Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001191121                                                           20     299
NP_001119713                                                           20     299
NP_001191117                                                           20     299
NP_001119712                                                           20     299
NP_001119714                                                           20     299
NP_005418                                                              20     299
NP_001191116                                                           20     299
NP_001191115                                                           20     299
NP_001191119                                                           20     299
NP_001191113                                                           20     299
NP_001191118                                                           20     299
NP_001191120                                                           20     299
NP_001191114                                                           20     299
NP_000537                                                              20     390
NP_001263689                                                           20     390
NP_001119584                                                           20     390
NP_001119586                                                           20     390
NP_001263625                                                           20     390
NP_001119590                                                           20     390
NP_001263690                                                           20     390
NP_001119585                                                           20     390
NP_001263624                                                           20     390
NP_001119588                                                           20     390
NP_001119587                                                           20     390
NP_001119589                                                           20     390
NP_001263627                                                           20     390
NP_001263628                                                           20     390
NP_001263626                                                           20     390
NP_001239553                                                           16    5631
NP_000443                                                              16    5631
NP_055690                                                              16    5631
NP_001106272                                                           16    5631
NP_001106271                                                           16    5631
NP_066920                                                              16    5631
NP_060043                                                              16    5631
XP_006722836                                                           16    5631
XP_006722835                                                           16    5631
XP_005259642                                                           16    5631
XP_006722834                                                           16    5631
XP_005259640                                                           16    5631
XP_006712149                                                           16    5631
XP_005264571                                                           16    5631
XP_005264570                                                           16    5631
XP_006712148                                                           16    5631
XP_006712147                                                           16    5631
XP_006712146                                                           16    5631
XP_006712145                                                           16    5631
XP_006712144                                                           16    5631
XP_006712143                                                           16    5631
XP_005264569                                                           16    5631
NP_001106273                                                           16    5631
NP_001124335                                                           16    7355
NP_006200                                                              16    7355
NP_001035181                                                           16    7355
NP_001077054                                                           16    7355
NP_004694                                                              16    7355
XP_006716650                                                           16    7355
XP_006716649                                                           16    7355
XP_006716648                                                           16    7355
XP_006716647                                                           16    7355
NP_056493                                                              15    9605
NP_006763                                                              15    9605
NP_003096                                                              15    9605
XP_006719869                                                           15    9605
XP_006719868                                                           15    9605
XP_005266409                                                           15    9605
XP_005266408                                                           15    9605
XP_005266407                                                           15    9605
XP_005266403                                                           15    9605
XP_006719867                                                           15    9605
XP_006719866                                                           15    9605
XP_005266405                                                           15    9605
XP_005266404                                                           15    9605
>NP_001191121
          Length = 565

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   RRSVVVPYE 9
           R+SVVVPYE
Sbjct: 162 RQSVVVPYE 170
>NP_001119713
          Length = 450

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   RRSVVVPYE 9
           R+SVVVPYE
Sbjct: 184 RQSVVVPYE 192
>NP_001191117
          Length = 540

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   RRSVVVPYE 9
           R+SVVVPYE
Sbjct: 233 RQSVVVPYE 241
>NP_001119712
          Length = 587

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   RRSVVVPYE 9
           R+SVVVPYE
Sbjct: 184 RQSVVVPYE 192
>NP_001119714
          Length = 426

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   RRSVVVPYE 9
           R+SVVVPYE
Sbjct: 184 RQSVVVPYE 192
>NP_005418
          Length = 636

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   RRSVVVPYE 9
           R+SVVVPYE
Sbjct: 233 RQSVVVPYE 241
>NP_001191116
          Length = 555

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   RRSVVVPYE 9
           R+SVVVPYE
Sbjct: 233 RQSVVVPYE 241
>NP_001191115
          Length = 403

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   RRSVVVPYE 9
           R+SVVVPYE
Sbjct: 233 RQSVVVPYE 241
>NP_001191119
          Length = 506

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   RRSVVVPYE 9
           R+SVVVPYE
Sbjct: 184 RQSVVVPYE 192
>NP_001191113
          Length = 499

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   RRSVVVPYE 9
           R+SVVVPYE
Sbjct: 233 RQSVVVPYE 241
>NP_001191118
          Length = 354

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   RRSVVVPYE 9
           R+SVVVPYE
Sbjct: 184 RQSVVVPYE 192
>NP_001191120
          Length = 491

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   RRSVVVPYE 9
           R+SVVVPYE
Sbjct: 184 RQSVVVPYE 192
>NP_001191114
          Length = 475

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   RRSVVVPYE 9
           R+SVVVPYE
Sbjct: 233 RQSVVVPYE 241
>NP_000537
          Length = 393

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RRSVVVPYE 9
           R SVVVPYE
Sbjct: 213 RHSVVVPYE 221
>NP_001263689
          Length = 354

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RRSVVVPYE 9
           R SVVVPYE
Sbjct: 174 RHSVVVPYE 182
>NP_001119584
          Length = 393

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RRSVVVPYE 9
           R SVVVPYE
Sbjct: 213 RHSVVVPYE 221
>NP_001119586
          Length = 341

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RRSVVVPYE 9
           R SVVVPYE
Sbjct: 213 RHSVVVPYE 221
>NP_001263625
          Length = 302

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RRSVVVPYE 9
           R SVVVPYE
Sbjct: 174 RHSVVVPYE 182
>NP_001119590
          Length = 354

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RRSVVVPYE 9
           R SVVVPYE
Sbjct: 174 RHSVVVPYE 182
>NP_001263690
          Length = 354

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RRSVVVPYE 9
           R SVVVPYE
Sbjct: 174 RHSVVVPYE 182
>NP_001119585
          Length = 346

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RRSVVVPYE 9
           R SVVVPYE
Sbjct: 213 RHSVVVPYE 221
>NP_001263624
          Length = 307

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RRSVVVPYE 9
           R SVVVPYE
Sbjct: 174 RHSVVVPYE 182
>NP_001119588
          Length = 209

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  RRSVVVPYE 9
          R SVVVPYE
Sbjct: 81 RHSVVVPYE 89
>NP_001119587
          Length = 261

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  RRSVVVPYE 9
          R SVVVPYE
Sbjct: 81 RHSVVVPYE 89
>NP_001119589
          Length = 214

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  RRSVVVPYE 9
          R SVVVPYE
Sbjct: 81 RHSVVVPYE 89
>NP_001263627
          Length = 182

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  RRSVVVPYE 9
          R SVVVPYE
Sbjct: 54 RHSVVVPYE 62
>NP_001263628
          Length = 187

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  RRSVVVPYE 9
          R SVVVPYE
Sbjct: 54 RHSVVVPYE 62
>NP_001263626
          Length = 234

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  RRSVVVPYE 9
          R SVVVPYE
Sbjct: 54 RHSVVVPYE 62
>NP_001239553
          Length = 965

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RRSVVVPYE 9
           R +V+VPY+
Sbjct: 567 RGNVIVPYK 575
>NP_000443
          Length = 348

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   SVVVPYE 9
           S+V+PY+
Sbjct: 157 SIVIPYD 163
>NP_055690
          Length = 1648

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   RRSVVVPY 8
           +RSV +PY
Sbjct: 646 QRSVFIPY 653
>NP_001106272
          Length = 960

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RRSVVVPYE 9
           R +V+VPY+
Sbjct: 567 RGNVIVPYK 575
>NP_001106271
          Length = 968

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RRSVVVPYE 9
           R +V+VPY+
Sbjct: 567 RGNVIVPYK 575
>NP_066920
          Length = 973

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RRSVVVPYE 9
           R +V+VPY+
Sbjct: 567 RGNVIVPYK 575
>NP_060043
          Length = 755

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RRSVVVP 7
           +RSVVVP
Sbjct: 112 KRSVVVP 118
>XP_006722836
          Length = 510

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RRSVVVP 7
           +RSVVVP
Sbjct: 112 KRSVVVP 118
>XP_006722835
          Length = 566

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RRSVVVP 7
           +RSVVVP
Sbjct: 112 KRSVVVP 118
>XP_005259642
          Length = 617

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RRSVVVP 7
           +RSVVVP
Sbjct: 112 KRSVVVP 118
>XP_006722834
          Length = 697

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RRSVVVP 7
           +RSVVVP
Sbjct: 112 KRSVVVP 118
>XP_005259640
          Length = 746

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RRSVVVP 7
           +RSVVVP
Sbjct: 112 KRSVVVP 118
>XP_006712149
          Length = 649

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RRSVVVPYE 9
           R +V+VPY+
Sbjct: 597 RGNVIVPYK 605
>XP_005264571
          Length = 937

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RRSVVVPYE 9
           R +V+VPY+
Sbjct: 567 RGNVIVPYK 575
>XP_005264570
          Length = 967

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RRSVVVPYE 9
           R +V+VPY+
Sbjct: 597 RGNVIVPYK 605
>XP_006712148
          Length = 973

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RRSVVVPYE 9
           R +V+VPY+
Sbjct: 567 RGNVIVPYK 575
>XP_006712147
          Length = 973

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RRSVVVPYE 9
           R +V+VPY+
Sbjct: 567 RGNVIVPYK 575
>XP_006712146
          Length = 973

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RRSVVVPYE 9
           R +V+VPY+
Sbjct: 567 RGNVIVPYK 575
>XP_006712145
          Length = 973

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RRSVVVPYE 9
           R +V+VPY+
Sbjct: 567 RGNVIVPYK 575
>XP_006712144
          Length = 973

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RRSVVVPYE 9
           R +V+VPY+
Sbjct: 567 RGNVIVPYK 575
>XP_006712143
          Length = 996

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RRSVVVPYE 9
           R +V+VPY+
Sbjct: 590 RGNVIVPYK 598
>XP_005264569
          Length = 1003

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RRSVVVPYE 9
           R +V+VPY+
Sbjct: 597 RGNVIVPYK 605
>NP_001106273
          Length = 937

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RRSVVVPYE 9
           R +V+VPY+
Sbjct: 567 RGNVIVPYK 575
>NP_001124335
          Length = 888

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   SVVVPYE 9
           SVV+P+E
Sbjct: 277 SVVIPHE 283
>NP_006200
          Length = 915

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   SVVVPYE 9
           SVV+P+E
Sbjct: 277 SVVIPHE 283
>NP_001035181
          Length = 863

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   SVVVPYE 9
           SVV+P+E
Sbjct: 277 SVVIPHE 283
>NP_001077054
          Length = 829

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RSVVVPYE 9
           RSVV+P E
Sbjct: 185 RSVVMPME 192
>NP_004694
          Length = 862

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RSVVVPYE 9
           RSVV+P E
Sbjct: 185 RSVVMPME 192
>XP_006716650
          Length = 911

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   SVVVPYE 9
           SVV+P+E
Sbjct: 277 SVVIPHE 283
>XP_006716649
          Length = 936

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   SVVVPYE 9
           SVV+P+E
Sbjct: 273 SVVIPHE 279
>XP_006716648
          Length = 936

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   SVVVPYE 9
           SVV+P+E
Sbjct: 277 SVVIPHE 283
>XP_006716647
          Length = 940

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   SVVVPYE 9
           SVV+P+E
Sbjct: 277 SVVIPHE 283
>NP_056493
          Length = 2946

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    RSVVVP 7
            RSVVVP
Sbjct: 1789 RSVVVP 1794
>NP_006763
          Length = 1343

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  RRSVVVPYE 9
          RR+V VP E
Sbjct: 83 RRTVSVPVE 91
>NP_003096
          Length = 2214

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    VVVPYE 9
            VVVPY+
Sbjct: 1911 VVVPYQ 1916
>XP_006719869
          Length = 2943

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    RSVVVP 7
            RSVVVP
Sbjct: 1786 RSVVVP 1791
>XP_006719868
          Length = 2938

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    RSVVVP 7
            RSVVVP
Sbjct: 1786 RSVVVP 1791
>XP_005266409
          Length = 1430

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   RSVVVP 7
           RSVVVP
Sbjct: 252 RSVVVP 257
>XP_005266408
          Length = 1934

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    RSVVVP 7
            RSVVVP
Sbjct: 1789 RSVVVP 1794
>XP_005266407
          Length = 2641

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    RSVVVP 7
            RSVVVP
Sbjct: 1463 RSVVVP 1468
>XP_005266403
          Length = 2941

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    RSVVVP 7
            RSVVVP
Sbjct: 1789 RSVVVP 1794
>XP_006719867
          Length = 2961

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    RSVVVP 7
            RSVVVP
Sbjct: 1789 RSVVVP 1794
>XP_006719866
          Length = 2962

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    RSVVVP 7
            RSVVVP
Sbjct: 1789 RSVVVP 1794
>XP_005266405
          Length = 2964

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    RSVVVP 7
            RSVVVP
Sbjct: 1786 RSVVVP 1791
>XP_005266404
          Length = 2967

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    RSVVVP 7
            RSVVVP
Sbjct: 1789 RSVVVP 1794
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.323    0.138    0.392 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 567,105
Number of extensions: 751
Number of successful extensions: 73
Number of sequences better than 10000.0: 73
Number of HSP's gapped: 73
Number of HSP's successfully gapped: 73
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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