Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_008835                                                              19     665
NP_001075109                                                           19     665
NP_116115                                                              17    4312
XP_006712867                                                           17    4312
XP_005246971                                                           17    4312
XP_006712866                                                           17    4312
XP_005246970                                                           17    4312
NP_001535                                                              16    7355
NP_071772                                                              16    7355
NP_005003                                                              15    9605
NP_001077061                                                           15    9605
NP_115689                                                              15    9605
NP_937791                                                              15    9605
XP_005269585                                                           15    9605
>NP_008835
          Length = 4128

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    SLVIYMESL 9
            +LVIYMESL
Sbjct: 1103 ALVIYMESL 1111
>NP_001075109
          Length = 4097

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    SLVIYMESL 9
            +LVIYMESL
Sbjct: 1103 ALVIYMESL 1111
>NP_116115
          Length = 762

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   SLVIYMESL 9
           SLVIY++S+
Sbjct: 495 SLVIYLKSV 503
>XP_006712867
          Length = 643

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   SLVIYMESL 9
           SLVIY++S+
Sbjct: 350 SLVIYLKSV 358
>XP_005246971
          Length = 785

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   SLVIYMESL 9
           SLVIY++S+
Sbjct: 492 SLVIYLKSV 500
>XP_006712866
          Length = 788

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   SLVIYMESL 9
           SLVIY++S+
Sbjct: 495 SLVIYLKSV 503
>XP_005246970
          Length = 788

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   SLVIYMESL 9
           SLVIY++S+
Sbjct: 495 SLVIYLKSV 503
>NP_001535
          Length = 271

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   SLVIYMESL 9
           S VIY ESL
Sbjct: 172 SRVIYSESL 180
>NP_071772
          Length = 237

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   SLVIYMESL 9
           S VIY ESL
Sbjct: 172 SRVIYSESL 180
>NP_005003
          Length = 937

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   IYMESL 9
           +YMESL
Sbjct: 187 VYMESL 192
>NP_001077061
          Length = 393

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   IYMESL 9
           +YMESL
Sbjct: 187 VYMESL 192
>NP_115689
          Length = 698

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SLVIYMESL 9
           SLV+YM  L
Sbjct: 215 SLVLYMVDL 223
>NP_937791
          Length = 756

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   SLVIYMESL 9
           SL+++ME +
Sbjct: 632 SLIVFMEQV 640
>XP_005269585
          Length = 704

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   SLVIYMESL 9
           SL+++ME +
Sbjct: 632 SLIVFMEQV 640
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.324    0.137    0.328 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 353,907
Number of extensions: 284
Number of successful extensions: 14
Number of sequences better than 10000.0: 14
Number of HSP's gapped: 14
Number of HSP's successfully gapped: 14
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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