    5631
XP_006713383                                                           16    5631
XP_005265485                                                           16    5631
XP_005263544                                                           16    5631
NP_003194                                                              16    7355
NP_001188263                                                           16    7355
NP_112181                                                              16    7355
NP_001167571                                                           16    7355
NP_127503                                                              16    7355
NP_127501                                                              16    7355
NP_065151                                                              16    7355
NP_940972                                                              16    7355
XP_006713333                                                           16    7355
XP_005265389                                                           16    7355
XP_005265388                                                           16    7355
XP_006713332                                                           16    7355
XP_006713331                                                           16    7355
XP_006713330                                                           16    7355
XP_006713329                                                           16    7355
XP_005265387                                                           16    7355
XP_005264578                                                           16    7355
XP_005264577                                                           16    7355
NP_001001921                                                           16    7355
NP_005793                                                              15    9605
NP_001182551                                                           15    9605
NP_056349                                                              15    9605
NP_001271236                                                           15    9605
NP_001271235                                                           15    9605
NP_071918                                                              15    9605
XP_005254649                                                           15    9605
XP_005254648                                                           15    9605
XP_006719364                                                           15    9605
XP_006719363                                                           15    9605
XP_005270784                                                           15    9605
XP_005270783                                                           15    9605
XP_005270782                                                           15    9605
NP_003954                                                              15    9605
>NP_997239
          Length = 243

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  STSLVTACL 9
          STS  TACL
Sbjct: 35 STSAKTACL 43
>NP_821158
          Length = 662

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TSLVTACL 9
           T +VTACL
Sbjct: 108 TVIVTACL 115
>NP_006333
          Length = 838

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   STSLVTAC 8
           STSL T+C
Sbjct: 495 STSLPTSC 502
>NP_006571
          Length = 305

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  LVTACL 9
          LVTACL
Sbjct: 8  LVTACL 13
>NP_003289
          Length = 615

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   STSLVTAC 8
           +TSLV AC
Sbjct: 434 NTSLVRAC 441
>NP_068752
          Length = 388

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  STSLVTAC 8
          STSL T+C
Sbjct: 59 STSLSTSC 66
>NP_463459
          Length = 563

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  LVTACL 9
          LVTACL
Sbjct: 39 LVTACL 44
>XP_006723459
          Length = 299

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   TSLVTACL 9
           TSL  ACL
Sbjct: 283 TSLAAACL 290
>XP_006723458
          Length = 329

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   TSLVTACL 9
           TSL  ACL
Sbjct: 313 TSLAAACL 320
>XP_005247987
          Length = 482

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   STSLVTAC 8
           STSL T+C
Sbjct: 135 STSLPTSC 142
>XP_006713918
          Length = 830

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   STSLVTAC 8
           STSL T+C
Sbjct: 483 STSLPTSC 490
>XP_005247986
          Length = 842

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   STSLVTAC 8
           STSL T+C
Sbjct: 495 STSLPTSC 502
>XP_006713542
          Length = 250

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  LVTACL 9
          LVTACL
Sbjct: 8  LVTACL 13
>XP_006713383
          Length = 615

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   STSLVTAC 8
           +TSLV AC
Sbjct: 434 NTSLVRAC 441
>XP_005265485
          Length = 596

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   STSLVTAC 8
           +TSLV AC
Sbjct: 415 NTSLVRAC 422
>XP_005263544
          Length = 366

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  STSLVTAC 8
          STSL T+C
Sbjct: 59 STSLSTSC 66
>NP_003194
          Length = 781

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   STSLVTAC 8
           +TSL+T C
Sbjct: 578 TTSLITHC 585
>NP_001188263
          Length = 612

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   STSLVTAC 8
           +TSL+T C
Sbjct: 409 TTSLITHC 416
>NP_112181
          Length = 615

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   TSLVTAC 8
           TS+ TAC
Sbjct: 441 TSITTAC 447
>NP_001167571
          Length = 403

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LVTACL 9
           L+TACL
Sbjct: 304 LITACL 309
>NP_127503
          Length = 403

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LVTACL 9
           L+TACL
Sbjct: 304 LITACL 309
>NP_127501
          Length = 403

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LVTACL 9
           L+TACL
Sbjct: 304 LITACL 309
>NP_065151
          Length = 360

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LVTACL 9
           L+TACL
Sbjct: 261 LITACL 266
>NP_940972
          Length = 325

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  STSLVTACL 9
          S+ LVT CL
Sbjct: 14 SSLLVTCCL 22
>XP_006713333
          Length = 360

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LVTACL 9
           L+TACL
Sbjct: 261 LITACL 266
>XP_005265389
          Length = 383

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LVTACL 9
           L+TACL
Sbjct: 284 LITACL 289
>XP_005265388
          Length = 403

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LVTACL 9
           L+TACL
Sbjct: 304 LITACL 309
>XP_006713332
          Length = 403

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LVTACL 9
           L+TACL
Sbjct: 304 LITACL 309
>XP_006713331
          Length = 403

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LVTACL 9
           L+TACL
Sbjct: 304 LITACL 309
>XP_006713330
          Length = 424

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LVTACL 9
           L+TACL
Sbjct: 325 LITACL 330
>XP_006713329
          Length = 424

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LVTACL 9
           L+TACL
Sbjct: 325 LITACL 330
>XP_005265387
          Length = 426

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LVTACL 9
           L+TACL
Sbjct: 327 LITACL 332
>XP_005264578
          Length = 710

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   STSLVTAC 8
           +TSL+T C
Sbjct: 586 TTSLITHC 593
>XP_005264577
          Length = 789

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   STSLVTAC 8
           +TSL+T C
Sbjct: 586 TTSLITHC 593
>NP_001001921
          Length = 324

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   STSLVTACL 9
           +TSLV  CL
Sbjct: 154 TTSLVHVCL 162
>NP_005793
          Length = 1045

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    TSLVTACL 9
            TSL++ CL
Sbjct: 1031 TSLMSVCL 1038
>NP_001182551
          Length = 980

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TSLVTACL 9
           TSL++ CL
Sbjct: 966 TSLMSVCL 973
>NP_056349
          Length = 903

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LVTACL 9
           +VTACL
Sbjct: 282 IVTACL 287
>NP_001271236
          Length = 1111

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LVTACL 9
           +VTACL
Sbjct: 981 MVTACL 986
>NP_001271235
          Length = 1068

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LVTACL 9
           +VTACL
Sbjct: 938 MVTACL 943
>NP_071918
          Length = 1883

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    LVTACL 9
            +VTACL
Sbjct: 1753 MVTACL 1758
>XP_005254649
          Length = 1819

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    LVTACL 9
            +VTACL
Sbjct: 1689 MVTACL 1694
>XP_005254648
          Length = 1906

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    LVTACL 9
            +VTACL
Sbjct: 1776 MVTACL 1781
>XP_006719364
          Length = 924

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LVTACL 9
           +VTACL
Sbjct: 202 IVTACL 207
>XP_006719363
          Length = 944

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LVTACL 9
           +VTACL
Sbjct: 202 IVTACL 207
>XP_005270784
          Length = 902

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LVTACL 9
           +VTACL
Sbjct: 282 IVTACL 287
>XP_005270783
          Length = 903

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LVTACL 9
           +VTACL
Sbjct: 282 IVTACL 287
>XP_005270782
          Length = 903

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LVTACL 9
           +VTACL
Sbjct: 282 IVTACL 287
>NP_003954
          Length = 197

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  SLVTACL 9
          SL+T CL
Sbjct: 13 SLITLCL 19
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.320    0.117    0.328 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 411,312
Number of extensions: 567
Number of successful extensions: 49
Number of sequences better than 10000.0: 49
Number of HSP's gapped: 49
Number of HSP's successfully gapped: 49
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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