Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_115927                                                              18    1135
XP_006715292                                                           18    1135
XP_006726157                                                           17    2528
XP_005275612                                                           17    2528
XP_005275610                                                           17    2528
XP_006726064                                                           17    2528
XP_005275460                                                           17    2528
XP_006715157                                                           17    2528
XP_005249149                                                           17    2528
NP_002254                                                              17    2528
NP_001273700                                                           17    4312
NP_001183959                                                           17    4312
NP_115593                                                              17    4312
NP_078944                                                              17    4312
NP_942592                                                              17    4312
NP_060217                                                              17    4312
NP_065741                                                              17    4312
XP_005265730                                                           17    4312
XP_005265729                                                           17    4312
XP_005265728                                                           17    4312
XP_005265724                                                           17    4312
NP_001129673                                                           16    7355
NP_060661                                                              16    7355
NP_001129674                                                           16    7355
NP_078986                                                              16    7355
NP_056002                                                              16    7355
NP_006706                                                              16    7355
NP_001243424                                                           16    7355
NP_001243425                                                           16    7355
NP_001243423                                                           16    7355
XP_005259322                                                           16    7355
XP_005258982                                                           16    7355
XP_006720571                                                           16    7355
XP_005254441                                                           16    7355
XP_005266498                                                           16    7355
XP_006714020                                                           16    7355
XP_005248200                                                           16    7355
XP_006714019                                                           16    7355
NP_001099040                                                           16    7355
NP_001265                                                              15    9605
NP_001107593                                                           15    9605
NP_001107594                                                           15    9605
NP_005520                                                              15    9605
NP_937784                                                              15    9605
NP_001171826                                                           15    9605
NP_055922                                                              15    9605
NP_001171825                                                           15    9605
NP_612119                                                              15    9605
NP_612117                                                              15    9605
NP_001171827                                                           15    9605
NP_612116                                                              15    9605
XP_006724648                                                           15    9605
XP_005262057                                                           15    9605
XP_005262055                                                           15    9605
XP_005262056                                                           15    9605
XP_005262054                                                           15    9605
XP_005262053                                                           15    9605
XP_006718822                                                           15    9605
XP_005245920                                                           15    9605
XP_006710660                                                           15    9605
XP_006710659                                                           15    9605
XP_006710658                                                           15    9605
XP_006710657                                                           15    9605
>NP_115927
          Length = 1321

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RLSTADGLV 9
           RLSTADG V
Sbjct: 461 RLSTADGRV 469
>XP_006715292
          Length = 759

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RLSTADGLV 9
           RLSTADG V
Sbjct: 456 RLSTADGRV 464
>XP_006726157
          Length = 414

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   RLSTADGLV 9
           RLST +GLV
Sbjct: 219 RLSTQEGLV 227
>XP_005275612
          Length = 633

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   RLSTADGLV 9
           RLST +GLV
Sbjct: 178 RLSTQEGLV 186
>XP_005275610
          Length = 674

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   RLSTADGLV 9
           RLST +GLV
Sbjct: 219 RLSTQEGLV 227
>XP_006726064
          Length = 414

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   RLSTADGLV 9
           RLST +GLV
Sbjct: 219 RLSTQEGLV 227
>XP_005275460
          Length = 674

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   RLSTADGLV 9
           RLST +GLV
Sbjct: 219 RLSTQEGLV 227
>XP_006715157
          Length = 414

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   RLSTADGLV 9
           RLST +GLV
Sbjct: 219 RLSTQEGLV 227
>XP_005249149
          Length = 674

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   RLSTADGLV 9
           RLST +GLV
Sbjct: 219 RLSTQEGLV 227
>NP_002254
          Length = 673

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   RLSTADGLV 9
           RLST +GLV
Sbjct: 219 RLSTQEGLV 227
>NP_001273700
          Length = 2490

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  RLSTADG 7
          +LSTADG
Sbjct: 73 KLSTADG 79
>NP_001183959
          Length = 581

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RLSTADG 7
           +LSTADG
Sbjct: 157 KLSTADG 163
>NP_115593
          Length = 2603

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RLSTADG 7
           +LSTADG
Sbjct: 186 KLSTADG 192
>NP_078944
          Length = 627

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RLSTADG 7
           +LSTADG
Sbjct: 157 KLSTADG 163
>NP_942592
          Length = 2352

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RLSTADG 7
           +LSTADG
Sbjct: 186 KLSTADG 192
>NP_060217
          Length = 2542

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RLSTADG 7
           +LSTADG
Sbjct: 157 KLSTADG 163
>NP_065741
          Length = 2617

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RLSTADG 7
           +LSTADG
Sbjct: 157 KLSTADG 163
>XP_005265730
          Length = 1480

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RLSTADG 7
           +LSTADG
Sbjct: 186 KLSTADG 192
>XP_005265729
          Length = 1543

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RLSTADG 7
           +LSTADG
Sbjct: 186 KLSTADG 192
>XP_005265728
          Length = 2351

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RLSTADG 7
           +LSTADG
Sbjct: 186 KLSTADG 192
>XP_005265724
          Length = 2602

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RLSTADG 7
           +LSTADG
Sbjct: 186 KLSTADG 192
>NP_001129673
          Length = 205

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LSTADGLV 9
           LST++GL+
Sbjct: 158 LSTSEGLI 165
>NP_060661
          Length = 531

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  LSTADGLV 9
          LST DG+V
Sbjct: 89 LSTEDGVV 96
>NP_001129674
          Length = 135

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  LSTADGLV 9
          LST++GL+
Sbjct: 88 LSTSEGLI 95
>NP_078986
          Length = 221

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LSTADGLV 9
           LST++GL+
Sbjct: 174 LSTSEGLI 181
>NP_056002
          Length = 1132

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RLSTADGL 8
           RLS+ DGL
Sbjct: 544 RLSSIDGL 551
>NP_006706
          Length = 1040

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   RLSTADGL 8
           RLS  DGL
Sbjct: 478 RLSNTDGL 485
>NP_001243424
          Length = 1017

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   RLSTADGL 8
           RLS  DGL
Sbjct: 478 RLSNTDGL 485
>NP_001243425
          Length = 941

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   RLSTADGL 8
           RLS  DGL
Sbjct: 379 RLSNTDGL 386
>NP_001243423
          Length = 1057

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   RLSTADGL 8
           RLS  DGL
Sbjct: 478 RLSNTDGL 485
>XP_005259322
          Length = 151

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LSTADGLV 9
           LST++GL+
Sbjct: 104 LSTSEGLI 111
>XP_005258982
          Length = 201

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LSTADGLV 9
           L TADG+V
Sbjct: 122 LLTADGMV 129
>XP_006720571
          Length = 949

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   RLSTADGL 8
           RLS  DGL
Sbjct: 379 RLSNTDGL 386
>XP_005254441
          Length = 1048

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   RLSTADGL 8
           RLS  DGL
Sbjct: 478 RLSNTDGL 485
>XP_005266498
          Length = 531

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  LSTADGLV 9
          LST DG+V
Sbjct: 89 LSTEDGVV 96
>XP_006714020
          Length = 1097

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RLSTADGL 8
           RLS+ DGL
Sbjct: 509 RLSSIDGL 516
>XP_005248200
          Length = 1103

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RLSTADGL 8
           RLS+ DGL
Sbjct: 544 RLSSIDGL 551
>XP_006714019
          Length = 1104

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RLSTADGL 8
           RLS+ DGL
Sbjct: 544 RLSSIDGL 551
>NP_001099040
          Length = 375

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LSTADGLV 9
           L TADG+V
Sbjct: 296 LLTADGMV 303
>NP_001265
          Length = 476

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   RLSTADGL 8
           RLS  DGL
Sbjct: 442 RLSKGDGL 449
>NP_001107593
          Length = 476

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   RLSTADGL 8
           RLS  DGL
Sbjct: 442 RLSKGDGL 449
>NP_001107594
          Length = 476

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   RLSTADGL 8
           RLS  DGL
Sbjct: 442 RLSKGDGL 449
>NP_005520
          Length = 4391

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    RLSTADGLV 9
            R STA GL+
Sbjct: 4235 RTSTASGLL 4243
>NP_937784
          Length = 914

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   RLSTADGLV 9
           +++TA+GL+
Sbjct: 549 QMATAEGLI 557
>NP_001171826
          Length = 948

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RLSTAD 6
           RLSTAD
Sbjct: 352 RLSTAD 357
>NP_055922
          Length = 1024

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RLSTAD 6
           RLSTAD
Sbjct: 352 RLSTAD 357
>NP_001171825
          Length = 1060

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RLSTAD 6
           RLSTAD
Sbjct: 388 RLSTAD 393
>NP_612119
          Length = 197

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RLSTAD 6
           RLSTAD
Sbjct: 180 RLSTAD 185
>NP_612117
          Length = 217

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RLSTAD 6
           RLSTAD
Sbjct: 200 RLSTAD 205
>NP_001171827
          Length = 878

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RLSTAD 6
           RLSTAD
Sbjct: 352 RLSTAD 357
>NP_612116
          Length = 241

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RLSTAD 6
           RLSTAD
Sbjct: 224 RLSTAD 229
>XP_006724648
          Length = 931

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RLSTAD 6
           RLSTAD
Sbjct: 388 RLSTAD 393
>XP_005262057
          Length = 984

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RLSTAD 6
           RLSTAD
Sbjct: 388 RLSTAD 393
>XP_005262055
          Length = 1049

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RLSTAD 6
           RLSTAD
Sbjct: 352 RLSTAD 357
>XP_005262056
          Length = 1049

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RLSTAD 6
           RLSTAD
Sbjct: 352 RLSTAD 357
>XP_005262054
          Length = 1049

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RLSTAD 6
           RLSTAD
Sbjct: 352 RLSTAD 357
>XP_005262053
          Length = 1085

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RLSTAD 6
           RLSTAD
Sbjct: 388 RLSTAD 393
>XP_006718822
          Length = 476

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   RLSTADGL 8
           RLS  DGL
Sbjct: 442 RLSKGDGL 449
>XP_005245920
          Length = 4392

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    RLSTADGLV 9
            R STA GL+
Sbjct: 4236 RTSTASGLL 4244
>XP_006710660
          Length = 4397

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    RLSTADGLV 9
            R STA GL+
Sbjct: 4241 RTSTASGLL 4249
>XP_006710659
          Length = 4556

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    RLSTADGLV 9
            R STA GL+
Sbjct: 4400 RTSTASGLL 4408
>XP_006710658
          Length = 4563

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    RLSTADGLV 9
            R STA GL+
Sbjct: 4407 RTSTASGLL 4415
>XP_006710657
          Length = 4579

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    RLSTADGLV 9
            R STA GL+
Sbjct: 4423 RTSTASGLL 4431
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.318    0.134    0.349 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 469,280
Number of extensions: 481
Number of successful extensions: 63
Number of sequences better than 10000.0: 63
Number of HSP's gapped: 63
Number of HSP's successfully gapped: 63
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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