Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

• Home Page
• Cancer-specific
• Epitope Search
• Data Retrieval
• Browse Gene
• Browse Tissue
• Sequence Similarity
• Partially Personalized
• Submit a Protein
• Vaccine Target
• Proteome Data
• NGS data
• BLAST & Predict
• Fully Personalized
• Proteins Pair
• Proteome Pair
• Advanced Tools
• Epitope Mapping
• Cross Reactivity
• Important Information
• Acknowledgement
• Algorithm
• Help
• Developers
• Contact

Blast-Search of mutated query peptide against human proteome

BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_009052                                                              18    1135
NP_001243576                                                           18    1135
NP_005684                                                              16    5631
NP_001238863                                                           16    5631
NP_001238864                                                           16    5631
NP_001123574                                                           16    5631
XP_006718179                                                           16    5631
XP_005252773                                                           16    5631
XP_005252772                                                           16    5631
XP_005252767                                                           16    5631
XP_005252766                                                           16    5631
XP_006718178                                                           16    5631
XP_006718177                                                           16    5631
XP_005252764                                                           16    5631
XP_005252763                                                           16    5631
XP_006718176                                                           16    5631
XP_006718175                                                           16    5631
XP_005252762                                                           16    5631
NP_848622                                                              15    9605
NP_056494                                                              15    9605

>NP_009052
          Length = 461

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   STIEIMLLK 9
           STIEIMLL+
Sbjct: 307 STIEIMLLE 315



>NP_001243576
          Length = 364

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   STIEIMLLK 9
           STIEIMLL+
Sbjct: 210 STIEIMLLE 218



>NP_005684
          Length = 447

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   STIEIMLLK 9
           S IE+MLL+
Sbjct: 293 SAIEVMLLE 301



>NP_001238863
          Length = 453

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   STIEIMLLK 9
           S IE+MLL+
Sbjct: 299 SAIEVMLLE 307



>NP_001238864
          Length = 453

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   STIEIMLLK 9
           S IE+MLL+
Sbjct: 299 SAIEVMLLE 307



>NP_001123574
          Length = 402

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   STIEIMLLK 9
           S IE+MLL+
Sbjct: 248 SAIEVMLLE 256



>XP_006718179
          Length = 402

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   STIEIMLLK 9
           S IE+MLL+
Sbjct: 248 SAIEVMLLE 256



>XP_005252773
          Length = 313

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   STIEIMLLK 9
           S IE+MLL+
Sbjct: 159 SAIEVMLLE 167



>XP_005252772
          Length = 358

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   STIEIMLLK 9
           S IE+MLL+
Sbjct: 204 SAIEVMLLE 212



>XP_005252767
          Length = 402

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   STIEIMLLK 9
           S IE+MLL+
Sbjct: 248 SAIEVMLLE 256



>XP_005252766
          Length = 402

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   STIEIMLLK 9
           S IE+MLL+
Sbjct: 248 SAIEVMLLE 256



>XP_006718178
          Length = 402

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   STIEIMLLK 9
           S IE+MLL+
Sbjct: 248 SAIEVMLLE 256



>XP_006718177
          Length = 447

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   STIEIMLLK 9
           S IE+MLL+
Sbjct: 293 SAIEVMLLE 301



>XP_005252764
          Length = 447

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   STIEIMLLK 9
           S IE+MLL+
Sbjct: 293 SAIEVMLLE 301



>XP_005252763
          Length = 447

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   STIEIMLLK 9
           S IE+MLL+
Sbjct: 293 SAIEVMLLE 301



>XP_006718176
          Length = 447

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   STIEIMLLK 9
           S IE+MLL+
Sbjct: 293 SAIEVMLLE 301



>XP_006718175
          Length = 447

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   STIEIMLLK 9
           S IE+MLL+
Sbjct: 293 SAIEVMLLE 301



>XP_005252762
          Length = 447

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   STIEIMLLK 9
           S IE+MLL+
Sbjct: 293 SAIEVMLLE 301



>NP_848622
          Length = 1124

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   STIEIMLLK 9
           ST++I++LK
Sbjct: 655 STLKIIILK 663



>NP_056494
          Length = 331

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  TIEIMLLK 9
          T+E+ LLK
Sbjct: 29 TVELQLLK 36



  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.324    0.138    0.314 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 282,049
Number of extensions: 454
Number of successful extensions: 20
Number of sequences better than 10000.0: 20
Number of HSP's gapped: 20
Number of HSP's successfully gapped: 20
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)