Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000258                                                              17    2528
NP_001035957                                                           17    2528
XP_006721991                                                           17    2528
XP_006721990                                                           17    2528
XP_006721989                                                           17    2528
XP_005258041                                                           17    2528
XP_006721988                                                           17    2528
XP_006721987                                                           17    2528
XP_006721986                                                           17    2528
XP_005258040                                                           17    2528
XP_006721985                                                           17    2528
NP_001181915                                                           17    4312
XP_006710703                                                           17    4312
NP_001129334                                                           16    5631
NP_612424                                                              16    5631
NP_001229379                                                           16    5631
NP_001271225                                                           16    5631
XP_006724185                                                           16    5631
NP_001231509                                                           16    7355
NP_003487                                                              16    7355
>NP_000258
          Length = 2818

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RVMALLRLI 9
           RVMALLR I
Sbjct: 758 RVMALLRRI 766
>NP_001035957
          Length = 2839

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RVMALLRLI 9
           RVMALLR I
Sbjct: 758 RVMALLRRI 766
>XP_006721991
          Length = 1632

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RVMALLRLI 9
           RVMALLR I
Sbjct: 768 RVMALLRRI 776
>XP_006721990
          Length = 2823

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RVMALLRLI 9
           RVMALLR I
Sbjct: 768 RVMALLRRI 776
>XP_006721989
          Length = 2823

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RVMALLRLI 9
           RVMALLR I
Sbjct: 768 RVMALLRRI 776
>XP_005258041
          Length = 2836

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RVMALLRLI 9
           RVMALLR I
Sbjct: 758 RVMALLRRI 766
>XP_006721988
          Length = 2846

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RVMALLRLI 9
           RVMALLR I
Sbjct: 768 RVMALLRRI 776
>XP_006721987
          Length = 2849

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RVMALLRLI 9
           RVMALLR I
Sbjct: 768 RVMALLRRI 776
>XP_006721986
          Length = 2854

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RVMALLRLI 9
           RVMALLR I
Sbjct: 755 RVMALLRRI 763
>XP_005258040
          Length = 2857

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RVMALLRLI 9
           RVMALLR I
Sbjct: 758 RVMALLRRI 766
>XP_006721985
          Length = 2867

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RVMALLRLI 9
           RVMALLR I
Sbjct: 768 RVMALLRRI 776
>NP_001181915
          Length = 517

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   RVMALLR 7
           RVMALLR
Sbjct: 310 RVMALLR 316
>XP_006710703
          Length = 552

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   RVMALLR 7
           RVMALLR
Sbjct: 310 RVMALLR 316
>NP_001129334
          Length = 489

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   RVMALLRLI 9
           R+ ALLRLI
Sbjct: 439 RLRALLRLI 447
>NP_612424
          Length = 531

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   RVMALLRLI 9
           R+ ALLRLI
Sbjct: 481 RLRALLRLI 489
>NP_001229379
          Length = 477

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   RVMALLRLI 9
           R+ ALLRLI
Sbjct: 427 RLRALLRLI 435
>NP_001271225
          Length = 327

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   RVMALLRLI 9
           R+ ALLRLI
Sbjct: 277 RLRALLRLI 285
>XP_006724185
          Length = 489

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   RVMALLRLI 9
           R+ ALLRLI
Sbjct: 439 RLRALLRLI 447
>NP_001231509
          Length = 3859

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    RVMALLRLI 9
            RV+ LLRL+
Sbjct: 3544 RVLQLLRLL 3552
>NP_003487
          Length = 3830

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    RVMALLRLI 9
            RV+ LLRL+
Sbjct: 3515 RVLQLLRLL 3523
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.361    0.165    0.404 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 250,018
Number of extensions: 398
Number of successful extensions: 20
Number of sequences better than 10000.0: 20
Number of HSP's gapped: 20
Number of HSP's successfully gapped: 20
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 14 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (17.2 bits)
S2: 28 (15.4 bits)

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