Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001155973                                                           20     509
NP_055903                                                              20     509
NP_001153844                                                           17    2528
NP_113654                                                              17    2528
XP_006716727                                                           17    2528
XP_005251134                                                           17    2528
NP_003866                                                              17    3301
NP_116165                                                              16    7355
NP_001269877                                                           16    7355
NP_004733                                                              16    7355
NP_001028229                                                           16    7355
NP_056335                                                              16    7355
NP_001185497                                                           16    7355
NP_061889                                                              16    7355
NP_640340                                                              16    7355
NP_001185521                                                           16    7355
NP_060423                                                              16    7355
XP_006721802                                                           16    7355
XP_005269685                                                           16    7355
XP_005269684                                                           16    7355
XP_005269683                                                           16    7355
XP_005269681                                                           16    7355
XP_006717770                                                           16    7355
XP_005269679                                                           16    7355
XP_005265631                                                           16    7355
XP_006713477                                                           16    7355
XP_006713476                                                           16    7355
XP_005265628                                                           16    7355
XP_005265627                                                           16    7355
XP_006713475                                                           16    7355
XP_006713474                                                           16    7355
XP_005265625                                                           16    7355
XP_006713473                                                           16    7355
XP_005265623                                                           16    7355
XP_005265622                                                           16    7355
XP_005265621                                                           16    7355
XP_005265620                                                           16    7355
XP_006713472                                                           16    7355
XP_006713471                                                           16    7355
XP_006713470                                                           16    7355
XP_006710766                                                           16    7355
NP_004027                                                              15    9605
NP_001069                                                              15    9605
NP_001186763                                                           15    9605
NP_542413                                                              15    9605
NP_001244126                                                           15    9605
NP_003581                                                              15    9605
NP_001244127                                                           15    9605
NP_001263281                                                           15    9605
NP_001182032                                                           15    9605
NP_000628                                                              15    9605
NP_115715                                                              15    9605
NP_955378                                                              15    9605
XP_005257793                                                           15    9605
XP_006719928                                                           15    9605
XP_006712863                                                           15    9605
XP_006712070                                                           15    9605
XP_005264349                                                           15    9605
XP_006711990                                                           15    9605
XP_005264162                                                           15    9605
XP_005264161                                                           15    9605
XP_005264159                                                           15    9605
XP_006711989                                                           15    9605
XP_006711988                                                           15    9605
NP_078822                                                              15    9605
>NP_001155973
          Length = 1833

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   SKMENAGV 8
           SKMENAGV
Sbjct: 348 SKMENAGV 355
>NP_055903
          Length = 1723

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   SKMENAGV 8
           SKMENAGV
Sbjct: 348 SKMENAGV 355
>NP_001153844
          Length = 1148

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SKMENAGVI 9
           SK +NAGVI
Sbjct: 335 SKYKNAGVI 343
>NP_113654
          Length = 1246

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SKMENAGVI 9
           SK +NAGVI
Sbjct: 433 SKYKNAGVI 441
>XP_006716727
          Length = 1139

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SKMENAGVI 9
           SK +NAGVI
Sbjct: 326 SKYKNAGVI 334
>XP_005251134
          Length = 1148

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SKMENAGVI 9
           SK +NAGVI
Sbjct: 335 SKYKNAGVI 343
>NP_003866
          Length = 693

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  SKMENAG 7
          SK+ENAG
Sbjct: 8  SKLENAG 14
>NP_116165
          Length = 2540

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    SKMENAG 7
            +KMEN+G
Sbjct: 1566 NKMENSG 1572
>NP_001269877
          Length = 2358

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    SKMENAG 7
            +KMEN+G
Sbjct: 1384 NKMENSG 1390
>NP_004733
          Length = 1256

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   MENAGVI 9
           M+NAG++
Sbjct: 228 MQNAGIV 234
>NP_001028229
          Length = 1462

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   MENAGVI 9
           M+NAG++
Sbjct: 228 MQNAGIV 234
>NP_056335
          Length = 1287

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   MENAGVI 9
           M+NAG++
Sbjct: 228 MQNAGIV 234
>NP_001185497
          Length = 1077

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    SKMENAGVI 9
            S+ME+ GV+
Sbjct: 1015 SRMESTGVL 1023
>NP_061889
          Length = 525

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   MENAGVI 9
           +ENAG+I
Sbjct: 211 VENAGII 217
>NP_640340
          Length = 1077

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    SKMENAGVI 9
            S+ME+ GV+
Sbjct: 1015 SRMESTGVL 1023
>NP_001185521
          Length = 1077

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    SKMENAGVI 9
            S+ME+ GV+
Sbjct: 1015 SRMESTGVL 1023
>NP_060423
          Length = 470

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KMENAGVI 9
           K ENAGV+
Sbjct: 108 KDENAGVL 115
>XP_006721802
          Length = 427

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   MENAGVI 9
           +ENAG+I
Sbjct: 113 VENAGII 119
>XP_005269685
          Length = 1700

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    SKMENAG 7
            +KMEN+G
Sbjct: 1566 NKMENSG 1572
>XP_005269684
          Length = 2032

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    SKMENAG 7
            +KMEN+G
Sbjct: 1566 NKMENSG 1572
>XP_005269683
          Length = 2252

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    SKMENAG 7
            +KMEN+G
Sbjct: 1278 NKMENSG 1284
>XP_005269681
          Length = 2321

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    SKMENAG 7
            +KMEN+G
Sbjct: 1347 NKMENSG 1353
>XP_006717770
          Length = 2358

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    SKMENAG 7
            +KMEN+G
Sbjct: 1384 NKMENSG 1390
>XP_005269679
          Length = 2502

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    SKMENAG 7
            +KMEN+G
Sbjct: 1528 NKMENSG 1534
>XP_005265631
          Length = 1288

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   MENAGVI 9
           M+NAG++
Sbjct: 228 MQNAGIV 234
>XP_006713477
          Length = 1290

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   MENAGVI 9
           M+NAG++
Sbjct: 228 MQNAGIV 234
>XP_006713476
          Length = 1375

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   MENAGVI 9
           M+NAG++
Sbjct: 110 MQNAGIV 116
>XP_005265628
          Length = 1395

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   MENAGVI 9
           M+NAG++
Sbjct: 228 MQNAGIV 234
>XP_005265627
          Length = 1425

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   MENAGVI 9
           M+NAG++
Sbjct: 228 MQNAGIV 234
>XP_006713475
          Length = 1463

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   MENAGVI 9
           M+NAG++
Sbjct: 228 MQNAGIV 234
>XP_006713474
          Length = 1465

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   MENAGVI 9
           M+NAG++
Sbjct: 228 MQNAGIV 234
>XP_005265625
          Length = 1478

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   MENAGVI 9
           M+NAG++
Sbjct: 228 MQNAGIV 234
>XP_006713473
          Length = 1479

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   MENAGVI 9
           M+NAG++
Sbjct: 228 MQNAGIV 234
>XP_005265623
          Length = 1479

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   MENAGVI 9
           M+NAG++
Sbjct: 228 MQNAGIV 234
>XP_005265622
          Length = 1481

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   MENAGVI 9
           M+NAG++
Sbjct: 228 MQNAGIV 234
>XP_005265621
          Length = 1491

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   MENAGVI 9
           M+NAG++
Sbjct: 228 MQNAGIV 234
>XP_005265620
          Length = 1492

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   MENAGVI 9
           M+NAG++
Sbjct: 228 MQNAGIV 234
>XP_006713472
          Length = 1492

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   MENAGVI 9
           M+NAG++
Sbjct: 228 MQNAGIV 234
>XP_006713471
          Length = 1492

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   MENAGVI 9
           M+NAG++
Sbjct: 228 MQNAGIV 234
>XP_006713470
          Length = 1493

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   MENAGVI 9
           M+NAG++
Sbjct: 228 MQNAGIV 234
>XP_006710766
          Length = 421

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KMENAGVI 9
           K ENAGV+
Sbjct: 108 KDENAGVL 115
>NP_004027
          Length = 1144

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    SKMENAGVI 9
            S+ME+ GV+
Sbjct: 1072 SRMESTGVM 1080
>NP_001069
          Length = 739

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SKMENAGV 8
           +KME++GV
Sbjct: 569 TKMEDSGV 576
>NP_001186763
          Length = 677

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SKMENAGV 8
           +KME++GV
Sbjct: 507 TKMEDSGV 514
>NP_542413
          Length = 647

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SKMENAGV 8
           +KME++GV
Sbjct: 477 TKMEDSGV 484
>NP_001244126
          Length = 702

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   KMENAGVI 9
           +MEN+G++
Sbjct: 212 EMENSGLV 219
>NP_003581
          Length = 768

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   KMENAGVI 9
           +MEN+G++
Sbjct: 278 EMENSGLV 285
>NP_001244127
          Length = 774

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   KMENAGVI 9
           +MEN+G++
Sbjct: 284 EMENSGLV 291
>NP_001263281
          Length = 217

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SKMENAG 7
           ++MENAG
Sbjct: 137 TEMENAG 143
>NP_001182032
          Length = 469

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   KMENAGV 8
           ++ENAGV
Sbjct: 281 ELENAGV 287
>NP_000628
          Length = 522

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   KMENAGV 8
           ++ENAGV
Sbjct: 281 ELENAGV 287
>NP_115715
          Length = 115

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  SKMENAG 7
          SK+EN G
Sbjct: 76 SKLENGG 82
>NP_955378
          Length = 129

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  SKMENAGVI 9
          +K EN GV+
Sbjct: 83 AKNENTGVV 91
>XP_005257793
          Length = 116

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  SKMENAG 7
          SK+EN G
Sbjct: 76 SKLENGG 82
>XP_006719928
          Length = 649

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   KMENAGVI 9
           K+EN G++
Sbjct: 112 KLENGGLV 119
>XP_006712863
          Length = 795

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   KMENAGVI 9
           +MEN+G++
Sbjct: 305 EMENSGLV 312
>XP_006712070
          Length = 129

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  SKMENAGVI 9
          +K EN GV+
Sbjct: 83 AKNENTGVV 91
>XP_005264349
          Length = 129

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  SKMENAGVI 9
          +K EN GV+
Sbjct: 83 AKNENTGVV 91
>XP_006711990
          Length = 1131

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    SKMENAGVI 9
            S+ME+ GV+
Sbjct: 1095 SRMESTGVM 1103
>XP_005264162
          Length = 1144

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    SKMENAGVI 9
            S+ME+ GV+
Sbjct: 1072 SRMESTGVM 1080
>XP_005264161
          Length = 1145

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    SKMENAGVI 9
            S+ME+ GV+
Sbjct: 1073 SRMESTGVM 1081
>XP_005264159
          Length = 1166

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    SKMENAGVI 9
            S+ME+ GV+
Sbjct: 1094 SRMESTGVM 1102
>XP_006711989
          Length = 1167

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    SKMENAGVI 9
            S+ME+ GV+
Sbjct: 1095 SRMESTGVM 1103
>XP_006711988
          Length = 1167

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    SKMENAGVI 9
            S+ME+ GV+
Sbjct: 1095 SRMESTGVM 1103
>NP_078822
          Length = 726

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   KMENAGVI 9
           K+EN G++
Sbjct: 189 KLENGGLV 196
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.304    0.121    0.296 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 483,302
Number of extensions: 767
Number of successful extensions: 65
Number of sequences better than 10000.0: 65
Number of HSP's gapped: 65
Number of HSP's successfully gapped: 65
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

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