Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

• Home Page
• Cancer-specific
• Epitope Search
• Data Retrieval
• Browse Gene
• Browse Tissue
• Sequence Similarity
• Partially Personalized
• Submit a Protein
• Vaccine Target
• Proteome Data
• NGS data
• BLAST & Predict
• Fully Personalized
• Proteins Pair
• Proteome Pair
• Advanced Tools
• Epitope Mapping
• Cross Reactivity
• Important Information
• Acknowledgement
• Algorithm
• Help
• Developers
• Contact

Blast-Search of mutated query peptide against human proteome

BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001167558                                                           20     509
NP_858045                                                              20     509
NP_006525                                                              20     509
NP_001167559                                                           20     509
NP_001091996                                                           16    5631
NP_694938                                                              16    5631
NP_001273500                                                           16    5631
NP_001273499                                                           16    5631
XP_005271464                                                           16    5631
XP_005271463                                                           16    5631
NP_055738                                                              16    7355
NP_001265367                                                           16    7355
NP_001073141                                                           16    7355
NP_005834                                                              16    7355
NP_776183                                                              16    7355
NP_597999                                                              16    7355
XP_006719840                                                           16    7355
XP_006712507                                                           16    7355
XP_006712506                                                           16    7355
XP_006712505                                                           16    7355
XP_006712504                                                           16    7355
XP_005246531                                                           16    7355
NP_001271247                                                           15    9605
NP_001271246                                                           15    9605
NP_077300                                                              15    9605
NP_001128573                                                           15    9605
XP_005261795                                                           15    9605
XP_005261794                                                           15    9605

>NP_001167558
          Length = 1423

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    SIYQSSEVK 9
            SIYQSSE+K
Sbjct: 1354 SIYQSSEMK 1362



>NP_858045
          Length = 1424

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    SIYQSSEVK 9
            SIYQSSE+K
Sbjct: 1355 SIYQSSEMK 1363



>NP_006525
          Length = 1420

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    SIYQSSEVK 9
            SIYQSSE+K
Sbjct: 1351 SIYQSSEMK 1359



>NP_001167559
          Length = 1415

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    SIYQSSEVK 9
            SIYQSSE+K
Sbjct: 1346 SIYQSSEMK 1354



>NP_001091996
          Length = 394

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   IYQSSEVK 9
           ++QS+EVK
Sbjct: 156 VFQSTEVK 163



>NP_694938
          Length = 384

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   IYQSSEVK 9
           ++QS+EVK
Sbjct: 146 VFQSTEVK 153



>NP_001273500
          Length = 355

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   IYQSSEVK 9
           ++QS+EVK
Sbjct: 117 VFQSTEVK 124



>NP_001273499
          Length = 355

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   IYQSSEVK 9
           ++QS+EVK
Sbjct: 117 VFQSTEVK 124



>XP_005271464
          Length = 384

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   IYQSSEVK 9
           ++QS+EVK
Sbjct: 146 VFQSTEVK 153



>XP_005271463
          Length = 394

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   IYQSSEVK 9
           ++QS+EVK
Sbjct: 156 VFQSTEVK 163



>NP_055738
          Length = 1142

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IYQSSEVK 9
           +YQ SEV+
Sbjct: 656 VYQGSEVE 663



>NP_001265367
          Length = 1198

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IYQSSEVK 9
           +YQ SEV+
Sbjct: 712 VYQGSEVE 719



>NP_001073141
          Length = 1198

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IYQSSEVK 9
           +YQ SEV+
Sbjct: 712 VYQGSEVE 719



>NP_005834
          Length = 525

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SIYQSSEVK 9
           S+Y SSE++
Sbjct: 190 SLYPSSEIQ 198



>NP_776183
          Length = 530

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  IYQSSEVK 9
          +Y+SSEV+
Sbjct: 63 LYRSSEVR 70



>NP_597999
          Length = 264

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  YQSSEV 8
          YQSSEV
Sbjct: 7  YQSSEV 12



>XP_006719840
          Length = 1080

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IYQSSEVK 9
           +YQ SEV+
Sbjct: 594 VYQGSEVE 601



>XP_006712507
          Length = 586

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  IYQSSEVK 9
          +Y+SSEV+
Sbjct: 63 LYRSSEVR 70



>XP_006712506
          Length = 586

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  IYQSSEVK 9
          +Y+SSEV+
Sbjct: 63 LYRSSEVR 70



>XP_006712505
          Length = 586

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  IYQSSEVK 9
          +Y+SSEV+
Sbjct: 63 LYRSSEVR 70



>XP_006712504
          Length = 586

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  IYQSSEVK 9
          +Y+SSEV+
Sbjct: 63 LYRSSEVR 70



>XP_005246531
          Length = 586

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  IYQSSEVK 9
          +Y+SSEV+
Sbjct: 63 LYRSSEVR 70



>NP_001271247
          Length = 321

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  SIYQSSEVK 9
          S Y+SSE++
Sbjct: 66 SKYESSEIR 74



>NP_001271246
          Length = 325

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  SIYQSSEVK 9
          S Y+SSE++
Sbjct: 66 SKYESSEIR 74



>NP_077300
          Length = 353

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  SIYQSSEVK 9
          S Y+SSE++
Sbjct: 66 SKYESSEIR 74



>NP_001128573
          Length = 402

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  SIYQSSEVK 9
          S Y+SSE++
Sbjct: 66 SKYESSEIR 74



>XP_005261795
          Length = 373

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  SIYQSSEVK 9
          S Y+SSE++
Sbjct: 66 SKYESSEIR 74



>XP_005261794
          Length = 403

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  SIYQSSEVK 9
          S Y+SSE++
Sbjct: 66 SKYESSEIR 74



  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.293    0.108    0.243 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 390,538
Number of extensions: 489
Number of successful extensions: 28
Number of sequences better than 10000.0: 28
Number of HSP's gapped: 28
Number of HSP's successfully gapped: 28
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.0 bits)
S2: 28 (15.4 bits)