Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001245210                                                           22     134
NP_000242                                                              22     134
XP_005264389                                                           22     134
NP_060988                                                              18    1135
NP_877428                                                              18    1135
NP_997400                                                              17    3301
NP_001277189                                                           17    3301
NP_055968                                                              17    3301
NP_001245344                                                           17    3301
NP_079488                                                              17    3301
NP_149989                                                              17    3301
NP_001277188                                                           17    3301
NP_065860                                                              17    3301
NP_001245347                                                           17    3301
NP_001245346                                                           17    3301
NP_001245345                                                           17    3301
XP_005272494                                                           17    3301
XP_005272493                                                           17    3301
XP_005272492                                                           17    3301
XP_006718956                                                           17    3301
XP_005248759                                                           17    3301
XP_006715489                                                           17    3301
XP_005248758                                                           17    3301
NP_001077086                                                           17    4312
NP_055596                                                              17    4312
XP_006716555                                                           17    4312
XP_006716554                                                           17    4312
XP_006715881                                                           17    4312
NP_002499                                                              16    5631
NP_683692                                                              16    5631
XP_005248208                                                           16    5631
XP_005248207                                                           16    5631
XP_006714021                                                           16    5631
XP_006711834                                                           16    5631
NP_057427                                                              16    7355
NP_001193976                                                           16    7355
NP_647537                                                              16    7355
NP_647538                                                              16    7355
NP_001265516                                                           16    7355
XP_005260918                                                           16    7355
XP_005260917                                                           16    7355
NP_001195                                                              15    9605
NP_001129334                                                           15    9605
NP_612424                                                              15    9605
NP_001229379                                                           15    9605
NP_001269880                                                           15    9605
NP_001271225                                                           15    9605
XP_005276807                                                           15    9605
XP_006724185                                                           15    9605
XP_006722001                                                           15    9605
XP_006722000                                                           15    9605
XP_006721999                                                           15    9605
XP_006721998                                                           15    9605
XP_006721997                                                           15    9605
XP_006721996                                                           15    9605
XP_006721995                                                           15    9605
XP_005246759                                                           15    9605
NP_057423                                                              15    9605
NP_065726                                                              15    9605
>NP_001245210
          Length = 868

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RQTANLQDC 9
           RQ ANLQDC
Sbjct: 330 RQAANLQDC 338
>NP_000242
          Length = 934

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RQTANLQDC 9
           RQ ANLQDC
Sbjct: 396 RQAANLQDC 404
>XP_005264389
          Length = 921

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RQTANLQDC 9
           RQ ANLQDC
Sbjct: 396 RQAANLQDC 404
>NP_060988
          Length = 874

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   QTANLQDC 9
           QT NL+DC
Sbjct: 401 QTVNLRDC 408
>NP_877428
          Length = 875

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   QTANLQDC 9
           QT NL+DC
Sbjct: 402 QTVNLRDC 409
>NP_997400
          Length = 1691

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   QTANLQDC 9
           QT NL DC
Sbjct: 472 QTCNLFDC 479
>NP_001277189
          Length = 736

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   QTANLQD 8
           +TANLQD
Sbjct: 463 ETANLQD 469
>NP_055968
          Length = 2039

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   QTANLQD 8
           +TANLQD
Sbjct: 463 ETANLQD 469
>NP_001245344
          Length = 1168

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RQTANLQDC 9
           RQ+AN++ C
Sbjct: 376 RQSANVKSC 384
>NP_079488
          Length = 367

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   QTANLQDC 9
           Q ANL DC
Sbjct: 273 QIANLADC 280
>NP_149989
          Length = 550

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RQTANLQDC 9
           RQTA+  DC
Sbjct: 394 RQTASALDC 402
>NP_001277188
          Length = 1951

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   QTANLQD 8
           +TANLQD
Sbjct: 375 ETANLQD 381
>NP_065860
          Length = 1191

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RQTANLQDC 9
           RQ+AN++ C
Sbjct: 399 RQSANVKSC 407
>NP_001245347
          Length = 1155

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RQTANLQDC 9
           RQ+AN++ C
Sbjct: 363 RQSANVKSC 371
>NP_001245346
          Length = 1155

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RQTANLQDC 9
           RQ+AN++ C
Sbjct: 363 RQSANVKSC 371
>NP_001245345
          Length = 1165

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RQTANLQDC 9
           RQ+AN++ C
Sbjct: 373 RQSANVKSC 381
>XP_005272494
          Length = 1670

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   QTANLQDC 9
           QT NL DC
Sbjct: 472 QTCNLFDC 479
>XP_005272493
          Length = 1674

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   QTANLQDC 9
           QT NL DC
Sbjct: 472 QTCNLFDC 479
>XP_005272492
          Length = 1682

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   QTANLQDC 9
           QT NL DC
Sbjct: 472 QTCNLFDC 479
>XP_006718956
          Length = 1191

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RQTANLQDC 9
           RQ+AN++ C
Sbjct: 399 RQSANVKSC 407
>XP_005248759
          Length = 1951

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   QTANLQD 8
           +TANLQD
Sbjct: 375 ETANLQD 381
>XP_006715489
          Length = 2039

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   QTANLQD 8
           +TANLQD
Sbjct: 463 ETANLQD 469
>XP_005248758
          Length = 2039

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   QTANLQD 8
           +TANLQD
Sbjct: 463 ETANLQD 469
>NP_001077086
          Length = 1591

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   ANLQDC 9
           ANL+DC
Sbjct: 155 ANLEDC 160
>NP_055596
          Length = 1594

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   ANLQDC 9
           ANL+DC
Sbjct: 155 ANLEDC 160
>XP_006716555
          Length = 1539

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   ANLQDC 9
           ANL+DC
Sbjct: 103 ANLEDC 108
>XP_006716554
          Length = 1591

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   ANLQDC 9
           ANL+DC
Sbjct: 155 ANLEDC 160
>XP_006715881
          Length = 223

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  RQTANLQDC 9
          R+T  L+DC
Sbjct: 60 RRTVGLKDC 68
>NP_002499
          Length = 1247

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   RQTANLQDC 9
           RQT   Q+C
Sbjct: 610 RQTITFQEC 618
>NP_683692
          Length = 3051

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    RQTANLQD 8
            ++TANLQ+
Sbjct: 2921 KETANLQE 2928
>XP_005248208
          Length = 3097

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    RQTANLQD 8
            ++TANLQ+
Sbjct: 2920 KETANLQE 2927
>XP_005248207
          Length = 3098

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    RQTANLQD 8
            ++TANLQ+
Sbjct: 2921 KETANLQE 2928
>XP_006714021
          Length = 3112

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    RQTANLQD 8
            ++TANLQ+
Sbjct: 2935 KETANLQE 2942
>XP_006711834
          Length = 1156

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   RQTANLQDC 9
           RQT   Q+C
Sbjct: 610 RQTITFQEC 618
>NP_057427
          Length = 3114

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    QTANLQD 8
            +T+NLQD
Sbjct: 1246 ETSNLQD 1252
>NP_001193976
          Length = 1156

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3   TANLQDC 9
           TAN  DC
Sbjct: 598 TANTNDC 604
>NP_647537
          Length = 1429

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3   TANLQDC 9
           TAN  DC
Sbjct: 714 TANTNDC 720
>NP_647538
          Length = 1272

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3   TANLQDC 9
           TAN  DC
Sbjct: 714 TANTNDC 720
>NP_001265516
          Length = 296

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  QTANLQDC 9
          QT+ L+DC
Sbjct: 38 QTSLLEDC 45
>XP_005260918
          Length = 1111

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3   TANLQDC 9
           TAN  DC
Sbjct: 714 TANTNDC 720
>XP_005260917
          Length = 1289

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3   TANLQDC 9
           TAN  DC
Sbjct: 714 TANTNDC 720
>NP_001195
          Length = 1038

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   QTANLQDC 9
           QTAN Q C
Sbjct: 725 QTANGQAC 732
>NP_001129334
          Length = 489

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RQTANLQDC 9
           ++ ANLQ C
Sbjct: 317 KRGANLQPC 325
>NP_612424
          Length = 531

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RQTANLQDC 9
           ++ ANLQ C
Sbjct: 359 KRGANLQPC 367
>NP_001229379
          Length = 477

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RQTANLQDC 9
           ++ ANLQ C
Sbjct: 305 KRGANLQPC 313
>NP_001269880
          Length = 209

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2  QTANLQDC 9
          + AN+Q+C
Sbjct: 48 ELANVQEC 55
>NP_001271225
          Length = 327

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RQTANLQDC 9
           ++ ANLQ C
Sbjct: 155 KRGANLQPC 163
>XP_005276807
          Length = 299

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   TANLQD 8
           TAN+QD
Sbjct: 175 TANIQD 180
>XP_006724185
          Length = 489

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RQTANLQDC 9
           ++ ANLQ C
Sbjct: 317 KRGANLQPC 325
>XP_006722001
          Length = 392

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RQTANLQ 7
           R+TANL+
Sbjct: 190 RETANLE 196
>XP_006722000
          Length = 456

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RQTANLQ 7
           R+TANL+
Sbjct: 254 RETANLE 260
>XP_006721999
          Length = 493

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RQTANLQ 7
           R+TANL+
Sbjct: 291 RETANLE 297
>XP_006721998
          Length = 493

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RQTANLQ 7
           R+TANL+
Sbjct: 291 RETANLE 297
>XP_006721997
          Length = 493

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RQTANLQ 7
           R+TANL+
Sbjct: 291 RETANLE 297
>XP_006721996
          Length = 511

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RQTANLQ 7
           R+TANL+
Sbjct: 309 RETANLE 315
>XP_006721995
          Length = 662

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RQTANLQ 7
           R+TANL+
Sbjct: 460 RETANLE 466
>XP_005246759
          Length = 299

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   TANLQD 8
           TAN+QD
Sbjct: 175 TANIQD 180
>NP_057423
          Length = 456

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RQTANLQ 7
           R+TANL+
Sbjct: 254 RETANLE 260
>NP_065726
          Length = 224

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   TANLQD 8
           TAN+QD
Sbjct: 100 TANIQD 105
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.321    0.124    0.388 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 460,967
Number of extensions: 625
Number of successful extensions: 59
Number of sequences better than 10000.0: 59
Number of HSP's gapped: 59
Number of HSP's successfully gapped: 59
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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