Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005350                                                              20     299
NP_060193                                                              18    1135
NP_055118                                                              17    2528
NP_001230154                                                           17    2528
XP_006724236                                                           17    2528
NP_060718                                                              17    3301
NP_006209                                                              17    4312
NP_001240813                                                           17    4312
NP_689624                                                              17    4312
NP_079420                                                              17    4312
NP_001095876                                                           17    4312
XP_005263305                                                           17    4312
XP_005263304                                                           17    4312
XP_006714389                                                           17    4312
XP_005263303                                                           17    4312
XP_005263302                                                           17    4312
XP_006713721                                                           17    4312
NP_001119580                                                           16    5631
NP_000330                                                              16    5631
NP_001119579                                                           16    5631
NP_054828                                                              16    5631
XP_005256176                                                           16    5631
NP_683762                                                              16    5631
NP_001265571                                                           16    7355
NP_055844                                                              16    7355
NP_001138508                                                           16    7355
NP_031383                                                              16    7355
NP_001139332                                                           16    7355
NP_061907                                                              16    7355
NP_005702                                                              16    7355
NP_001005205                                                           16    7355
NP_001166245                                                           16    7355
XP_006723108                                                           16    7355
XP_005258618                                                           16    7355
XP_005273481                                                           16    7355
NP_997208                                                              16    7355
NP_001139333                                                           16    7355
NP_001027006                                                           16    7355
NP_871001                                                              16    7355
NP_001004064                                                           16    7355
NP_060668                                                              15    9605
NP_005852                                                              15    9605
NP_001004063                                                           15    9605
NP_056207                                                              15    9605
NP_000439                                                              15    9605
NP_078788                                                              15    9605
NP_997223                                                              15    9605
NP_000951                                                              15    9605
NP_001073918                                                           15    9605
XP_005259152                                                           15    9605
XP_005259150                                                           15    9605
XP_005273931                                                           15    9605
XP_005273930                                                           15    9605
XP_005253098                                                           15    9605
XP_006717743                                                           15    9605
NP_001005275                                                           15    9605
>NP_005350
          Length = 552

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   RRLCILRM 8
           RRLCILRM
Sbjct: 496 RRLCILRM 503
>NP_060193
          Length = 423

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  RRLCILRMR 9
          RR+C+LR R
Sbjct: 34 RRVCVLRKR 42
>NP_055118
          Length = 588

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  RRLCILR 7
          RRLCIL+
Sbjct: 35 RRLCILK 41
>NP_001230154
          Length = 583

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  RRLCILR 7
          RRLCIL+
Sbjct: 35 RRLCILK 41
>XP_006724236
          Length = 587

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  RRLCILR 7
          RRLCIL+
Sbjct: 35 RRLCILK 41
>NP_060718
          Length = 605

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RLCILRM 8
           RLCILR+
Sbjct: 512 RLCILRV 518
>NP_006209
          Length = 1068

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  RRLCILRM 8
          RRLC LR+
Sbjct: 87 RRLCDLRL 94
>NP_001240813
          Length = 1166

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   RLCILR 7
           RLCILR
Sbjct: 795 RLCILR 800
>NP_689624
          Length = 782

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RRLCILR 7
           R+LC+LR
Sbjct: 251 RKLCLLR 257
>NP_079420
          Length = 1244

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   RLCILR 7
           RLCILR
Sbjct: 873 RLCILR 878
>NP_001095876
          Length = 1244

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   RLCILR 7
           RLCILR
Sbjct: 873 RLCILR 878
>XP_005263305
          Length = 1167

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   RLCILR 7
           RLCILR
Sbjct: 795 RLCILR 800
>XP_005263304
          Length = 1167

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   RLCILR 7
           RLCILR
Sbjct: 795 RLCILR 800
>XP_006714389
          Length = 1225

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   RLCILR 7
           RLCILR
Sbjct: 853 RLCILR 858
>XP_005263303
          Length = 1245

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   RLCILR 7
           RLCILR
Sbjct: 873 RLCILR 878
>XP_005263302
          Length = 1245

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   RLCILR 7
           RLCILR
Sbjct: 873 RLCILR 878
>XP_006713721
          Length = 1068

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  RRLCILRM 8
          RRLC LR+
Sbjct: 87 RRLCDLRL 94
>NP_001119580
          Length = 1021

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   LCILRMR 9
           +C++RMR
Sbjct: 771 VCVMRMR 777
>NP_000330
          Length = 1030

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   LCILRMR 9
           +C++RMR
Sbjct: 771 VCVMRMR 777
>NP_001119579
          Length = 1029

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   LCILRMR 9
           +C++RMR
Sbjct: 770 VCVMRMR 776
>NP_054828
          Length = 1390

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1    RRLCILRM 8
            + +C+LRM
Sbjct: 1289 KEMCVLRM 1296
>XP_005256176
          Length = 1020

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   LCILRMR 9
           +C++RMR
Sbjct: 770 VCVMRMR 776
>NP_683762
          Length = 278

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2  RLCILRMR 9
          ++C+LR+R
Sbjct: 28 KVCVLRVR 35
>NP_001265571
          Length = 470

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   RRLCILRM 8
           RR C LRM
Sbjct: 292 RRHCTLRM 299
>NP_055844
          Length = 1024

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   LCILRMR 9
           LC+LR R
Sbjct: 803 LCVLRSR 809
>NP_001138508
          Length = 737

 Score = 15.8 bits (29), Expect =  7355
 Identities = 3/8 (37%), Positives = 8/8 (100%)

Query: 1   RRLCILRM 8
           +++C+LR+
Sbjct: 126 KKMCVLRL 133
>NP_031383
          Length = 738

 Score = 15.8 bits (29), Expect =  7355
 Identities = 3/8 (37%), Positives = 8/8 (100%)

Query: 1   RRLCILRM 8
           +++C+LR+
Sbjct: 126 KKMCVLRL 133
>NP_001139332
          Length = 1024

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   LCILRMR 9
           LC+LR R
Sbjct: 803 LCVLRSR 809
>NP_061907
          Length = 211

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   RRLCIL 6
           RRLC+L
Sbjct: 205 RRLCLL 210
>NP_005702
          Length = 480

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   RRLCILRM 8
           RR C LRM
Sbjct: 302 RRHCTLRM 309
>NP_001005205
          Length = 316

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   RRLCIL 6
           RRLC+L
Sbjct: 138 RRLCLL 143
>NP_001166245
          Length = 716

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   RRLCILR 7
           +R+CI+R
Sbjct: 518 KRICIMR 524
>XP_006723108
          Length = 520

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   RRLCILR 7
           +R+CI+R
Sbjct: 322 KRICIMR 328
>XP_005258618
          Length = 682

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   RRLCILR 7
           +R+CI+R
Sbjct: 484 KRICIMR 490
>XP_005273481
          Length = 726

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   RLCILRM 8
           RLC L+M
Sbjct: 544 RLCFLKM 550
>NP_997208
          Length = 716

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   RRLCILR 7
           +R+CI+R
Sbjct: 518 KRICIMR 524
>NP_001139333
          Length = 1024

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   LCILRMR 9
           LC+LR R
Sbjct: 803 LCVLRSR 809
>NP_001027006
          Length = 1149

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   RLCILRM 8
           RLC L+M
Sbjct: 544 RLCFLKM 550
>NP_871001
          Length = 374

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   RLCILR 7
           RLC+LR
Sbjct: 189 RLCLLR 194
>NP_001004064
          Length = 315

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   RRLCIL 6
           RRLC+L
Sbjct: 138 RRLCLL 143
>NP_060668
          Length = 559

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  RRLCIL 6
          RRLC+L
Sbjct: 35 RRLCML 40
>NP_005852
          Length = 303

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  RRLCILRMR 9
          R LC L+M+
Sbjct: 66 RALCYLKMQ 74
>NP_001004063
          Length = 311

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   RRLCIL 6
           RRLC++
Sbjct: 138 RRLCVI 143
>NP_056207
          Length = 325

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  LCILRMR 9
          LC+ RMR
Sbjct: 77 LCVPRMR 83
>NP_000439
          Length = 1043

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   RLCILR 7
           R+CILR
Sbjct: 314 RVCILR 319
>NP_078788
          Length = 371

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   LCILRM 8
           +C+LRM
Sbjct: 231 ICVLRM 236
>NP_997223
          Length = 284

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   RLCILR 7
           R+CILR
Sbjct: 114 RVCILR 119
>NP_000951
          Length = 386

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   CILRMR 9
           C LRMR
Sbjct: 170 CFLRMR 175
>NP_001073918
          Length = 1060

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  RRLCILR 7
          + LCILR
Sbjct: 77 KELCILR 83
>XP_005259152
          Length = 257

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   CILRMR 9
           C LRMR
Sbjct: 170 CFLRMR 175
>XP_005259150
          Length = 342

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   CILRMR 9
           C LRMR
Sbjct: 170 CFLRMR 175
>XP_005273931
          Length = 202

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   RLCILR 7
           R+CILR
Sbjct: 114 RVCILR 119
>XP_005273930
          Length = 202

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   RLCILR 7
           R+CILR
Sbjct: 114 RVCILR 119
>XP_005253098
          Length = 1043

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   RLCILR 7
           R+CILR
Sbjct: 314 RVCILR 319
>XP_006717743
          Length = 1090

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   RRLCILR 7
           + LCILR
Sbjct: 107 KELCILR 113
>NP_001005275
          Length = 344

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   RRLCILRM 8
           RR+C+L +
Sbjct: 166 RRVCVLML 173
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.366    0.161    0.546 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 588,684
Number of extensions: 857
Number of successful extensions: 56
Number of sequences better than 10000.0: 56
Number of HSP's gapped: 56
Number of HSP's successfully gapped: 56
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 14 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (17.4 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package