Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_055365                                                              19     665
NP_473368                                                              17    4312
NP_001013007                                                           17    4312
XP_006714546                                                           17    4312
NP_001190187                                                           16    5631
NP_079229                                                              16    5631
XP_005253995                                                           16    5631
XP_006719669                                                           16    5631
NP_001038944                                                           16    5631
NP_001277131                                                           16    7355
NP_849191                                                              16    7355
NP_001092105                                                           16    7355
NP_001640                                                              16    7355
XP_005274557                                                           16    7355
NP_002212                                                              15    9605
NP_060821                                                              15    9605
XP_005269081                                                           15    9605
>NP_055365
          Length = 1032

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   SERIMLDIL 9
           SERI+LDIL
Sbjct: 313 SERILLDIL 321
>NP_473368
          Length = 492

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   SERIMLDIL 9
           SE+I++DI+
Sbjct: 349 SEKILIDII 357
>NP_001013007
          Length = 153

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  ERIMLDIL 9
          ERI LDIL
Sbjct: 85 ERISLDIL 92
>XP_006714546
          Length = 504

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   SERIMLDIL 9
           SE+I++DI+
Sbjct: 361 SEKILIDII 369
>NP_001190187
          Length = 430

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SERIMLDIL 9
           S RI+LDIL
Sbjct: 400 SLRILLDIL 408
>NP_079229
          Length = 972

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   SERIMLDIL 9
           +ER++LD+L
Sbjct: 614 TERMLLDLL 622
>XP_005253995
          Length = 836

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   SERIMLDIL 9
           +ER++LD+L
Sbjct: 478 TERMLLDLL 486
>XP_006719669
          Length = 944

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   SERIMLDIL 9
           +ER++LD+L
Sbjct: 586 TERMLLDLL 594
>NP_001038944
          Length = 112

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  ERIMLDIL 9
          E++MLDI+
Sbjct: 18 EKVMLDIV 25
>NP_001277131
          Length = 869

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   ERIMLDI 8
           +RIMLDI
Sbjct: 504 KRIMLDI 510
>NP_849191
          Length = 994

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   ERIMLDI 8
           +RIMLDI
Sbjct: 629 KRIMLDI 635
>NP_001092105
          Length = 993

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   ERIMLDI 8
           +RIMLDI
Sbjct: 629 KRIMLDI 635
>NP_001640
          Length = 1616

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    ERIMLDIL 9
            ERI+ DIL
Sbjct: 1556 ERIVFDIL 1563
>XP_005274557
          Length = 1615

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    ERIMLDIL 9
            ERI+ DIL
Sbjct: 1555 ERIVFDIL 1562
>NP_002212
          Length = 946

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   ERIMLDIL 9
           +R+M+D+L
Sbjct: 701 DRLMVDVL 708
>NP_060821
          Length = 1430

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   SERIMLDIL 9
           SE++ +D+L
Sbjct: 882 SEKVFVDVL 890
>XP_005269081
          Length = 1389

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   SERIMLDIL 9
           SE++ +D+L
Sbjct: 882 SEKVFVDVL 890
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.333    0.151    0.367 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 417,214
Number of extensions: 565
Number of successful extensions: 17
Number of sequences better than 10000.0: 17
Number of HSP's gapped: 17
Number of HSP's successfully gapped: 17
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

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