Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_619639                                                              16    7355
NP_056127                                                              16    7355
XP_006714407                                                           16    7355
XP_006714405                                                           16    7355
XP_005263349                                                           16    7355
XP_005263348                                                           16    7355
XP_005263347                                                           16    7355
XP_005263346                                                           16    7355
XP_005263345                                                           16    7355
XP_005263344                                                           16    7355
XP_005263343                                                           16    7355
XP_005263342                                                           16    7355
XP_005263341                                                           16    7355
XP_005263340                                                           16    7355
XP_005263339                                                           16    7355
NP_004971                                                              15    9605
NP_751948                                                              15    9605
NP_036377                                                              15    9605
NP_006176                                                              15    9605
NP_071928                                                              15    9605
NP_001273490                                                           15    9605
XP_005267471                                                           15    9605
XP_005267470                                                           15    9605
XP_006718633                                                           15    9605
XP_006718632                                                           15    9605
XP_006718631                                                           15    9605
XP_006718630                                                           15    9605
XP_006718629                                                           15    9605
XP_006718628                                                           15    9605
XP_006718627                                                           15    9605
XP_006718626                                                           15    9605
XP_006718625                                                           15    9605
XP_006714549                                                           15    9605
XP_006714548                                                           15    9605
XP_005248392                                                           15    9605
XP_005248393                                                           15    9605
XP_005248391                                                           15    9605
XP_005248390                                                           15    9605
XP_006710694                                                           15    9605
XP_006710693                                                           15    9605
XP_006710692                                                           15    9605
XP_005270908                                                           15    9605
>NP_619639
          Length = 4074

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    RTTSLISSL 9
            R+T +ISSL
Sbjct: 3673 RSTGMISSL 3681
>NP_056127
          Length = 5005

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    TTSLISS 8
            TTSL+SS
Sbjct: 4025 TTSLVSS 4031
>XP_006714407
          Length = 5004

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    TTSLISS 8
            TTSL+SS
Sbjct: 4024 TTSLVSS 4030
>XP_006714405
          Length = 4103

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    TTSLISS 8
            TTSL+SS
Sbjct: 3123 TTSLVSS 3129
>XP_005263349
          Length = 4410

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    TTSLISS 8
            TTSL+SS
Sbjct: 3430 TTSLVSS 3436
>XP_005263348
          Length = 4443

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    TTSLISS 8
            TTSL+SS
Sbjct: 3463 TTSLVSS 3469
>XP_005263347
          Length = 4640

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    TTSLISS 8
            TTSL+SS
Sbjct: 4046 TTSLVSS 4052
>XP_005263346
          Length = 4983

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    TTSLISS 8
            TTSL+SS
Sbjct: 4003 TTSLVSS 4009
>XP_005263345
          Length = 4991

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    TTSLISS 8
            TTSL+SS
Sbjct: 4011 TTSLVSS 4017
>XP_005263344
          Length = 5005

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    TTSLISS 8
            TTSL+SS
Sbjct: 4025 TTSLVSS 4031
>XP_005263343
          Length = 5009

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    TTSLISS 8
            TTSL+SS
Sbjct: 4029 TTSLVSS 4035
>XP_005263342
          Length = 5025

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    TTSLISS 8
            TTSL+SS
Sbjct: 4045 TTSLVSS 4051
>XP_005263341
          Length = 5026

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    TTSLISS 8
            TTSL+SS
Sbjct: 4046 TTSLVSS 4052
>XP_005263340
          Length = 5026

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    TTSLISS 8
            TTSL+SS
Sbjct: 4046 TTSLVSS 4052
>XP_005263339
          Length = 5026

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    TTSLISS 8
            TTSL+SS
Sbjct: 4046 TTSLVSS 4052
>NP_004971
          Length = 655

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RTTSLISS 8
           +TTSLI S
Sbjct: 467 KTTSLIES 474
>NP_751948
          Length = 636

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RTTSLISS 8
           +TTSLI S
Sbjct: 467 KTTSLIES 474
>NP_036377
          Length = 536

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  RTTSLISS 8
          R TSL+SS
Sbjct: 30 RQTSLVSS 37
>NP_006176
          Length = 2115

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    RTTSLISSL 9
            R  SLISSL
Sbjct: 1222 RKNSLISSL 1230
>NP_071928
          Length = 215

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  TTSLISSL 9
          T SLISSL
Sbjct: 17 TESLISSL 24
>NP_001273490
          Length = 2101

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    RTTSLISSL 9
            R  SLISSL
Sbjct: 1222 RKNSLISSL 1230
>XP_005267471
          Length = 571

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  RTTSLISS 8
          R TSL+SS
Sbjct: 30 RQTSLVSS 37
>XP_005267470
          Length = 430

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  RTTSLISS 8
          R TSL+SS
Sbjct: 30 RQTSLVSS 37
>XP_006718633
          Length = 2101

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    RTTSLISSL 9
            R  SLISSL
Sbjct: 1222 RKNSLISSL 1230
>XP_006718632
          Length = 2115

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    RTTSLISSL 9
            R  SLISSL
Sbjct: 1222 RKNSLISSL 1230
>XP_006718631
          Length = 2115

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    RTTSLISSL 9
            R  SLISSL
Sbjct: 1222 RKNSLISSL 1230
>XP_006718630
          Length = 2115

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    RTTSLISSL 9
            R  SLISSL
Sbjct: 1222 RKNSLISSL 1230
>XP_006718629
          Length = 2115

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    RTTSLISSL 9
            R  SLISSL
Sbjct: 1222 RKNSLISSL 1230
>XP_006718628
          Length = 2115

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    RTTSLISSL 9
            R  SLISSL
Sbjct: 1222 RKNSLISSL 1230
>XP_006718627
          Length = 2115

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    RTTSLISSL 9
            R  SLISSL
Sbjct: 1222 RKNSLISSL 1230
>XP_006718626
          Length = 2115

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    RTTSLISSL 9
            R  SLISSL
Sbjct: 1222 RKNSLISSL 1230
>XP_006718625
          Length = 2115

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    RTTSLISSL 9
            R  SLISSL
Sbjct: 1222 RKNSLISSL 1230
>XP_006714549
          Length = 215

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  TTSLISSL 9
          T SLISSL
Sbjct: 17 TESLISSL 24
>XP_006714548
          Length = 215

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  TTSLISSL 9
          T SLISSL
Sbjct: 17 TESLISSL 24
>XP_005248392
          Length = 215

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  TTSLISSL 9
          T SLISSL
Sbjct: 17 TESLISSL 24
>XP_005248393
          Length = 215

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  TTSLISSL 9
          T SLISSL
Sbjct: 17 TESLISSL 24
>XP_005248391
          Length = 215

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  TTSLISSL 9
          T SLISSL
Sbjct: 17 TESLISSL 24
>XP_005248390
          Length = 215

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  TTSLISSL 9
          T SLISSL
Sbjct: 17 TESLISSL 24
>XP_006710694
          Length = 510

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RTTSLISS 8
           +TTSLI S
Sbjct: 467 KTTSLIES 474
>XP_006710693
          Length = 636

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RTTSLISS 8
           +TTSLI S
Sbjct: 467 KTTSLIES 474
>XP_006710692
          Length = 655

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RTTSLISS 8
           +TTSLI S
Sbjct: 467 KTTSLIES 474
>XP_005270908
          Length = 655

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RTTSLISS 8
           +TTSLI S
Sbjct: 467 KTTSLIES 474
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.310    0.116    0.256 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 270,118
Number of extensions: 390
Number of successful extensions: 42
Number of sequences better than 10000.0: 42
Number of HSP's gapped: 42
Number of HSP's successfully gapped: 42
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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