Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_733751                                                              18    1135
XP_006716142                                                           18    1135
XP_005250088                                                           18    1135
XP_006716141                                                           18    1135
XP_005250085                                                           18    1135
XP_006716140                                                           18    1135
XP_005250084                                                           18    1135
XP_005250083                                                           18    1135
XP_005250082                                                           18    1135
NP_005151                                                              18    1482
XP_006724221                                                           18    1482
NP_065777                                                              17    2528
NP_003240                                                              17    2528
NP_001610                                                              17    2528
NP_542389                                                              17    2528
XP_006714724                                                           17    2528
XP_005248616                                                           17    2528
NP_112199                                                              17    3301
XP_006710997                                                           17    3301
XP_006710996                                                           17    3301
XP_006710995                                                           17    3301
XP_006710994                                                           17    3301
XP_005244860                                                           17    3301
NP_001161362                                                           16    7355
NP_056322                                                              16    7355
NP_742093                                                              16    7355
NP_001269238                                                           16    7355
NP_001269239                                                           16    7355
NP_473361                                                              16    7355
NP_078951                                                              15    9605
NP_775321                                                              15    9605
NP_001106649                                                           15    9605
NP_619728                                                              15    9605
NP_006590                                                              15    9605
NP_001004298                                                           15    9605
NP_619727                                                              15    9605
NP_775322                                                              15    9605
NP_005473                                                              15    9605
XP_005255834                                                           15    9605
XP_006721188                                                           15    9605
XP_005269549                                                           15    9605
XP_005269548                                                           15    9605
>NP_733751
          Length = 4911

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SLRADVFQR 9
            S RADVFQR
Sbjct: 2011 SPRADVFQR 2019
>XP_006716142
          Length = 4927

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SLRADVFQR 9
            S RADVFQR
Sbjct: 2028 SPRADVFQR 2036
>XP_005250088
          Length = 4928

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SLRADVFQR 9
            S RADVFQR
Sbjct: 2028 SPRADVFQR 2036
>XP_006716141
          Length = 4959

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SLRADVFQR 9
            S RADVFQR
Sbjct: 2028 SPRADVFQR 2036
>XP_005250085
          Length = 4979

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SLRADVFQR 9
            S RADVFQR
Sbjct: 2028 SPRADVFQR 2036
>XP_006716140
          Length = 4982

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SLRADVFQR 9
            S RADVFQR
Sbjct: 2028 SPRADVFQR 2036
>XP_005250084
          Length = 4982

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SLRADVFQR 9
            S RADVFQR
Sbjct: 2028 SPRADVFQR 2036
>XP_005250083
          Length = 4982

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SLRADVFQR 9
            S RADVFQR
Sbjct: 2027 SPRADVFQR 2035
>XP_005250082
          Length = 4983

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SLRADVFQR 9
            S RADVFQR
Sbjct: 2028 SPRADVFQR 2036
>NP_005151
          Length = 688

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SLRADVFQR 9
           SLR D+FQ+
Sbjct: 156 SLRGDIFQK 164
>XP_006724221
          Length = 575

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  SLRADVFQR 9
          SLR D+FQ+
Sbjct: 43 SLRGDIFQK 51
>NP_065777
          Length = 704

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SLRADVFQR 9
           S+R D+F+R
Sbjct: 137 SMRGDIFER 145
>NP_003240
          Length = 689

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SLRADVFQR 9
           S+R DV+QR
Sbjct: 113 SMREDVYQR 121
>NP_001610
          Length = 689

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SLRADVFQR 9
           +LR DVFQ+
Sbjct: 156 NLRGDVFQK 164
>NP_542389
          Length = 319

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LRADVFQR 9
           LRAD+F R
Sbjct: 187 LRADIFSR 194
>XP_006714724
          Length = 681

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SLRADVFQR 9
           S+R D+F+R
Sbjct: 114 SMRGDIFER 122
>XP_005248616
          Length = 686

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SLRADVFQR 9
           S+R D+F+R
Sbjct: 137 SMRGDIFER 145
>NP_112199
          Length = 520

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   SLRADVFQR 9
           SLR DVF R
Sbjct: 226 SLRTDVFVR 234
>XP_006710997
          Length = 298

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  SLRADVFQR 9
          SLR DVF R
Sbjct: 4  SLRTDVFVR 12
>XP_006710996
          Length = 363

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   SLRADVFQR 9
           SLR DVF R
Sbjct: 226 SLRTDVFVR 234
>XP_006710995
          Length = 389

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   SLRADVFQR 9
           SLR DVF R
Sbjct: 95  SLRTDVFVR 103
>XP_006710994
          Length = 398

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   SLRADVFQR 9
           SLR DVF R
Sbjct: 104 SLRTDVFVR 112
>XP_005244860
          Length = 404

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   SLRADVFQR 9
           SLR DVF R
Sbjct: 110 SLRTDVFVR 118
>NP_001161362
          Length = 554

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   SLRADVF 7
           SLR DVF
Sbjct: 361 SLRGDVF 367
>NP_056322
          Length = 553

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   SLRADVF 7
           SLR DVF
Sbjct: 361 SLRGDVF 367
>NP_742093
          Length = 530

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LRADVFQR 9
           L+AD+F+R
Sbjct: 362 LKADMFKR 369
>NP_001269238
          Length = 528

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LRADVFQR 9
           L+AD+F+R
Sbjct: 362 LKADMFKR 369
>NP_001269239
          Length = 534

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LRADVFQR 9
           L+AD+F+R
Sbjct: 368 LKADMFKR 375
>NP_473361
          Length = 528

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LRADVFQR 9
           L+AD+F+R
Sbjct: 362 LKADMFKR 369
>NP_078951
          Length = 1186

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    SLRADVFQ 8
            SLR+ VFQ
Sbjct: 1084 SLRSPVFQ 1091
>NP_775321
          Length = 1455

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LRADVFQR 9
           L AD+FQ+
Sbjct: 750 LSADIFQQ 757
>NP_001106649
          Length = 1548

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LRADVFQR 9
           L AD+FQ+
Sbjct: 843 LSADIFQQ 850
>NP_619728
          Length = 1455

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LRADVFQR 9
           L AD+FQ+
Sbjct: 750 LSADIFQQ 757
>NP_006590
          Length = 1531

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LRADVFQR 9
           L AD+FQ+
Sbjct: 826 LSADIFQQ 833
>NP_001004298
          Length = 699

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LRADVFQR 9
           LRA+VF++
Sbjct: 680 LRAEVFKK 687
>NP_619727
          Length = 1549

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LRADVFQR 9
           L AD+FQ+
Sbjct: 844 LSADIFQQ 851
>NP_775322
          Length = 1455

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LRADVFQR 9
           L AD+FQ+
Sbjct: 750 LSADIFQQ 757
>NP_005473
          Length = 395

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   RADVFQR 9
           R D+FQR
Sbjct: 287 RTDLFQR 293
>XP_005255834
          Length = 1264

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LRADVFQR 9
           L AD+FQ+
Sbjct: 559 LSADIFQQ 566
>XP_006721188
          Length = 1484

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LRADVFQR 9
           L AD+FQ+
Sbjct: 779 LSADIFQQ 786
>XP_005269549
          Length = 292

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LRADVFQR 9
           LRA+VF++
Sbjct: 273 LRAEVFKK 280
>XP_005269548
          Length = 738

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LRADVFQR 9
           LRA+VF++
Sbjct: 719 LRAEVFKK 726
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.337    0.140    0.374 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 351,468
Number of extensions: 504
Number of successful extensions: 42
Number of sequences better than 10000.0: 42
Number of HSP's gapped: 42
Number of HSP's successfully gapped: 42
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.4 bits)
S2: 28 (15.4 bits)

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