Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

• Home Page
• Cancer-specific
• Epitope Search
• Data Retrieval
• Browse Gene
• Browse Tissue
• Sequence Similarity
• Partially Personalized
• Submit a Protein
• Vaccine Target
• Proteome Data
• NGS data
• BLAST & Predict
• Fully Personalized
• Proteins Pair
• Proteome Pair
• Advanced Tools
• Epitope Mapping
• Cross Reactivity
• Important Information
• Acknowledgement
• Algorithm
• Help
• Developers
• Contact

Blast-Search of mutated query peptide against human proteome

BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005148                                                              20     299
NP_009297                                                              20     299
NP_055553                                                              17    4312
XP_005257925                                                           17    4312
XP_005257924                                                           17    4312
XP_005257923                                                           17    4312
XP_005257922                                                           17    4312
XP_005257921                                                           17    4312
XP_006722263                                                           17    4312
XP_005257920                                                           17    4312
NP_055054                                                              16    7355
NP_005742                                                              15    9605
NP_671714                                                              15    9605
NP_001002836                                                           15    9605
NP_001230126                                                           15    9605
XP_006724643                                                           15    9605
XP_006723482                                                           15    9605
XP_005259380                                                           15    9605
XP_005259381                                                           15    9605
XP_005259373                                                           15    9605
XP_006723481                                                           15    9605
XP_006723480                                                           15    9605
XP_006715890                                                           15    9605
XP_005250160                                                           15    9605
XP_005250159                                                           15    9605
NP_055890                                                              15    9605
NP_115799                                                              15    9605

>NP_005148
          Length = 1130

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    RSSEQMASH 9
            R+SEQMASH
Sbjct: 1045 RNSEQMASH 1053



>NP_009297
          Length = 1149

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    RSSEQMASH 9
            R+SEQMASH
Sbjct: 1064 RNSEQMASH 1072



>NP_055553
          Length = 1356

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SSEQMASH 9
           S+EQM SH
Sbjct: 696 STEQMLSH 703



>XP_005257925
          Length = 850

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SSEQMASH 9
           S+EQM SH
Sbjct: 160 STEQMLSH 167



>XP_005257924
          Length = 1122

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SSEQMASH 9
           S+EQM SH
Sbjct: 432 STEQMLSH 439



>XP_005257923
          Length = 1131

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SSEQMASH 9
           S+EQM SH
Sbjct: 441 STEQMLSH 448



>XP_005257922
          Length = 1366

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SSEQMASH 9
           S+EQM SH
Sbjct: 706 STEQMLSH 713



>XP_005257921
          Length = 1370

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SSEQMASH 9
           S+EQM SH
Sbjct: 710 STEQMLSH 717



>XP_006722263
          Length = 1390

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SSEQMASH 9
           S+EQM SH
Sbjct: 700 STEQMLSH 707



>XP_005257920
          Length = 1390

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SSEQMASH 9
           S+EQM SH
Sbjct: 700 STEQMLSH 707



>NP_055054
          Length = 351

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  RSSEQMA 7
          RSSE+MA
Sbjct: 29 RSSEEMA 35



>NP_005742
          Length = 3907

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    RSSEQMASH 9
            R  EQ+A+H
Sbjct: 2109 REVEQLANH 2117



>NP_671714
          Length = 3899

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    RSSEQMASH 9
            R  EQ+A+H
Sbjct: 2109 REVEQLANH 2117



>NP_001002836
          Length = 382

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  EQMASH 9
          +QMASH
Sbjct: 18 QQMASH 23



>NP_001230126
          Length = 73

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  RSSEQMASH 9
          RSS   ASH
Sbjct: 6  RSSRSTASH 14



>XP_006724643
          Length = 1283

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  RSSEQMASH 9
          RSS   ASH
Sbjct: 6  RSSRSTASH 14



>XP_006723482
          Length = 395

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  RSSEQMASH 9
          RSS ++A H
Sbjct: 46 RSSSKLAQH 54



>XP_005259380
          Length = 566

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RSSEQMASH 9
           RSS ++A H
Sbjct: 217 RSSSKLAQH 225



>XP_005259381
          Length = 566

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RSSEQMASH 9
           RSS ++A H
Sbjct: 217 RSSSKLAQH 225



>XP_005259373
          Length = 664

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RSSEQMASH 9
           RSS ++A H
Sbjct: 315 RSSSKLAQH 323



>XP_006723481
          Length = 712

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RSSEQMASH 9
           RSS ++A H
Sbjct: 363 RSSSKLAQH 371



>XP_006723480
          Length = 748

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RSSEQMASH 9
           RSS ++A H
Sbjct: 399 RSSSKLAQH 407



>XP_006715890
          Length = 3860

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    RSSEQMASH 9
            R  EQ+A+H
Sbjct: 2062 REVEQLANH 2070



>XP_005250160
          Length = 3939

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    RSSEQMASH 9
            R  EQ+A+H
Sbjct: 2141 REVEQLANH 2149



>XP_005250159
          Length = 3952

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    RSSEQMASH 9
            R  EQ+A+H
Sbjct: 2154 REVEQLANH 2162



>NP_055890
          Length = 949

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  RSSEQMASH 9
          RSS   ASH
Sbjct: 6  RSSRSTASH 14



>NP_115799
          Length = 628

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RSSEQMASH 9
           RSS ++A H
Sbjct: 279 RSSSKLAQH 287



  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.296   0.0958    0.229 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 354,329
Number of extensions: 491
Number of successful extensions: 27
Number of sequences better than 10000.0: 27
Number of HSP's gapped: 27
Number of HSP's successfully gapped: 27
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)