Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001185761                                                           18    1482
NP_071754                                                              18    1482
NP_001185763                                                           18    1482
NP_001002810                                                           18    1482
NP_055459                                                              18    1482
NP_001182189                                                           18    1482
NP_001002812                                                           18    1482
NP_001182190                                                           18    1482
XP_006711719                                                           18    1482
XP_006711717                                                           18    1482
XP_006711716                                                           18    1482
XP_006711715                                                           18    1482
XP_006711714                                                           18    1482
XP_006711713                                                           18    1482
XP_006711710                                                           18    1482
XP_006711709                                                           18    1482
NP_060719                                                              16    5631
NP_001258968                                                           16    5631
NP_001011649                                                           16    5631
NP_060066                                                              16    5631
NP_001239029                                                           16    5631
NP_001239032                                                           16    5631
NP_001239031                                                           16    5631
XP_006717248                                                           16    5631
XP_006717247                                                           16    5631
XP_006717246                                                           16    5631
XP_006717245                                                           16    5631
XP_006717244                                                           16    5631
XP_006717243                                                           16    5631
XP_006717242                                                           16    5631
NP_689879                                                              15    9605
NP_001182740                                                           15    9605
NP_689777                                                              15    9605
NP_060360                                                              15    9605
NP_060103                                                              15    9605
XP_005250858                                                           15    9605
XP_005250857                                                           15    9605
XP_006711815                                                           15    9605
NP_443175                                                              15    9605
NP_060179                                                              15    9605
>NP_001185761
          Length = 2240

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RNIELKVVV 9
           RNIELKV V
Sbjct: 113 RNIELKVEV 121
>NP_071754
          Length = 310

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RNIELKVVV 9
           RNIELKV V
Sbjct: 184 RNIELKVEV 192
>NP_001185763
          Length = 2362

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  RNIELKVVV 9
          RNIELKV V
Sbjct: 47 RNIELKVEV 55
>NP_001002810
          Length = 173

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  RNIELKVVV 9
          RNIELKV V
Sbjct: 47 RNIELKVEV 55
>NP_055459
          Length = 2346

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  RNIELKVVV 9
          RNIELKV V
Sbjct: 47 RNIELKVEV 55
>NP_001182189
          Length = 141

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  RNIELKVVV 9
          RNIELKV V
Sbjct: 15 RNIELKVEV 23
>NP_001002812
          Length = 969

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  RNIELKVVV 9
          RNIELKV V
Sbjct: 47 RNIELKVEV 55
>NP_001182190
          Length = 176

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  RNIELKVVV 9
          RNIELKV V
Sbjct: 50 RNIELKVEV 58
>XP_006711719
          Length = 2302

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RNIELKVVV 9
           RNIELKV V
Sbjct: 113 RNIELKVEV 121
>XP_006711717
          Length = 2385

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RNIELKVVV 9
           RNIELKV V
Sbjct: 113 RNIELKVEV 121
>XP_006711716
          Length = 2411

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RNIELKVVV 9
           RNIELKV V
Sbjct: 113 RNIELKVEV 121
>XP_006711715
          Length = 2428

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  RNIELKVVV 9
          RNIELKV V
Sbjct: 47 RNIELKVEV 55
>XP_006711714
          Length = 2429

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  RNIELKVVV 9
          RNIELKV V
Sbjct: 47 RNIELKVEV 55
>XP_006711713
          Length = 2432

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  RNIELKVVV 9
          RNIELKV V
Sbjct: 50 RNIELKVEV 58
>XP_006711710
          Length = 2494

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RNIELKVVV 9
           RNIELKV V
Sbjct: 113 RNIELKVEV 121
>XP_006711709
          Length = 2495

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RNIELKVVV 9
           RNIELKV V
Sbjct: 113 RNIELKVEV 121
>NP_060719
          Length = 1893

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   NIELKVVV 9
           NIELKV V
Sbjct: 103 NIELKVEV 110
>NP_001258968
          Length = 1663

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   NIELKVVV 9
           NIELKV V
Sbjct: 103 NIELKVEV 110
>NP_001011649
          Length = 1814

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   NIELKVVV 9
           NIELKV V
Sbjct: 103 NIELKVEV 110
>NP_060066
          Length = 1624

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   RNIELKVVV 9
           RNI+ KVVV
Sbjct: 368 RNIKNKVVV 376
>NP_001239029
          Length = 1637

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   RNIELKVVV 9
           RNI+ KVVV
Sbjct: 368 RNIKNKVVV 376
>NP_001239032
          Length = 1610

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   RNIELKVVV 9
           RNI+ KVVV
Sbjct: 368 RNIKNKVVV 376
>NP_001239031
          Length = 1623

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   RNIELKVVV 9
           RNI+ KVVV
Sbjct: 368 RNIKNKVVV 376
>XP_006717248
          Length = 1664

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   NIELKVVV 9
           NIELKV V
Sbjct: 103 NIELKVEV 110
>XP_006717247
          Length = 1670

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   NIELKVVV 9
           NIELKV V
Sbjct: 103 NIELKVEV 110
>XP_006717246
          Length = 1820

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   NIELKVVV 9
           NIELKV V
Sbjct: 103 NIELKVEV 110
>XP_006717245
          Length = 1861

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   NIELKVVV 9
           NIELKV V
Sbjct: 103 NIELKVEV 110
>XP_006717244
          Length = 1867

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   NIELKVVV 9
           NIELKV V
Sbjct: 103 NIELKVEV 110
>XP_006717243
          Length = 1889

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   NIELKVVV 9
           NIELKV V
Sbjct: 93  NIELKVEV 100
>XP_006717242
          Length = 1898

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   NIELKVVV 9
           NIELKV V
Sbjct: 102 NIELKVEV 109
>NP_689879
          Length = 536

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   RNIELKVV 8
           +NIE+K+V
Sbjct: 179 QNIEIKLV 186
>NP_001182740
          Length = 474

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   RNIELKVV 8
           +NIE+K+V
Sbjct: 117 QNIEIKLV 124
>NP_689777
          Length = 3997

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    RNIELKVV 8
            ++IELKVV
Sbjct: 2714 QSIELKVV 2721
>NP_060360
          Length = 4022

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    RNIELKVV 8
            ++IELKVV
Sbjct: 2739 QSIELKVV 2746
>NP_060103
          Length = 442

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   RNIELKVV 8
           +N+ELK V
Sbjct: 212 KNVELKFV 219
>XP_005250858
          Length = 4022

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    RNIELKVV 8
            ++IELKVV
Sbjct: 2739 QSIELKVV 2746
>XP_005250857
          Length = 4022

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    RNIELKVV 8
            ++IELKVV
Sbjct: 2739 QSIELKVV 2746
>XP_006711815
          Length = 536

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   RNIELKVV 8
           +NIE+K+V
Sbjct: 179 QNIEIKLV 186
>NP_443175
          Length = 425

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   RNIELKVV 8
           +N+ELK V
Sbjct: 198 KNVELKFV 205
>NP_060179
          Length = 391

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   RNIELKVV 8
           +N+ELK V
Sbjct: 163 KNVELKFV 170
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.326    0.145    0.350 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 355,005
Number of extensions: 442
Number of successful extensions: 40
Number of sequences better than 10000.0: 40
Number of HSP's gapped: 40
Number of HSP's successfully gapped: 40
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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