Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_057502                                                              20     299
NP_861969                                                              20     299
NP_000259                                                              20     299
NP_861968                                                              20     299
NP_861966                                                              20     299
NP_861970                                                              20     299
NP_861546                                                              20     299
NP_861967                                                              20     299
NP_002435                                                              18    1135
XP_005262326                                                           18    1135
NP_003370                                                              17    2528
NP_001104547                                                           17    2528
NP_001247421                                                           17    2528
NP_001247423                                                           17    2528
NP_001247422                                                           17    2528
NP_002897                                                              17    2528
XP_006715624                                                           17    2528
NP_001188405                                                           17    4312
NP_113634                                                              17    4312
NP_001274324                                                           17    4312
XP_005258421                                                           17    4312
XP_006712547                                                           17    4312
NP_001269569                                                           16    5631
NP_001269572                                                           16    5631
NP_071931                                                              16    5631
NP_899236                                                              16    7355
NP_001714                                                              16    7355
NP_056363                                                              16    7355
NP_001138241                                                           16    7355
NP_001138242                                                           16    7355
NP_001231509                                                           16    7355
NP_003487                                                              16    7355
NP_001153889                                                           16    7355
NP_110403                                                              16    7355
NP_001153890                                                           16    7355
NP_689414                                                              16    7355
XP_006723941                                                           16    7355
XP_006715232                                                           16    7355
XP_005249383                                                           16    7355
XP_005249382                                                           16    7355
XP_005249381                                                           16    7355
XP_005249380                                                           16    7355
XP_005249379                                                           16    7355
XP_005249377                                                           16    7355
XP_005249376                                                           16    7355
XP_005249375                                                           16    7355
XP_005249374                                                           16    7355
XP_005249373                                                           16    7355
XP_005249372                                                           16    7355
XP_005249371                                                           16    7355
XP_005249370                                                           16    7355
XP_005249369                                                           16    7355
XP_005249368                                                           16    7355
XP_005249367                                                           16    7355
XP_006711002                                                           16    7355
NP_001277007                                                           15    9605
NP_000450                                                              15    9605
NP_001277006                                                           15    9605
NP_001020414                                                           15    9605
NP_001020413                                                           15    9605
NP_001560                                                              15    9605
NP_057191                                                              15    9605
NP_056473                                                              15    9605
NP_003747                                                              15    9605
NP_065823                                                              15    9605
XP_005274725                                                           15    9605
XP_005255669                                                           15    9605
XP_005251620                                                           15    9605
XP_005251618                                                           15    9605
XP_006714540                                                           15    9605
XP_006713468                                                           15    9605
XP_005265616                                                           15    9605
>NP_057502
          Length = 590

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   SRLTPKISF 9
           +RLTPKISF
Sbjct: 248 NRLTPKISF 256
>NP_861969
          Length = 507

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   SRLTPKISF 9
           +RLTPKISF
Sbjct: 165 NRLTPKISF 173
>NP_000259
          Length = 595

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   SRLTPKISF 9
           +RLTPKISF
Sbjct: 248 NRLTPKISF 256
>NP_861968
          Length = 507

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   SRLTPKISF 9
           +RLTPKISF
Sbjct: 165 NRLTPKISF 173
>NP_861966
          Length = 548

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   SRLTPKISF 9
           +RLTPKISF
Sbjct: 206 NRLTPKISF 214
>NP_861970
          Length = 590

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   SRLTPKISF 9
           +RLTPKISF
Sbjct: 248 NRLTPKISF 256
>NP_861546
          Length = 590

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   SRLTPKISF 9
           +RLTPKISF
Sbjct: 248 NRLTPKISF 256
>NP_861967
          Length = 549

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   SRLTPKISF 9
           +RLTPKISF
Sbjct: 207 NRLTPKISF 215
>NP_002435
          Length = 577

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   RLTPKISF 9
           RLTPKI F
Sbjct: 233 RLTPKIGF 240
>XP_005262326
          Length = 578

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   RLTPKISF 9
           RLTPKI F
Sbjct: 234 RLTPKIGF 241
>NP_003370
          Length = 586

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RLTPKISF 9
           +LTPKI F
Sbjct: 233 KLTPKIGF 240
>NP_001104547
          Length = 586

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RLTPKISF 9
           +LTPKI F
Sbjct: 233 KLTPKIGF 240
>NP_001247421
          Length = 604

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RLTPKISF 9
           +LTPKI F
Sbjct: 233 KLTPKIGF 240
>NP_001247423
          Length = 447

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RLTPKISF 9
           +LTPKI F
Sbjct: 97  KLTPKIGF 104
>NP_001247422
          Length = 604

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RLTPKISF 9
           +LTPKI F
Sbjct: 233 KLTPKIGF 240
>NP_002897
          Length = 583

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RLTPKISF 9
           +LTPKI F
Sbjct: 233 KLTPKIGF 240
>XP_006715624
          Length = 543

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RLTPKISF 9
           +LTPKI F
Sbjct: 233 KLTPKIGF 240
>NP_001188405
          Length = 130

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  SRLTPKI 7
          +RLTPKI
Sbjct: 63 ARLTPKI 69
>NP_113634
          Length = 220

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  SRLTPKI 7
          +RLTPKI
Sbjct: 63 ARLTPKI 69
>NP_001274324
          Length = 1688

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    SRLTPKIS 8
            SRL+P+IS
Sbjct: 1203 SRLSPRIS 1210
>XP_005258421
          Length = 226

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  SRLTPKI 7
          +RLTPKI
Sbjct: 69 ARLTPKI 75
>XP_006712547
          Length = 1674

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    SRLTPKIS 8
            SRL+P+IS
Sbjct: 1200 SRLSPRIS 1207
>NP_001269569
          Length = 757

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RLTPKISF 9
           R+ PKIS+
Sbjct: 320 RINPKISY 327
>NP_001269572
          Length = 722

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RLTPKISF 9
           R+ PKIS+
Sbjct: 320 RINPKISY 327
>NP_071931
          Length = 747

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RLTPKISF 9
           R+ PKIS+
Sbjct: 320 RINPKISY 327
>NP_899236
          Length = 5497

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SRLTPKIS 8
           SRLTP ++
Sbjct: 545 SRLTPSVT 552
>NP_001714
          Length = 2649

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SRLTPKIS 8
           SRLTP ++
Sbjct: 219 SRLTPSVT 226
>NP_056363
          Length = 5171

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SRLTPKIS 8
           SRLTP ++
Sbjct: 219 SRLTPSVT 226
>NP_001138241
          Length = 5675

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SRLTPKIS 8
           SRLTP ++
Sbjct: 723 SRLTPSVT 730
>NP_001138242
          Length = 5537

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SRLTPKIS 8
           SRLTP ++
Sbjct: 585 SRLTPSVT 592
>NP_001231509
          Length = 3859

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    RLTPKIS 8
            RLTP IS
Sbjct: 3730 RLTPNIS 3736
>NP_003487
          Length = 3830

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    RLTPKIS 8
            RLTP IS
Sbjct: 3701 RLTPNIS 3707
>NP_001153889
          Length = 428

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SRLTPKI 7
           S+LTPK+
Sbjct: 389 SKLTPKL 395
>NP_110403
          Length = 429

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SRLTPKI 7
           S+LTPK+
Sbjct: 390 SKLTPKL 396
>NP_001153890
          Length = 354

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SRLTPKI 7
           S+LTPK+
Sbjct: 315 SKLTPKL 321
>NP_689414
          Length = 852

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SRLTPKI 7
           SRL+PK+
Sbjct: 290 SRLSPKV 296
>XP_006723941
          Length = 378

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SRLTPKI 7
           S+LTPK+
Sbjct: 339 SKLTPKL 345
>XP_006715232
          Length = 7498

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SRLTPKIS 8
           SRLTP ++
Sbjct: 545 SRLTPSVT 552
>XP_005249383
          Length = 3186

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SRLTPKIS 8
           SRLTP ++
Sbjct: 756 SRLTPSVT 763
>XP_005249382
          Length = 5732

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SRLTPKIS 8
           SRLTP ++
Sbjct: 756 SRLTPSVT 763
>XP_005249381
          Length = 7281

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SRLTPKIS 8
           SRLTP ++
Sbjct: 219 SRLTPSVT 226
>XP_005249380
          Length = 7607

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SRLTPKIS 8
           SRLTP ++
Sbjct: 545 SRLTPSVT 552
>XP_005249379
          Length = 7633

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SRLTPKIS 8
           SRLTP ++
Sbjct: 571 SRLTPSVT 578
>XP_005249377
          Length = 7640

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SRLTPKIS 8
           SRLTP ++
Sbjct: 578 SRLTPSVT 585
>XP_005249376
          Length = 7647

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SRLTPKIS 8
           SRLTP ++
Sbjct: 585 SRLTPSVT 592
>XP_005249375
          Length = 7680

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SRLTPKIS 8
           SRLTP ++
Sbjct: 618 SRLTPSVT 625
>XP_005249374
          Length = 7709

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SRLTPKIS 8
           SRLTP ++
Sbjct: 756 SRLTPSVT 763
>XP_005249373
          Length = 7723

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SRLTPKIS 8
           SRLTP ++
Sbjct: 661 SRLTPSVT 668
>XP_005249372
          Length = 7785

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SRLTPKIS 8
           SRLTP ++
Sbjct: 723 SRLTPSVT 730
>XP_005249371
          Length = 7788

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SRLTPKIS 8
           SRLTP ++
Sbjct: 756 SRLTPSVT 763
>XP_005249370
          Length = 7794

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SRLTPKIS 8
           SRLTP ++
Sbjct: 756 SRLTPSVT 763
>XP_005249369
          Length = 7797

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SRLTPKIS 8
           SRLTP ++
Sbjct: 735 SRLTPSVT 742
>XP_005249368
          Length = 7812

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SRLTPKIS 8
           SRLTP ++
Sbjct: 756 SRLTPSVT 763
>XP_005249367
          Length = 7818

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SRLTPKIS 8
           SRLTP ++
Sbjct: 756 SRLTPSVT 763
>XP_006711002
          Length = 535

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SRLTPKI 7
           SRL+PK+
Sbjct: 290 SRLSPKV 296
>NP_001277007
          Length = 976

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   RLTPKI 7
           R+TPKI
Sbjct: 200 RMTPKI 205
>NP_000450
          Length = 1124

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   RLTPKI 7
           R+TPKI
Sbjct: 347 RMTPKI 352
>NP_001277006
          Length = 1081

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   RLTPKI 7
           R+TPKI
Sbjct: 304 RMTPKI 309
>NP_001020414
          Length = 633

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   RLTPKI 7
           RLTPK+
Sbjct: 351 RLTPKL 356
>NP_001020413
          Length = 682

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   RLTPKI 7
           RLTPK+
Sbjct: 351 RLTPKL 356
>NP_001560
          Length = 712

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   RLTPKI 7
           RLTPK+
Sbjct: 351 RLTPKL 356
>NP_057191
          Length = 1074

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TPKISF 9
           TPKI+F
Sbjct: 499 TPKINF 504
>NP_056473
          Length = 749

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   RLTPKI 7
           RLTPK+
Sbjct: 164 RLTPKL 169
>NP_003747
          Length = 352

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   RLTPKI 7
           RLTPK+
Sbjct: 168 RLTPKL 173
>NP_065823
          Length = 695

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   SRLTPKISF 9
           +++ PKIS+
Sbjct: 350 AKIVPKISY 358
>XP_005274725
          Length = 708

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   RLTPKI 7
           RLTPK+
Sbjct: 377 RLTPKL 382
>XP_005255669
          Length = 360

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  RLTPKISF 9
          RL P ISF
Sbjct: 20 RLAPVISF 27
>XP_005251620
          Length = 1080

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   RLTPKI 7
           R+TPKI
Sbjct: 304 RMTPKI 309
>XP_005251618
          Length = 1123

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   RLTPKI 7
           R+TPKI
Sbjct: 347 RMTPKI 352
>XP_006714540
          Length = 1030

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TPKISF 9
           TPKI+F
Sbjct: 455 TPKINF 460
>XP_006713468
          Length = 330

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3 LTPKISF 9
         +TPKIS+
Sbjct: 1 MTPKISW 7
>XP_005265616
          Length = 385

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  LTPKISF 9
          +TPKIS+
Sbjct: 56 MTPKISW 62
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.324    0.134    0.373 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 652,500
Number of extensions: 633
Number of successful extensions: 72
Number of sequences better than 10000.0: 72
Number of HSP's gapped: 72
Number of HSP's successfully gapped: 72
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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