Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001013433                                                           20     390
NP_060785                                                              20     390
NP_361014                                                              20     390
NP_705898                                                              17    3301
NP_065871                                                              17    3301
NP_079446                                                              17    3301
NP_079146                                                              17    3301
XP_005260528                                                           17    3301
NP_001007026                                                           17    4312
NP_004862                                                              17    4312
NP_001007025                                                           17    4312
XP_006725527                                                           17    4312
XP_006726289                                                           17    4312
XP_006724995                                                           17    4312
XP_005258129                                                           17    4312
XP_005258128                                                           17    4312
XP_005258127                                                           17    4312
XP_006714809                                                           17    4312
XP_006710182                                                           17    4312
NP_001153468                                                           16    7355
NP_001153471                                                           16    7355
NP_001153467                                                           16    7355
NP_039254                                                              16    7355
NP_001153480                                                           16    7355
NP_039250                                                              16    7355
NP_001153473                                                           16    7355
NP_001153476                                                           16    7355
NP_039258                                                              16    7355
NP_039251                                                              16    7355
XP_006716398                                                           16    7355
XP_005273544                                                           16    7355
XP_005273543                                                           16    7355
XP_005273542                                                           16    7355
NP_000485                                                              15    9605
NP_001269939                                                           15    9605
NP_001269938                                                           15    9605
NP_116575                                                              15    9605
NP_057518                                                              15    9605
NP_001276062                                                           15    9605
NP_001002860                                                           15    9605
NP_055820                                                              15    9605
NP_001127878                                                           15    9605
NP_001127877                                                           15    9605
NP_671736                                                              15    9605
NP_055042                                                              15    9605
NP_612147                                                              15    9605
NP_004458                                                              15    9605
NP_963847                                                              15    9605
NP_963846                                                              15    9605
XP_006725229                                                           15    9605
XP_006724371                                                           15    9605
XP_006720258                                                           15    9605
XP_005267607                                                           15    9605
XP_005273507                                                           15    9605
XP_005250215                                                           15    9605
XP_005250214                                                           15    9605
XP_005250213                                                           15    9605
NP_001135780                                                           15    9605
>NP_001013433
          Length = 589

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  SEYTSTAGL 9
          SEYTST GL
Sbjct: 73 SEYTSTTGL 81
>NP_060785
          Length = 627

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SEYTSTAGL 9
           SEYTST GL
Sbjct: 111 SEYTSTTGL 119
>NP_361014
          Length = 707

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SEYTSTAGL 9
           SEYTST GL
Sbjct: 191 SEYTSTTGL 199
>NP_705898
          Length = 564

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  SEYTSTAGL 9
          S Y STAG+
Sbjct: 3  SRYNSTAGI 11
>NP_065871
          Length = 1659

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EYTSTAGL 9
           EY STAG+
Sbjct: 858 EYVSTAGV 865
>NP_079446
          Length = 979

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EYTSTAGL 9
           EY STAG+
Sbjct: 824 EYDSTAGI 831
>NP_079146
          Length = 1606

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EYTSTAGL 9
           EY STAG+
Sbjct: 824 EYDSTAGI 831
>XP_005260528
          Length = 956

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EYTSTAGL 9
           EY STAG+
Sbjct: 155 EYVSTAGV 162
>NP_001007026
          Length = 248

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  SEYTSTAGL 9
          +EYT++AG+
Sbjct: 87 AEYTNSAGV 95
>NP_004862
          Length = 250

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  SEYTSTAGL 9
          +EYT++AG+
Sbjct: 89 AEYTNSAGV 97
>NP_001007025
          Length = 185

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  SEYTSTAGL 9
          +EYT++AG+
Sbjct: 24 AEYTNSAGV 32
>XP_006725527
          Length = 1322

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SEYTSTAGL 9
           S Y+ST GL
Sbjct: 241 SSYSSTGGL 249
>XP_006726289
          Length = 900

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  SEYTSTAGL 9
          S Y+ST GL
Sbjct: 83 SSYSSTGGL 91
>XP_006724995
          Length = 462

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SEYTSTAGL 9
           S Y+ST GL
Sbjct: 124 SSYSSTGGL 132
>XP_005258129
          Length = 185

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  SEYTSTAGL 9
          +EYT++AG+
Sbjct: 24 AEYTNSAGV 32
>XP_005258128
          Length = 298

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   SEYTSTAGL 9
           +EYT++AG+
Sbjct: 137 AEYTNSAGV 145
>XP_005258127
          Length = 300

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   SEYTSTAGL 9
           +EYT++AG+
Sbjct: 139 AEYTNSAGV 147
>XP_006714809
          Length = 1574

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SEYTSTAGL 9
           S Y+ST GL
Sbjct: 241 SSYSSTGGL 249
>XP_006710182
          Length = 423

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SEYTSTAGL 9
           S Y+ST GL
Sbjct: 124 SSYSSTGGL 132
>NP_001153468
          Length = 308

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   SEYTSTA 7
           S YTSTA
Sbjct: 181 SHYTSTA 187
>NP_001153471
          Length = 624

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   SEYTSTA 7
           S YTSTA
Sbjct: 319 SHYTSTA 325
>NP_001153467
          Length = 607

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   SEYTSTA 7
           S YTSTA
Sbjct: 302 SHYTSTA 308
>NP_039254
          Length = 462

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   SEYTSTA 7
           S YTSTA
Sbjct: 335 SHYTSTA 341
>NP_001153480
          Length = 420

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   SEYTSTA 7
           S YTSTA
Sbjct: 332 SHYTSTA 338
>NP_039250
          Length = 645

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   SEYTSTA 7
           S YTSTA
Sbjct: 340 SHYTSTA 346
>NP_001153473
          Length = 590

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   SEYTSTA 7
           S YTSTA
Sbjct: 285 SHYTSTA 291
>NP_001153476
          Length = 459

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   SEYTSTA 7
           S YTSTA
Sbjct: 332 SHYTSTA 338
>NP_039258
          Length = 640

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   SEYTSTA 7
           S YTSTA
Sbjct: 335 SHYTSTA 341
>NP_039251
          Length = 637

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   SEYTSTA 7
           S YTSTA
Sbjct: 332 SHYTSTA 338
>XP_006716398
          Length = 420

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   SEYTSTA 7
           S YTSTA
Sbjct: 115 SHYTSTA 121
>XP_005273544
          Length = 692

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   SEYTSTA 7
           S YTSTA
Sbjct: 387 SHYTSTA 393
>XP_005273543
          Length = 695

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   SEYTSTA 7
           S YTSTA
Sbjct: 390 SHYTSTA 396
>XP_005273542
          Length = 700

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   SEYTSTA 7
           S YTSTA
Sbjct: 395 SHYTSTA 401
>NP_000485
          Length = 1497

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    SEYTSTAGL 9
            S Y  TAGL
Sbjct: 1202 SSYLHTAGL 1210
>NP_001269939
          Length = 996

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   YTSTAGL 9
           +T+TAGL
Sbjct: 160 FTNTAGL 166
>NP_001269938
          Length = 1300

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   YTSTAGL 9
           +T+TAGL
Sbjct: 383 FTNTAGL 389
>NP_116575
          Length = 1243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   YTSTAGL 9
           +T+TAGL
Sbjct: 407 FTNTAGL 413
>NP_057518
          Length = 1219

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   YTSTAGL 9
           +T+TAGL
Sbjct: 383 FTNTAGL 389
>NP_001276062
          Length = 781

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   TSTAGL 9
           TSTAGL
Sbjct: 477 TSTAGL 482
>NP_001002860
          Length = 1132

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   TSTAGL 9
           TSTAGL
Sbjct: 828 TSTAGL 833
>NP_055820
          Length = 1519

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    SEYTSTA 7
            S+YTST+
Sbjct: 1185 SDYTSTS 1191
>NP_001127878
          Length = 407

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   SEYTSTA 7
           SEY STA
Sbjct: 139 SEYISTA 145
>NP_001127877
          Length = 456

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   SEYTSTA 7
           SEY STA
Sbjct: 139 SEYISTA 145
>NP_671736
          Length = 312

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   EYTSTAG 8
           EY+ TAG
Sbjct: 206 EYSGTAG 212
>NP_055042
          Length = 659

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   YTSTAGL 9
           YT+T GL
Sbjct: 191 YTTTGGL 197
>NP_612147
          Length = 473

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   SEYTSTA 7
           SEY STA
Sbjct: 156 SEYISTA 162
>NP_004458
          Length = 312

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   EYTSTAG 8
           EY+ TAG
Sbjct: 206 EYSGTAG 212
>NP_963847
          Length = 312

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   EYTSTAG 8
           EY+ TAG
Sbjct: 206 EYSGTAG 212
>NP_963846
          Length = 312

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   EYTSTAG 8
           EY+ TAG
Sbjct: 206 EYSGTAG 212
>XP_006725229
          Length = 1132

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   TSTAGL 9
           TSTAGL
Sbjct: 828 TSTAGL 833
>XP_006724371
          Length = 613

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   YTSTAGL 9
           YT+T GL
Sbjct: 145 YTTTGGL 151
>XP_006720258
          Length = 1132

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   TSTAGL 9
           TSTAGL
Sbjct: 828 TSTAGL 833
>XP_005267607
          Length = 1589

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    SEYTSTA 7
            S+YTST+
Sbjct: 1255 SDYTSTS 1261
>XP_005273507
          Length = 362

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   EYTSTAG 8
           EY+ TAG
Sbjct: 256 EYSGTAG 262
>XP_005250215
          Length = 336

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  SEYTSTA 7
          SEY STA
Sbjct: 19 SEYISTA 25
>XP_005250214
          Length = 342

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  SEYTSTA 7
          SEY STA
Sbjct: 25 SEYISTA 31
>XP_005250213
          Length = 454

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   SEYTSTA 7
           SEY STA
Sbjct: 139 SEYISTA 145
>NP_001135780
          Length = 2156

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    SEYTSTAG 8
            + YTST G
Sbjct: 1720 AHYTSTTG 1727
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.293    0.109    0.272 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 494,916
Number of extensions: 736
Number of successful extensions: 58
Number of sequences better than 10000.0: 58
Number of HSP's gapped: 58
Number of HSP's successfully gapped: 58
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.0 bits)
S2: 28 (15.4 bits)

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