Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_006197                                                              21     229
XP_005265800                                                           21     229
XP_006714103                                                           21     229
XP_006714102                                                           21     229
NP_057009                                                              17    2528
NP_991404                                                              17    2528
NP_001247419                                                           17    2528
NP_991403                                                              17    2528
NP_060480                                                              17    2528
NP_066270                                                              17    3301
NP_001234930                                                           17    3301
NP_001234929                                                           17    3301
NP_001015001                                                           17    3301
NP_003002                                                              17    3301
NP_001116293                                                           17    3301
NP_001274666                                                           17    3301
NP_003365                                                              17    4312
XP_005272132                                                           17    4312
NP_003357                                                              16    5631
NP_996898                                                              16    7355
NP_001247418                                                           16    7355
NP_877398                                                              16    7355
NP_056007                                                              16    7355
XP_006724409                                                           16    7355
XP_005261851                                                           16    7355
XP_005261850                                                           16    7355
XP_005260738                                                           16    7355
XP_006723618                                                           16    7355
XP_005259039                                                           16    7355
XP_005259037                                                           16    7355
XP_005247321                                                           16    7355
XP_006713623                                                           16    7355
NP_001138678                                                           16    7355
NP_000213                                                              15    9605
NP_001087241                                                           15    9605
NP_004932                                                              15    9605
NP_005493                                                              15    9605
NP_201570                                                              15    9605
NP_201569                                                              15    9605
NP_003663                                                              15    9605
NP_065717                                                              15    9605
NP_000687                                                              15    9605
XP_006726856                                                           15    9605
XP_006723958                                                           15    9605
XP_005257171                                                           15    9605
XP_005257170                                                           15    9605
XP_005251837                                                           15    9605
XP_005251835                                                           15    9605
XP_006717058                                                           15    9605
XP_005251833                                                           15    9605
XP_005251831                                                           15    9605
XP_005251830                                                           15    9605
XP_006714959                                                           15    9605
XP_006714958                                                           15    9605
XP_005266004                                                           15    9605
XP_005265799                                                           15    9605
XP_005265798                                                           15    9605
XP_005265797                                                           15    9605
XP_005265253                                                           15    9605
XP_005271353                                                           15    9605
XP_005271351                                                           15    9605
XP_006710150                                                           15    9605
NP_886552                                                              15    9605
>NP_006197
          Length = 1089

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   SKIKSGYRM 9
           +KIKSGYRM
Sbjct: 907 NKIKSGYRM 915
>XP_005265800
          Length = 1089

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   SKIKSGYRM 9
           +KIKSGYRM
Sbjct: 907 NKIKSGYRM 915
>XP_006714103
          Length = 1111

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   SKIKSGYRM 9
           +KIKSGYRM
Sbjct: 929 NKIKSGYRM 937
>XP_006714102
          Length = 1114

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   SKIKSGYRM 9
           +KIKSGYRM
Sbjct: 932 NKIKSGYRM 940
>NP_057009
          Length = 630

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   SKIKSGYRM 9
           S+++SGYR+
Sbjct: 366 SEVRSGYRI 374
>NP_991404
          Length = 581

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   SKIKSGYRM 9
           S+++SGYR+
Sbjct: 317 SEVRSGYRI 325
>NP_001247419
          Length = 541

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   SKIKSGYRM 9
           S+++SGYR+
Sbjct: 277 SEVRSGYRI 285
>NP_991403
          Length = 649

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   SKIKSGYRM 9
           S+++SGYR+
Sbjct: 385 SEVRSGYRI 393
>NP_060480
          Length = 429

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   SKIKSGY 7
           SK+KSGY
Sbjct: 134 SKLKSGY 140
>NP_066270
          Length = 417

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   SKIKSGY 7
           SKI+SGY
Sbjct: 147 SKIRSGY 153
>NP_001234930
          Length = 266

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   IKSGYRM 9
           IKSGYR+
Sbjct: 107 IKSGYRI 113
>NP_001234929
          Length = 268

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   IKSGYRM 9
           IKSGYR+
Sbjct: 109 IKSGYRI 115
>NP_001015001
          Length = 417

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   SKIKSGY 7
           SKI+SGY
Sbjct: 147 SKIRSGY 153
>NP_003002
          Length = 277

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   IKSGYRM 9
           IKSGYR+
Sbjct: 118 IKSGYRI 124
>NP_001116293
          Length = 290

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   IKSGYRM 9
           IKSGYR+
Sbjct: 131 IKSGYRI 137
>NP_001274666
          Length = 302

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   IKSGYRM 9
           IKSGYR+
Sbjct: 141 IKSGYRI 147
>NP_003365
          Length = 283

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SKIKSGYR 8
           +KIK+GY+
Sbjct: 112 AKIKTGYK 119
>XP_005272132
          Length = 283

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SKIKSGYR 8
           +KIK+GY+
Sbjct: 112 AKIKTGYK 119
>NP_003357
          Length = 453

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SKIKSGYRM 9
           +K+K+GY M
Sbjct: 376 NKLKAGYLM 384
>NP_996898
          Length = 795

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SKIKSGYR 8
           SK+K G+R
Sbjct: 479 SKVKRGWR 486
>NP_001247418
          Length = 629

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   SKIKSGYRM 9
           + ++SGYR+
Sbjct: 365 ASVRSGYRI 373
>NP_877398
          Length = 1173

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   KSGYRM 9
           KSGYR+
Sbjct: 645 KSGYRL 650
>NP_056007
          Length = 1216

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   KSGYRM 9
           KSGYR+
Sbjct: 645 KSGYRL 650
>XP_006724409
          Length = 1806

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    KIKSGYR 8
            KI+ GYR
Sbjct: 1189 KIRDGYR 1195
>XP_005261851
          Length = 1806

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    KIKSGYR 8
            KI+ GYR
Sbjct: 1189 KIRDGYR 1195
>XP_005261850
          Length = 1806

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    KIKSGYR 8
            KI+ GYR
Sbjct: 1189 KIRDGYR 1195
>XP_005260738
          Length = 877

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   KSGYRM 9
           KSGYR+
Sbjct: 645 KSGYRL 650
>XP_006723618
          Length = 1173

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   KSGYRM 9
           KSGYR+
Sbjct: 645 KSGYRL 650
>XP_005259039
          Length = 580

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   SKIKSGYRM 9
           + ++SGYR+
Sbjct: 316 ASVRSGYRI 324
>XP_005259037
          Length = 648

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   SKIKSGYRM 9
           + ++SGYR+
Sbjct: 384 ASVRSGYRI 392
>XP_005247321
          Length = 746

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SKIKSGYR 8
           SK+K G+R
Sbjct: 479 SKVKRGWR 486
>XP_006713623
          Length = 778

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SKIKSGYR 8
           SK+K G+R
Sbjct: 462 SKVKRGWR 469
>NP_001138678
          Length = 1806

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    KIKSGYR 8
            KI+ GYR
Sbjct: 1189 KIRDGYR 1195
>NP_000213
          Length = 976

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   IKSGYRM 9
           IK G+RM
Sbjct: 883 IKEGFRM 889
>NP_001087241
          Length = 972

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   IKSGYRM 9
           IK G+RM
Sbjct: 879 IKEGFRM 885
>NP_004932
          Length = 1220

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SKIKSGYR 8
           +K+KS YR
Sbjct: 216 NKVKSRYR 223
>NP_005493
          Length = 2261

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   SKIKSGY 7
           +KIK GY
Sbjct: 567 NKIKDGY 573
>NP_201570
          Length = 383

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SKIKSGY 7
           SKI++GY
Sbjct: 198 SKIENGY 204
>NP_201569
          Length = 623

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SKIKSGY 7
           SKI++GY
Sbjct: 198 SKIENGY 204
>NP_003663
          Length = 594

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SKIKSGY 7
           SKI++GY
Sbjct: 198 SKIENGY 204
>NP_065717
          Length = 481

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  IKSGYRM 9
          I+SGYR+
Sbjct: 93 IESGYRI 99
>NP_000687
          Length = 518

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   KIKSGYRM 9
           K+K GY M
Sbjct: 390 KLKDGYYM 397
>XP_006726856
          Length = 199

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   KIKSGYR 8
           ++KSG+R
Sbjct: 184 RVKSGFR 190
>XP_006723958
          Length = 199

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   KIKSGYR 8
           ++KSG+R
Sbjct: 184 RVKSGFR 190
>XP_005257171
          Length = 1181

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SKIKSGYR 8
           +K+KS YR
Sbjct: 216 NKVKSRYR 223
>XP_005257170
          Length = 1218

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SKIKSGYR 8
           +K+KS YR
Sbjct: 214 NKVKSRYR 221
>XP_005251837
          Length = 1659

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   SKIKSGY 7
           +KIK GY
Sbjct: 567 NKIKDGY 573
>XP_005251835
          Length = 2074

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   SKIKSGY 7
           +KIK GY
Sbjct: 567 NKIKDGY 573
>XP_006717058
          Length = 2100

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   SKIKSGY 7
           +KIK GY
Sbjct: 567 NKIKDGY 573
>XP_005251833
          Length = 2203

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   SKIKSGY 7
           +KIK GY
Sbjct: 507 NKIKDGY 513
>XP_005251831
          Length = 2263

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   SKIKSGY 7
           +KIK GY
Sbjct: 567 NKIKDGY 573
>XP_005251830
          Length = 2263

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   SKIKSGY 7
           +KIK GY
Sbjct: 567 NKIKDGY 573
>XP_006714959
          Length = 445

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  IKSGYRM 9
          I+SGYR+
Sbjct: 57 IESGYRI 63
>XP_006714958
          Length = 445

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  IKSGYRM 9
          I+SGYR+
Sbjct: 57 IESGYRI 63
>XP_005266004
          Length = 484

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IKSGYRM 9
           I+SGYR+
Sbjct: 96  IESGYRI 102
>XP_005265799
          Length = 973

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   IKSGYRM 9
           IK G+RM
Sbjct: 880 IKEGFRM 886
>XP_005265798
          Length = 976

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   IKSGYRM 9
           IK G+RM
Sbjct: 883 IKEGFRM 889
>XP_005265797
          Length = 977

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   IKSGYRM 9
           IK G+RM
Sbjct: 884 IKEGFRM 890
>XP_005265253
          Length = 434

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   KSGYRM 9
           KSGY+M
Sbjct: 417 KSGYQM 422
>XP_005271353
          Length = 595

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SKIKSGY 7
           SKI++GY
Sbjct: 199 SKIENGY 205
>XP_005271351
          Length = 624

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SKIKSGY 7
           SKI++GY
Sbjct: 199 SKIENGY 205
>XP_006710150
          Length = 199

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   KIKSGYR 8
           ++KSG+R
Sbjct: 184 RVKSGFR 190
>NP_886552
          Length = 434

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   KSGYRM 9
           KSGY+M
Sbjct: 417 KSGYQM 422
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.315    0.128    0.338 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 536,090
Number of extensions: 947
Number of successful extensions: 63
Number of sequences better than 10000.0: 63
Number of HSP's gapped: 63
Number of HSP's successfully gapped: 63
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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