Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000537                                                              20     509
NP_001263689                                                           20     509
NP_001119584                                                           20     509
NP_001119586                                                           20     509
NP_001263625                                                           20     509
NP_001119590                                                           20     509
NP_001263690                                                           20     509
NP_001119585                                                           20     509
NP_001263624                                                           20     509
NP_001119588                                                           20     509
NP_001119587                                                           20     509
NP_001119589                                                           20     509
NP_001263627                                                           20     509
NP_001263628                                                           20     509
NP_001263626                                                           20     509
NP_612152                                                              17    2528
XP_006715715                                                           17    2528
NP_542415                                                              17    4312
NP_542416                                                              17    4312
NP_542414                                                              17    4312
NP_006255                                                              17    4312
XP_005263224                                                           17    4312
NP_001274141                                                           16    5631
NP_001269714                                                           16    5631
NP_006368                                                              16    5631
NP_060476                                                              16    5631
NP_065867                                                              16    5631
NP_001116291                                                           16    5631
NP_001269711                                                           16    5631
XP_006716779                                                           16    5631
XP_005246008                                                           16    5631
XP_005246007                                                           16    5631
NP_001157032                                                           16    7355
NP_689977                                                              16    7355
NP_653213                                                              16    7355
XP_006722450                                                           16    7355
XP_006722449                                                           16    7355
XP_006722448                                                           16    7355
XP_006722447                                                           16    7355
NP_065948                                                              15    9605
NP_114037                                                              15    9605
NP_114036                                                              15    9605
NP_061732                                                              15    9605
XP_005276805                                                           15    9605
XP_005245431                                                           15    9605
NP_114062                                                              15    9605
NP_061734                                                              15    9605
>NP_000537
          Length = 393

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   RNSFEVRV 8
           RNSFEVRV
Sbjct: 267 RNSFEVRV 274
>NP_001263689
          Length = 354

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   RNSFEVRV 8
           RNSFEVRV
Sbjct: 228 RNSFEVRV 235
>NP_001119584
          Length = 393

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   RNSFEVRV 8
           RNSFEVRV
Sbjct: 267 RNSFEVRV 274
>NP_001119586
          Length = 341

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   RNSFEVRV 8
           RNSFEVRV
Sbjct: 267 RNSFEVRV 274
>NP_001263625
          Length = 302

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   RNSFEVRV 8
           RNSFEVRV
Sbjct: 228 RNSFEVRV 235
>NP_001119590
          Length = 354

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   RNSFEVRV 8
           RNSFEVRV
Sbjct: 228 RNSFEVRV 235
>NP_001263690
          Length = 354

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   RNSFEVRV 8
           RNSFEVRV
Sbjct: 228 RNSFEVRV 235
>NP_001119585
          Length = 346

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   RNSFEVRV 8
           RNSFEVRV
Sbjct: 267 RNSFEVRV 274
>NP_001263624
          Length = 307

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   RNSFEVRV 8
           RNSFEVRV
Sbjct: 228 RNSFEVRV 235
>NP_001119588
          Length = 209

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   RNSFEVRV 8
           RNSFEVRV
Sbjct: 135 RNSFEVRV 142
>NP_001119587
          Length = 261

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   RNSFEVRV 8
           RNSFEVRV
Sbjct: 135 RNSFEVRV 142
>NP_001119589
          Length = 214

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   RNSFEVRV 8
           RNSFEVRV
Sbjct: 135 RNSFEVRV 142
>NP_001263627
          Length = 182

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   RNSFEVRV 8
           RNSFEVRV
Sbjct: 108 RNSFEVRV 115
>NP_001263628
          Length = 187

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   RNSFEVRV 8
           RNSFEVRV
Sbjct: 108 RNSFEVRV 115
>NP_001263626
          Length = 234

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   RNSFEVRV 8
           RNSFEVRV
Sbjct: 108 RNSFEVRV 115
>NP_612152
          Length = 2849

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   RNSFEVRVF 9
           RNS E RVF
Sbjct: 874 RNSSETRVF 882
>XP_006715715
          Length = 2023

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   RNSFEVRVF 9
           RNS E RVF
Sbjct: 826 RNSSETRVF 834
>NP_542415
          Length = 2294

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    NSFEVRVF 9
            N+FEV++F
Sbjct: 1307 NTFEVKLF 1314
>NP_542416
          Length = 2490

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    NSFEVRVF 9
            N+FEV++F
Sbjct: 1503 NTFEVKLF 1510
>NP_542414
          Length = 2485

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    NSFEVRVF 9
            N+FEV++F
Sbjct: 1498 NTFEVKLF 1505
>NP_006255
          Length = 2466

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    NSFEVRVF 9
            N+FEV++F
Sbjct: 1479 NTFEVKLF 1486
>XP_005263224
          Length = 2491

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    NSFEVRVF 9
            N+FEV++F
Sbjct: 1504 NTFEVKLF 1511
>NP_001274141
          Length = 929

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   RNSFEVRV 8
           RNS++VR+
Sbjct: 342 RNSYDVRL 349
>NP_001269714
          Length = 376

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   RNSFEVR 7
           RN FEVR
Sbjct: 152 RNRFEVR 158
>NP_006368
          Length = 1591

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    NSFEVRV 8
            NSF+VR+
Sbjct: 1224 NSFQVRI 1230
>NP_060476
          Length = 421

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   RNSFEVR 7
           RN FEVR
Sbjct: 152 RNRFEVR 158
>NP_065867
          Length = 1029

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   RNSFEVRV 8
           RNS++VR+
Sbjct: 442 RNSYDVRL 449
>NP_001116291
          Length = 1028

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   RNSFEVRV 8
           RNS++VR+
Sbjct: 442 RNSYDVRL 449
>NP_001269711
          Length = 307

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  RNSFEVR 7
          RN FEVR
Sbjct: 38 RNRFEVR 44
>XP_006716779
          Length = 2399

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    NSFEVRV 8
            NSF+VR+
Sbjct: 2032 NSFQVRI 2038
>XP_005246008
          Length = 984

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   RNSFEVRV 8
           RNS++VR+
Sbjct: 442 RNSYDVRL 449
>XP_005246007
          Length = 985

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   RNSFEVRV 8
           RNS++VR+
Sbjct: 442 RNSYDVRL 449
>NP_001157032
          Length = 471

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  NSFEVRVF 9
          NSF  R+F
Sbjct: 3  NSFAARIF 10
>NP_689977
          Length = 442

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  NSFEVRVF 9
          NSF  R+F
Sbjct: 3  NSFAARIF 10
>NP_653213
          Length = 2211

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    RNSFEVRV 8
            RN++EV+V
Sbjct: 1021 RNTYEVQV 1028
>XP_006722450
          Length = 1249

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  RNSFEVRV 8
          RN++EV+V
Sbjct: 52 RNTYEVQV 59
>XP_006722449
          Length = 1256

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  RNSFEVRV 8
          RN++EV+V
Sbjct: 52 RNTYEVQV 59
>XP_006722448
          Length = 1304

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  RNSFEVRV 8
          RN++EV+V
Sbjct: 52 RNTYEVQV 59
>XP_006722447
          Length = 1933

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   RNSFEVRV 8
           RN++EV+V
Sbjct: 743 RNTYEVQV 750
>NP_065948
          Length = 774

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  NSFEVRVF 9
          N F +RVF
Sbjct: 58 NKFSLRVF 65
>NP_114037
          Length = 686

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   RNSFEVRVF 9
           ++ +EVR+F
Sbjct: 244 QSEYEVRIF 252
>NP_114036
          Length = 803

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   RNSFEVRVF 9
           ++ +EVR+F
Sbjct: 244 QSEYEVRIF 252
>NP_061732
          Length = 950

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   RNSFEVRVF 9
           ++ +EVR+F
Sbjct: 244 QSEYEVRIF 252
>XP_005276805
          Length = 416

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  NSFEVRVF 9
          N F +RVF
Sbjct: 58 NKFSLRVF 65
>XP_005245431
          Length = 416

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  NSFEVRVF 9
          N F +RVF
Sbjct: 58 NKFSLRVF 65
>NP_114062
          Length = 814

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   RNSFEVRVF 9
           ++ +EVR+F
Sbjct: 244 QSEYEVRIF 252
>NP_061734
          Length = 950

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   RNSFEVRVF 9
           ++ +EVR+F
Sbjct: 244 QSEYEVRIF 252
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.340    0.146    0.412 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 409,412
Number of extensions: 638
Number of successful extensions: 47
Number of sequences better than 10000.0: 47
Number of HSP's gapped: 47
Number of HSP's successfully gapped: 47
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.5 bits)
S2: 28 (15.4 bits)

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