Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001895                                                              20     509
NP_001091680                                                           20     509
NP_001091679                                                           20     509
XP_006713048                                                           20     509
XP_006713047                                                           20     509
XP_006713046                                                           20     509
XP_005264943                                                           20     509
NP_001274103                                                           18    1935
NP_000343                                                              18    1935
XP_006718349                                                           18    1935
NP_005088                                                              16    5631
NP_005126                                                              16    7355
NP_598408                                                              16    7355
NP_001035959                                                           16    7355
NP_001035962                                                           16    7355
NP_001035960                                                           16    7355
NP_001035961                                                           16    7355
NP_694972                                                              16    7355
NP_001258563                                                           16    7355
NP_005435                                                              16    7355
NP_001258564                                                           16    7355
XP_006720856                                                           16    7355
XP_006712895                                                           16    7355
XP_005247000                                                           16    7355
XP_005246999                                                           16    7355
NP_060960                                                              15    9605
NP_054644                                                              15    9605
NP_000784                                                              15    9605
NP_001007024                                                           15    9605
NP_001229431                                                           15    9605
NP_001136017                                                           15    9605
NP_065154                                                              15    9605
NP_001314                                                              15    9605
NP_001229432                                                           15    9605
XP_005267943                                                           15    9605
XP_005267942                                                           15    9605
XP_005268698                                                           15    9605
NP_001004134                                                           15    9605
>NP_001895
          Length = 781

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SQMLKHVVV 9
           SQMLKH VV
Sbjct: 129 SQMLKHAVV 137
>NP_001091680
          Length = 781

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SQMLKHVVV 9
           SQMLKH VV
Sbjct: 129 SQMLKHAVV 137
>NP_001091679
          Length = 781

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SQMLKHVVV 9
           SQMLKH VV
Sbjct: 129 SQMLKHAVV 137
>XP_006713048
          Length = 720

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SQMLKHVVV 9
           SQMLKH VV
Sbjct: 129 SQMLKHAVV 137
>XP_006713047
          Length = 774

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SQMLKHVVV 9
           SQMLKH VV
Sbjct: 122 SQMLKHAVV 130
>XP_006713046
          Length = 774

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SQMLKHVVV 9
           SQMLKH VV
Sbjct: 122 SQMLKHAVV 130
>XP_005264943
          Length = 781

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SQMLKHVVV 9
           SQMLKH VV
Sbjct: 129 SQMLKHAVV 137
>NP_001274103
          Length = 1582

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1    SQMLKHVVV 9
            SQ+LKH+V+
Sbjct: 1019 SQLLKHMVL 1027
>NP_000343
          Length = 1581

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1    SQMLKHVVV 9
            SQ+LKH+V+
Sbjct: 1018 SQLLKHMVL 1026
>XP_006718349
          Length = 1646

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1    SQMLKHVVV 9
            SQ+LKH+V+
Sbjct: 1018 SQLLKHMVL 1026
>NP_005088
          Length = 557

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SQMLKHVVV 9
           +Q+ KHV+V
Sbjct: 545 TQIYKHVIV 553
>NP_005126
          Length = 1099

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SQMLKHV 7
           SQML+H+
Sbjct: 947 SQMLRHM 953
>NP_598408
          Length = 1150

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    SQMLKHV 7
            SQML+H+
Sbjct: 998  SQMLRHM 1004
>NP_001035959
          Length = 1091

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SQMLKHV 7
           SQML+H+
Sbjct: 939 SQMLRHM 945
>NP_001035962
          Length = 1135

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SQMLKHV 7
           SQML+H+
Sbjct: 983 SQMLRHM 989
>NP_001035960
          Length = 1091

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SQMLKHV 7
           SQML+H+
Sbjct: 939 SQMLRHM 945
>NP_001035961
          Length = 1141

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SQMLKHV 7
           SQML+H+
Sbjct: 989 SQMLRHM 995
>NP_694972
          Length = 1330

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    SQMLKHV 7
            SQM KHV
Sbjct: 1230 SQMKKHV 1236
>NP_001258563
          Length = 331

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SQMLKHVV 8
           +++LKHVV
Sbjct: 258 ARLLKHVV 265
>NP_005435
          Length = 299

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SQMLKHVV 8
           +++LKHVV
Sbjct: 226 ARLLKHVV 233
>NP_001258564
          Length = 258

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SQMLKHVV 8
           +++LKHVV
Sbjct: 226 ARLLKHVV 233
>XP_006720856
          Length = 1101

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SQMLKHV 7
           SQML+H+
Sbjct: 949 SQMLRHM 955
>XP_006712895
          Length = 246

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SQMLKHVV 8
           +++LKHVV
Sbjct: 173 ARLLKHVV 180
>XP_005247000
          Length = 260

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SQMLKHVV 8
           +++LKHVV
Sbjct: 228 ARLLKHVV 235
>XP_005246999
          Length = 301

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SQMLKHVV 8
           +++LKHVV
Sbjct: 228 ARLLKHVV 235
>NP_060960
          Length = 951

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   SQMLKHV 7
           S M+KHV
Sbjct: 743 SSMIKHV 749
>NP_054644
          Length = 273

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  MLKHVVV 9
          +LKHVV+
Sbjct: 33 LLKHVVL 39
>NP_000784
          Length = 273

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  MLKHVVV 9
          +LKHVV+
Sbjct: 33 LLKHVVL 39
>NP_001007024
          Length = 309

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  MLKHVVV 9
          +LKHVV+
Sbjct: 33 LLKHVVL 39
>NP_001229431
          Length = 146

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  MLKHVVV 9
          +LKHVV+
Sbjct: 33 LLKHVVL 39
>NP_001136017
          Length = 455

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   SQMLKH 6
           SQML+H
Sbjct: 169 SQMLRH 174
>NP_065154
          Length = 523

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   SQMLKH 6
           SQML+H
Sbjct: 237 SQMLRH 242
>NP_001314
          Length = 149

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   SQMLKH 6
           SQ+LKH
Sbjct: 139 SQLLKH 144
>NP_001229432
          Length = 110

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  MLKHVVV 9
          +LKHVV+
Sbjct: 33 LLKHVVL 39
>XP_005267943
          Length = 457

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   SQMLKH 6
           SQML+H
Sbjct: 237 SQMLRH 242
>XP_005267942
          Length = 484

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   SQMLKH 6
           SQML+H
Sbjct: 237 SQMLRH 242
>XP_005268698
          Length = 321

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  QMLKHVVV 9
          QML H+VV
Sbjct: 85 QMLIHLVV 92
>NP_001004134
          Length = 317

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  QMLKHVVV 9
          QML H+VV
Sbjct: 81 QMLIHLVV 88
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.329    0.130    0.335 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 506,131
Number of extensions: 687
Number of successful extensions: 38
Number of sequences better than 10000.0: 38
Number of HSP's gapped: 38
Number of HSP's successfully gapped: 38
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.3 bits)
S2: 28 (15.4 bits)

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