Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001013433                                                           20     509
NP_060785                                                              20     509
NP_361014                                                              20     509
NP_036432                                                              18    1482
NP_387449                                                              18    1482
NP_387448                                                              18    1482
NP_001243785                                                           18    1482
NP_378663                                                              18    1482
NP_003930                                                              18    1482
XP_005270321                                                           18    1482
XP_006718117                                                           18    1482
XP_005265916                                                           18    1482
XP_005265915                                                           18    1482
XP_005265914                                                           18    1482
XP_005265913                                                           18    1482
XP_005265912                                                           18    1482
XP_006721506                                                           17    2528
XP_005256500                                                           17    2528
XP_006721505                                                           17    2528
XP_006721504                                                           17    2528
NP_998762                                                              17    2528
NP_612433                                                              17    4312
NP_000246                                                              17    4312
XP_005251743                                                           17    4312
XP_005251742                                                           17    4312
XP_006717010                                                           17    4312
XP_005251741                                                           17    4312
XP_005251740                                                           17    4312
XP_005249200                                                           17    4312
NP_065901                                                              16    5631
XP_005259076                                                           16    5631
XP_006721302                                                           16    5631
XP_006721301                                                           16    5631
XP_005256129                                                           16    5631
XP_005256127                                                           16    5631
NP_060178                                                              16    5631
NP_004575                                                              16    7355
NP_001230153                                                           16    7355
XP_006718715                                                           16    7355
NP_775738                                                              16    7355
NP_000247                                                              15    9605
NP_002766                                                              15    9605
NP_001017975                                                           15    9605
NP_079220                                                              15    9605
NP_056234                                                              15    9605
NP_057133                                                              15    9605
NP_055671                                                              15    9605
NP_065159                                                              15    9605
XP_006725392                                                           15    9605
XP_005274542                                                           15    9605
XP_005258070                                                           15    9605
XP_005267778                                                           15    9605
XP_006718301                                                           15    9605
XP_006711754                                                           15    9605
XP_005245736                                                           15    9605
XP_005245735                                                           15    9605
XP_006711753                                                           15    9605
XP_006710458                                                           15    9605
NP_001186880                                                           15    9605
NP_079423                                                              15    9605
>NP_001013433
          Length = 589

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   RRVVSGAY 8
           RRVVSGAY
Sbjct: 394 RRVVSGAY 401
>NP_060785
          Length = 627

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   RRVVSGAY 8
           RRVVSGAY
Sbjct: 432 RRVVSGAY 439
>NP_361014
          Length = 707

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   RRVVSGAY 8
           RRVVSGAY
Sbjct: 512 RRVVSGAY 519
>NP_036432
          Length = 542

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   RRVVSGAY 8
           +R+VSGAY
Sbjct: 454 KRIVSGAY 461
>NP_387449
          Length = 508

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   RRVVSGAY 8
           +R+VSGAY
Sbjct: 420 KRIVSGAY 427
>NP_387448
          Length = 529

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   RRVVSGAY 8
           +R+VSGAY
Sbjct: 441 KRIVSGAY 448
>NP_001243785
          Length = 579

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   RRVVSGAY 8
           +R+VSGAY
Sbjct: 491 KRIVSGAY 498
>NP_378663
          Length = 605

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   RRVVSGAY 8
           +R+VSGAY
Sbjct: 517 KRIVSGAY 524
>NP_003930
          Length = 569

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   RRVVSGAY 8
           +R+VSGAY
Sbjct: 481 KRIVSGAY 488
>XP_005270321
          Length = 326

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   RRVVSGAY 8
           +R+VSGAY
Sbjct: 238 KRIVSGAY 245
>XP_006718117
          Length = 732

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   RRVVSGAY 8
           +R+VSGAY
Sbjct: 644 KRIVSGAY 651
>XP_005265916
          Length = 494

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   RRVVSGAY 8
           +R+VSGAY
Sbjct: 406 KRIVSGAY 413
>XP_005265915
          Length = 510

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   RRVVSGAY 8
           +R+VSGAY
Sbjct: 422 KRIVSGAY 429
>XP_005265914
          Length = 515

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   RRVVSGAY 8
           +R+VSGAY
Sbjct: 427 KRIVSGAY 434
>XP_005265913
          Length = 531

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   RRVVSGAY 8
           +R+VSGAY
Sbjct: 443 KRIVSGAY 450
>XP_005265912
          Length = 563

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   RRVVSGAY 8
           +R+VSGAY
Sbjct: 475 KRIVSGAY 482
>XP_006721506
          Length = 410

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RVVSGAYH 9
           ++VSG YH
Sbjct: 264 KIVSGKYH 271
>XP_005256500
          Length = 458

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RVVSGAYH 9
           ++VSG YH
Sbjct: 312 KIVSGKYH 319
>XP_006721505
          Length = 492

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RVVSGAYH 9
           ++VSG YH
Sbjct: 346 KIVSGKYH 353
>XP_006721504
          Length = 492

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RVVSGAYH 9
           ++VSG YH
Sbjct: 346 KIVSGKYH 353
>NP_998762
          Length = 492

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RVVSGAYH 9
           ++VSG YH
Sbjct: 346 KIVSGKYH 353
>NP_612433
          Length = 513

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RRVVSGAYH 9
           RR++S  YH
Sbjct: 329 RRLLSACYH 337
>NP_000246
          Length = 750

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RVVSGAY 8
           R+VSGAY
Sbjct: 581 RMVSGAY 587
>XP_005251743
          Length = 404

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RRVVSGAYH 9
           RR++S  YH
Sbjct: 202 RRLLSACYH 210
>XP_005251742
          Length = 542

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RRVVSGAYH 9
           RR++S  YH
Sbjct: 467 RRLLSACYH 475
>XP_006717010
          Length = 635

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RRVVSGAYH 9
           RR++S  YH
Sbjct: 433 RRLLSACYH 441
>XP_005251741
          Length = 651

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RRVVSGAYH 9
           RR++S  YH
Sbjct: 467 RRLLSACYH 475
>XP_005251740
          Length = 669

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RRVVSGAYH 9
           RR++S  YH
Sbjct: 467 RRLLSACYH 475
>XP_005249200
          Length = 750

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RVVSGAY 8
           R+VSGAY
Sbjct: 581 RMVSGAY 587
>NP_065901
          Length = 620

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RVVSGAY 8
           R+V+GAY
Sbjct: 473 RIVNGAY 479
>XP_005259076
          Length = 478

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RVVSGAY 8
           RV+SG+Y
Sbjct: 246 RVISGSY 252
>XP_006721302
          Length = 391

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RVVSGAY 8
           R+V+GAY
Sbjct: 244 RIVNGAY 250
>XP_006721301
          Length = 494

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RVVSGAY 8
           R+V+GAY
Sbjct: 347 RIVNGAY 353
>XP_005256129
          Length = 518

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RVVSGAY 8
           R+V+GAY
Sbjct: 371 RIVNGAY 377
>XP_005256127
          Length = 650

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RVVSGAY 8
           R+V+GAY
Sbjct: 503 RIVNGAY 509
>NP_060178
          Length = 478

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RVVSGAY 8
           RV+SG+Y
Sbjct: 246 RVISGSY 252
>NP_004575
          Length = 391

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RRVVSGAYH 9
           RRV+  +YH
Sbjct: 174 RRVILRSYH 182
>NP_001230153
          Length = 315

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RRVVSGAYH 9
           RRV+  +YH
Sbjct: 98  RRVILRSYH 106
>XP_006718715
          Length = 402

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RRVVSGAYH 9
           RRV+  +YH
Sbjct: 185 RRVILRSYH 193
>NP_775738
          Length = 390

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   VSGAYH 9
           VSGA+H
Sbjct: 265 VSGAFH 270
>NP_000247
          Length = 1274

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    RRVVSGAY 8
            RRV SG Y
Sbjct: 1036 RRVHSGTY 1043
>NP_002766
          Length = 480

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   VVSGAY 8
           V+SGAY
Sbjct: 408 VISGAY 413
>NP_001017975
          Length = 1435

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   RRVVSGAY 8
           R+VV GA+
Sbjct: 595 RKVVEGAF 602
>NP_079220
          Length = 273

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  RRVVSG 6
          RRVVSG
Sbjct: 22 RRVVSG 27
>NP_056234
          Length = 2828

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1    RRVVSGAYH 9
            R+V+ G+Y+
Sbjct: 1762 RKVIPGSYN 1770
>NP_057133
          Length = 208

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  VVSGAYH 9
          VV+G YH
Sbjct: 77 VVAGYYH 83
>NP_055671
          Length = 1496

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    RRVVSGAY 8
            RRV SGA+
Sbjct: 1257 RRVESGAW 1264
>NP_065159
          Length = 148

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RRVVSGA 7
           +R+VSGA
Sbjct: 114 KRIVSGA 120
>XP_006725392
          Length = 148

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RRVVSGA 7
           +R+VSGA
Sbjct: 114 KRIVSGA 120
>XP_005274542
          Length = 2853

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1    RRVVSGAYH 9
            R+V+ G+Y+
Sbjct: 1787 RKVIPGSYN 1795
>XP_005258070
          Length = 148

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RRVVSGA 7
           +R+VSGA
Sbjct: 114 KRIVSGA 120
>XP_005267778
          Length = 208

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  VVSGAYH 9
          VV+G YH
Sbjct: 77 VVAGYYH 83
>XP_006718301
          Length = 1268

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    RRVVSGAY 8
            RRV SG Y
Sbjct: 1030 RRVHSGTY 1037
>XP_006711754
          Length = 1164

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RRVVSGAY 8
           RRV SGA+
Sbjct: 925 RRVESGAW 932
>XP_005245736
          Length = 1496

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    RRVVSGAY 8
            RRV SGA+
Sbjct: 1257 RRVESGAW 1264
>XP_005245735
          Length = 1507

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    RRVVSGAY 8
            RRV SGA+
Sbjct: 1268 RRVESGAW 1275
>XP_006711753
          Length = 1521

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    RRVVSGAY 8
            RRV SGA+
Sbjct: 1282 RRVESGAW 1289
>XP_006710458
          Length = 846

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  RRVVSGAY 8
          R+VV GA+
Sbjct: 6  RKVVEGAF 13
>NP_001186880
          Length = 148

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RRVVSGA 7
           +R+VSGA
Sbjct: 114 KRIVSGA 120
>NP_079423
          Length = 238

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  RRVVSG 6
          RRVVSG
Sbjct: 11 RRVVSG 16
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.329    0.137    0.420 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 488,809
Number of extensions: 715
Number of successful extensions: 60
Number of sequences better than 10000.0: 60
Number of HSP's gapped: 60
Number of HSP's successfully gapped: 60
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

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