Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000206                                                              17    4312
XP_006722808                                                           17    4312
XP_005259953                                                           17    4312
XP_005254804                                                           17    4312
XP_006720791                                                           17    4312
XP_005254803                                                           17    4312
XP_005254800                                                           17    4312
XP_005254799                                                           17    4312
NP_003913                                                              17    4312
NP_000159                                                              16    5631
XP_005249761                                                           16    5631
XP_005249760                                                           16    5631
XP_006713927                                                           16    5631
NP_660334                                                              16    5631
NP_001167639                                                           16    7355
NP_001167638                                                           16    7355
NP_001128524                                                           16    7355
NP_003168                                                              16    7355
NP_115627                                                              16    7355
NP_001131136                                                           16    7355
NP_057322                                                              16    7355
XP_005253960                                                           16    7355
XP_006719513                                                           16    7355
XP_006718582                                                           16    7355
XP_005252204                                                           16    7355
NP_000278                                                              15    9605
NP_004000                                                              15    9605
NP_004001                                                              15    9605
NP_003997                                                              15    9605
NP_000100                                                              15    9605
NP_056207                                                              15    9605
XP_006724538                                                           15    9605
XP_006724537                                                           15    9605
XP_006724536                                                           15    9605
XP_006724535                                                           15    9605
XP_006724534                                                           15    9605
XP_006724533                                                           15    9605
XP_006724532                                                           15    9605
XP_006724531                                                           15    9605
>NP_000206
          Length = 1124

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   DGLALIRV 9
           DGL L+RV
Sbjct: 266 DGLGLLRV 273
>XP_006722808
          Length = 1124

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   DGLALIRV 9
           DGL L+RV
Sbjct: 266 DGLGLLRV 273
>XP_005259953
          Length = 1167

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   DGLALIRV 9
           DGL L+RV
Sbjct: 309 DGLGLLRV 316
>XP_005254804
          Length = 4796

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    SDGLALI 7
            SDGLAL+
Sbjct: 3692 SDGLALV 3698
>XP_006720791
          Length = 4853

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    SDGLALI 7
            SDGLAL+
Sbjct: 3749 SDGLALV 3755
>XP_005254803
          Length = 4854

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    SDGLALI 7
            SDGLAL+
Sbjct: 3750 SDGLALV 3756
>XP_005254800
          Length = 4861

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    SDGLALI 7
            SDGLAL+
Sbjct: 3757 SDGLALV 3763
>XP_005254799
          Length = 4861

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    SDGLALI 7
            SDGLAL+
Sbjct: 3757 SDGLALV 3763
>NP_003913
          Length = 4861

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    SDGLALI 7
            SDGLAL+
Sbjct: 3757 SDGLALV 3763
>NP_000159
          Length = 1580

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    SDGLALIRV 9
            S+GLAL RV
Sbjct: 1013 SEGLALPRV 1021
>XP_005249761
          Length = 1580

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    SDGLALIRV 9
            S+GLAL RV
Sbjct: 1013 SEGLALPRV 1021
>XP_005249760
          Length = 1580

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    SDGLALIRV 9
            S+GLAL RV
Sbjct: 1013 SEGLALPRV 1021
>XP_006713927
          Length = 765

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SDGLALIR 8
           +DG+A+IR
Sbjct: 706 ADGMAMIR 713
>NP_660334
          Length = 765

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SDGLALIR 8
           +DG+A+IR
Sbjct: 706 ADGMAMIR 713
>NP_001167639
          Length = 612

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  SDGLALIR 8
          SDGL L+R
Sbjct: 35 SDGLYLLR 42
>NP_001167638
          Length = 635

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  SDGLALIR 8
          SDGL L+R
Sbjct: 35 SDGLYLLR 42
>NP_001128524
          Length = 612

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  SDGLALIR 8
          SDGL L+R
Sbjct: 35 SDGLYLLR 42
>NP_003168
          Length = 635

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  SDGLALIR 8
          SDGL L+R
Sbjct: 35 SDGLYLLR 42
>NP_115627
          Length = 1476

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  SDGLALIRV 9
          SDG  L+RV
Sbjct: 57 SDGALLLRV 65
>NP_001131136
          Length = 537

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   DGLALIR 8
           DG+AL+R
Sbjct: 494 DGIALLR 500
>NP_057322
          Length = 599

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   DGLALIR 8
           DG+AL+R
Sbjct: 494 DGIALLR 500
>XP_005253960
          Length = 378

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   DGLALIR 8
           DG+AL+R
Sbjct: 273 DGIALLR 279
>XP_006719513
          Length = 552

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   DGLALIR 8
           DG+AL+R
Sbjct: 447 DGIALLR 453
>XP_006718582
          Length = 1560

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  SDGLALIRV 9
          SDG  L+RV
Sbjct: 57 SDGALLLRV 65
>XP_005252204
          Length = 635

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  SDGLALIR 8
          SDGL L+R
Sbjct: 35 SDGLYLLR 42
>NP_000278
          Length = 980

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SDGLALI 7
           +DGLAL+
Sbjct: 267 ADGLALV 273
>NP_004000
          Length = 3681

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SDGLAL 6
           SDGLAL
Sbjct: 160 SDGLAL 165
>NP_004001
          Length = 3562

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  SDGLAL 6
          SDGLAL
Sbjct: 41 SDGLAL 46
>NP_003997
          Length = 3685

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SDGLAL 6
           SDGLAL
Sbjct: 164 SDGLAL 169
>NP_000100
          Length = 3677

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SDGLAL 6
           SDGLAL
Sbjct: 156 SDGLAL 161
>NP_056207
          Length = 325

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DGLALIRV 9
           DGLAL+ +
Sbjct: 181 DGLALVLI 188
>XP_006724538
          Length = 3575

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SDGLAL 6
           SDGLAL
Sbjct: 164 SDGLAL 169
>XP_006724537
          Length = 3593

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SDGLAL 6
           SDGLAL
Sbjct: 164 SDGLAL 169
>XP_006724536
          Length = 3657

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SDGLAL 6
           SDGLAL
Sbjct: 164 SDGLAL 169
>XP_006724535
          Length = 3660

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SDGLAL 6
           SDGLAL
Sbjct: 164 SDGLAL 169
>XP_006724534
          Length = 3668

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SDGLAL 6
           SDGLAL
Sbjct: 164 SDGLAL 169
>XP_006724533
          Length = 3690

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SDGLAL 6
           SDGLAL
Sbjct: 164 SDGLAL 169
>XP_006724532
          Length = 3695

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SDGLAL 6
           SDGLAL
Sbjct: 156 SDGLAL 161
>XP_006724531
          Length = 3703

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SDGLAL 6
           SDGLAL
Sbjct: 164 SDGLAL 169
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.327    0.147    0.383 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 443,938
Number of extensions: 657
Number of successful extensions: 39
Number of sequences better than 10000.0: 39
Number of HSP's gapped: 39
Number of HSP's successfully gapped: 39
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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