Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_443179                                                              20     509
XP_005266703                                                           20     509
NP_057263                                                              17    3301
NP_001129430                                                           17    3301
NP_001129428                                                           17    3301
NP_001129427                                                           17    3301
NP_003297                                                              17    3301
NP_001129429                                                           17    3301
NP_001075019                                                           16    7355
NP_066277                                                              16    7355
XP_006724836                                                           16    7355
XP_005262507                                                           16    7355
XP_006724835                                                           16    7355
XP_006724834                                                           16    7355
XP_006724833                                                           16    7355
XP_006724832                                                           16    7355
XP_006724831                                                           16    7355
XP_006724830                                                           16    7355
XP_005262504                                                           16    7355
NP_001116244                                                           15    9605
NP_001193928                                                           15    9605
NP_001092284                                                           15    9605
NP_009105                                                              15    9605
XP_005268682                                                           15    9605
XP_005253886                                                           15    9605
XP_006719269                                                           15    9605
NP_061754                                                              15    9605
>NP_443179
          Length = 2170

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    SQTVDRAD 8
            SQTVDRAD
Sbjct: 1111 SQTVDRAD 1118
>XP_005266703
          Length = 1501

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   SQTVDRAD 8
           SQTVDRAD
Sbjct: 442 SQTVDRAD 449
>NP_057263
          Length = 977

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SQTVDRADL 9
           SQ +DR+DL
Sbjct: 384 SQHIDRSDL 392
>NP_001129430
          Length = 804

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SQTVDRADL 9
           SQ +DR+DL
Sbjct: 211 SQHIDRSDL 219
>NP_001129428
          Length = 828

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SQTVDRADL 9
           SQ +DR+DL
Sbjct: 384 SQHIDRSDL 392
>NP_001129427
          Length = 893

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SQTVDRADL 9
           SQ +DR+DL
Sbjct: 384 SQHIDRSDL 392
>NP_003297
          Length = 982

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SQTVDRADL 9
           SQ +DR+DL
Sbjct: 384 SQHIDRSDL 392
>NP_001129429
          Length = 836

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SQTVDRADL 9
           SQ +DR+DL
Sbjct: 384 SQHIDRSDL 392
>NP_001075019
          Length = 1593

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SQTVDRA 7
           +QT+DRA
Sbjct: 543 AQTIDRA 549
>NP_066277
          Length = 366

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  TVDRADL 9
          T+DRAD+
Sbjct: 42 TLDRADM 48
>XP_006724836
          Length = 1582

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SQTVDRA 7
           +QT+DRA
Sbjct: 543 AQTIDRA 549
>XP_005262507
          Length = 1594

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SQTVDRA 7
           +QT+DRA
Sbjct: 543 AQTIDRA 549
>XP_006724835
          Length = 1615

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SQTVDRA 7
           +QT+DRA
Sbjct: 543 AQTIDRA 549
>XP_006724834
          Length = 1615

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SQTVDRA 7
           +QT+DRA
Sbjct: 543 AQTIDRA 549
>XP_006724833
          Length = 1620

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SQTVDRA 7
           +QT+DRA
Sbjct: 543 AQTIDRA 549
>XP_006724832
          Length = 1640

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SQTVDRA 7
           +QT+DRA
Sbjct: 543 AQTIDRA 549
>XP_006724831
          Length = 1640

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SQTVDRA 7
           +QT+DRA
Sbjct: 543 AQTIDRA 549
>XP_006724830
          Length = 1642

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SQTVDRA 7
           +QT+DRA
Sbjct: 543 AQTIDRA 549
>XP_005262504
          Length = 1642

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SQTVDRA 7
           +QT+DRA
Sbjct: 543 AQTIDRA 549
>NP_001116244
          Length = 1192

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SQTVDRADL 9
           S+T+D +DL
Sbjct: 273 SKTLDNSDL 281
>NP_001193928
          Length = 2069

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    QTVDRADL 9
            + +DRADL
Sbjct: 1221 EALDRADL 1228
>NP_001092284
          Length = 473

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   VDRADL 9
           +DRADL
Sbjct: 215 IDRADL 220
>NP_009105
          Length = 2027

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    QTVDRADL 9
            + +DRADL
Sbjct: 1179 EALDRADL 1186
>XP_005268682
          Length = 1172

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SQTVDRADL 9
           S+T+D +DL
Sbjct: 273 SKTLDNSDL 281
>XP_005253886
          Length = 1545

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QTVDRADL 9
           + +DRADL
Sbjct: 713 EALDRADL 720
>XP_006719269
          Length = 2054

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    QTVDRADL 9
            + +DRADL
Sbjct: 1221 EALDRADL 1228
>NP_061754
          Length = 797

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  SQTVDRADL 9
          S+T+DR +L
Sbjct: 87 SETLDREEL 95
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.310    0.122    0.304 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 382,951
Number of extensions: 348
Number of successful extensions: 27
Number of sequences better than 10000.0: 27
Number of HSP's gapped: 27
Number of HSP's successfully gapped: 27
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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