Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004324                                                              20     299
XP_005250103                                                           20     299
XP_005250102                                                           20     299
NP_056374                                                              16    5631
NP_003694                                                              16    5631
NP_060959                                                              16    5631
XP_006722501                                                           16    5631
XP_005258301                                                           16    5631
XP_005258300                                                           16    5631
XP_006713992                                                           16    5631
XP_005245394                                                           16    5631
XP_005245393                                                           16    5631
XP_006711515                                                           16    5631
XP_006711514                                                           16    5631
XP_006711513                                                           16    5631
NP_775821                                                              16    7355
NP_005286                                                              16    7355
NP_665803                                                              16    7355
XP_005251455                                                           16    7355
XP_005251456                                                           16    7355
XP_005251454                                                           16    7355
NP_001258754                                                           15    9605
NP_001258753                                                           15    9605
NP_004559                                                              15    9605
NP_002010                                                              15    9605
NP_001153392                                                           15    9605
NP_116195                                                              15    9605
NP_057095                                                              15    9605
NP_001182220                                                           15    9605
NP_001258752                                                           15    9605
NP_778203                                                              15    9605
NP_001258751                                                           15    9605
NP_001153502                                                           15    9605
NP_001834                                                              15    9605
NP_001019903                                                           15    9605
XP_006719777                                                           15    9605
XP_006719304                                                           15    9605
XP_005268708                                                           15    9605
XP_006715176                                                           15    9605
XP_006715175                                                           15    9605
XP_005249238                                                           15    9605
XP_006713424                                                           15    9605
XP_005265572                                                           15    9605
XP_005245943                                                           15    9605
XP_006710737                                                           15    9605
XP_005245946                                                           15    9605
XP_005245945                                                           15    9605
XP_005245944                                                           15    9605
XP_005245942                                                           15    9605
NP_055632                                                              15    9605
NP_065090                                                              15    9605
>NP_004324
          Length = 766

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   NRMKTLGR 9
           NRMKTLGR
Sbjct: 436 NRMKTLGR 443
>XP_005250103
          Length = 758

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   NRMKTLGR 9
           NRMKTLGR
Sbjct: 436 NRMKTLGR 443
>XP_005250102
          Length = 767

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   NRMKTLGR 9
           NRMKTLGR
Sbjct: 436 NRMKTLGR 443
>NP_056374
          Length = 1596

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NRMKTLGR 9
           N+MKTL R
Sbjct: 667 NKMKTLKR 674
>NP_003694
          Length = 857

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SNRMKT 6
           SNRMKT
Sbjct: 269 SNRMKT 274
>NP_060959
          Length = 2964

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NRMKTLGR 9
           N+MKTL R
Sbjct: 987 NKMKTLKR 994
>XP_006722501
          Length = 1403

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NRMKTLGR 9
           N+MKTL R
Sbjct: 667 NKMKTLKR 674
>XP_005258301
          Length = 1539

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NRMKTLGR 9
           N+MKTL R
Sbjct: 667 NKMKTLKR 674
>XP_005258300
          Length = 1596

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NRMKTLGR 9
           N+MKTL R
Sbjct: 667 NKMKTLKR 674
>XP_006713992
          Length = 857

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SNRMKT 6
           SNRMKT
Sbjct: 269 SNRMKT 274
>XP_005245394
          Length = 1741

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NRMKTLGR 9
           N+MKTL R
Sbjct: 987 NKMKTLKR 994
>XP_005245393
          Length = 2663

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NRMKTLGR 9
           N+MKTL R
Sbjct: 987 NKMKTLKR 994
>XP_006711515
          Length = 2904

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NRMKTLGR 9
           N+MKTL R
Sbjct: 987 NKMKTLKR 994
>XP_006711514
          Length = 2964

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NRMKTLGR 9
           N+MKTL R
Sbjct: 987 NKMKTLKR 994
>XP_006711513
          Length = 2964

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NRMKTLGR 9
           N+MKTL R
Sbjct: 987 NKMKTLKR 994
>NP_775821
          Length = 1326

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SNRMKTLGR 9
           +NR+K LG+
Sbjct: 811 ANRLKILGQ 819
>NP_005286
          Length = 433

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SNRMKTLGR 9
           +NR+ T+GR
Sbjct: 148 ANRILTMGR 156
>NP_665803
          Length = 1025

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   SNRMKTL 7
           SNR KTL
Sbjct: 867 SNRFKTL 873
>XP_005251455
          Length = 1334

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SNRMKTLGR 9
           +NR+K LG+
Sbjct: 819 ANRLKILGQ 827
>XP_005251456
          Length = 1334

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SNRMKTLGR 9
           +NR+K LG+
Sbjct: 819 ANRLKILGQ 827
>XP_005251454
          Length = 1334

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SNRMKTLGR 9
           +NR+K LG+
Sbjct: 819 ANRLKILGQ 827
>NP_001258754
          Length = 376

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  NRMKTLGR 9
          N +KTLG+
Sbjct: 14 NLLKTLGK 21
>NP_001258753
          Length = 376

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  NRMKTLGR 9
          N +KTLG+
Sbjct: 14 NLLKTLGK 21
>NP_004559
          Length = 376

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  NRMKTLGR 9
          N +KTLG+
Sbjct: 14 NLLKTLGK 21
>NP_002010
          Length = 1338

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SNRMKTLGR 9
           SN++ T+GR
Sbjct: 538 SNKVGTVGR 546
>NP_001153392
          Length = 687

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SNRMKTLGR 9
           SN++ T+GR
Sbjct: 538 SNKVGTVGR 546
>NP_116195
          Length = 580

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RMKTLGR 9
           ++KTLGR
Sbjct: 219 QLKTLGR 225
>NP_057095
          Length = 373

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SNRMKTLG 8
           S+R+K+LG
Sbjct: 225 SDRLKSLG 232
>NP_001182220
          Length = 380

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  NRMKTLGR 9
          N +KTLG+
Sbjct: 18 NLLKTLGK 25
>NP_001258752
          Length = 395

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  NRMKTLGR 9
          N +KTLG+
Sbjct: 33 NLLKTLGK 40
>NP_778203
          Length = 1007

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SNRMKTLG 8
           SNR+KT G
Sbjct: 685 SNRIKTDG 692
>NP_001258751
          Length = 390

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  NRMKTLGR 9
          N +KTLG+
Sbjct: 28 NLLKTLGK 35
>NP_001153502
          Length = 733

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SNRMKTLGR 9
           SN++ T+GR
Sbjct: 538 SNKVGTVGR 546
>NP_001834
          Length = 1018

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SNRMKTLG 8
           SNR+KT G
Sbjct: 696 SNRIKTDG 703
>NP_001019903
          Length = 297

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SNRMKTLG 8
           S+R+K+LG
Sbjct: 149 SDRLKSLG 156
>XP_006719777
          Length = 421

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SNRMKTLGR 9
           +NR K LG+
Sbjct: 410 TNRQKLLGK 418
>XP_006719304
          Length = 1018

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SNRMKTLG 8
           SNR+KT G
Sbjct: 696 SNRIKTDG 703
>XP_005268708
          Length = 1018

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SNRMKTLG 8
           SNR+KT G
Sbjct: 696 SNRIKTDG 703
>XP_006715176
          Length = 380

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  NRMKTLGR 9
          N +KTLG+
Sbjct: 18 NLLKTLGK 25
>XP_006715175
          Length = 380

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  NRMKTLGR 9
          N +KTLG+
Sbjct: 18 NLLKTLGK 25
>XP_005249238
          Length = 409

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  NRMKTLGR 9
          N +KTLG+
Sbjct: 47 NLLKTLGK 54
>XP_006713424
          Length = 580

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RMKTLGR 9
           ++KTLGR
Sbjct: 219 QLKTLGR 225
>XP_005265572
          Length = 580

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RMKTLGR 9
           ++KTLGR
Sbjct: 219 QLKTLGR 225
>XP_005245943
          Length = 297

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SNRMKTLG 8
           S+R+K+LG
Sbjct: 149 SDRLKSLG 156
>XP_006710737
          Length = 297

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SNRMKTLG 8
           S+R+K+LG
Sbjct: 149 SDRLKSLG 156
>XP_005245946
          Length = 297

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SNRMKTLG 8
           S+R+K+LG
Sbjct: 149 SDRLKSLG 156
>XP_005245945
          Length = 297

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SNRMKTLG 8
           S+R+K+LG
Sbjct: 149 SDRLKSLG 156
>XP_005245944
          Length = 297

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SNRMKTLG 8
           S+R+K+LG
Sbjct: 149 SDRLKSLG 156
>XP_005245942
          Length = 401

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SNRMKTLG 8
           S+R+K+LG
Sbjct: 253 SDRLKSLG 260
>NP_055632
          Length = 811

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SNRMKTLGR 9
           SNR++ LG+
Sbjct: 188 SNRIRFLGK 196
>NP_065090
          Length = 178

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   RMKTLGR 9
           RMK +GR
Sbjct: 131 RMKNIGR 137
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.317    0.126    0.336 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 370,336
Number of extensions: 565
Number of successful extensions: 51
Number of sequences better than 10000.0: 51
Number of HSP's gapped: 51
Number of HSP's successfully gapped: 51
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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