Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005091                                                              19     869
NP_653080                                                              19     869
XP_005267292                                                           19     869
XP_005267291                                                           19     869
XP_005267290                                                           19     869
NP_001265546                                                           17    4312
NP_001265545                                                           17    4312
NP_004327                                                              17    4312
NP_056210                                                              17    4312
NP_001269119                                                           17    4312
NP_057562                                                              17    4312
NP_001269120                                                           17    4312
XP_005250460                                                           17    4312
XP_005250310                                                           17    4312
NP_001185885                                                           16    5631
NP_001185886                                                           16    5631
NP_060912                                                              16    5631
NP_001017977                                                           16    5631
NP_060896                                                              16    5631
NP_001136271                                                           16    5631
NP_001136270                                                           16    5631
XP_005249274                                                           16    5631
XP_005249273                                                           16    5631
XP_005249272                                                           16    5631
XP_005249271                                                           16    5631
XP_006715198                                                           16    5631
XP_005249269                                                           16    5631
XP_005249270                                                           16    5631
XP_005249268                                                           16    5631
XP_005245390                                                           16    5631
XP_005245389                                                           16    5631
XP_005245388                                                           16    5631
NP_777553                                                              16    5631
NP_060021                                                              16    7355
XP_006717867                                                           16    7355
NP_055880                                                              15    9605
NP_055268                                                              15    9605
NP_940818                                                              15    9605
NP_071903                                                              15    9605
NP_001264992                                                           15    9605
NP_001157918                                                           15    9605
XP_005258804                                                           15    9605
XP_005258803                                                           15    9605
XP_006722588                                                           15    9605
XP_005271520                                                           15    9605
XP_005271519                                                           15    9605
XP_005271518                                                           15    9605
XP_005249616                                                           15    9605
XP_005249615                                                           15    9605
XP_005249613                                                           15    9605
XP_005249612                                                           15    9605
>NP_005091
          Length = 1782

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SALTDTDAS 9
            SAL DTDAS
Sbjct: 1712 SALADTDAS 1720
>NP_653080
          Length = 1684

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SALTDTDAS 9
            SAL DTDAS
Sbjct: 1614 SALADTDAS 1622
>XP_005267292
          Length = 1677

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SALTDTDAS 9
            SAL DTDAS
Sbjct: 1607 SALADTDAS 1615
>XP_005267291
          Length = 1684

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SALTDTDAS 9
            SAL DTDAS
Sbjct: 1614 SALADTDAS 1622
>XP_005267290
          Length = 1782

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SALTDTDAS 9
            SAL DTDAS
Sbjct: 1712 SALADTDAS 1720
>NP_001265546
          Length = 1028

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LTDTDAS 9
           LTDTDA+
Sbjct: 700 LTDTDAA 706
>NP_001265545
          Length = 1065

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LTDTDAS 9
           LTDTDA+
Sbjct: 680 LTDTDAA 686
>NP_004327
          Length = 1085

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LTDTDAS 9
           LTDTDA+
Sbjct: 700 LTDTDAA 706
>NP_056210
          Length = 1165

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SALTDTDAS 9
           SA +DTDAS
Sbjct: 409 SAPSDTDAS 417
>NP_001269119
          Length = 481

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SALTDTDAS 9
           S++TD DAS
Sbjct: 268 SSMTDLDAS 276
>NP_057562
          Length = 502

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SALTDTDAS 9
           S++TD DAS
Sbjct: 289 SSMTDLDAS 297
>NP_001269120
          Length = 431

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SALTDTDAS 9
           S++TD DAS
Sbjct: 289 SSMTDLDAS 297
>XP_005250460
          Length = 378

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SALTDTDAS 9
           S++TD DAS
Sbjct: 165 SSMTDLDAS 173
>XP_005250310
          Length = 1165

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SALTDTDAS 9
           SA +DTDAS
Sbjct: 409 SAPSDTDAS 417
>NP_001185885
          Length = 951

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   SALTDTDAS 9
           SAL DTD S
Sbjct: 726 SALQDTDDS 734
>NP_001185886
          Length = 920

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   SALTDTDAS 9
           SAL DTD S
Sbjct: 695 SALQDTDDS 703
>NP_060912
          Length = 880

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   SALTDTDAS 9
           SAL DTD S
Sbjct: 669 SALQDTDDS 677
>NP_001017977
          Length = 860

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   SALTDTDAS 9
           SAL DTD S
Sbjct: 649 SALQDTDDS 657
>NP_060896
          Length = 832

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ALTDTD 7
           ALTDTD
Sbjct: 812 ALTDTD 817
>NP_001136271
          Length = 138

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SALTDTDAS 9
           SAL D+DA+
Sbjct: 107 SALNDSDAN 115
>NP_001136270
          Length = 192

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SALTDTDAS 9
           SAL D+DA+
Sbjct: 141 SALNDSDAN 149
>XP_005249274
          Length = 832

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ALTDTD 7
           ALTDTD
Sbjct: 812 ALTDTD 817
>XP_005249273
          Length = 814

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ALTDTD 7
           ALTDTD
Sbjct: 794 ALTDTD 799
>XP_005249272
          Length = 819

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ALTDTD 7
           ALTDTD
Sbjct: 799 ALTDTD 804
>XP_005249271
          Length = 828

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ALTDTD 7
           ALTDTD
Sbjct: 808 ALTDTD 813
>XP_006715198
          Length = 832

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ALTDTD 7
           ALTDTD
Sbjct: 812 ALTDTD 817
>XP_005249269
          Length = 832

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ALTDTD 7
           ALTDTD
Sbjct: 812 ALTDTD 817
>XP_005249270
          Length = 832

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ALTDTD 7
           ALTDTD
Sbjct: 812 ALTDTD 817
>XP_005249268
          Length = 841

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ALTDTD 7
           ALTDTD
Sbjct: 821 ALTDTD 826
>XP_005245390
          Length = 874

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   SALTDTDAS 9
           SAL DTD S
Sbjct: 649 SALQDTDDS 657
>XP_005245389
          Length = 894

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   SALTDTDAS 9
           SAL DTD S
Sbjct: 669 SALQDTDDS 677
>XP_005245388
          Length = 937

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   SALTDTDAS 9
           SAL DTD S
Sbjct: 726 SALQDTDDS 734
>NP_777553
          Length = 172

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SALTDTDAS 9
           SAL D+DA+
Sbjct: 141 SALNDSDAN 149
>NP_060021
          Length = 1009

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SALTDTDAS 9
           +ALTD D S
Sbjct: 749 AALTDDDCS 757
>XP_006717867
          Length = 896

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SALTDTDAS 9
           +ALTD D S
Sbjct: 749 AALTDDDCS 757
>NP_055880
          Length = 1989

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SALTDT 6
           SALTDT
Sbjct: 851 SALTDT 856
>NP_055268
          Length = 222

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   SALTDTDA 8
           SAL D DA
Sbjct: 203 SALADADA 210
>NP_940818
          Length = 222

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   SALTDTDA 8
           SAL D DA
Sbjct: 203 SALADADA 210
>NP_071903
          Length = 490

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SALTDTDAS 9
           SAL D DA+
Sbjct: 169 SALIDNDAA 177
>NP_001264992
          Length = 1015

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LTDTDAS 9
           +TD+DAS
Sbjct: 902 ITDSDAS 908
>NP_001157918
          Length = 1188

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   SALTDTDAS 9
           S+LT+T+A+
Sbjct: 535 SSLTETEAA 543
>XP_005258804
          Length = 265

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   SALTDTDA 8
           SAL D DA
Sbjct: 246 SALADADA 253
>XP_005258803
          Length = 265

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   SALTDTDA 8
           SAL D DA
Sbjct: 246 SALADADA 253
>XP_006722588
          Length = 1015

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LTDTDAS 9
           +TD+DAS
Sbjct: 902 ITDSDAS 908
>XP_005271520
          Length = 1801

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SALTDT 6
           SALTDT
Sbjct: 663 SALTDT 668
>XP_005271519
          Length = 1833

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SALTDT 6
           SALTDT
Sbjct: 695 SALTDT 700
>XP_005271518
          Length = 1982

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SALTDT 6
           SALTDT
Sbjct: 844 SALTDT 849
>XP_005249616
          Length = 284

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  SALTDTDAS 9
          SAL D DA+
Sbjct: 17 SALIDNDAA 25
>XP_005249615
          Length = 304

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SALTDTDAS 9
           SAL D DA+
Sbjct: 169 SALIDNDAA 177
>XP_005249613
          Length = 338

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  SALTDTDAS 9
          SAL D DA+
Sbjct: 17 SALIDNDAA 25
>XP_005249612
          Length = 436

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SALTDTDAS 9
           SAL D DA+
Sbjct: 169 SALIDNDAA 177
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.289    0.101    0.235 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 493,915
Number of extensions: 567
Number of successful extensions: 51
Number of sequences better than 10000.0: 51
Number of HSP's gapped: 51
Number of HSP's successfully gapped: 51
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.0 bits)
S2: 28 (15.4 bits)

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