Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001167558                                                           19     665
NP_858045                                                              19     665
NP_006525                                                              19     665
NP_001167559                                                           19     665
NP_056164                                                              17    4312
NP_003326                                                              17    4312
XP_005249030                                                           17    4312
XP_005249029                                                           17    4312
XP_005265487                                                           17    4312
XP_006713384                                                           17    4312
NP_004570                                                              16    5631
NP_006725                                                              16    5631
XP_006718714                                                           16    5631
XP_005274200                                                           16    5631
XP_006718713                                                           16    5631
XP_005274199                                                           16    5631
XP_005267014                                                           16    5631
NP_203752                                                              16    7355
NP_001139381                                                           16    7355
NP_003150                                                              16    7355
NP_001032420                                                           16    7355
NP_008988                                                              16    7355
NP_001005413                                                           16    7355
NP_127490                                                              16    7355
XP_005274642                                                           16    7355
XP_005274641                                                           16    7355
XP_006724574                                                           16    7355
XP_005269520                                                           16    7355
XP_006712877                                                           16    7355
XP_006712876                                                           16    7355
XP_006712875                                                           16    7355
XP_006712874                                                           16    7355
XP_006712873                                                           16    7355
XP_006712872                                                           16    7355
XP_005246976                                                           16    7355
XP_005246975                                                           16    7355
NP_000089                                                              15    9605
NP_001094383                                                           15    9605
NP_056012                                                              15    9605
NP_001269889                                                           15    9605
NP_115560                                                              15    9605
NP_055517                                                              15    9605
NP_001157789                                                           15    9605
NP_001269888                                                           15    9605
NP_060707                                                              15    9605
NP_065829                                                              15    9605
NP_775764                                                              15    9605
NP_001230056                                                           15    9605
NP_055532                                                              15    9605
NP_055501                                                              15    9605
NP_001275739                                                           15    9605
XP_006723575                                                           15    9605
XP_005259502                                                           15    9605
XP_005259501                                                           15    9605
XP_006720155                                                           15    9605
XP_006720154                                                           15    9605
XP_006720153                                                           15    9605
XP_006720152                                                           15    9605
XP_006720151                                                           15    9605
XP_006720150                                                           15    9605
XP_005267520                                                           15    9605
XP_006720149                                                           15    9605
XP_005267519                                                           15    9605
XP_006720148                                                           15    9605
XP_005265039                                                           15    9605
XP_005265038                                                           15    9605
XP_005265035                                                           15    9605
XP_005265034                                                           15    9605
XP_005271313                                                           15    9605
XP_005271311                                                           15    9605
XP_006711009                                                           15    9605
XP_005271309                                                           15    9605
XP_006711008                                                           15    9605
XP_005270541                                                           15    9605
NP_940857                                                              15    9605
>NP_001167558
          Length = 1423

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SKAGIMEPM 9
           SKAG MEPM
Sbjct: 925 SKAGRMEPM 933
>NP_858045
          Length = 1424

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SKAGIMEPM 9
           SKAG MEPM
Sbjct: 925 SKAGRMEPM 933
>NP_006525
          Length = 1420

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SKAGIMEPM 9
           SKAG MEPM
Sbjct: 925 SKAGRMEPM 933
>NP_001167559
          Length = 1415

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SKAGIMEPM 9
           SKAG MEPM
Sbjct: 920 SKAGRMEPM 928
>NP_056164
          Length = 1079

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SKAGIMEPM 9
           +K G+ EPM
Sbjct: 865 AKTGVTEPM 873
>NP_003326
          Length = 1012

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SKAGIMEPM 9
           S AG++ PM
Sbjct: 352 SSAGVLSPM 360
>XP_005249030
          Length = 1079

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SKAGIMEPM 9
           +K G+ EPM
Sbjct: 865 AKTGVTEPM 873
>XP_005249029
          Length = 1079

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SKAGIMEPM 9
           +K G+ EPM
Sbjct: 865 AKTGVTEPM 873
>XP_005265487
          Length = 987

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SKAGIMEPM 9
           S AG++ PM
Sbjct: 352 SSAGVLSPM 360
>XP_006713384
          Length = 1005

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SKAGIMEPM 9
           S AG++ PM
Sbjct: 352 SSAGVLSPM 360
>NP_004570
          Length = 820

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SKAGIMEPM 9
           S AG++EP+
Sbjct: 646 SPAGMLEPL 654
>NP_006725
          Length = 2446

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KAGIMEPM 9
           + GIMEP+
Sbjct: 452 RKGIMEPL 459
>XP_006718714
          Length = 637

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SKAGIMEPM 9
           S AG++EP+
Sbjct: 463 SPAGMLEPL 471
>XP_005274200
          Length = 816

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SKAGIMEPM 9
           S AG++EP+
Sbjct: 642 SPAGMLEPL 650
>XP_006718713
          Length = 837

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SKAGIMEPM 9
           S AG++EP+
Sbjct: 686 SPAGMLEPL 694
>XP_005274199
          Length = 860

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SKAGIMEPM 9
           S AG++EP+
Sbjct: 686 SPAGMLEPL 694
>XP_005267014
          Length = 2446

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KAGIMEPM 9
           + GIMEP+
Sbjct: 452 RKGIMEPL 459
>NP_203752
          Length = 1861

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   KAGIMEPM 9
           K G++EP+
Sbjct: 566 KRGVLEPL 573
>NP_001139381
          Length = 1390

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   KAGIMEPM 9
           K G++EP+
Sbjct: 558 KRGVLEPL 565
>NP_003150
          Length = 1030

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SKAGIMEP 8
           SKAG ++P
Sbjct: 453 SKAGTLQP 460
>NP_001032420
          Length = 1030

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SKAGIMEP 8
           SKAG ++P
Sbjct: 453 SKAGTLQP 460
>NP_008988
          Length = 277

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  AGIMEPM 9
          AGI+EP+
Sbjct: 20 AGILEPV 26
>NP_001005413
          Length = 230

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  AGIMEPM 9
          AGI+EP+
Sbjct: 20 AGILEPV 26
>NP_127490
          Length = 277

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  AGIMEPM 9
          AGI+EP+
Sbjct: 20 AGILEPV 26
>XP_005274642
          Length = 984

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SKAGIMEP 8
           SKAG ++P
Sbjct: 436 SKAGTLQP 443
>XP_005274641
          Length = 1001

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SKAGIMEP 8
           SKAG ++P
Sbjct: 453 SKAGTLQP 460
>XP_006724574
          Length = 1030

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SKAGIMEP 8
           SKAG ++P
Sbjct: 453 SKAGTLQP 460
>XP_005269520
          Length = 277

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  AGIMEPM 9
          AGI+EP+
Sbjct: 20 AGILEPV 26
>XP_006712877
          Length = 1677

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   KAGIMEPM 9
           K G++EP+
Sbjct: 382 KRGVLEPL 389
>XP_006712876
          Length = 1783

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   KAGIMEPM 9
           K G++EP+
Sbjct: 488 KRGVLEPL 495
>XP_006712875
          Length = 1826

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   KAGIMEPM 9
           K G++EP+
Sbjct: 531 KRGVLEPL 538
>XP_006712874
          Length = 1836

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   KAGIMEPM 9
           K G++EP+
Sbjct: 541 KRGVLEPL 548
>XP_006712873
          Length = 1861

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   KAGIMEPM 9
           K G++EP+
Sbjct: 566 KRGVLEPL 573
>XP_006712872
          Length = 1861

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   KAGIMEPM 9
           K G++EP+
Sbjct: 566 KRGVLEPL 573
>XP_005246976
          Length = 1864

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   KAGIMEPM 9
           K G++EP+
Sbjct: 569 KRGVLEPL 576
>XP_005246975
          Length = 1871

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   KAGIMEPM 9
           K G++EP+
Sbjct: 576 KRGVLEPL 583
>NP_000089
          Length = 658

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   KAGIMEP 8
           +AG++EP
Sbjct: 167 RAGLLEP 173
>NP_001094383
          Length = 904

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   KAGIMEP 8
           K GI+EP
Sbjct: 695 KVGIVEP 701
>NP_056012
          Length = 889

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   KAGIMEP 8
           K GI+EP
Sbjct: 680 KVGIVEP 686
>NP_001269889
          Length = 1135

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   KAGIMEP 8
           KAG+++P
Sbjct: 260 KAGLLQP 266
>NP_115560
          Length = 1194

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SKAGIMEP 8
           ++ GIMEP
Sbjct: 491 TELGIMEP 498
>NP_055517
          Length = 694

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   SKAGIMEPM 9
           SK G ++P+
Sbjct: 128 SKVGFLDPL 136
>NP_001157789
          Length = 2633

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1    SKAGIMEPM 9
            +K G++EP+
Sbjct: 1492 NKTGLVEPV 1500
>NP_001269888
          Length = 1135

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   KAGIMEP 8
           KAG+++P
Sbjct: 260 KAGLLQP 266
>NP_060707
          Length = 1150

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   KAGIMEP 8
           KAG+++P
Sbjct: 275 KAGLLQP 281
>NP_065829
          Length = 1907

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   GIMEPM 9
           GI+EPM
Sbjct: 785 GIIEPM 790
>NP_775764
          Length = 773

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   KAGIMEPM 9
           +AG+M+P+
Sbjct: 334 QAGLMDPV 341
>NP_001230056
          Length = 814

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   KAGIMEP 8
           K GI+EP
Sbjct: 605 KVGIVEP 611
>NP_055532
          Length = 1300

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   KAGIMEP 8
           KAG+ EP
Sbjct: 443 KAGLSEP 449
>NP_055501
          Length = 1070

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   KAGIMEP 8
           KAG M+P
Sbjct: 683 KAGAMQP 689
>NP_001275739
          Length = 455

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   SKAGIMEPM 9
           S+AG+ +P+
Sbjct: 406 SQAGLFQPL 414
>XP_006723575
          Length = 1302

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   KAGIMEP 8
           KAG+ EP
Sbjct: 443 KAGLSEP 449
>XP_005259502
          Length = 1313

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   KAGIMEP 8
           KAG+ EP
Sbjct: 456 KAGLSEP 462
>XP_005259501
          Length = 1070

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   KAGIMEP 8
           KAG M+P
Sbjct: 683 KAGAMQP 689
>XP_006720155
          Length = 881

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   KAGIMEP 8
           K GI+EP
Sbjct: 672 KVGIVEP 678
>XP_006720154
          Length = 894

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   KAGIMEP 8
           K GI+EP
Sbjct: 685 KVGIVEP 691
>XP_006720153
          Length = 905

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   KAGIMEP 8
           K GI+EP
Sbjct: 696 KVGIVEP 702
>XP_006720152
          Length = 911

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   KAGIMEP 8
           K GI+EP
Sbjct: 681 KVGIVEP 687
>XP_006720151
          Length = 915

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   KAGIMEP 8
           K GI+EP
Sbjct: 685 KVGIVEP 691
>XP_006720150
          Length = 918

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   KAGIMEP 8
           K GI+EP
Sbjct: 688 KVGIVEP 694
>XP_005267520
          Length = 921

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   KAGIMEP 8
           K GI+EP
Sbjct: 691 KVGIVEP 697
>XP_006720149
          Length = 922

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   KAGIMEP 8
           K GI+EP
Sbjct: 692 KVGIVEP 698
>XP_005267519
          Length = 925

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   KAGIMEP 8
           K GI+EP
Sbjct: 695 KVGIVEP 701
>XP_006720148
          Length = 926

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   KAGIMEP 8
           K GI+EP
Sbjct: 696 KVGIVEP 702
>XP_005265039
          Length = 2177

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1    SKAGIMEPM 9
            +K G++EP+
Sbjct: 1492 NKTGLVEPV 1500
>XP_005265038
          Length = 2181

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1    SKAGIMEPM 9
            +K G++EP+
Sbjct: 1492 NKTGLVEPV 1500
>XP_005265035
          Length = 2609

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1    SKAGIMEPM 9
            +K G++EP+
Sbjct: 1492 NKTGLVEPV 1500
>XP_005265034
          Length = 2622

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1    SKAGIMEPM 9
            +K G++EP+
Sbjct: 1492 NKTGLVEPV 1500
>XP_005271313
          Length = 936

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SKAGIMEP 8
           ++ GIMEP
Sbjct: 233 TELGIMEP 240
>XP_005271311
          Length = 1051

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SKAGIMEP 8
           ++ GIMEP
Sbjct: 688 TELGIMEP 695
>XP_006711009
          Length = 1108

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SKAGIMEP 8
           ++ GIMEP
Sbjct: 688 TELGIMEP 695
>XP_005271309
          Length = 1228

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SKAGIMEP 8
           ++ GIMEP
Sbjct: 688 TELGIMEP 695
>XP_006711008
          Length = 1262

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SKAGIMEP 8
           ++ GIMEP
Sbjct: 688 TELGIMEP 695
>XP_005270541
          Length = 635

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   KAGIMEP 8
           +AG++EP
Sbjct: 167 RAGLLEP 173
>NP_940857
          Length = 5147

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1    SKAGIMEP 8
            S+ G++EP
Sbjct: 1159 SRQGVLEP 1166
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.311    0.125    0.339 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 559,500
Number of extensions: 855
Number of successful extensions: 75
Number of sequences better than 10000.0: 75
Number of HSP's gapped: 75
Number of HSP's successfully gapped: 75
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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