Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_705691                                                              17    2528
XP_006715120                                                           17    2528
XP_006715119                                                           17    2528
NP_001166289                                                           17    3301
NP_003740                                                              17    3301
NP_000129                                                              17    3301
NP_001990                                                              17    4312
NP_659001                                                              17    4312
NP_001154178                                                           17    4312
NP_003834                                                              17    4312
NP_115823                                                              17    4312
XP_006722988                                                           17    4312
XP_006719949                                                           17    4312
XP_006719948                                                           17    4312
XP_005266635                                                           17    4312
XP_006719947                                                           17    4312
XP_006719946                                                           17    4312
XP_006719945                                                           17    4312
NP_059116                                                              16    5631
NP_937816                                                              16    5631
NP_067003                                                              16    5631
NP_001181939                                                           16    5631
NP_937817                                                              16    5631
NP_579812                                                              16    5631
NP_579803                                                              16    5631
XP_005267816                                                           16    5631
NP_579808                                                              16    5631
NP_001991                                                              16    5631
NP_579806                                                              16    5631
NP_579811                                                              16    5631
NP_579813                                                              16    5631
NP_001005746                                                           16    7355
NP_000717                                                              16    7355
NP_001005747                                                           16    7355
NP_001139270                                                           16    7355
NP_001229943                                                           16    7355
NP_982269                                                              16    7355
NP_062570                                                              16    7355
NP_062571                                                              16    7355
NP_001231293                                                           16    7355
NP_663615                                                              16    7355
NP_005083                                                              16    7355
NP_001073948                                                           16    7355
NP_006211                                                              16    7355
NP_003250                                                              16    7355
NP_001171164                                                           16    7355
XP_005253615                                                           16    7355
XP_006719377                                                           16    7355
XP_005248625                                                           16    7355
XP_006714732                                                           16    7355
XP_005246895                                                           16    7355
XP_006712794                                                           16    7355
NP_689673                                                              16    7355
NP_005560                                                              15    9605
NP_057952                                                              15    9605
NP_001026971                                                           15    9605
NP_001274103                                                           15    9605
NP_001184033                                                           15    9605
NP_000343                                                              15    9605
NP_036564                                                              15    9605
XP_005255316                                                           15    9605
XP_006718903                                                           15    9605
XP_006718902                                                           15    9605
XP_006718349                                                           15    9605
XP_006711735                                                           15    9605
XP_005245698                                                           15    9605
NP_001138887                                                           15    9605
NP_001007241                                                           15    9605
NP_001493                                                              15    9605
>NP_705691
          Length = 955

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SENISGTYR 9
           S ++SGTYR
Sbjct: 505 SRDMSGTYR 513
>XP_006715120
          Length = 539

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SENISGTYR 9
           S ++SGTYR
Sbjct: 505 SRDMSGTYR 513
>XP_006715119
          Length = 973

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SENISGTYR 9
           S ++SGTYR
Sbjct: 505 SRDMSGTYR 513
>NP_001166289
          Length = 580

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  ENISGTYR 9
          E ISGTYR
Sbjct: 6  EWISGTYR 13
>NP_003740
          Length = 1338

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SENISGTYR 9
           S+N++G YR
Sbjct: 210 SKNLTGVYR 218
>NP_000129
          Length = 2871

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ENISGTYR 9
           EN+ GTY+
Sbjct: 740 ENLRGTYK 747
>NP_001990
          Length = 2912

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ENISGTYR 9
           EN+ G+YR
Sbjct: 785 ENLRGSYR 792
>NP_659001
          Length = 688

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   ENISGTY 8
           ENISG Y
Sbjct: 597 ENISGKY 603
>NP_001154178
          Length = 646

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   ENISGTY 8
           ENISG Y
Sbjct: 555 ENISGKY 561
>NP_003834
          Length = 668

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   ENISGTY 8
           ENISG Y
Sbjct: 577 ENISGKY 583
>NP_115823
          Length = 2809

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ENISGTYR 9
           EN+ G+YR
Sbjct: 699 ENLRGSYR 706
>XP_006722988
          Length = 2818

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ENISGTYR 9
           EN+ G+YR
Sbjct: 708 ENLRGSYR 715
>XP_006719949
          Length = 619

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   ENISGTY 8
           ENISG Y
Sbjct: 528 ENISGKY 534
>XP_006719948
          Length = 648

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   ENISGTY 8
           ENISG Y
Sbjct: 557 ENISGKY 563
>XP_005266635
          Length = 665

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   ENISGTY 8
           ENISG Y
Sbjct: 574 ENISGKY 580
>XP_006719947
          Length = 666

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   ENISGTY 8
           ENISG Y
Sbjct: 575 ENISGKY 581
>XP_006719946
          Length = 668

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   ENISGTY 8
           ENISG Y
Sbjct: 577 ENISGKY 583
>XP_006719945
          Length = 668

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   ENISGTY 8
           ENISG Y
Sbjct: 577 ENISGKY 583
>NP_059116
          Length = 781

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   SENISGT 7
           SENISG+
Sbjct: 596 SENISGS 602
>NP_937816
          Length = 602

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SENISGT 7
           +EN+SGT
Sbjct: 114 TENVSGT 120
>NP_067003
          Length = 607

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SENISGT 7
           +EN+SGT
Sbjct: 119 TENVSGT 125
>NP_001181939
          Length = 556

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  SENISGT 7
          +EN+SGT
Sbjct: 68 TENVSGT 74
>NP_937817
          Length = 626

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SENISGT 7
           +EN+SGT
Sbjct: 114 TENVSGT 120
>NP_579812
          Length = 253

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   NISGTYR 9
           N+SG YR
Sbjct: 174 NVSGIYR 180
>NP_579803
          Length = 265

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   NISGTYR 9
           N+SG YR
Sbjct: 186 NVSGIYR 192
>XP_005267816
          Length = 773

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   SENISGT 7
           SENISG+
Sbjct: 588 SENISGS 594
>NP_579808
          Length = 209

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   NISGTYR 9
           N+SG YR
Sbjct: 174 NVSGIYR 180
>NP_001991
          Length = 287

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   NISGTYR 9
           N+SG YR
Sbjct: 186 NVSGIYR 192
>NP_579806
          Length = 275

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   NISGTYR 9
           N+SG YR
Sbjct: 174 NVSGIYR 180
>NP_579811
          Length = 178

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  NISGTYR 9
          N+SG YR
Sbjct: 77 NVSGIYR 83
>NP_579813
          Length = 239

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   NISGTYR 9
           N+SG YR
Sbjct: 186 NVSGIYR 192
>NP_001005746
          Length = 502

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ENISGTYR 9
           E +SGT+R
Sbjct: 168 EMVSGTFR 175
>NP_000717
          Length = 520

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ENISGTYR 9
           E +SGT+R
Sbjct: 186 EMVSGTFR 193
>NP_001005747
          Length = 486

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ENISGTYR 9
           E +SGT+R
Sbjct: 152 EMVSGTFR 159
>NP_001139270
          Length = 458

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ENISGTYR 9
           E +SGT+R
Sbjct: 186 EMVSGTFR 193
>NP_001229943
          Length = 681

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ENISGTYR 9
           EN++ TYR
Sbjct: 507 ENVTFTYR 514
>NP_982269
          Length = 683

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ENISGTYR 9
           EN++ TYR
Sbjct: 507 ENVTFTYR 514
>NP_062570
          Length = 723

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ENISGTYR 9
           EN++ TYR
Sbjct: 464 ENVTFTYR 471
>NP_062571
          Length = 766

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ENISGTYR 9
           EN++ TYR
Sbjct: 507 ENVTFTYR 514
>NP_001231293
          Length = 1392

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   SENISGT 7
           SEN+ GT
Sbjct: 117 SENVEGT 123
>NP_663615
          Length = 402

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  ENISGTY 8
          EN+SG Y
Sbjct: 41 ENVSGYY 47
>NP_005083
          Length = 199

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   ENISGTY 8
           +N+ GTY
Sbjct: 156 QNVGGTY 162
>NP_001073948
          Length = 1731

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   SENISGT 7
           SEN+ GT
Sbjct: 430 SENVEGT 436
>NP_006211
          Length = 421

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   NISGTYR 9
           +ISGTY+
Sbjct: 319 SISGTYK 325
>NP_003250
          Length = 924

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   ISGTYR 9
           +SGTYR
Sbjct: 464 LSGTYR 469
>NP_001171164
          Length = 1705

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   SENISGT 7
           SEN+ GT
Sbjct: 430 SENVEGT 436
>XP_005253615
          Length = 548

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ENISGTYR 9
           EN++ TYR
Sbjct: 289 ENVTFTYR 296
>XP_006719377
          Length = 687

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ENISGTYR 9
           EN++ TYR
Sbjct: 507 ENVTFTYR 514
>XP_005248625
          Length = 1418

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   SENISGT 7
           SEN+ GT
Sbjct: 117 SENVEGT 123
>XP_006714732
          Length = 1633

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   SENISGT 7
           SEN+ GT
Sbjct: 332 SENVEGT 338
>XP_005246895
          Length = 207

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ENISGTYR 9
           E +SGT+R
Sbjct: 152 EMVSGTFR 159
>XP_006712794
          Length = 473

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ENISGTYR 9
           E +SGT+R
Sbjct: 139 EMVSGTFR 146
>NP_689673
          Length = 243

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   ENISGT 7
           EN+SGT
Sbjct: 135 ENVSGT 140
>NP_005560
          Length = 638

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   ENISGTYR 9
           EN+ GT R
Sbjct: 273 ENLEGTLR 280
>NP_057952
          Length = 617

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   ENISGTYR 9
           EN+ GT R
Sbjct: 252 ENLEGTLR 259
>NP_001026971
          Length = 686

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   ENISGTYR 9
           EN+ GT R
Sbjct: 252 ENLEGTLR 259
>NP_001274103
          Length = 1582

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  SENISGTYR 9
          SEN S  YR
Sbjct: 8  SENHSAAYR 16
>NP_001184033
          Length = 3972

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    ENISGT 7
            EN+SGT
Sbjct: 1600 ENLSGT 1605
>NP_000343
          Length = 1581

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  SENISGTYR 9
          SEN S  YR
Sbjct: 8  SENHSAAYR 16
>NP_036564
          Length = 1290

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   SENISG 6
           SEN+SG
Sbjct: 512 SENVSG 517
>XP_005255316
          Length = 659

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ENISGTYR 9
           +N+SG YR
Sbjct: 212 KNMSGWYR 219
>XP_006718903
          Length = 2673

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   ENISGT 7
           EN+SGT
Sbjct: 301 ENLSGT 306
>XP_006718902
          Length = 2964

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   ENISGT 7
           EN+SGT
Sbjct: 592 ENLSGT 597
>XP_006718349
          Length = 1646

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  SENISGTYR 9
          SEN S  YR
Sbjct: 8  SENHSAAYR 16
>XP_006711735
          Length = 739

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   SENISG 6
           SEN+SG
Sbjct: 513 SENVSG 518
>XP_005245698
          Length = 1292

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   SENISG 6
           SEN+SG
Sbjct: 513 SENVSG 518
>NP_001138887
          Length = 1291

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   SENISG 6
           SEN+SG
Sbjct: 512 SENVSG 517
>NP_001007241
          Length = 537

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  ENISGTYR 9
          +N+SG YR
Sbjct: 87 KNMSGWYR 94
>NP_001493
          Length = 534

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  ENISGTYR 9
          +N+SG YR
Sbjct: 87 KNMSGWYR 94
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.300    0.120    0.317 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 619,741
Number of extensions: 1199
Number of successful extensions: 69
Number of sequences better than 10000.0: 69
Number of HSP's gapped: 69
Number of HSP's successfully gapped: 69
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.2 bits)
S2: 28 (15.4 bits)

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